MX2012012345A - Metodo de reduccion de biopeliculas. - Google Patents
Metodo de reduccion de biopeliculas.Info
- Publication number
- MX2012012345A MX2012012345A MX2012012345A MX2012012345A MX2012012345A MX 2012012345 A MX2012012345 A MX 2012012345A MX 2012012345 A MX2012012345 A MX 2012012345A MX 2012012345 A MX2012012345 A MX 2012012345A MX 2012012345 A MX2012012345 A MX 2012012345A
- Authority
- MX
- Mexico
- Prior art keywords
- gram
- relates
- present
- bacterial
- foodstuff
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 5
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 108010062877 Bacteriocins Proteins 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000000645 desinfectant Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 abstract 1
- 208000027136 gram-positive bacterial infections Diseases 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a métodos de eliminación, reducción o prevención de biopelículas bacterianas por medio de una proteína de fusión que comprende una endolisina, una autolisina o una bacteriocina a la cual un péptido con actividad perturbadora de membrana o LPS es fusionado. Además, la presente invención se refiere a proteínas de fusión para usarse como un medicamento, en particular para el tratamiento o prevención de infecciones por bacterias Gram-negativas y/o Gram-positivas asociadas con biopelícula bacteriana, como medio de diagnóstico, desinfectante o como sustancia cosmética. La presente invención también se refiere a la remoción o reducción o prevención de contaminación por bacterias Gram-negativas y/o Gram-positivas asociadas con biopelícula bacteriana de productos alimenticios, de equipo de procesamiento de alimentos, de plantas de procesamiento de alimentos, de superficies que entran en contacto con productos alimenticios, de dispositivos médicos, de superficies en hospitales y cirugías. Además, la presente invención se refiere al uso de la proteína de fusión como un medio de diagnóstico en medicinas, alimento o alimento para animales o diagnóstico ambiental asociados con biopelícula bacteriana.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10161170 | 2010-04-27 | ||
PCT/EP2011/056657 WO2011134998A1 (en) | 2010-04-27 | 2011-04-27 | Method of reducing biofilms |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012012345A true MX2012012345A (es) | 2013-05-20 |
MX340520B MX340520B (es) | 2016-07-12 |
Family
ID=44201821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012012345A MX340520B (es) | 2010-04-27 | 2011-04-27 | Metodo de reduccion de biopeliculas. |
Country Status (16)
Country | Link |
---|---|
US (2) | US9534223B2 (es) |
EP (1) | EP2563916B1 (es) |
JP (2) | JP2013532955A (es) |
KR (1) | KR20130100062A (es) |
CN (1) | CN103119158B (es) |
AU (1) | AU2011247584B2 (es) |
BR (1) | BR112012026880B1 (es) |
CA (1) | CA2794603C (es) |
DK (1) | DK2563916T3 (es) |
EA (1) | EA037276B1 (es) |
HK (1) | HK1183687A1 (es) |
IL (1) | IL222713A (es) |
MX (1) | MX340520B (es) |
SG (1) | SG184836A1 (es) |
TW (1) | TWI527521B (es) |
WO (1) | WO2011134998A1 (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
BRPI1015203B1 (pt) | 2009-06-26 | 2021-06-01 | Lysando Ag | Proteína de fusão composta por uma endolisina e uma extensão de peptídeo anfifática, usos da mesma e composição farmacêutica que compreende a dita proteína |
KR20170024129A (ko) | 2009-06-26 | 2017-03-06 | 카톨리에케 유니버시테이트 루벤 | 항균제 |
CN102575240B (zh) * | 2009-08-24 | 2016-01-13 | 勒芬天主教大学,K.U.勒芬R&D | 新的细胞内溶素OBPgpLYS |
CN103119158B (zh) * | 2010-04-27 | 2015-04-08 | 莱桑多公司 | 减少生物膜的方法 |
EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
AU2011367262B2 (en) * | 2011-05-04 | 2016-11-03 | Micreos Human Health B.V. | A polypeptide |
BR112014023068B1 (pt) * | 2012-03-23 | 2022-03-03 | Amicrobe, Inc | Composição aquosa para prevenir, inibir ou tratar infecção e respectivo uso |
MX369056B (es) * | 2012-05-09 | 2019-10-28 | Contrafect Corp | Prevención, interrupción y tratamiento de biopelículas con lisina de bacteriófago. |
US9388400B2 (en) | 2012-06-29 | 2016-07-12 | Lysando Ag | Composition for use in mycobacteria diagnosis |
EP2679677A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria therapy |
CN102949750B (zh) * | 2012-11-15 | 2014-11-05 | 中国人民解放军第三军医大学 | 双层电纺仿生骨膜及其制备 |
DE102013106455A1 (de) * | 2013-06-20 | 2014-12-24 | Airbus Defence and Space GmbH | Verfahren zur Dekontamination von bakteriologischen Verunreinigungen |
WO2015038731A1 (en) * | 2013-09-12 | 2015-03-19 | The Johns Hopkins University | Biofilm formation to define risk for colon cancer |
WO2015070911A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
WO2015070912A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
US10329550B2 (en) | 2014-02-14 | 2019-06-25 | Lysando Ag | Antimicrobial agents |
EP3129044B1 (en) * | 2014-04-08 | 2022-09-07 | Lysando AG | Peptidoglycan hydrolase for use in the treatment of chronic bacterial infections |
BR112016030580B1 (pt) | 2014-06-26 | 2023-12-19 | The Rockefeller University | Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas |
CN107207570A (zh) * | 2014-09-01 | 2017-09-26 | 弗拉芒区生物技术研究所 | 突变csgg孔 |
WO2016130024A1 (en) * | 2015-02-13 | 2016-08-18 | Supreme Biotechnologies Limited | Endolysin expression platform |
TW201710282A (zh) * | 2015-09-04 | 2017-03-16 | 佛教慈濟醫療財團法人 | 衍生自鮑氏不動桿菌噬菌體之新穎抗菌胜肽及其用途 |
AU2017264967A1 (en) * | 2016-05-12 | 2019-01-03 | The Trustees Of The University Of Pennsylvania | Compositions and methods for inhibiting biofilm deposition and production |
CN106854247A (zh) * | 2016-12-12 | 2017-06-16 | 华南农业大学 | 一种可以裂解大肠杆菌及沙门氏菌的噬菌体裂解酶的制备方法 |
WO2018109229A1 (en) * | 2016-12-16 | 2018-06-21 | Universidade Do Minho | Novel endolysin |
EP3378485A1 (en) * | 2017-03-24 | 2018-09-26 | Nomad Bioscience GmbH | Bacteriocins for control of salmonella enterica |
SG11201909016TA (en) | 2017-04-06 | 2019-10-30 | Amicrobe Inc | Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety |
KR20200024940A (ko) | 2017-07-27 | 2020-03-09 | 로커스 아이피 컴퍼니 엘엘씨 | 의약품, 보충제 및 섭취된 물질의 생체 이용률을 향상시키기 위한 조성물 |
WO2019046577A1 (en) * | 2017-08-31 | 2019-03-07 | Syngulon Sa | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF BACTERIOCIN AND ANTIMICROBIAL PEPTIDES |
CN107723280B (zh) * | 2017-11-10 | 2019-09-17 | 扬州大学 | 波罗的海希瓦氏菌噬菌体SppYZU01及其用途 |
CN111971058A (zh) * | 2017-12-12 | 2020-11-20 | 康特拉费克特公司 | 对铜绿假单胞菌具有细菌活性的溶素及其衍生物的鉴定 |
EP3731643A4 (en) | 2017-12-26 | 2021-12-29 | Locus IP Company, LLC | Organic food preservative compositions |
CN108251330B (zh) * | 2017-12-28 | 2021-03-23 | 江苏世邦生物工程科技有限公司 | 用于治理土壤污染的复合微生物菌剂及其制备方法和应用 |
CA3085343A1 (en) | 2017-12-28 | 2019-07-04 | Locus Ip Company, Llc | Oral health composition comprising purified biosurfactants and/or their derivatives |
KR20210014673A (ko) | 2018-05-30 | 2021-02-09 | 뤼산도 아게 | 신규 항균성 단백질 |
AU2019276252A1 (en) | 2018-05-30 | 2020-11-26 | Lysando Ag | Novel antimicrobial fusion proteins |
MX2021013491A (es) * | 2019-05-08 | 2022-02-21 | Phagomed Biopharma Gmbh | Nuevas endolisinas de gardnerella y usos de las mismas. |
SG11202112387UA (en) * | 2019-05-10 | 2021-12-30 | Locus Ip Co Llc | Compositions and methods for treating biofilm-related lung conditions |
ES2895800B2 (es) * | 2019-10-10 | 2024-01-22 | Univ Alicante | USOS DE PROTEINAS VIRICAS CON ACTIVIDAD ANTIBACTERIANA FRENTE A Escherichia coli |
KR20220163970A (ko) | 2020-03-19 | 2022-12-12 | 마이크레오스 휴먼 헬스 비.브이. | 안정화된 목적 단백질 |
CN111876400B (zh) * | 2020-08-06 | 2022-05-24 | 昆明理工大学 | 一种常温裂解酶Sly和编码此酶的多核苷酸 |
CN114908077A (zh) * | 2021-02-08 | 2022-08-16 | 武汉乐斯吉生物科技有限公司 | 噬菌体裂解酶、其嵌合物及应用 |
CA3213821A1 (en) | 2021-03-19 | 2022-09-22 | Eligo Bioscience | Therapeutic use of engineered postbiotics comprising bacteriocins and/or endolysins |
WO2022195108A2 (en) | 2021-03-19 | 2022-09-22 | Eligo Bioscience | Cosmetic use of engineered postbiotics comprising bacteriocins and/or endolysins |
WO2023089544A1 (en) * | 2021-11-18 | 2023-05-25 | Sasinapas Co., Ltd. | Pharmaceutical composition comprising an endolysin or an artilysin and an anti-cancer agent |
KR102551061B1 (ko) * | 2022-05-26 | 2023-07-03 | 중앙대학교 산학협력단 | Saha를 유효성분으로 포함하는 살모넬라 속 균주에 의한 바이오필름 생성 저해용 조성물 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8816693D0 (en) | 1988-07-13 | 1988-08-17 | Agricultural & Food Res | Viral enzyme & gene |
US20020037260A1 (en) * | 1997-10-16 | 2002-03-28 | Budny John A. | Compositions for treating biofilm |
CA2661634C (en) | 2006-09-06 | 2017-03-28 | The Regents Of The University Of California | Selectively targeted antimicrobial peptides and the use thereof |
MX340736B (es) * | 2007-09-25 | 2016-07-22 | Pastoral Greenhouse Gas Res Ltd * | Vacunas y componentes de vacunas para inhibicion de celulas microbianas. |
GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
GB0905451D0 (en) * | 2009-03-31 | 2009-05-13 | Novabiotics Ltd | Biofilms |
KR20170024129A (ko) * | 2009-06-26 | 2017-03-06 | 카톨리에케 유니버시테이트 루벤 | 항균제 |
CN103119158B (zh) * | 2010-04-27 | 2015-04-08 | 莱桑多公司 | 减少生物膜的方法 |
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2011
- 2011-04-27 CN CN201180032048.5A patent/CN103119158B/zh active Active
- 2011-04-27 MX MX2012012345A patent/MX340520B/es active IP Right Grant
- 2011-04-27 BR BR112012026880-5A patent/BR112012026880B1/pt active IP Right Grant
- 2011-04-27 DK DK11718001.8T patent/DK2563916T3/en active
- 2011-04-27 JP JP2013506649A patent/JP2013532955A/ja active Pending
- 2011-04-27 KR KR1020127031100A patent/KR20130100062A/ko not_active Application Discontinuation
- 2011-04-27 WO PCT/EP2011/056657 patent/WO2011134998A1/en active Application Filing
- 2011-04-27 AU AU2011247584A patent/AU2011247584B2/en active Active
- 2011-04-27 EA EA201270774A patent/EA037276B1/ru not_active IP Right Cessation
- 2011-04-27 US US13/643,900 patent/US9534223B2/en active Active
- 2011-04-27 CA CA2794603A patent/CA2794603C/en active Active
- 2011-04-27 TW TW100114595A patent/TWI527521B/zh active
- 2011-04-27 EP EP11718001.8A patent/EP2563916B1/en active Active
- 2011-04-27 SG SG2012075933A patent/SG184836A1/en unknown
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JP2016208985A (ja) | 2016-12-15 |
CA2794603A1 (en) | 2011-11-03 |
TWI527521B (zh) | 2016-04-01 |
IL222713A (en) | 2017-08-31 |
DK2563916T3 (en) | 2015-10-05 |
MX340520B (es) | 2016-07-12 |
KR20130100062A (ko) | 2013-09-09 |
TW201204262A (en) | 2012-02-01 |
IL222713A0 (en) | 2012-12-31 |
BR112012026880A2 (pt) | 2015-09-22 |
JP2013532955A (ja) | 2013-08-22 |
AU2011247584B2 (en) | 2016-01-14 |
AU2011247584A1 (en) | 2012-10-11 |
EP2563916A1 (en) | 2013-03-06 |
WO2011134998A8 (en) | 2011-12-15 |
CN103119158B (zh) | 2015-04-08 |
EP2563916B1 (en) | 2015-07-08 |
CN103119158A (zh) | 2013-05-22 |
SG184836A1 (en) | 2012-11-29 |
EA037276B1 (ru) | 2021-03-03 |
US20130052182A1 (en) | 2013-02-28 |
EA201270774A1 (ru) | 2013-04-30 |
US10485854B2 (en) | 2019-11-26 |
WO2011134998A1 (en) | 2011-11-03 |
BR112012026880B1 (pt) | 2021-03-16 |
US9534223B2 (en) | 2017-01-03 |
HK1183687A1 (en) | 2014-01-03 |
CA2794603C (en) | 2019-05-21 |
US20170173121A1 (en) | 2017-06-22 |
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