CN114908077A - 噬菌体裂解酶、其嵌合物及应用 - Google Patents
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Abstract
本发明涉及医药生物领域，具体提供一种噬菌体裂解酶或其嵌合物在制备预防、治疗或改善痤疮或由痤疮丙酸杆菌引起的感染或与痤疮丙酸杆菌有关的病症的药物、化妆品或医疗设备中的应用，所述噬菌体裂解酶包括来源于类诺卡氏菌科(Nocardioidaceae)和丙酸杆菌科(Propionibacteriaceae)细菌的噬菌体裂解酶。本发明提供的噬菌体裂解酶或其嵌合物能够特异性、有效地杀死痤疮丙酸杆菌，同时保持其他共生细菌完整无损，可以提供一种安全有效的痤疮解决方案，适合长期使用，而不会有很高的生态失调和获得性耐药风险。
Description
本申请主张如下优先权：CN202110187030.8，申请日2021.02.08。
技术领域
本发明涉及医药生物领域，具体提供一种具有抗痤疮丙酸杆菌活性的噬菌体裂解酶、其嵌合物及应用。
背景技术
痤疮是一种皮肤炎症性疾病，尤其是在面部、颈部、肩膀、胸部、背部和上臂。毛囊皮脂腺单元由于被过度分泌的油脂堵塞及致病性痤疮丙酸杆菌(Cutibacterium acnes，简称C.acnes,下同)的增殖导致的死皮细胞积累而产生炎症。根据美国国家健康研究所的数据，11到30岁的人群中有80％都有不同程度的痤疮。痤疮通常开始于青春期，可能持续到四五十岁。不同因素可能会引起痤疮的爆发，例如压力、激素水平的变化、过敏原等。2010年的全球疾病负担研究估计，痤疮影响了全球9.4％的人口，并将其列为世界第八大最流行的疾病。据美国皮肤学会估计，在2013年痤疮患者治疗和生产力损失相关的费用超过了12亿美元。虽然它本身很少危及生命，但它会造成皮肤上持久的疤痕和患者相当大的情绪困扰。
目前治疗轻度痤疮的选择是使用含有过氧化苯甲酰、间苯二酚、水杨酸和硫等化学物质的非处方外用药物，以及处方外用药物，如抗生素、过氧化苯甲酰、壬二酸、氨苯砜、皮质类固醇和称为类视黄醇(retinoids)的维生素A衍生物。中至重度病情可采用外用处方药或口服药物治疗。干预的目的是为了去除死皮细胞和多余的油脂，以使毛囊皮脂腺单元畅通并且减少细菌负荷。由于痤疮是一种慢性疾病，需要长时间的治疗并且有时需要防止复发。然而，现有的治疗方案没有一种适合长期治疗。当延长这些药物的使用时间，即使是最温和的化学物质也会引起皮肤的过敏反应和刺激，导致皮肤干燥、起皮、龟裂等。由于耐药性痤疮丙酸杆菌在世界上越来越普遍，抗生素治疗选择也越来越局限。此外，长期使用抗生素已被证明会通过对耐药细菌种类施加选择压力而干扰微生物群的稳定状态。这转而会引发无数的并发症，例如菌群失调和免疫异常。有文献表明，在抗生素治疗过程中痤疮患者的皮肤葡萄球菌菌群会由大多数抗生素敏感转化为大多数耐药。不仅是患者本人，患者的密切接触者也会受到多药耐药性细菌的影响。值得注意的是，长期接受抗生素治疗的痤疮患者患上呼吸道感染的可能性增加两倍。因此，现在迫切需要一种更安全、更有效、更适合长期使用的治疗方案。一种这样的方案是病原体特异性抗菌药，其能够特异性杀死痤疮丙酸杆菌而不会影响其他共生菌，无需考虑抗生素耐药性。
此外，痤疮丙酸杆菌还与一系列侵袭性感染有关，包括术后肩部感染、椎间盘感染等。在此类感染中，痤疮丙酸杆菌表现出慢性进展性生物膜类感染。在生物膜中发现的细菌对抗生素具有固有耐药性。一种具有强烈抗生物膜特性的痤疮丙酸杆菌杀菌剂是治疗此类感染的理想药物。
一种此类病原体特异性抗菌药的备选药物是噬菌体细胞内溶素。噬菌体用这类酶破坏细胞壁稳定性进行裂解，从而从细胞内部释放噬菌体子代。它们被归类为肽聚糖水解酶，可以断裂细菌肽聚糖中的各种键。除了少数例外，每种裂解酶的目标细菌都属于单一的属或种。已经证明，重组的抗革兰氏阳性菌裂解酶是能够引起低渗裂解的有效杀菌剂(如抗若干种链球菌的PlyC，抗炭疽芽孢杆菌的PlyG等)。考虑到裂解酶为了持续成功感染细胞在数十亿年中受到选择性进化压力，目标肽聚糖键高度保守，不太可能被细菌轻易改变。这个特性导致目标细菌对裂解酶产生耐药性的可能很小，因此适合长期治疗使用。迄今为止还未检测出对各自的噬菌体裂解酶的细菌耐药性。通常，抗革兰氏阳性菌的裂解酶是由一个或两个N-末端催化结构域(CD)和一个C-末端细胞壁结合结构域(BD)组成，结构域间有不同长度的接头(linkers)。裂解酶作为模块蛋白质，可以通过配对来自不同裂解酶的催化结构域和结合结构域来产生嵌合裂解酶。接头的长度和序列也是可变的。然而，开发作为抗菌剂的裂解酶的主要瓶颈是不能可溶性表达高活性裂解酶。事实上，到目前为止没有报道过高水平可溶性表达并能有效杀死痤疮丙酸杆菌的裂解酶。
专利CN102482655A公开了一种抗微生物剂，其由具有降解革兰氏阳性细菌细胞壁的活性的细胞内溶素和在N端或C端或两端融合于该细胞内溶素的两亲肽段构成，能够用于治疗或预防革兰氏阳性细菌感染，作为诊断手段或作为美容用物质的用途。但是，该专利中虽然描述了PA6具有抗P.acnes DSMZ 1897株和DSMZ 16379株活性，但并未提供初始cfu/mL；此外，PA6不能解决提高可溶性表达水平的问题。
综上所述，对治疗痤疮丙酸杆菌的新治疗方式显然还有很大的需求，并且迄今为止没有报道过适合工业规模生产的高痤疮丙酸杆菌杀伤活性的噬菌体裂解酶。噬菌体裂解酶能够特异性、有效地杀死痤疮丙酸杆菌，同时保持其他共生细菌完整无损，可以提供一种安全有效的痤疮解决方案，适合长期使用，而不会有很高的生态失调和获得性耐药风险。
发明内容
针对以上技术现状，本发明提供了具有抗痤疮丙酸杆菌活性的噬菌体裂解酶、其嵌合物及应用。具体发明如下：
本发明提供了一种噬菌体裂解酶或其嵌合物在制备预防、治疗或改善痤疮或由痤疮丙酸杆菌引起的感染或与痤疮丙酸杆菌有关的病症的药物、化妆品或医疗设备中的应用，所述噬菌体裂解酶包括来源于类诺卡氏菌科(Nocardioidaceae)和丙酸杆菌科(Propionibacteriaceae)细菌的噬菌体裂解酶。
本发明的应用中，作为实施方案之一，所述类诺卡氏菌科(Nocardioidaceae)细菌包括微白霜菌属(Micropruina)、产丙酸单孢菌属(Propionicimonas)、产丙酸细胞菌属(Propionicicella)、弗莱德门氏菌属(Friedmanniella)细菌；所述丙酸杆菌科(Propionibacteriaceae)细菌包括产丙酸菌属(Propioniferax)、海马球菌属(Mariniluteicoccus)、颗粒球菌属(Granulicoccus)、瑙曼氏菌属(Naumannella)、棒状丙酸菌属(Propioniciclava)、光球菌属(Auraticoccus)、小月菌属(Microlunatus)、河口微菌属(Aestuariimicrobium)、黄球菌属(Luteococcus)、四合球菌属(Tessaracoccus)、布克劳氏菌属(Brooklawnia)、产丙酸微球菌属(Propionimicrobium)、丙酸杆菌属(Propionibacterium)、痤疮丙酸杆菌属(Cutibacterium)、酸性丙酸杆菌属(Acidipropionibacterium)、或假丙酸杆菌属(Pseudopropionibacterium)细菌，优选丙酸杆菌属(Propionibacterium)、痤疮丙酸杆菌属(Cutibacterium)、酸性丙酸杆菌属(Acidipropionibacterium)、或假丙酸杆菌属(Pseudopropionibacterium)细菌。
本发明的应用中，作为实施方案之一，所述噬菌体裂解酶包括来源于痤疮丙酸杆菌(Cutibacterium acnes)、肱丙酸杆菌(Propionibacterium humerusii)、贪婪丙酸杆菌(Cutibacterium avidum)、颗粒丙酸杆菌(Cutibacterium granulosum)、特氏丙酸杆菌(Acidipropionibacterium thoenii)、詹氏丙酸杆菌(Acidipropionibacteriumjensenii)、产丙酸丙酸杆菌(Acidipropionibacterium acidipropionici)、潮汐滩菌(Aestuariimicrobium kwangyangense)、细粒球菌(Granulicoccus phenolivorans)、积磷小月菌(Microlunatus phosphovorus)、丙酸丙酸杆菌(Pseudopropionibacteriumpropionicum)、四合球菌(Tessaracoccus sp.)、极底产丙酸细胞菌(Propionicicellasuperfundia)、费氏丙酸杆菌(Propionibacterium freudenreichii)、费氏丙酸杆菌费氏亚种(Propionibacterium freudenreichii subsp.freudenreichii)、费氏丙酸杆菌舍氏亚种(Propionibacterium freudenreichii subsp.shermanii)、产酸丙酸杆菌(Propionibacterium acidifaciens)、嗜淋巴丙酸杆菌(Propionibacteriumlymphophilum)、丙酸杆菌属细菌(Propionibacteriaceae bacterium)、丙酸杆菌分类群192(Propionibacterium sp.oral taxon 192)、无毒产丙酸菌(Propioniferax innocua)、盐藻瑙曼氏菌(Naumannella halotolerans)、慢生棒状丙酸菌(Propioniciclava tarda)、糖原微白霜菌(Micropruina glycogenica)、淡水产丙酸单孢菌(Propionicimonaspaludicola)、纪念性光球菌(Auraticoccus monumenti)、日本黄球菌(Luteococcusjaponicus)、油田四合球菌(Tessaracoccus oleiagri)、本迪戈四合球菌(Tessaracoccusbendigoensis)、拉帕迪卡四合球菌(Tessaracoccus lapidicaptus)、微嗜气丙酸杆菌(Acidipropionibacterium microaerophilum)、橄榄体丙酸杆菌(Acidipropionibacterium olivae)、丹诺氏丙酸杆菌(Acidipropionibacteriumdamnosum)细菌的噬菌体裂解酶。
本发明的应用中，作为实施方案之一，所述噬菌体裂解酶包括来源于詹氏丙酸杆菌(Acidipropionibacterium jensenii)、特氏丙酸杆菌(Acidipropionibacteriumthoenii)、产丙酸丙酸杆菌(Acidipropionibacterium acidipropionici)、微嗜气丙酸杆菌(Acidipropionibacterium microaerophilum)、橄榄体丙酸杆菌(Acidipropionibacterium olivae)、丹诺氏丙酸杆菌(Acidipropionibacteriumdamnosum)、痤疮丙酸杆菌(Cutibacterium acnes)、贪婪丙酸杆菌(Cutibacteriumavidum)、颗粒丙酸杆菌(Cutibacterium granulosum)、丙酸丙酸杆菌(Pseudopropionibacterium propionicum)细菌的噬菌体裂解酶。
本发明的应用中，作为实施方案之一，所述噬菌体裂解酶具有SEQ ID NO:1～SEQID NO:28中任一所示的氨基酸序列；
本发明的应用中，作为实施方案之一，所述噬菌体裂解酶具有SEQ ID NO:29～SEQID NO:56中任一所示的核苷酸序列；
本发明的应用中，作为实施方案之一，所述噬菌体裂解酶优选具有SEQ ID NO:10所示的氨基酸序列的PACL10；
本发明的应用中，作为实施方案之一，所述噬菌体裂解酶优选具有SEQ ID NO:38所示的核苷酸序列的PACL10。
本发明的应用中，作为实施方案之一，所述嵌合物包含来源于噬菌体裂解酶的催化结构域，或包含来源于噬菌体裂解酶的催化结构域和结合结构域的组合。
本发明的应用中，作为实施方案之一，所述催化结构域具有全C-末端接头、半C-末端接头、无C-末端接头、或所述接头的任何部分；所述结合结构域具有全N-末端接头、半N-末端接头、无N-末端接头、或所述接头的任何部分。
本发明的应用中，作为实施方案之一，可以用合成接头还包括合成接头。来源于噬菌体裂解酶的可能的接头的非限制性实例见下表3。合成接头的非限制性实例见下表4。
本发明的应用中，作为实施方案之一，所述嵌合物由来源于不同噬菌体裂解酶的催化结构域和结合结构域配对而成。
本发明的应用中，作为实施方案之一，所述嵌合物包括一个或两个催化结构域而没有结合结构域；
作为实施方案之一，所述嵌合物包括一个或多个催化结构域和一个或多个结合结构域
作为实施方案之一，所述嵌合物可以为一个或多个催化结构域与单个结合结构域连接；
作为实施方案之一，所述嵌合物可以为单个催化结构域与单个结合结构域连接；
作为实施方案之一，所述嵌合物可以为裂解酶N-末端中的单个催化结构域与裂解酶C-末端中的单个结合结构域连接。
此外，可以在不存在结合结构域的情况下使用一个或多个催化结构域。进一步地，对于诸如检测的专门应用，可在不存在催化结构域的情况下使用一个或多个结合结构域，并将其融合至不同分子以促进检测。此类分子包括但不限于生物素、flag标签、myc标签、抗生物素蛋白、链霉亲和素、卵清蛋白、萤火虫荧光素酶、生物素、荧光分子如FITC，TRITC，Alexafluor等。
本发明的应用中，作为实施方案之一，所述嵌合物进一步包含催化结构域和结合结构域之间的接头，所述接头包括：
1)来源于所述亲本裂解酶分子的接头区或其任何部分，所述催化结构域来源于该亲本裂解酶分子；
本发明的应用中，作为实施方案之一，所述来源于所述亲本裂解酶分子的接头区具有SEQ ID NO:343～SEQ ID NO:367任一所示的氨基酸序列。
2)来源于所述亲本裂解酶分子的接头区或其任何部分，所述结合结构域来源于该亲本裂解酶分子；
本发明的应用中，作为实施方案之一，所述来源于所述亲本裂解酶分子的接头区具有SEQ ID NO:368～SEQ ID NO:392任一所示的核苷酸序列；或
3)具有SEQ ID NO:393～SEQ ID NO:406任一所示的氨基酸序列，或为(GGGS)n、(GGGGS)n、(GGGGGS)n、(Gly)3-8、(EAAAK)n、(Ala-Pro)n、A(EAAAK)nALEA(EAAAK)nA氨基酸序列(其中1≤n≤15，n为整数)的合成接头结构域，作为示例性说明，n可以为1、2、3、4、5、6、7、8、9、10、11、12、13、14或15。
本发明的应用中，作为实施方案之一，所述嵌合物包括所述催化结构域具有SEQID NO:57、SEQ ID NO:58、SEQ ID NO:59、SEQ ID NO:61、SEQ ID NO:62、SEQ ID NO:63、SEQID NO:64、SEQ ID NO:65、SEQ ID NO:66、SEQ ID NO:67、SEQ ID NO:69、SEQ ID NO:70、SEQID NO:71、SEQ ID NO:73、SEQ ID NO:74、SEQ ID NO:77、SEQ ID NO:80、SEQ ID NO:81、SEQID NO:85、SEQ ID NO:86、SEQ ID NO:87、SEQ ID NO:91、SEQ ID NO:93、SEQ ID NO:95、SEQID NO:97、SEQ ID NO:98、SEQ ID NO:99、SEQ ID NO:100、SEQ ID NO:102、SEQ ID NO:104、SEQ ID NO:105、SEQ ID NO:106、SEQ ID NO:107、SEQ ID NO:108、SEQ ID NO:110、SEQ IDNO:111、SEQ ID NO:113、SEQ ID NO:114、SEQ ID NO:117、SEQ ID NO:118、SEQ ID NO:121、SEQ ID NO:122、SEQ ID NO:125、SEQ ID NO:127、SEQ ID NO:128、SEQ ID NO:131、SEQ IDNO:132、SEQ ID NO:133、SEQ ID NO:135或SEQ ID NO:136中所示的氨基酸序列；
所述结合结构域具有SEQ ID NO:60、SEQ ID NO:62、SEQ ID NO:68、SEQ ID NO:72、SEQ ID NO:75、SEQ ID NO:76、SEQ ID NO:78、SEQ ID NO:79、SEQ ID NO:82、SEQ IDNO:83、SEQ ID NO:84、SEQ ID NO:88、SEQ ID NO:89、SEQ ID NO:90、SEQ ID NO:92、SEQ IDNO:94、SEQ ID NO:96、SEQ ID NO:101、SEQ ID NO:103、SEQ ID NO:109、SEQ ID NO:112、SEQ ID NO:115、SEQ ID NO:116、SEQ ID NO:119、SEQ ID NO:120、SEQ ID NO:123、SEQ IDNO:124、SEQ ID NO:126、SEQ ID NO:129、SEQ ID NO:130、SEQ ID NO:134、SEQ ID NO:137、SEQ ID NO:138、或SEQ ID NO:139所示的氨基酸序列。
本发明的应用中，作为实施方案之一，所述催化结构域具有SEQ ID NO:140、SEQID NO:141、SEQ ID NO:142、SEQ ID NO:144、SEQ ID NO:146、SEQ ID NO:147、SEQ ID NO:148、SEQ ID NO:149、SEQ ID NO:150、SEQ ID NO:152、SEQ ID NO:153、SEQ ID NO:154、SEQID NO:156、SEQ ID NO:157、SEQ ID NO:160、SEQ ID NO:163、SEQ ID NO:164、SEQ ID NO:168、SEQ ID NO:169、SEQ ID NO:170、SEQ ID NO:174、SEQ ID NO:176、SEQ ID NO:178、SEQID NO:180、SEQ ID NO:181、SEQ ID NO:182、SEQ ID NO:183、SEQ ID NO:185、SEQ ID NO:187、SEQ ID NO:188、SEQ ID NO:189、SEQ ID NO:190、SEQ ID NO:191、SEQ ID NO:193、SEQID NO:194、SEQ ID NO:196、SEQ ID NO:197、SEQ ID NO:200、SEQ ID NO:201、SEQ ID NO:204、SEQ ID NO:205、SEQ ID NO:208、SEQ ID NO:210、SEQ ID NO:211、SEQ ID NO:214、SEQID NO:215、SEQ ID NO:216、SEQ ID NO:218、SEQ ID NO:219、所示的核苷酸序列；
所述结合结构域具有SEQ ID NO:143、SEQ ID NO:145、SEQ ID NO:151、SEQ IDNO:155、SEQ ID NO:158、SEQ ID NO:159、SEQ ID NO:161、SEQ ID NO:162、SEQ ID NO:165、SEQ ID NO:166、SEQ ID NO:167、SEQ ID NO:171、SEQ ID NO:172、SEQ ID NO:173、SEQ IDNO:175、SEQ ID NO:177、SEQ ID NO:179、SEQ ID NO:184、SEQ ID NO:186、SEQ ID NO:192、SEQ ID NO:195、SEQ ID NO:198、SEQ ID NO:199、SEQ ID NO:202、SEQ ID NO:203、SEQ IDNO:206、SEQ ID NO:207、SEQ ID NO:209、SEQ ID NO:212、SEQ ID NO:213、SEQ ID NO:217、SEQ ID NO:220、SEQ ID NO:221、或SEQ ID NO:222所示的核苷酸序列。
本发明的应用中，作为实施方案之一，所述嵌合物具有SEQ ID NO:223～SEQ IDNO:282中任一所示的氨基酸序列；优选SEQ ID NO:258、SEQ ID NO:259、SEQ ID NO:260、SEQ ID NO:271或SEQ ID NO:272所示的氨基酸序列；更优选SEQ ID NO:260或SEQ ID NO:271所示的氨基酸序列；
本发明的应用中，作为实施方案之一，所述嵌合物具有SEQ ID NO:283～SEQ IDNO:342中任一所示的核苷酸序列；优选SEQ ID NO:316、SEQ ID NO:317、SEQ ID NO:318、SEQ ID NO:329或SEQ ID NO:330所示的核苷酸序列；更优选SEQ ID NO:318或SEQ ID NO:329所示的核苷酸序列。
本发明的应用中，作为实施方案之一，所述由痤疮丙酸杆菌引起的感染包括侵入性感染、术后感染和/或器械相关的感染。
本发明的应用中，作为实施方案之一，所述器械相关的感染包括关节假体、分流管和人工心脏瓣膜相关的感染。
本发明的应用中，作为实施方案之一，所述感染包括骨骼和/或关节的感染，尤其是术后肩部感染，以及口腔、眼、椎间盘和脑部的感染。
本发明的应用中，作为实施方案之一，所述与痤疮丙酸杆菌有关的病症包括导致癌症的前列腺炎、SAPHO(滑膜炎、痤疮、脓疱病、肥大、骨炎)综合征、结节病、或坐骨神经痛。
本发明的应用中，作为实施方案之一，所述医疗设备包括用于将裂解酶或其嵌合物释放到受影响区域的任何设备，优选施加至皮肤表面的夹具或贴剂或喷雾剂，使用微针增强裂解酶或其嵌合物的皮肤渗透性的设备，美容专业人员使用的将裂解酶或其嵌合物专门施加至受痤疮影响的毛囊上的细针，或其他类似的设备。
本发明的应用中，作为实施方案之一，所述医疗设备包括将将裂解酶或其嵌合物固定在易于感染痤疮丙酸杆菌的位置中的假体装置上，优选用于特别容易感染痤疮丙酸杆菌的肩部手术中的假体植入物。
本发明还提供了前述应用中所述的噬菌体裂解酶嵌合物。作为实施方案之一，所述嵌合物具有SEQ ID NO:223～SEQ ID NO:282中任一所示的氨基酸序列；优选SEQ ID NO:258、SEQ ID NO:259、SEQ ID NO:260、SEQ ID NO:271或SEQ ID NO:272所示的氨基酸序列；更优选SEQ ID NO:260或SEQ ID NO:271所示的氨基酸序列；
本发明的应用中，作为实施方案之一，所述嵌合物具有SEQ ID NO:283～SEQ IDNO:342中任一所示的核苷酸序列；优选SEQ ID NO:316、SEQ ID NO:317、SEQ ID NO:318、SEQ ID NO:329或SEQ ID NO:330所示的核苷酸序列；更优选SEQ ID NO:318或SEQ ID NO:329所示的核苷酸序列。
本发明还提供了一种前述嵌合物的制备方法，包括：
(1)合成结构域序列及扩增结构域序列的引物；
(2)采用Taq DNA聚合酶PCR扩增结构域序列；
(3)PCR产物凝胶纯化，与表达质粒pET28连接；
(4)重组质粒转移到大肠杆菌BL21(DE3)；
(5)培养含有重组质粒的大肠杆菌BL21(DE3)，诱导表达，离心收集细胞，裂解，纯化得到所述嵌合物。
本发明的制备方法中，作为实施方案之一，所述方法进一步包括：
将含有重组嵌合裂解酶表达质粒的大肠杆菌BL21(DE3)置于自诱导培养基中在37℃、300rpm下培养至OD600达到0.6-0.8，随后在18℃、300rpm下，持续培养16-18小时。离心收集细胞，重悬于50mM pH 7.4的磷酸钠中，高压均质裂解。裂解液再次离心以收集可溶性粗裂解液。将可溶性组分与等体积的5M NaCl混合，混合物上样到疏水柱中。上样后，用5倍柱体积的20mM磷酸钠(pH 7.4)、2.5M NaCl洗涤柱子。然后用10mM磷酸钠(pH 7.4)洗脱重组嵌合裂解酶。可选择地，本领域技术人员可以对表达和纯化进行优化，可以在不同的温度、通气和诱导时间下使用不同浓度的IPTG在LB中表达裂解酶。可以将细胞重悬于不同的缓冲液中以提高溶解度，并通过机械或化学手段进行裂解。可以采用不同的蛋白质色谱方法来纯化裂解酶。可以优化这些变量以获得更好的裂解酶蛋白产量。
本发明还提供了含有前述嵌合物的制剂，所述制剂进一步包含抗生素、其他裂解酶、或非活性赋形剂。
本发明还提供了编码前述嵌合物的氨基酸序列，与前述序列相似度80％及以上、85％及以上、90％及以上、95％及以上或99％及以上的氨基酸序列，或具有相同官能团的替代氨基酸序列。作为示例性的说明，本发明还提供了与前述序列相似度80％、81％、82％、83％、84％、85％、86％、87％、88％、89％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％的氨基酸序列。
作为实施方案之一，所述替代氨基酸序列为使用同一组氨基酸中的氨基酸的保守替换，所述氨基酸组包括：
脂肪族的：甘氨酸、丙氨酸、缬氨酸、亮氨酸、异亮氨酸；
含羟基或硫/硒的：丝氨酸、半胱氨酸、苏氨酸、甲硫氨酸；
环状的：脯氨酸；
芳族的：苯基丙氨酸、酪氨酸、色氨酸；
碱性的：组氨酸、赖氨酸、精氨酸；
酸性的以及它们的酰胺：天冬氨酸、谷氨酸、天冬酰胺、谷氨酰胺。
本发明还提供了编码前述嵌合物的核苷酸序列，或其同义密码子序列。
本发明还提供了前述嵌合物用作细菌裂解的试剂的应用，所述细菌裂解用于使用基于PCR的试剂盒进行DNA提取和分型。
本发明还提供了前述嵌合物用作非生物表面上的消毒剂或灭菌剂的应用，所述消毒剂或灭菌剂通过去除浮游形式或生物膜中的痤疮丙酸杆菌以防止感染，优选在手术过程中对手术设备或假体植入装置进行消毒。
本发明还提供了前述嵌合物、前述嵌合物中的单个结合结构域，或前述嵌合物中的相似或不同的结合结构域串联的组合在制备用于痤疮丙酸杆菌的诊断工具中的应用，所述裂解酶、嵌合物或结合结构域与检测标志物联合使用。
作为实施方案之一，所述裂解酶、嵌合物或结合结构域与信号分子通过基因融合或化学偶联形成融合物。
作为实施方案之一，所述融合物用于通过荧光或其他手段直接检测显微镜载玻片上的痤疮丙酸杆菌，用于通过免疫组织化学标记痤疮丙酸杆菌，用作ELISA测定中的检测试剂，用作Western blot上的检测试剂，用于与在MACS或其他pull-down测定中的磁珠连接，或用于抗体作为检测试剂的测定中的检测试剂。作为实施方案之一，所述信号分子包括蛋白质或化学荧光染料、蛋白质标签、酶、抗生物素蛋白、链霉亲和素、卵清蛋白、生物素、对点击化学标记敏感的标签、内含肽、或能够引起产生信号的二级蛋白质或分子募集的其他分子，
所述荧光染料包括GFP、RFP、mCherry、FITC、TRITC、Alexafluor 488、Cy3或Cy5；
所述蛋白质标签包括Flag-标签、myc-标签、halo-标签、his-标签、或能够与抗体或其他高亲和力分子结合产生信号的任何其他标签；
所述酶包括萤火虫荧光素酶、β-内酰胺酶、碱性磷酸酶、辣根过氧化物酶、或引起诸如光、颜色变化、底物沉积或其他能够在试验中检测到的反应的任何其他的酶。
本发明还提供了前述嵌合物中的催化结构域在制备治疗痤疮丙酸杆菌感染的药物中的应用，所述催化结构域与寻靶模块结合。
本发明提供了用于预防和治疗痤疮丙酸杆菌感染和皮肤定植以及与这种感染或定植相关的痤疮病变的组合物和方法。在广泛的方面，本发明提供了裂解酶的用途和应用，所述裂解酶具有对皮肤相关的生物体的广泛杀伤活性，所述生物体涉及痤疮病变的发生或恶化以及痤疮病变的继发感染，包括但不限于丙酸杆菌属(Propionibacterium)、痤疮丙酸杆菌属(Cutibacterium)、酸性丙酸杆菌属(Acidipropionibacterium)、假丙酸杆菌属(Pseudopropionibacterium)的细菌。特别地，本发明描述了用于皮肤中已建立的细菌群落的去定植、分散和去除的方法，特别着重于痤疮丙酸杆菌(Cutibacterium acnes，以前称作Propionibacterium acnes)。此外，本发明还提供了生产嵌合裂解酶的方法，所述嵌合裂解酶包含来自不同裂解酶的催化结构域和结合结构域，从而产生各种有利的特性，包括但不限于改善的活性、宿主范围、表达、溶解性、稳定性或更适合于商品化。
根据本发明，在本发明的方法和应用中使用了来源于丙酸杆菌属(Propionibacterium)、痤疮丙酸杆菌属(Cutibacterium)、酸性丙酸杆菌属(Acidipropionibacterium)、假丙酸杆菌属(Pseudopropionibacterium)细菌的噬菌体裂解酶。表2提供了本发明中使用的裂解酶和多肽。
在本发明的一个方面，SEQ ID NO:1～SEQ ID NO:28中所示的裂解酶由SEQ IDNO:29～SEQ ID NO:56中所示的核苷酸序列编码。
本发明还提供了一种在不同噬菌体裂解酶的结合结构域和催化结构域之间产生嵌合体的方法。SEQ ID NO:57～SEQ ID NO:139示出了提供编码本发明所述来源于噬菌体裂解酶的催化结构域和结合结构域的多肽序列的实例的非限制性序列表。
在本发明的一个方面，SEQ ID NO:57～SEQ ID NO:139中所示的催化结构域和结合结构域由SEQ ID NO:140～SEQ ID NO:222中示出的核苷酸序列编码。
本发明还提供了如本发明所述的通过配对不同裂解酶的催化结构域和结合结构域而产生的嵌合裂解酶的非限制性实例。SEQ ID NO:223～SEQ ID NO:282提供了由本发明所述方法产生的抗痤疮丙酸杆菌活性的嵌合裂解酶的非限制性序列表。
在本发明的一个方面，使用SEQ ID NO:283～SEQ ID NO:342中所述的核苷酸序列产生本发明所述的嵌合裂解酶。
在本发明的一个方面，所述多肽序列由插入到表达载体pET28中的核苷酸序列编码。
在本发明的一个方面，编码本发明所述多肽的表达载体在大肠杆菌(E.coli)BL21(DE3)菌株中表达。
此外，本发明提供了一种筛选和评价噬菌体裂解酶抗痤疮丙酸杆菌活性的方法。
此外，本发明证明了确定的噬菌体裂解酶抗痤疮丙酸杆菌的活性。
在本发明的一个方面，用于治疗丙酸杆菌的裂解酶为PACL10。本发明提供了一种表达和纯化PACL10的方法。此外，本发明证明PACL10对痤疮丙酸杆菌具有较高的抗菌活性。
通过最小抑菌浓度(MIC)试验和时间杀菌试验评价了PACL10对一系列不同进化枝的痤疮丙酸杆菌株的活性，结果一致表明PACL10具有很高的有效性。
本发明中产生的噬菌体裂解酶及其衍生物适合工业规模生产，能够特异性、有效地杀死痤疮丙酸杆菌，同时保持其他共生细菌完整无损，可以提供一种安全有效的痤疮解决方案，适合长期使用，而不会有很高的生态失调和获得性耐药风险。本发明中产生的噬菌体裂解酶及其衍生物具有如下优点：
(1)能够杀死痤疮丙酸杆菌(C.acnes)而不损伤天然菌群。
(2)与需要很长时间才能起效的抗生素相比，活性迅速(几分钟之内)。
(3)没有耐药性。细菌会迅速对抗生素产生耐药性，因此裂解酶是一种解决方案。C.acnes是一种强烈分泌生物膜的生物。即使对于对抗生素敏感的生物，当以生物膜形式发现它们时，它们会对抗生素产生耐药性。裂解酶对生物膜高度有效。
(4)与其他裂解酶相比，本发明更有效——在其他测定中MIC低，活性高。
(5)能够可溶性表达，其产量适于大规模和工业生产。
(6)对所有进化枝的P.acnes.都有效。
定义
由于Scholz等对丙酸杆菌属(Propionibacterium)的重新分类，新旧名称对照的非限制性实例如下表1所示：
表1
本领域人员应该理解，细菌的重新分类、新旧名称、中文名称等不应影响对该细菌的认定，本发明无论采用新名称或旧名称，其代表为同一菌种。
本发明涉及序列的非限制性实例如下表2：
表2
本发明中所述天然接头的非限制性示例如下表3：
表3
本发明中所述合成接头的非限制性示例如下表4：
表4
| 序号 | 接头名称 | 氨基酸序列 |
| 1 | (GGGS)n，1≤n≤8，n为整数 | — |
| 2 | (GGGGS)n，1≤n≤8，n为整数 | — |
| 3 | (GGGGGS)n，1≤n≤8，n为整数 | — |
| 4 | (Gly)<sub>3-8</sub> | — |
| 5 | (EAAAK)n，1≤n≤8，n为整数 | — |
| 6 | PAPAP | SEQ ID NO:393 |
| 7 | AEAAAKEAAAKA | SEQ ID NO:394 |
| 8 | (Ala-Pro)<sub>n</sub>，1≤n≤15，n为整数 | — |
| 9 | A(EAAAK)<sub>n</sub>ALEA(EAAAK)<sub>n</sub>A，1≤n≤8，n为整数 | — |
| 10 | VSQTSKLTRAETVFPDV | SEQ ID NO:395 |
| 11 | PLG LWA | SEQ ID NO:396 |
| 12 | RVLAEA | SEQ ID NO:397 |
| 13 | EDVVCCSMSY | SEQ ID NO:398 |
| 14 | GGIEGRGS | SEQ ID NO:399 |
| 15 | TRHRQPRGWE | SEQ ID NO:400 |
| 16 | AGNRVRRSVG | SEQ ID NO:401 |
| 17 | RRRRRRRRR | SEQ ID NO:402 |
| 18 | GFLG | SEQ ID NO:403 |
| 19 | KESGSVSSEQLAQFRSLD | SEQ ID NO:404 |
| 20 | EGKSSGSGSESKST | SEQ ID NO:405 |
| 21 | GSAGSAAGSGEF | SEQ ID NO:406 |
附图说明
图1实施例3中示出了所选裂解酶对痤疮丙酸杆菌的有效杀伤作用。裂解酶在含有IPTG的LB琼脂上的大肠杆菌BL21(DE3)中表达，并通过大肠杆菌渗透释放。大肠杆菌周围的透明区或晕圈表明，表达的裂解酶可以抑制生长或杀死嵌入在琼脂覆盖层中的痤疮丙酸杆菌。
图2实施例3中示出了由含有诱导的所选裂解酶的大肠杆菌粗裂解液在痤疮丙酸杆菌覆盖层上形成的清除区。
图3实施例4中证明PACL10可以可溶性表达和纯化。所有样品在5-12％的三甘氨酸凝胶中在150V运行50分钟，并用考马斯亮蓝染色。PACL10使用pET表达系统在大肠杆菌BL21(DE3)中表达，并通过疏水作用纯化。洗脱级分示出了在29.4kDa处的纯化的PACL10。
图4实施例7示出了PACL10降低痤疮丙酸杆菌34A菌株的cfu/mL的动力学。当MIC为6.4μg/mL、2x MIC为12.8μg/mL时,cfu/mL可分别在3小时和2小时内降至检测限以下。
图5示出了用于MIC测定的单步纯化的裂解酶。上样至5-12％Tris-HCl SDS凝胶的裂解酶浓度为：0.62mg/mL PACL10,1.41mg/mL PACL390,2.12mg/mL PACL391,2.10mg/mLPACL392,1.49mg/mL PACL403和1.60mg/mL PACL404。
图6示出了通过混合模式和离子交换色谱法纯化的PACL392。
图7示出了PACL392相对于菌株10的杀菌活性。
图8示出了通过混合模式色谱法纯化的PACL403。
图9示出了PACL403相对于菌株10的杀菌活性—OD减少。
图10示出了PACL403相对于菌株10的杀菌活性—CFU减少。
图11示出了PACL403相对于生物膜相关的菌株10的杀菌活性。
具体实施方式
以下实施例和/或实验例仅用于进一步阐述本发明，但不以任何的方式限制本发明的有效范围。采用标准实验方法进行实验得出实施例所示结果。
实施例1
通过分析丙酸杆菌科细菌基因组中前噬菌体的序列，我们鉴定出可以可溶性表达和纯化的痤疮丙酸杆菌噬菌体裂解酶。表达噬菌体裂解酶的基因序列由Sangon合成，并与表达质粒pET28连接。然后将每种重组质粒转入大肠杆菌BL21(DE3)菌株。
实施例2
嵌合物构建为N-末端催化结构域(CD)和C-末端结合结构域(BD)，其间有可变长度的接头(linker)。通过使用NCBI恒定区数据库和用于计算机模拟蛋白质结构预测的RaptorX网络服务器进行序列分析来鉴别结构域。催化结构域具有全C-末端、半C-末端或无C-末端接头。同样的，结合结构域具有全N-末端、半N-末端或无N-末端连接。扩增结构域序列的引物由GeneCreate合成。采用Taq DNA聚合酶PCR在55℃退火温度下扩增结构域序列。PCR产物经凝胶纯化，与表达质粒pET28连接。然后将重组质粒转移到大肠杆菌BL21(DE3)。
实施例3
痤疮丙酸杆菌覆盖试验证实了裂解酶的抗菌活性。简单地说，将含有重组裂解酶质粒的大肠杆菌BL21(DE3)克隆置于含IPTG的LB琼脂上进行诱导。一旦裂解酶过表达，大肠杆菌克隆就会渗透释放裂解酶。包埋有痤疮丙酸杆菌的软琼脂被覆盖并培养以使痤疮丙酸杆菌生长。活性裂解酶的存在会在大肠杆菌周围形成透明区或晕圈。实验结果见图1。
在类似的试验中，含有重组裂解酶质粒的大肠杆菌BL21(DE3)克隆在液体培养基中诱导。离心收集细胞，在50mM磷酸钠pH 7.4缓冲液中超声裂解。裂解液离心分离可溶和不溶性组分。将可溶性粗裂解液在包埋有痤疮丙酸杆菌的软琼脂上点样。在培养以使痤疮丙酸杆菌生长后，可溶性粗裂解物中的活性裂解酶形成了清除区。实验结果见图2。
实施例4
PACL10的表达和纯化
PACL10表达及纯化如下。简单地说，将含有重组PACL10表达质粒的大肠杆菌BL21(DE3)置于自诱导培养基中在37℃、300rpm下培养至OD600达到0.6-0.8，随后18℃、300rpm，持续培养16-18小时。离心收集细胞，重悬于50mM pH 7.4的磷酸钠中，高压均质裂解。裂解液再次离心以收集可溶性粗裂解液。将可溶性组分与等体积的5M NaCl混合，混合物上样到疏水柱中。上样后，用5倍柱体积的20mM磷酸钠(pH 7.4)、2.5M NaCl洗涤柱子。然后用10mM磷酸钠(pH 7.4)洗脱PACL10。实验结果见图3。
实施例5
以类似于PACL10的方式表达和纯化嵌合裂解酶。将含有重组嵌合裂解酶表达质粒的大肠杆菌BL21(DE3)置于自诱导培养基中在37℃、300rpm下培养至OD600达到0.6-0.8，随后在18℃、300rpm下，持续培养16-18小时。离心收集细胞，重悬于50mM pH 7.4的磷酸钠中，高压均质裂解。裂解液再次离心以收集可溶性粗裂解液。将可溶性组分与等体积的5M NaCl混合，混合物上样到疏水柱中。上样后，用5倍柱体积的20mM磷酸钠(pH 7.4)、2.5M NaCl洗涤柱子。然后用10mM磷酸钠(pH 7.4)洗脱重组嵌合裂解酶。
实施例6
最小抑菌浓度测定
最小抑菌浓度(MIC)测定方法如下。首先在0.9％生理盐水中制备菌落悬浮液至OD600为0.05以制备接种物，相当于每毫升107菌落形成单位(cfu/mL)。悬浮液在无琼脂强化梭菌培养基(RCM)中稀释20倍至接种物为5*105cfu/mL。用0.9％的生理盐水制备2倍连续稀释的PACL10或万古霉素，并且加入不超过总培养物的十分之一。培养物在厌氧条件下于37℃培养3天。MIC为肉眼观察不到痤疮丙酸杆菌的生长时的PACL10或万古霉素的最低浓度。通过将上述培养物在含有0.1％吐温-80的强化梭菌琼脂(RCA)平板上传代培养来测定最小杀菌浓度(MBC)。MBC为在强化梭菌琼脂(RCA)平板上未见痤疮丙酸杆菌菌落时的PACL10或万古霉素的最低浓度。
实验结果：表6-1示出了PACL10与万古霉素相比，对来自IA1、IA2、II进化枝的12株痤疮丙酸杆菌菌株的最小抑菌浓度(MIC)和最小杀菌浓度(MBC)。
表6-1
实施例7
时间杀菌试验
时间杀菌试验方法如下。将痤疮丙酸杆菌34A菌株菌落重新悬浮于0.9％生理盐水中至OD600为0.05，相当于107cfu/mL。悬浮液在50mM磷酸钠(pH 6.0)中稀释10倍至～106cfu/mL。34A菌株分别加入0、0.5x、1x、2x MIC的两倍连续稀释的PACL10。在每个时间点将试验中的十倍系列稀释液(0,1,2,3log)铺板在强化梭菌琼脂(RCA)上，并在厌氧条件下于37℃培养3天。实验结果见图4。
实施例8
单步纯化后所选裂解酶的最小抑菌浓度
表达PACL 10、390、391、392、403和404参照实施例1～4的方法，并进行如下的单步纯化：将含有每种重组表达质粒的大肠杆菌BL21(DE3)置于自诱导培养基中在37℃、300rpm下培养3h，随后在18℃、300rpm下培养16-18小时。离心收集细胞，高压均质裂解。来自1L表达目标蛋白的大肠杆菌培养基的澄清裂解液上样至含有70mL纯化树脂的26mm/200mm柱。根据表8-1中的条件纯化裂解酶，单步纯化后的裂解酶的纯度测定如图5所示。这些裂解酶用于测定最小抑菌浓度(MIC)。
最小抑菌浓度(MIC)测定方法如下。痤疮丙酸杆菌在强化梭菌琼脂(具有1.5％琼脂的强化梭菌培养基RCM，根据修订后的配方配制RCM，每升-10g酸水解酪蛋白、10g牛肉提取物、3g酵母提取物、5gD-葡萄糖、5g氯化钠、3g醋酸钠、0.5g L-半胱氨酸盐酸盐)上划线。平板在37℃下厌氧培养72小时。首先在0.9％生理盐水中重悬来自RCA的单克隆至OD600为0.05以制备用于MIC测定的接种物，相当于每毫升107菌落形成单位(cfu/mL)。悬浮液在RCM中稀释20倍至接种物为5*105cfu/mL。用0.9％的生理盐水制备2倍连续稀释的每种裂解酶，并且加入不超过总培养物体积的十分之一。培养物在厌氧条件下于37℃培养48-72小时。MIC为肉眼观察不到痤疮丙酸杆菌的生长时的裂解酶的最低浓度。MIC结果如表8-2所示。
表8-1所选裂解酶的纯化条件
表8-2所选裂解酶相对痤疮丙酸杆菌的MIC(μg/mL)
实施例9
PACL392的纯化和杀菌活性
PACL392在含有重组表达质粒的大肠杆菌BL21(DE3)中通过置于自诱导培养基中在37℃、300rpm下培养3h，随后18℃、300rpm培养16-18小时进行表达。离心收集细胞，在20mM、pH 7.4的磷酸钠中高压均质裂解。裂解液在12,000rpm、4℃下离心1h。将上清液与等体积的20mM、pH 7.4的磷酸钠、1M硫酸铵混合，在12,000rpm、4℃下再次离心1h。上清液用0.22μm滤膜过滤，上样到用20mM、pH 7.4的磷酸钠、0.5M硫酸铵平衡的混合模式色谱柱(70mL纯化树脂的26mm/200mm柱)。上样后，用一系列缓冲液洗涤柱：20mM、pH 7.4的磷酸钠，0.5M硫酸铵；20mM、pH 7.4的磷酸钠，2.5M NaCl；20mM、pH 7.4的磷酸钠和50mM、pH 10.02的哌嗪，50mM NaCl。用50mM、pH 10.02的哌嗪和750mM NaCl洗脱PACL392。洗脱液用50mM、pH7.4的磷酸钠透析以中和pH并去除阳离子。透析样品过滤并上样到离子交换色谱柱(70mL纯化树脂的26mm/200mm柱)。PACL392纯化的最终结果如图6所示。
PACL392的杀菌活性通过在一系列添加剂如NaCl、CaCl2、MgCl2、EDTA、DTT、吐温-20、吐温-80和透明质酸(浓度如图7所示)存在下的50mM、pH 7.0的HEPES中的CFU减少来测定。
实施例10
PACL403的纯化和杀菌活性
PACL403在含有重组表达质粒的大肠杆菌BL21(DE3)中通过置于自诱导培养基中在37℃、300rpm下培养3h，随后18℃、300rpm培养16-18小时进行表达。离心收集细胞，在20mM、pH 7.4的磷酸钠中高压均质裂解。将裂解物溶液调节至20mM、pH 7.4的磷酸钠、1MNaCl，并在12,000rpm、4℃下离心1h。上清液用0.22μm滤膜过滤，上样到用20mM、pH 7.4的磷酸钠、1M NaCl平衡的混合模式色谱柱(70mL纯化树脂的26mm/200mm柱)。上样后，用一系列缓冲液洗涤柱：20mM、pH 7.4的磷酸钠，1M NaCl；20mM、pH 7.4的磷酸钠，2.5M NaCl；20mM、pH 7.4的磷酸钠；20mM、pH 7.4的磷酸钠，0.1％Triton X-114和再次加入20mM、pH 7.4的磷酸钠。用50mM、pH 9.5的哌嗪、1M NaCl洗脱PACL403。通过加入五分之一体积的500mM、pH7.4的磷酸钠来中和高pH。然后将洗脱液用50mM、pH 7.4的磷酸钠透析以去除阳离子。透析样品过滤。PACL403纯化的最终结果如图8所示。
PACL403的杀菌活性通过在如图9所示浓度的吐温-20和吐温-80存在下的50mM、pH7.0的磷酸钠中的OD减少来测定。
PACL403的杀菌活性通过在如图10所示浓度的吐温-20和吐温-80存在下的50mM、pH 7.0的HEPES中的CFU减少来测定。
PACL403还能杀死生物膜相关的痤疮丙酸杆菌(图11)。将OD600为1.0的菌株10加入96孔聚苯乙烯平板，以在厌氧气体混合物中过夜接种生物膜。去除上清液，孔用0.9％NaCl轻轻冲洗。加入生物膜形成培养基(RCM+5％葡萄糖)，以使生物膜在厌氧气体混合物中过夜生长。去除培养基，孔用0.9％NaCl轻轻冲洗。然后用缓冲液或PACL403在25℃、厌氧下过夜处理生物膜。去除缓冲液或PACL403，孔用0.9％NaCl冲洗。重悬于0.9％NaCl中，在RCM琼脂上铺板，对生物膜相关的CFU进行计数。
序列表
<110> 武汉乐斯吉生物科技有限公司
<120> 噬菌体裂解酶、其嵌合物及应用
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Asn Thr Leu Arg Glu Val Met Gly Asn Tyr Arg Asn Val Asn Tyr Asp
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Ala Met Val Gly Pro Met Asn Glu Ala Met Ile Ala Ala Gly Cys Thr
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Glu Gly Leu Thr Ala Met Glu Glu Tyr Ala Ser Gly Ala Gly Tyr Glu
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Ser Phe Tyr Trp Thr Val Arg Arg Pro Asp Ile Asn Ser Leu Ala Asp
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Gly Leu Ser Asp Arg Ile Ala Arg Tyr Asn Arg Ala Met Ala Leu Gly
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Asp Arg Ile Leu Pro Ser Ala Ser Glu Thr Gly Thr Gln Thr Ser Lys
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Gln Asp Thr Tyr Tyr Asn Cys Gly Pro Ala Ser Cys Gln Thr Val Ile
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Gly Ala Ala Thr Gly Asn Tyr Pro Gly Glu Val Glu Leu Ala Ala Ala
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Met Thr Lys Ile Leu Thr Ile Glu Lys Ala Arg Glu Phe Asp Ala Phe
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Arg Asn Pro Arg Gln Ser Thr Asp Cys Ser Gly Leu Val Leu Gln Ser
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Gly Ala Arg Ala Trp Asn Asp Gly Leu Phe His Asp Phe Trp Tyr Leu
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Asp Met Arg Leu Gly Glu Leu Ala Pro Pro Val Asn Glu Ile Asn Ala
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Glu Phe Glu Arg Ala Lys Gly Trp Ile Gly Lys Arg Ile Asp Val Ala
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Glu Lys Pro Cys Pro Asp Gly Glu Gly Lys Tyr Ile Arg Cys Glu Gly
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Gly His Ile Tyr Phe His Pro Lys Val Asn Val Gly Ala Lys Pro Gly
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Glu Arg Ala Ile Ala Ile Pro Ala Asp Val Phe Glu Val Trp Lys Arg
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Gln Gly Phe Glu Lys Gly Pro Leu Gly Tyr Pro Thr Arg Arg His Ala
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Tyr Arg Lys Phe Gly Thr Asp Gly Gly Ile Val Asn Gly Lys Ile Leu
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Glu Arg Trp Ala Arg Glu Gly His Glu Lys Gly Arg Leu Gly Trp Pro
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Leu Gly Asp Glu Lys Phe Phe Asp Gly Gly Arg Val Gln Ala Phe Glu
305 310 315 320
Asn Gly Asp Ala Tyr Phe His Pro Thr Ala Val Val Glu Phe Leu Asn
325 330 335
Asp Pro Ala Ala Pro Lys Gln
340
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Met Arg Pro Tyr Arg Ala Arg His Leu Ala Thr Pro Pro Thr Pro Asp
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Ser Thr Pro Asp Thr Ser Ser Gly Ala Ser Arg Arg Ser Val Leu Arg
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Gly Gly Val Leu Gly Ala Ala Ala Leu Ser Thr Gly Ala Ala Ala Val
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Gly Trp Gln Gly Glu Ile Asp Trp Ser Ala Gln Ala Asp Leu Gly Ser
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Arg Phe Ala Tyr Val Lys Ala Thr Glu Gly Arg Ser Tyr Arg Ser Pro
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Ala Phe Asn Gln Gln Tyr Arg Gly Ala Gly Asn Ala Gly Leu Val Arg
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Gly Gly Tyr His Phe Ala Arg Pro Asp Ser Gly Gly Pro Glu Glu Gln
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Val Asp Phe Phe Leu Asn Asn Gly Gly Gly Trp Ser Asp Asp Gly Ile
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Thr Leu Pro Gly Met Val Asp Phe Glu Ala Tyr Ser Gly Leu Pro Arg
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Asp Tyr Gly Leu Ser Gln Gln Glu Met Arg Asn Trp Ile Met Ala Phe
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Ser Thr Arg Tyr Arg Asp Ser Val Gly Arg Arg Pro Val Leu Tyr Thr
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Asn Leu His Trp Trp Asn Asp Val Val Gly Asp Trp Thr Pro Val Asn
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Ser Pro Leu Phe Leu Ala Ser Tyr Ser Ser Ser Ala Pro Thr Thr Leu
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Pro Gly Arg Trp Trp Ala Tyr Glu Met Trp Gln Tyr Ser Asp Ser Gly
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Glu Ser Phe Val Ser Asp Gly Asp Tyr His Ala Ile Gly Ile
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Met Arg Phe Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Ser Pro
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Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
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Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
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Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
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Met Ala Thr Met Pro Val Lys Lys Gly Phe Tyr Val Thr Ser Gly Phe
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Gly Pro Arg Trp Gly Thr Thr His Tyr Gly Thr Asp Phe Gly Val Asp
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Gly Gly Ser Gly Gly His Pro Ile Phe Ala Ile Lys Ser Gly Thr Val
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Thr Ala Ser Gly Pro Ala Ser Gly Phe Gly Gln Trp Ile Asn Val Asp
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His Pro Ala Ser Asp Gly Gly Gly Leu Ser Val Tyr Gly His Ile Ile
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Pro Glu Val Arg Val Gly Asp Gln Val Val Glu Gly Gln Arg Ile Gly
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Arg Ile Asn Pro Asp Gln Asn Thr Asn Gly Gly Val Ala Pro His Leu
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His Leu Glu Phe His Arg Ser Val Trp Ser Pro Pro Gly Gly Asp Arg
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Ala Pro Ser Asn Ser Ser Ala Lys Pro Glu Thr Gly Lys Val Lys Asn
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Leu Ile Gly Ala Glu Gly Phe Glu Phe Cys Ile Ile Lys Ala Thr Glu
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Gly Thr Trp Lys Asp Pro Ile Leu His Ser His Leu Ala Asp Val Arg
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Lys Asn Ser Gly Met Gln Val Gly Ala Tyr Val Tyr Val Arg Gly Glu
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Thr Ser Pro Glu Ala His Ala Ile Ala Leu His Glu His Leu Asn Asp
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Thr Ser Val Pro Val Ala Leu Asp Ile Glu His Asn Ser Gly Ser Asn
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Pro Asp His Trp Arg Ala Ile Lys Thr Ala Ile Glu Ala Arg Gly Tyr
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Arg Val Ile Leu Thr Tyr Leu Pro Glu Trp Tyr Trp Ser Gln Val Gly
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Gln Pro Asn Leu Ala Gly Leu Pro Pro Leu Trp Ala Ser Arg Tyr Val
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Gly Thr Thr Pro Gly Val Ala Ser Val Leu Tyr Ser Thr Ala Gly Arg
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Arg Gly Trp Gln Gly Tyr Gly Gly Leu Glu Val Ala Met Trp Gln Phe
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Glu Gly Thr Glu Lys Gln Leu Arg Ala Leu Phe His Gly Asp Thr Pro
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Glu Ile Glu Glu Glu Phe Asp Met Ser Ala Val Gln Glu Ile Lys Asp
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Tyr Ile Asp Thr Arg Leu Thr Gly Pro Val Gly Thr Asp Val Lys Asp
385 390 395 400
Ile Arg Gln Gln Ile Thr Gly Gly Arg Asp Ser Ile Pro Gly Asp Leu
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Lys Ala Ser Tyr Pro Gly Trp Asp Leu Gly Gln Leu Val Arg Ala Ala
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Arg Glu Lys Glu Phe Thr Gly Leu Thr Met Met Glu Ile Leu Ala Val
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Asn Ile Ala Gly Asn Asp Asp Asp Phe Arg Ala Ala Arg Val Ala Ala
450 455 460
Gly Thr Glu Glu Ala Gly Asn Ala Glu
465 470
<210> 6
<211> 426
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 6
Met Ala Asp Tyr Phe Tyr Pro Leu Ser Gln Gly Ala His Val Thr Ser
1 5 10 15
Pro Phe Gly Pro Arg Ala Gly Gly Tyr His Trp Gly Thr Asp Tyr Gly
20 25 30
Arg Ala Gly Gly Ser Gly Gly Asn Ala Val Tyr Ala Pro Gln Ala Gly
35 40 45
Thr Val Ile Met Ala Gly Pro Ala Ser Gly Phe Gly Gly Pro Asp Pro
50 55 60
Ala Gly Trp Ile Val Ile Asp His Pro Thr Ala Ala Gly Gly Gly Val
65 70 75 80
Ser Val Leu Gly His Ile Ile Arg Glu Val Ala Val Gly Asp Thr Val
85 90 95
Arg Ala Gly Gln Arg Ile Gly Arg Val Asn Pro Ser Ser Ala Thr Asn
100 105 110
Gly Gly Val Ala Pro His Val His Phe Glu His His Arg Tyr Val Trp
115 120 125
Ser Pro Pro Gly Pro Asp Arg Leu Asp Pro His Ala Trp Leu Ala Thr
130 135 140
Arg Gly Ala Arg Trp Pro Gly Ala Pro Ala Thr Pro Thr Arg Lys Glu
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Ser Met Asn Ala Leu Thr Ala Asp Ile Asp Leu Leu Thr Pro Asn Asp
165 170 175
Asp Gly Arg Ala Thr Lys Pro Arg Asn Leu Leu Cys Ile His Thr Phe
180 185 190
Glu Asp Asp Gly Thr Trp Ser Ala Asp Arg Met Ala Lys Tyr Gln Gln
195 200 205
Ser Pro Ala Ala Gly Gly Ser Tyr His Leu Val Ile Asp Leu Asn Gly
210 215 220
Arg Ile Ala Arg Glu Asn Asp Asp Ala Phe Ile Pro Trp Ala Ala Met
225 230 235 240
Phe Thr Gly Asn Arg Val Ala Phe His Phe Ser Leu Ser Gly Lys Ala
245 250 255
Ser Trp Thr Arg Gln Gln Trp Leu Ala Arg Pro Lys Gln Met Asp Ala
260 265 270
Leu Ala Lys Val Leu Ala Ala Tyr Ser Lys Ala Lys Gly Ile Pro Leu
275 280 285
Ile Arg Arg Gly Pro Gln Asp Val Arg Ala Gly Lys Trp Gly Val Cys
290 295 300
Gly His Asp Asp Ile Ser Lys Ala Phe Gly Glu Ser Thr His Trp Asp
305 310 315 320
Pro Gly Pro Asn Phe Pro Phe Asp Val Val Ile Asp Lys Ala Lys Ala
325 330 335
Ile Leu Ala Glu Pro Lys Pro Thr Pro Ala Pro Pro Ser Asp Pro Ala
340 345 350
Pro Arg Pro Ile Pro Pro Lys Glu Thr Leu Val Pro Thr Thr Leu Asp
355 360 365
Thr Val Leu Pro Ser Leu Val Asp Gly Ser Thr Phe Glu Ala Pro Leu
370 375 380
Ala Thr Phe Ile Arg Thr Ala Asp Lys Gln Ala Tyr Glu Ala Asn Gln
385 390 395 400
Arg Ile Ala Arg Leu Glu Ala Lys Phe Asp Arg Leu Leu Asp Ala Met
405 410 415
Gly Glu Lys Pro Asp Pro Lys Pro Gly Gln
420 425
<210> 7
<211> 285
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 7
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Ser Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ala Gly Gly Ser Ala His Tyr Val Cys Asp Val Gly Glu
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Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Lys Ala Ala Val Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys Tyr Asn Val Pro Lys Arg Lys Leu Ser Val Ser
130 135 140
Asp Leu Lys Ala Gly Arg Arg Gly Val Cys Gly His Thr Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Arg Phe Met Ala Val Val Asn Gly Gly Ser Gly Glu Ser Gly
180 185 190
Glu Leu Ser Met Ala Asp Val Lys Ala Leu His Asp Gln Ile Lys Gln
195 200 205
Leu Ser Gly Gln Val Ala Gln Ser Val Asn Lys Leu His His Asp Val
210 215 220
Gly Val Val Gln Val Gln Asn Gly Asn Leu Lys Lys Gln Val Asp Ser
225 230 235 240
Leu Ser Met Val Lys Asn Pro Val Thr Gly Lys Leu Trp Arg Thr Arg
245 250 255
Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val Leu Glu Cys Arg Ser Arg
260 265 270
Ile Gly Lys Leu Glu Ala Glu Val Ala Arg Leu Lys Lys
275 280 285
<210> 8
<211> 245
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 8
Met Ser Thr Ala Asn Tyr Phe Ala Ser Pro Ser Ser Gly Gly Ser Ala
1 5 10 15
His Tyr Val Cys Asp Ile Ser Glu Thr Val Gln Cys Leu Ser Glu Ser
20 25 30
Thr Ile Gly Trp His Ala Pro Pro Asn Pro His Ser Leu Gly Ile Glu
35 40 45
Ile Cys Ala Asp Gly Gly Ser His Ala Ser Phe Arg Val Pro Gly His
50 55 60
Ala Tyr Thr Arg Glu Gln Trp Leu Asp Pro Arg Val Trp Pro Ala Val
65 70 75 80
Glu Lys Ala Ala Ile Leu Cys Arg Arg Leu Cys Asp Lys Tyr Asn Val
85 90 95
Pro Lys Arg Lys Leu Ser Val Ala Asp Leu Lys Ala Gly Arg Arg Gly
100 105 110
Val Cys Gly His Val Asp Val Thr Asp Ala Trp His Gln Ser Asp His
115 120 125
Asp Asp Pro Gly Pro Trp Phe Pro Trp Asp Arg Phe Met Ala Val Val
130 135 140
Asn Gly Gly Ser Gly Asp Ser Gly Glu Leu Thr Val Ala Asp Val Lys
145 150 155 160
Ala Leu His Asp Gln Ile Lys Gln Leu Ser Ala Gln Leu Thr Gly Ser
165 170 175
Val Asn Lys Leu His His Asp Val Gly Val Val Gln Val Gln Asn Gly
180 185 190
Asp Leu Gly Lys Arg Val Asp Ala Leu Ser Trp Val Lys Asn Pro Val
195 200 205
Thr Gly Lys Leu Trp Arg Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr
210 215 220
Tyr Val Leu Glu Cys Arg Ser Arg Ile Asp Arg Leu Glu Ser Ala Val
225 230 235 240
Asn Gly Leu Lys Lys
245
<210> 9
<211> 281
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 9
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Lys Asn Thr Asn Lys Gly
180 185 190
Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala
195 200 205
Ser Asn Asn Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn
210 215 220
Gly Thr Leu Lys Ser Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro
225 230 235 240
Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp
245 250 255
Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg
260 265 270
Leu Ser Asp Ile Glu Lys Lys Val Lys
275 280
<210> 10
<211> 269
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 10
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Val Ser Gln Phe Ser Asp Leu Thr Lys Arg Leu
195 200 205
Gln Gly Met Gln Glu Gln Thr His His Asp Leu Gly Val Val Gln Thr
210 215 220
Lys Leu Ala Thr Met Asp Thr Val Lys Asn Pro Arg Thr Gly Ala Lys
225 230 235 240
Trp Ser Leu Lys Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val Leu Glu
245 250 255
Asn Arg Asp Arg Ile Ala Ala Leu Glu Lys Lys Val Lys
260 265
<210> 11
<211> 284
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 11
Met Asp Trp Thr Asn Leu Asn Ala Asp Val Thr Lys Leu Met Asn Val
1 5 10 15
His Phe Thr Pro Gly Arg Glu Gly His Thr Ile Asp Lys Ile Val Ile
20 25 30
His His Asn Gly Gly Asn Leu Ser Ile Asp Gln Ile Trp Asn Val Trp
35 40 45
Gln Asp Arg Glu Ala Ser Ala His Tyr Gln Val Gln Ser Asp Gly Arg
50 55 60
Ile Gly Gln Leu Val Asn Asp Trp Asp Thr Ala Trp His Ala Gly Asp
65 70 75 80
Trp Asp Ala Asn Leu Thr Ser Ile Gly Ile Glu His Ala Asp Asp Ser
85 90 95
Thr Asp Pro Trp His Val Ser Asp Ala Ala Val Asp Ala Gly Ala His
100 105 110
Leu Val Ala Ala Leu Cys Arg Gly Tyr Asn Leu Gly Arg Pro Glu Trp
115 120 125
Met Arg Asn Val Phe Pro His Ser His Phe Ser Ala Thr Ser Cys Pro
130 135 140
Ala Ser Leu Ala Glu Asn Gln Arg Ala Asp Tyr Met Ala Arg Ala Gln
145 150 155 160
Ala Tyr Phe Asp Gly Ala Pro Val Thr Gly Arg Ser Ser Val Pro Ala
165 170 175
Pro Ala Pro Ala Pro Ala Gly Ile His Val Asp Leu Pro Ala Trp Thr
180 185 190
Leu Pro Ala Gly Asn Phe Tyr Gly Ser Ile Asp Gly Gly Glu Asp Ser
195 200 205
His Gly Gly Tyr Tyr Glu Gly Glu Arg Pro Ala Ile Ala Ala Ile Gln
210 215 220
Arg Trp Leu Ile Arg His Gly Tyr Ala Gly Ala Val Asp Asp Ser Trp
225 230 235 240
Ala Asp Gly Leu Tyr Glu Gln Pro Thr Val Asp Ala Val Thr Arg Phe
245 250 255
Gln Arg Ala Glu Arg Pro Asn Ser Thr Asp Arg Trp Gly Glu Val Trp
260 265 270
Ala Asp Asp Leu Ala Thr Met Ala Ala Asn Asn Gly
275 280
<210> 12
<211> 298
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 12
Met Asp Arg Gly Ile Asp Val Ser Ser Tyr Gln Ala Pro Asp Gly Gly
1 5 10 15
Leu Leu Glu Gly Met Ser Phe Cys Ile Ile Lys Ala Thr Glu Gly Thr
20 25 30
Gly Tyr Val Asn Pro Asn Arg Thr Gln Trp Tyr Lys Val Ala Thr Asp
35 40 45
Arg Gly Val Thr Thr Gly Ala Tyr His Phe Met Arg Gly Gly Asp Pro
50 55 60
Val Ala Gln Ala Asp Tyr Phe Leu Ala His Leu Pro Gly Asp Val Asp
65 70 75 80
Trp Leu Ala Leu Asp Val Glu Asp Pro Ser Asp Gly Leu Ser Trp Ala
85 90 95
Gly Arg Val Ser Phe Ile Leu Ala Trp Thr Asp Arg Val Lys Ala Thr
100 105 110
Gly Lys Pro Thr Leu Val Tyr Cys Ser Arg Ser Trp Ala Asn Ala Leu
115 120 125
Leu Gly Ala Ala Ser Ser Asp Glu Arg Ala Arg Leu Ala Gln Leu Pro
130 135 140
Leu Trp Met Ala Asp Tyr Thr Gln Arg Pro Gly Glu Tyr Ser Gly Pro
145 150 155 160
Trp Pro Gly Gly Trp Pro Ile Ala Ile His Gln Tyr Thr Ser Ala Pro
165 170 175
Ile Asp Lys Asn Val Leu Leu Thr Asp Asp Leu Gln Gly Gly Asp Asp
180 185 190
Met Pro Leu Ser Thr Asp Asp Leu Arg Asn Ile Ala Thr Ala Val Trp
195 200 205
Gly Gly Gly Gly Ala Ala Ser Pro Met Tyr Ala Asp Arg Leu Asp Gly
210 215 220
His Gln Glu Tyr Pro Glu Thr Ala Leu Phe Ser Leu Gln Gln Arg Leu
225 230 235 240
Gly Ala Arg Phe Gly Glu Leu Ser Gly Lys Ile Asp Gly Leu Ala Glu
245 250 255
Ala Leu Lys Gln Val Gln Gly Gly Asn Gly Val Asp Ala Asp Ala Ile
260 265 270
Arg Ala Ala Ala Ala Glu Gly Ala Lys Ala Gly Val Gln Ala Met Ile
275 280 285
Asp Thr Ala Thr Val Asn Leu Glu Ala Lys
290 295
<210> 13
<211> 297
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 13
Met Cys Gly Ala Phe Ser Phe Leu Lys Asp Leu Glu Thr Phe Met Asp
1 5 10 15
Trp Thr Asn Leu Asn Ala Asp Val Thr Lys Leu Met Gly Val His Phe
20 25 30
Thr Pro Gly Arg Glu Gly Arg Thr Ile Asp Lys Ile Val Ile His His
35 40 45
Asn Gly Gly Asn Leu Ser Ile Asp Gln Ile Trp Asn Val Trp Gln Thr
50 55 60
Arg Glu Ala Ser Ala His Tyr Gln Val Glu Ala Gly Gly Arg Ile Gly
65 70 75 80
Gln Leu Val Asn Asp Leu Asp Thr Ala Trp His Ala Gly Asp Trp Asp
85 90 95
Ala Asn Leu Thr Ser Ile Gly Ile Glu His Ala Asp Asp Ser Thr Asp
100 105 110
Pro Trp His Val Ser Asp Ala Ala Val Asp Ala Gly Ala His Leu Val
115 120 125
Ala Ala Leu Cys Arg Gly Tyr Asn Leu Gly Arg Pro Glu Trp Met Arg
130 135 140
Asn Val Phe Pro His Ser Gln Phe Thr Ser Thr Ser Cys Pro Ala Ser
145 150 155 160
Leu Ala Arg Asp Gln Leu Gly Asp Tyr Met Gly Arg Ala Gln Ala Tyr
165 170 175
Phe Asp Gly Ala Pro Val Ala Ala Val His Gln Ser Val Pro Ala Pro
180 185 190
Ala Pro Ala Pro Ser Arg His Val Asp Leu Pro Ala Trp Asn Leu Pro
195 200 205
Glu Gly Asn Phe Tyr Gly Leu Val Ser Gly Gly Asn Asp Ser His Gly
210 215 220
Gly Phe Tyr Pro Ala Glu Arg Pro Ala Val Arg Ala Ile Gln Leu Trp
225 230 235 240
Leu Ile Arg His Gly Tyr Ala Gly Ala Val Pro Asp Ser Trp Ala Asp
245 250 255
Gly Ile Tyr Glu Gln Pro Thr Ala Asp Ala Val Thr Ala Phe Gln His
260 265 270
Ala Glu Arg Pro Asn Ser Thr Asp Arg Trp Gly Glu Val Trp Ala Asp
275 280 285
Asp Leu Ala Thr Met Ala Ala Asn Asn
290 295
<210> 14
<211> 354
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 14
Met Lys Ala Ser Arg Val Ile Val Val Ala Ser Val Val Ala Leu Ile
1 5 10 15
Leu Ala Gly Leu Ala Met Ser Ser Ala Ala Val Ile Val Val Pro Leu
20 25 30
Leu Ser Val Gly Ala Gly Ala Leu Asp Asp Asn Ser Gly Ala Gly Gly
35 40 45
Val Gly Gly Asp Pro Cys Ile Gly Thr Val Thr Gly Gly Ala Val Ser
50 55 60
Val Gly Gly Leu Thr Thr Arg Gln Lys Gln Leu Val Thr Thr Ile Val
65 70 75 80
Thr Val Val Gln Arg Asp Lys Leu Pro Val Gln Ala Ala Val Ile Ala
85 90 95
Ile Met Thr Ala Lys Gln Glu Ser Asp Leu Gly Ala Asn Pro Ala Ala
100 105 110
Thr Lys Pro Asn Gly Asp Gly Asp Ala Gly Pro Phe Gln Gln Arg Val
115 120 125
Leu Pro Gly Trp Tyr Gly Thr Leu Asp Gln Val Asn Asn Asp Ala Tyr
130 135 140
Ala Thr Glu Thr Phe Leu Lys Gly His Thr Ile Thr Tyr Ala Gly Pro
145 150 155 160
Thr Ser Ala Gly Gly Pro Gly Tyr His Ile Pro Gly Leu Val Asp Val
165 170 175
Pro Asp Trp Gln Ser Lys Ser Pro Ala Gln Ala Ala Gln Ala Val Gln
180 185 190
Ala Ser Ala Leu Pro Asn Ala Tyr Ala Lys Trp Glu Ala Ile Ala Lys
195 200 205
Gln Met Val Gly Ala Thr Thr Thr Gly Arg Leu Ser Asn Asp Cys Val
210 215 220
Thr Gly Thr Ala Asn Glu Thr Gly Val Ser Lys Asn Leu Thr Lys Ala
225 230 235 240
Val Glu Trp Ala Lys Ser Ile Ala Ala Asn Asn Ser Tyr Thr Tyr Val
245 250 255
Trp Gly Gly Asn Gly Ala Ser Asp Gly Gly Tyr Asp Cys Ser Gly Leu
260 265 270
Thr Ser Ala Leu Tyr Arg Arg Ile Gly Ile Asn Leu Pro Arg Thr Ala
275 280 285
Ala Glu Gln Gln Lys Val Gly Thr Pro Val Asn Arg Asn Gln Leu Lys
290 295 300
Val Gly Asp Leu Ile Phe Trp Gly Ile Pro Ala His His Val Ala Thr
305 310 315 320
Tyr Ile Gly Arg Gly Gln Met Ile Ser Ala Asp Asn Gln Ala Arg Gly
325 330 335
Ile Asn Val Glu Lys Ile Tyr Gly Asn Pro Ser Ser Tyr Arg Arg Ile
340 345 350
Val Lys
<210> 15
<211> 280
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 15
Met Asp Trp Thr Asn Leu Asn Ala Asp Val Thr Lys Leu Met Asn Val
1 5 10 15
His Phe Thr Pro Gly Arg Glu Gly Arg Thr Ile Asp Lys Ile Val Ile
20 25 30
His His Asn Gly Gly Asn Leu Ser Ile Asp Gln Ile Trp Asn Val Trp
35 40 45
Gln Asp Arg Glu Ala Ser Ala His Tyr Gln Val Glu Ser Ser Gly Arg
50 55 60
Ile Gly Gln Leu Val Asn Asp Trp Asp Thr Ala Trp His Ala Gly Asp
65 70 75 80
Trp Asp Ala Asn Leu Thr Ser Ile Gly Ile Glu His Ala Asp Asp Ser
85 90 95
Thr Asp Pro Trp His Val Ser Asp Ala Ala Ile Asp Ser Gly Ala His
100 105 110
Leu Val Ala Ala Leu Cys Arg Ala Tyr Asn Leu Gly Arg Pro Glu Trp
115 120 125
Met His Asn Val Phe Pro His Ser His Phe Ser Ala Thr Ser Cys Pro
130 135 140
Ala Ser Leu Ala Glu Asn Gln Arg Ala Asp Tyr Met Ser Arg Ala Gln
145 150 155 160
Ala Tyr Tyr Asp Gly Thr Ser Val Ala Ala Ala Pro Ala Ala Pro Ser
165 170 175
Ala Pro Ala Gly Ile His Val Asp Leu Pro Ser Trp Thr Leu Pro Ile
180 185 190
Gly His Tyr Tyr Gly Leu Val Thr Gly Pro Asn Asp Ser His Gly Gly
195 200 205
Phe Tyr Glu Ser Glu Arg Pro Ala Val Arg Ala Ile Gln Leu Trp Leu
210 215 220
Ile Arg His Gly Tyr Ala Gly Ala Val Pro Asp Ser Trp Ala Asp Gly
225 230 235 240
Ile Tyr Glu Gln Pro Thr Ala Asp Ala Val Thr Ala Phe Gln His Ala
245 250 255
Glu Arg Pro Asn Ser Thr Asp Arg Trp Gly Glu Val Trp Ala Asp Asp
260 265 270
Leu Ala Thr Met Ala Ala Asn Asn
275 280
<210> 16
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 16
Met Asp Trp Thr Asn Leu Ile Ala Asp Thr Thr Lys Leu Met Gly Val
1 5 10 15
His Phe Thr Pro Gly Arg Glu Gly Arg Lys Ile Asp Lys Ile Val Ile
20 25 30
His His Asn Gly Gly Asn Leu Ser Ile Asp Gln Ile Trp Asn Val Trp
35 40 45
Gln Thr Arg Glu Ala Ser Ala His Tyr Gln Val Glu Thr Gly Gly Arg
50 55 60
Ile Gly Gln Leu Val Asn Asp Trp Asp Thr Ala Trp His Ala Gly Asp
65 70 75 80
Trp Asp Ala Asn Leu Thr Ser Ile Gly Ile Glu His Ala Asp Asp Ser
85 90 95
Thr Asp Pro Trp His Val Ser Asp Ala Ala Val Asp Ala Gly Ala His
100 105 110
Leu Val Ala Ala Leu Cys Lys Ala Tyr Ser Leu Gly Arg Pro Glu Trp
115 120 125
Met Arg Asn Val Phe Pro His Ser His Phe Ser Ala Thr Ser Cys Pro
130 135 140
Ala Ser Leu Ala Glu Asn Gln Arg Ala Asp Tyr Met Ser Arg Ala Gln
145 150 155 160
Ala Tyr Tyr Asp Gly Ala Pro Val Ala Ala Val His Gln Ser Ala Pro
165 170 175
Ala Pro Ala Pro Ala Ser Ser Arg His Val Asp Leu Pro Ala Trp Asn
180 185 190
Leu Pro Glu Gly Asn Phe Tyr Gly Leu Ala Ser Gly Gly Glu Asp Ser
195 200 205
His Gly Gly Phe Tyr Glu Gly Glu Arg Pro Ala Ile Arg Gln Ile Gln
210 215 220
Leu Trp Leu Ile Arg His Gly Tyr Ala Gly Ala Val Pro Asp Ser Trp
225 230 235 240
Ala Asp Gly Ile Tyr Glu Gln Pro Thr Ala Asp Ala Val Ala Ala Phe
245 250 255
Gln His Ala Glu Arg Pro Asn Ser Thr Asp Arg Trp Gly Glu Val Trp
260 265 270
Ala Asp Asp Leu Ala Thr Met Ala Ala Asn Asn
275 280
<210> 17
<211> 290
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 17
Met Met Arg Met Leu Lys Ala Ala Ser Pro Trp Leu Leu Arg Ala Cys
1 5 10 15
Val Leu Leu Val Ala Leu Ser Phe Val Ile Glu Val Pro Val Trp Leu
20 25 30
Val Phe Ala Pro Leu Gly Leu Ala Ile Ala Val Pro Ser Pro Arg Ala
35 40 45
Asp Asp Glu Ser Pro Gln Thr Met His Ala Pro Val Thr Gly Arg Trp
50 55 60
Val Ala Ile Asn Ser Pro Ala Thr Lys Val Pro Ser His Gly Val Arg
65 70 75 80
Thr Leu Gly Gln Ala Phe Ala Val Asp Ile Leu Gln Ala Ser Asp Ser
85 90 95
Pro Arg Glu Ser Ala Pro Gly Trp Gln Trp Arg Gln Ala Glu Pro Gln
100 105 110
Glu Phe Pro Ser Phe Gly Glu Pro Val Leu Ala Ala Gly Cys Gly Thr
115 120 125
Val Ile Ala Ala His Asp Gly Lys Arg Asp His Arg Ala Arg Asn Thr
130 135 140
Trp Pro Gly Leu Ile Tyr Met Met Ser Leu Glu Ala Phe Gly Arg Glu
145 150 155 160
Leu Ala Gly His Arg Ser Ile Ile Gly Asn His Val Ile Leu Asp His
165 170 175
Ser Asp Gly Thr Phe Ser Met Tyr Ala His Leu Lys His Gly Ser Ala
180 185 190
Ala Val Cys Val Gly Gln Lys Val Arg Ala Gly Asp Val Leu Gly Ala
195 200 205
Val Gly Asn Thr Gly Asn Thr Ser Glu Pro His Leu His Phe Gln Leu
210 215 220
Met Asp Arg Pro Gln Ala Ala Met Ala Ala Gly Leu Pro Phe Arg Trp
225 230 235 240
Ser Pro Leu Thr Ile Glu Pro Asp Pro Asp Pro His Trp Ala Pro Lys
245 250 255
Lys Pro Val Ala Glu Thr Val Glu Gly Leu Pro Ala Thr Gly Gln Ile
260 265 270
Phe Arg Thr Pro Glu Ser Gly Val Met Pro Gln Pro Lys Arg Glu Ala
275 280 285
Ser Cys
290
<210> 18
<211> 252
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 18
Met Arg Arg Ser Val Cys Ile Ser Leu Leu Ile Ile Thr Val Gly Ile
1 5 10 15
Cys Leu Leu Ala Phe Pro Ala Pro Ser His Ser Ile Ala Ala Val Pro
20 25 30
Ala Arg Ser Val Ala Asn Arg Pro Thr Pro Pro Val Leu Gly Pro Val
35 40 45
Ile Lys Gly Phe Ala Pro Pro Ala Glu Lys Trp Leu Pro Gly Ser Arg
50 55 60
Gly Val Glu Phe Ala Ala Ser Val Gly Glu Pro Val Thr Thr Val Thr
65 70 75 80
Ala Gly Val Val Val Phe Ala Gly Gln Val Ala Gly Ala Gly Val Val
85 90 95
Ser Ile Leu Leu Ala Asp Gly Arg Arg Thr Thr His Met Pro Val Val
100 105 110
Pro Ser Val Ala Val Gly Gln Val Val Val Pro Gly Gln Gln Ile Gly
115 120 125
Val Val Gly Met Gly Pro Pro Cys Thr Arg Thr Cys Leu His Trp Gly
130 135 140
Leu Lys Lys Gly Asp Val Tyr Gln Asn Pro Met Thr Leu Leu Gln Leu
145 150 155 160
Gln Val Arg Leu Leu Pro Leu Asp Ser Arg Pro His Ser Ala Ser Gly
165 170 175
His Gly Trp Pro Val Arg Pro Leu Ser Leu Pro Gly Gly Ser Arg Arg
180 185 190
Lys Ala Ala Ser Ser Gly Ala Leu Met Pro Pro Trp Arg Gly Ala Gly
195 200 205
Arg Asp Ala Ala Leu Gly Ile Asp Thr Thr Val Thr Glu Ala Thr Arg
210 215 220
Gly Gly Ser Gly Ala Gly Met Ser Leu Ala Lys Arg Ser Ala Gln Ser
225 230 235 240
Phe Gly Gly Asn Val Gly Val Asp Leu Arg Gly Gly
245 250
<210> 19
<211> 216
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 19
Met Ala Lys Thr Leu Ser Arg Ile Ala Ser Val Ala Ala Ala Ala Ala
1 5 10 15
Leu Ala Gly Gly Val Ser Val Thr Ala Ala Gln Ser Ala Ser Ala Asp
20 25 30
Asp Val Asn Trp Asp Ala Ile Ala Asn Cys Glu Ser Gly Gly Asn Trp
35 40 45
Ser Thr Asn Thr Gly Asn Gly Tyr Tyr Gly Gly Leu Gln Phe Ser Gln
50 55 60
Ser Thr Trp Ala Ala Tyr Gly Gly Ser Gly Ser Ala Ser Asn Ala Ser
65 70 75 80
Arg Glu Glu Gln Ile Ala Val Ala Glu Arg Val Leu Ala Gly Gln Gly
85 90 95
Ile Gly Ala Trp Pro Val Cys Gly Ala Tyr Ala Tyr Ser Gly Glu Ser
100 105 110
Tyr Thr Gly Thr Asn Thr Glu Gly Ser Tyr Gly Ser Ser Tyr Asp Thr
115 120 125
Ser Ala Gln Asp Ala Ser Tyr Asp Gly Ser Tyr Ser Tyr Asp Asn Ser
130 135 140
Tyr Ser Tyr Asp Asn Ser Ala Gly Tyr Asp Ser Ser Ser Ala Tyr Ser
145 150 155 160
Gly Gly Tyr Gln Ala Thr Arg Glu Ala Thr Gly Thr Tyr Glu Ile Gln
165 170 175
Pro Gly Asp Thr Leu Asn Ala Ile Ala Glu Ala His Gly Thr Thr Trp
180 185 190
Gln Glu Leu Ala Ala Leu Asn Ser Ser Ile Val Asp Ala Asn Leu Ile
195 200 205
Tyr Ala Gly Glu Thr Ile Asn Val
210 215
<210> 20
<211> 250
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 20
Met Ala Tyr Pro Tyr Ile Gly Ala Leu Lys His Gly Gly Lys Gln Gly
1 5 10 15
Lys Ile Gln Arg Ile Val Ile His Ala Thr Val Ser Pro Cys Val Arg
20 25 30
Gly Gly Ala Arg Asn Val Ala Lys Tyr Phe Gln Ser Ser Ala Ala Gly
35 40 45
Gly Ser Ala His Tyr Val Val Asp Pro Gly Glu Ile Ile Gln Cys Val
50 55 60
Lys Asp Asp Val Val Ala Tyr His Ala Pro Pro Asn Thr Gly Thr Leu
65 70 75 80
Gly Ile Glu Leu Cys Asp Pro Gln Ala Gly Ser Pro Lys Arg Trp Ser
85 90 95
Asn Glu Ala His Gln Ala Met Leu Val Leu Ala Ala Lys Leu Val Arg
100 105 110
Glu Leu Ala Ala Lys His Asp Val Pro Leu Val Arg Val Thr Ala Ala
115 120 125
Gln Leu Arg Ala Gly Lys Arg Gly Ile Cys Ser His Val Ala Val Ser
130 135 140
Asp Ala Phe Gly Gln Ser Asp His Gly Asp Pro Glu Val Ala Gly Pro
145 150 155 160
Phe Pro Trp Ala Lys Phe Met Gln Leu Ile Lys Glu Glu Asp Asp Met
165 170 175
Pro Ser Pro Lys Glu Ile Tyr Glu Ala Val Trp Glu Gln Asp Val Met
180 185 190
Ala Ala Pro Asp Gly Ser Lys Ser Asn Pro Thr Trp Lys Pro Ser Ser
195 200 205
Val Leu Thr Asp Val Asp Lys Lys Val Arg Ala Leu Gln Ser Gln Val
210 215 220
Thr Gly Leu Glu Ser Glu Leu Ala Ala Thr Asn Ala Lys Leu Asp Gln
225 230 235 240
Val Leu Thr Leu Leu Arg Ala Ser Val Ser
245 250
<210> 21
<211> 282
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 21
Met Thr Phe Ile Gln Ala Ala His Arg Gly Gly Thr Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Ala Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys His Arg His His Ile Pro Ile Arg Arg Leu Ser Val Ala
130 135 140
Gln Val Arg Ala Gly Glu Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr Thr Pro Glu
180 185 190
Gly Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys
195 200 205
Ala Ser Asn Asp Gln Leu His Tyr Asp Ile Gly Val Val Gln Thr Gln
210 215 220
Asn Gly Asn Ile Lys Lys Lys Ile Asp Asn Leu Ser Trp Val Lys Asn
225 230 235 240
Pro Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val
245 250 255
Trp Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn
260 265 270
Arg Ile Tyr Asp Leu Glu Lys Lys Val Lys
275 280
<210> 22
<211> 287
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 22
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Lys Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ser Gly Gly Ser Ala His Tyr Val Cys Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys His Gly Val Pro Lys Arg Lys Leu Ser Val Ala
130 135 140
Asp Leu Lys Ala Gly Lys Arg Gly Val Cys Gly His Val Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly Gly Ser Ser
180 185 190
Ser Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His Asn Gln Ile
195 200 205
Lys Gln Leu Ser Ala Gln Val Ala Gln Ser Val Asn Lys Leu His His
210 215 220
Asp Val Gly Val Val Gln Val Gln Asn Gly Asp Leu Gly Lys Arg Val
225 230 235 240
Asp Ala Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Leu Trp Arg
245 250 255
Ser Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg
260 265 270
Ser Arg Leu Asp Arg Leu Glu Ser Ala Val Asn Asp Leu Lys Lys
275 280 285
<210> 23
<211> 281
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 23
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Ala Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Thr Thr Asp Arg Pro Ala Ser Ala His Tyr Val Cys Asp Ile Ala Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Asp Gln Trp Leu
100 105 110
Ser Asp Asp Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys Gln Arg His Arg Ile Pro Val Arg Lys Leu Ser Thr Ala
130 135 140
Gln Val Lys Ala Gly Leu Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Gly Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gln Phe Met Ala Leu Val Gln Gly Lys Pro Ala Thr Pro Gly
180 185 190
Asp Leu Thr Met Ala Asp Ile Ser Lys Leu Thr Asp Ala Ile Lys Ala
195 200 205
Ser Asn Arg Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn
210 215 220
Gly Lys Leu Arg Glu Gln Ile Glu Arg Ile Thr Trp Val Lys Asn Pro
225 230 235 240
Val Thr Gly Lys Lys Trp Arg Ile Thr Asp Ala Leu Trp Ser Ile Trp
245 250 255
His Tyr Val Leu Glu Cys Arg Thr Arg Ile Gln Arg Leu Asp Ala Arg
260 265 270
Leu Ser Glu Val Glu Lys Lys Val Lys
275 280
<210> 24
<211> 282
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 24
Met Thr Phe Ile Gln Ala Ala His Arg Gly Gly Thr Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Ala Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Ile Gly Ile Glu Ile Cys Ala Ala Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys His Arg His His Ile Pro Ile Arg Arg Leu Ser Val Ala
130 135 140
Gln Val Arg Ala Gly Glu Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr Thr Pro Glu
180 185 190
Gly Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys
195 200 205
Ala Ser Asn Asp Gln Leu His Tyr Asp Ile Gly Val Val Gln Thr Gln
210 215 220
Asn Gly Asn Ile Lys Lys Lys Ile Asp Asn Leu Ser Trp Val Lys Asn
225 230 235 240
Pro Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val
245 250 255
Trp Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn
260 265 270
Arg Ile Tyr Asp Leu Glu Lys Lys Val Lys
275 280
<210> 25
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 25
Met Thr Phe Ile Gln Ala Lys His His Gly Gly His Asn Asn Pro Pro
1 5 10 15
Val Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala His Tyr Phe Gln
35 40 45
Glu Thr Thr Arg Pro Ala Ser Ala His Tyr Ile Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Val Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Ser Asn Pro Ala His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Met Leu Ala Arg
115 120 125
Gly Ile Cys Gln Arg His Asn Ile Pro Ile Arg Arg Leu Ser Ile Ala
130 135 140
Asp Val Lys Ala Gly Lys Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gly Phe Ile Ala Leu Val Asn Gly His Ser Ala Pro Ser Arg
180 185 190
Gln Glu Glu Leu Thr Val Ser Asp Val Asn Met Leu Lys Gly Leu Ile
195 200 205
Gln Gln Ser Asn Lys Gln Leu His His Asp Ile Gly Val Val Gln Thr
210 215 220
Gln Ala Gly Asn Leu Arg Arg Gln Leu Glu Ser Leu Ser Trp Val Lys
225 230 235 240
Asn Pro Val Ser Gly Lys Leu Trp Arg Thr Lys Asp Ala Leu Trp Ser
245 250 255
Ile Trp Tyr Tyr Val Leu Asp Cys Arg Ser Arg Leu Gly Lys Leu Glu
260 265 270
Ala Arg Leu Ser Thr Leu Glu Lys Lys Val Lys
275 280
<210> 26
<211> 267
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 26
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Asp Trp Gln Arg Met Glu Arg Leu
195 200 205
Val Asp Ala Arg Leu Lys Tyr Ala Gly Ile Ala Lys Asn Asp Asp Pro
210 215 220
Val Phe Lys Pro Asp Lys Ser Ser Ser Trp Pro Trp Arg Thr Ala Leu
225 230 235 240
Trp Ser Ile Ser Tyr Tyr Ala Thr His Ser Tyr Asn Thr Ile Cys Asn
245 250 255
Ile Ala Arg Lys Leu Gly Ala Glu Val Ser Lys
260 265
<210> 27
<211> 284
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 27
Met Lys Tyr Ile Pro Ala Thr His His Gly Gly His Thr Asn Thr Pro
1 5 10 15
Phe Thr Arg Ile Val Ile His Ala Thr Cys Pro Asp Leu Gly Phe Pro
20 25 30
His Ala Ser Ala Gly Gly Gln Ala Lys Ala Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Glu Gln Ser Ala Gly Ser Ala His Tyr Val Cys Asp Ile Ala Glu
50 55 60
Thr Ile Gln Cys Leu Pro Asp Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Arg Arg Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ser Ser Phe Gln His Pro Glu His Ala Tyr Thr Arg Ser Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Ala Arg Ala Ala Ala Leu Thr Arg
115 120 125
Asp Leu Cys His Arg His Asn Ile Pro Met Gln Gln Leu Ser Val Ala
130 135 140
Asp Val Lys Ala Gly Lys His Gly Ile Cys Gly His Asn Asp Val Ser
145 150 155 160
Glu Ala Phe His Lys Ser Asp His Asp Asp Pro Gly Pro Thr Phe Pro
165 170 175
Trp Asp Gln Phe Ile Lys Glu Val Arg Thr Pro Gly Gln Gln Asp Thr
180 185 190
Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp
195 200 205
Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu
210 215 220
Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn
225 230 235 240
Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly
245 250 255
Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val
260 265 270
Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
275 280
<210> 28
<211> 489
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 28
Met Val Ala His Ser Val Trp Ser Gly Gly Gln Ala Arg Gly Val His
1 5 10 15
Gly Asn Pro Thr Gly Gly Arg Gln Val Phe Gly Trp Val Ala Pro Ala
20 25 30
Ser Asp Glu Pro Lys Thr Val Gly Gln Glu Arg Leu Val Val Gly Leu
35 40 45
Gln Val Thr Ile Gly Ala Gln Leu Leu Pro Leu Met Thr Gln Leu Val
50 55 60
Ile Trp Ala Thr Thr Arg Leu Val Pro Met Leu Lys Arg Thr Gly Asp
65 70 75 80
Trp Leu Lys Asn His His Arg Gln Ile Ala Asp Leu Ala Pro Lys Ile
85 90 95
Leu Lys Val Ala Leu Ala Leu Ala Gly Val Phe Ser Ala Ile Lys Leu
100 105 110
Val Asn Ile Ala Thr Ser Leu Thr Thr Ser Ile Leu Gly Leu Val Ala
115 120 125
Thr Pro Val Gly Gln Val Val Leu Ala Val Gly Ala Val Ala Ala Ala
130 135 140
Ile Ala Gly Leu Val Ala Ala Leu Ile Tyr Ala Tyr His His Cys Arg
145 150 155 160
Glu Phe His Asp Gly Gly Thr Arg Trp Ser Thr Ala Ser Cys Arg Pro
165 170 175
Gly Val Gly Arg Ser Gly Ser Ser Arg Cys Gly Cys Arg Arg Arg Arg
180 185 190
Trp Arg Gly Arg Arg Ser Ala Ser Pro Pro Leu His Pro Ser Leu His
195 200 205
Arg Thr Leu Asn Pro His His Val Glu Glu Asn Asp Met Gln Phe Ile
210 215 220
Gln Ala Ala His His Ser Ala Asp Pro Asn Leu Pro Pro Thr Arg Val
225 230 235 240
Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro Ser Ala Ser Arg
245 250 255
Ala Gly Arg Ala Val Gly Thr Ala Gly Tyr Leu Ala Ser Ile Ser Ala
260 265 270
Ser Gly Ser Ala His Tyr Val Cys Asp Ala Thr Glu Thr Val Gln Tyr
275 280 285
Leu Gly Glu Asp Val Ile Gly Trp Leu Ala Pro Pro His Gly His Ser
290 295 300
Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg Ala Ser Phe Asn
305 310 315 320
Asn Pro Ser His Ala Tyr Ser Pro Lys Gln Trp Leu Ser Pro Gln Val
325 330 335
Trp Leu Ala Val Glu Lys Ala Ala His Leu Thr Arg Gln Ile Cys His
340 345 350
Arg Tyr Ala Ile Pro Met Arg Arg Leu Thr Val Ala Gly Thr Pro Arg
355 360 365
Arg Gly Cys Val Arg Cys Arg Arg Arg Arg Ser Val Ser Arg Val Ala
370 375 380
Gly Asn Arg Arg Cys Arg Trp Met Phe Leu Thr Ala Arg Arg Gly Gly
385 390 395 400
Pro Ala Arg Val Gln Val Arg Leu Arg Cys Pro Ala Arg Ser Pro Glu
405 410 415
Arg Gly Pro Leu Leu Gly Trp Leu Pro Gly Gly Gly Ala Phe Val Met
420 425 430
Pro Arg His Leu Pro Ser Pro Val Gly Val Ile Val Pro Gly Thr Ile
435 440 445
Ser Ser Arg Ser Gln Gln Glu Ile Pro Ser Gln Arg Arg Thr Gln Leu
450 455 460
Arg Ser Pro Asp Ser Pro Pro Asp Tyr Pro Gln Asn Arg Pro Thr Pro
465 470 475 480
Ser Pro Glu Gly Lys Lys Lys Thr Ser
485
<210> 29
<211> 1509
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 29
atgtcacttg ggtctggcag gaaggagaga atacataaga tggatgttaa cacactaagg 60
gaggtgatgg ggaattaccg aaacgttaac tatgacgcta tggtaggccc catgaatgag 120
gcgatgatcg ctgctggatg cactaacctc cggcgagctg ctatgtggtg tgctcagatc 180
ggccacgagt cagaaggcct caccgcgatg gaagagtacg ccagcggagc tggctacgaa 240
ggaaggcttg atctaggcaa tactcagcct ggagacggag tgcgctacaa gggccgaggc 300
cctatccagc tcacgggtag gtccaactat cgagccttta ctacgtgggc tagaagcaag 360
ggctatacaa ctatcgactt tgaggcggaa ccacacaagg tttccgagcc taagtgggga 420
ttccttgcag cgtccttcta ttggacggtg aggaggcctg acattaactc tctggccgac 480
cagggagatg taacgagagt aactcacagg attaacggag gagaaaacgg actcagtgac 540
cgtatagcga gatataatcg cgcgatggca ctcggggacc gaatccttcc ttcagcctct 600
gagacaggca cacagacatc gaaaacgacg gctgcggaga aggtcctgga ttataagcga 660
gactgggtga agcaggacac ctactataac tgcggtcccg cttcttgtca gacagtaatc 720
ggcgcagcta cagggaatta ccctggagag gttgagctgg cagcagctct caagaccacg 780
attaacggaa ctgactggat cggagtcttc cctggagtcc taaacaggta cattcccgga 840
ggaaagtact cctccaggga gatacctaac gatccgccaa ggagcgacca gagagatcag 900
ctctggaagg acatcataaa ctccatcaac tccggttatg gagtcgtggc aaacattgtt 960
gctcctccaa gcaactaccc gagagcgagc tacaagtcca cacagtcccc agcctatgca 1020
ggcggaacag tgtatcacta cgttgcggtg atgggttacg ccattgacga cagcggaaga 1080
tctcatgtgt gggtcgcaga ttccggtttc gcaccctatg gctactggat gactctccag 1140
cagctatcca cgcttatccc accaaaggga tatgcgtact ccaccaacat tcctcaggaa 1200
ggactagata tggacgcagt aaagcaaatc atcgactttg ttaagggctg gacaggcccg 1260
atgatccagg acatcaagga catcagacag cagctgaccg gaggcaggga tactgtctac 1320
cgagaggatg gctctgttga ccttgttgcc agctacccag gctggaggca gctaggaacc 1380
gacaagaacg gaaacccgct ctctatggtc gatagtatcg cctggagcca tgtgaagtca 1440
gataagatca tcgagatcct tacggctctc caggatcgta tcaccgaact agaaaagaag 1500
gttaagtaa 1509
<210> 30
<211> 1032
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 30
atgaccaaga ttctgaccat cgaaaaggca cgcgagttcg acgctttcgc gcgcgcccgc 60
gacaacctgt actacgggta cggcgaggca ttcacccgta accctcgcca gtcgaccgac 120
tgctccgggc tcgtcctgca gtcgggtgcg atcctcggtg gccgcaccga ctgggtggga 180
aaccgctacg gatcgaccga gtcgttccgc ctcgactacg cgatcgtgta cgcgctggga 240
ttcaagcgca tgcctcgagg tgggttgccg ttcgtgccgg tgatgaaggt cggtctgcag 300
cacggtggcg gcgggatcta ctcccacacc gcgtgcacgc tgatgttcct cgacaagccc 360
ggtggcccga tcaaggagtc tgcgcggggc gtcgactggg agtcccaggg cgccggcgtc 420
ttttactacg agggcgcccg tgcctggaat gatggtctgt tccacgattt ctggtacctc 480
gacatgcgcc tcggtgagct cgcgccgccg gtgaacgaga tcaacgccga gttcgagcgg 540
gcgaagggct ggatcggcaa gcgcatcgac gtcgctgaga agccctgccc cgacggcgaa 600
ggcaagtaca tcaggtgcga gggcggccat atctacttcc acccgaaggt caacgtcggc 660
gcgaagccgg gcgagcgtgc gatcgcgatc ccggctgacg tcttcgaggt gtggaagcgc 720
cagggattcg agaagggacc gctcggctac ccgacgcgcc gtcacgccac ggtcaacggt 780
gtcggcacca tccaggcatt tcagaacggc gcggtctatc gcaagttcgg caccgacggc 840
ggcatcgtca acggcaagat cctcgagcgc tgggcgcgcg aaggtcacga gaagggccgc 900
ctcggttggc ctctcggcga cgagaagttc ttcgacggcg gtcgcgtcca ggcgttcgag 960
aacggtgacg cctacttcca ccccaccgcg gtggtcgagt tcctcaacga tcccgcagcc 1020
cccaagcagt aa 1032
<210> 31
<211> 813
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 31
atgcgtccct accgtgcacg ccatctcgcc actcctccca cccccgactc gactcccgac 60
acctcatccg gtgcgtcgcg ccgttccgtc ctgcgcgggg gtgtcctcgg tgccgcggca 120
ctgagcaccg gcgccgccgc cgtcgcgacc ccggcggcga acgccgccgg cctctacgga 180
caggacgtct ccggctggca gggagagatc gactggtccg cccaggcgga cctcggctct 240
cgcttcgcct atgtgaaggc caccgagggt cggtcctacc gcagccccgc cttcaaccag 300
cagtaccgcg gcgccggcaa tgccggcctg gtccgcggcg gctaccactt cgcccgcccc 360
gactccggcg gccccgagga gcaggtcgac ttcttcctca acaacggcgg gggatggtcc 420
gacgacggca tcacgctgcc gggcatggtc gacttcgagg cctactccgg actgcctcgc 480
gactacgggc tgagccagca ggagatgcgg aactggatca tggcgttctc cactcgctac 540
cgggacagcg tcgggcgtcg gcccgtcctc tacacgaacc tccactggtg gaacgacgtg 600
gtgggggact ggaccccggt caactccccg ctgttcctcg cgtcctacag cagcagcgcg 660
ccgaccaccc tgccgggccg ctggtgggcc tacgagatgt ggcagtactc ggattcgggt 720
cccttcgccg gtgactcgaa cctctggcac ggctccgagt cccagttcga gagcttcgtc 780
tccgacgggg actaccacgc gatcggcatc tga 813
<210> 32
<211> 432
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 32
atgaggttta ttcctgcggc gcatcattct gccggctcga atagtccggt gaatagggtt 60
gtgatccatg cgacatgccc tgatgtgggg tttccgtctg cctcacgtaa ggggcgggcg 120
gtgtctacag caaactattt tgcttcccca tcgtcggggg gttcggcgca ttatgtgtgt 180
gatgttgggg agacggtgca gtgcctgtca gaggggacta ttggttggca tgccccgccg 240
aatccgcatt ctttgggtat agagatttgc gcggatgggg gttcgcacgc ctcgttccgt 300
gtgccggggc atgcttacac gagggagcag tggcttgatc ctcgcgtgtg gcctgcggtg 360
gagaaggctg ccatcctgtg tagacgtttg tgtgacaaat ataaatgctt acacgaggga 420
gcagtggctt ga 432
<210> 33
<211> 1422
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 33
atggcaacca tgcctgtcaa aaaaggcttt tatgtcactt cggggtttgg cccgcgttgg 60
ggcactacgc attacggcac ggattttggt gttgatggtg gctcaggtgg gcaccctatt 120
ttcgctatca aatctggcac tgtgaccgct tctggcccgg cttctggttt tgggcagtgg 180
atcaatgtgg atcatcctgc aagtgatggc ggtggcttgt cggtgtatgg gcacatcatc 240
ccagaggtgc gcgtaggtga tcaggtggtg gaggggcagc ggatcggacg aatcaacccc 300
gatcaaaaca ctaacggcgg ggttgcgcct catcttcatt tggagtttca ccgctccgtg 360
tggtcaccac ctggtggtga tcgcctcgac cccatgaaaa ctgtgctcgc tggtgcagac 420
tggccgggtg atgcgccctc aaattcgagc gcgaaaccgg aaacggggaa ggtcaaaaac 480
atctttggtg tggatatttc caatcatcaa aatggtattt tggctgaatt gatcggtgcg 540
gaaggttttg aattctgcat catcaaagcc accgagggta cgtggaaaga ccctattttg 600
cattcgcatt tggcggatgt tcgcaaaaat tccggcatgc aggttggcgc atatgtgtat 660
gtgcgtgggg aaacctcacc agaagcgcat gctatcgctc tacatgagca tctgaatgac 720
acgtcggtgc cggttgcttt ggatattgag cataattccg gctctaatcc tgatcattgg 780
cgggcaatta aaacggcgat cgaggcccgt ggctaccgcg tgatcctaac atacttgccg 840
gagtggtact ggagccaagt cgggcagcca aacttggcgg ggctaccgcc gttgtgggct 900
tcccgttatg tcggcaccac accaggggtt gccagcgtct tatattccac ggctggtcgg 960
cgtggctggc aaggatacgg cggccttgaa gttgcgatgt ggcagttcac cgaccgggcg 1020
caggtcgcag gccaaaagat cgacgccaat gtttttgagg gcacggagaa acagcttcgt 1080
gcccttttcc atggggacac cccagaaata gaggaggagt tcgatatgag cgcagtccag 1140
gaaatcaaag actatattga cacccgactg acaggacctg tcggcaccga tgtcaaggac 1200
atcaggcagc agatcaccgg agggcgcgac tctatcccag gtgacctcaa agcgtcttac 1260
cctgggtggg atttaggtca gctggtgcgt gcggcacgtg aaaaagaatt tactggcctg 1320
acgatgatgg aaattcttgc agtcaatatt gctggtaatg atgatgattt ccgtgcagca 1380
cgtgttgctg caggtaccga ggaggctggc aatgctgaat aa 1422
<210> 34
<211> 1281
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 34
atggccgact acttctaccc actcagccag ggcgctcacg tcaccagccc attcgggccc 60
cgagctggcg gctatcactg gggcaccgac tacggccgcg ccggaggctc cggcggcaac 120
gccgtctacg ccccgcaagc cggaaccgtc atcatggccg gccccgccag cggcttcggc 180
ggccccgacc ccgccggatg gatcgtcatc gaccacccaa ccgccgccgg cggcggagtc 240
agcgtcctcg gccacatcat ccgtgaagtc gccgtcggcg acaccgtccg cgccgggcag 300
cgcatcgggc gggtcaatcc ttcctcggcc accaatggcg gcgtggcgcc gcacgtccac 360
ttcgagcatc accgttacgt ctggtccccg ccgggaccgg accgtctgga cccgcacgct 420
tggctggcca cccgcggcgc ccgatggccg ggagccccgg ccacacctac ccgaaaggaa 480
tccatgaacg cgctcaccgc tgacatcgac ctgctgaccc ccaacgacga tggccgggcg 540
acgaagcccc gcaacctttt gtgcatccat accttcgaag acgacggcac gtggtcggcc 600
gacaggatgg cgaagtacca gcagtcgccc gccgccggcg gctcgtacca cctggtcatt 660
gacctcaacg gccgcatcgc tcgtgagaac gacgacgcgt tcatcccatg ggcggcgatg 720
ttcacgggca accgggtggc gttccacttc tcgctgtcgg gcaaggcgtc ctggacgcgc 780
cagcagtggc tggcccgtcc gaagcagatg gacgccctgg cgaaggtgct ggcggcgtac 840
tcgaaggcca agggcatccc gctcatccgc cgcggaccgc aggacgtgcg agccgggaag 900
tggggcgtgt gcggccacga cgacatttcc aaggcattcg gtgagtcgac gcactgggac 960
ccgggcccga acttcccgtt cgacgtcgtc atcgacaagg ccaaggcgat cctcgccgag 1020
ccgaagccga cgcccgcccc gccgtcggat ccggcgcccc gtccgattcc cccgaaggag 1080
actctggtgc ccaccacgct cgacaccgtc ctgccgtcgc tcgtcgacgg ctccacgttc 1140
gaggctccgt tggccacgtt catccgcacc gcggacaaac aggcctacga agccaaccag 1200
cggatcgccc gcctggaggc gaagttcgat cggctgctcg atgccatggg cgaaaagccc 1260
gaccccaagc ccggccagta g 1281
<210> 35
<211> 858
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 35
atgagataca ttcctgcggc gcatcactcg gccggctcta atagtccggt gaacagggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtccg cttcccgtaa aggacgggcg 120
gtgtccacgg caaactattt cgcgtcccca tcggcgggcg gttctgccca ttatgtgtgt 180
gatgttgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcgttccgt 300
gtgccggggc atgcttacac tcgtgagcag tggcttgatc cgagggtgtg gcctgcggtg 360
gagaaggcgg ctgtgctgtg tagacagttg tgtgacaaat ataatgttcc gaagaggaaa 420
ctgtctgtat ccgatttgaa ggctggcagg cggggtgtgt gcggccatac ggatgtgacg 480
gatgcgtggc atcagtcgga tcatgatgat ccggggccgt ggtttccgtg ggacaggttt 540
atggccgtcg tcaacggcgg cagtggagag agtggagagt tgagtatggc tgatgtgaaa 600
gccttgcatg atcagattaa acagttgtcg gggcaggtgg cccagtcggt gaataagctg 660
catcacgatg tgggtgtggt tcaggttcag aatgggaatc ttaaaaagca ggttgattcc 720
ctgtctatgg tgaagaatcc tgtgacgggg aagctgtggc gtaccaggga tgcgatctgg 780
tcgatctggt attacgtgtt ggagtgtcgt agccgtatcg gcaagttgga ggccgaggtg 840
gcccggttga agaagtga 858
<210> 36
<211> 738
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 36
atgtccacgg caaactattt tgcttcccca tcgtcgggtg gttcggcgca ttatgtttgc 60
gatattagtg agacggtgca atgcctgtcg gagtctacga tcgggtggca tgccccgccg 120
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcgtttagg 180
gtgccagggc acgcttacac tcgtgagcag tggctggatc ctagggtgtg gcctgccgtg 240
gagaaggctg ccatcctgtg tagacgtttg tgtgacaaat ataatgttcc gaagcggaaa 300
ctgtctgtag ccgatttgaa ggctggcagg cggggtgtgt gcggccacgt ggatgtgacg 360
gatgcgtggc atcagtcgga tcatgacgat ccggggccgt ggtttccgtg ggacaggttt 420
atggccgtcg tcaacggcgg tagtggagat agtggggagt taactgtggc tgatgtgaaa 480
gccttgcatg atcagattaa acaattgtct gctcagctta ctggttcggt gaataagctg 540
caccatgatg ttggtgtggt acaggtacag aatggtgatt tgggtaaacg tgttgatgcc 600
ttgtcgtggg tgaagaatcc ggtgacgggg aagctgtggc gcaccaaaga cgctttgtgg 660
agtgtctggt attacgtgct ggagtgtcgc agccgcatag acaggctcga gtctgctgtt 720
aacggtttga aaaagtga 738
<210> 37
<211> 846
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 37
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggaaa aaacaccaac aagggagaac tcagcatgtc cgacgtcaac 600
accctgacca agctcatcaa ggccagcaac aatcagctcc accacgacat tggcgtcgtc 660
cagacacaga acggcaccct caaaagcaag atcgacaact tgtcgtgggt gaagaatccc 720
gtcaccggca agaagtggtc caccaaggat gcgctgtggt ctgtctggta ctacgtgctg 780
gaatgccgca accgcatcca ggctatcgaa aaccgcctct ctgacatcga aaagaaggtg 840
aagtga 846
<210> 38
<211> 810
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 38
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac agtgtctcaa 600
ttcagtgacc tgaccaagcg cctgcagggc atgcaggagc agacccacca cgacctcggc 660
gtcgtccaga ccaagctggc caccatggac accgtcaaga acccccgcac cggcgccaag 720
tggagcctca aggacgccat ctggtcgatc tggtactacg tgctggagaa cagggaccgg 780
atcgccgccc tcgagaagaa ggtgaagtga 810
<210> 39
<211> 855
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 39
atggactgga ccaatctgaa cgctgacgtg acgaagctga tgaacgtgca cttcaccccc 60
gggcgtgaag gccacacgat cgacaagatc gtgattcacc acaacggcgg caacctgagc 120
atcgaccaga tctggaatgt gtggcaggac cgtgaagcat cggcccacta tcaggtgcaa 180
tctgatggcc gtatcggcca gctcgtcaac gactgggaca ccgcctggca cgccggcgac 240
tgggacgcca acctgacctc gatcggcatc gagcacgccg acgactcgac cgacccgtgg 300
catgtgtcgg atgccgccgt cgatgccggc gcgcacctgg tggctgcact gtgtcgcggc 360
tacaaccttg gccggccgga gtggatgcgc aacgtcttcc cgcactcgca tttctcggcg 420
acctcgtgcc cggcctcgct tgccgagaat cagcgcgcgg attacatggc gcgcgctcag 480
gcctatttcg atggcgctcc cgtcacaggc cgttcttcgg tccctgcacc ggctccggcg 540
cctgccggga tccatgtgga cctgcctgcc tggactctcc ccgcaggcaa cttttacggg 600
tcgatcgatg gcggcgagga ctcgcatggc ggctactacg agggtgagcg tcctgcaatc 660
gcagcgattc agcgctggct tatccgccac ggctacgcgg gtgcagtgga cgactcatgg 720
gccgatggtc tgtacgagca gcccaccgtc gacgccgtga cccgcttcca gcgtgccgag 780
cgaccaaact ccacggaccg gtggggcgag gtctgggccg acgatctggc caccatggcc 840
gccaacaacg gctga 855
<210> 40
<211> 897
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 40
atggatcgtg gtattgacgt gtcgtcctat caggcccccg atggtggcct gctggagggc 60
atgtcgtttt gcatcatcaa ggccaccgaa ggcaccggct atgtgaaccc gaaccgtacc 120
cagtggtaca aggtcgccac ggatcgtggg gtgaccaccg gcgcctatca cttcatgcgt 180
ggcggcgatc ccgtggcgca ggccgattac ttcctcgcgc atctgcccgg tgatgtcgat 240
tggctcgccc ttgatgtcga ggatcccagc gacggcctgt catgggccgg gcgcgtcagc 300
ttcatcctcg cctggaccga tcgggtgaag gcgaccggca agcccacctt ggtctattgc 360
tcgcgctcct gggcgaatgc cctgttgggt gcggccagca gcgacgagcg ggcacggctc 420
gcgcaattgc cgctgtggat ggctgattac acccaacgcc ccggcgaata ttcggggccg 480
tggccgggcg gctggccgat tgccatacac cagtacacct cggccccgat cgacaagaac 540
gtcctgctca ccgacgatct ccaaggagga gacgacatgc ccctgtcaac cgacgacctt 600
cgaaatatcg ccactgccgt gtggggtggc ggcggcgctg caagcccaat gtatgccgac 660
cggctcgatg ggcatcaaga atatccggag acagcccttt tcagcctgca acagcggctg 720
ggtgcccgct tcggtgagct gtcgggcaag atcgacggtc tggccgaggc gctcaagcag 780
gtgcagggag ggaacggcgt ggacgcggac gccattaggg ctgctgctgc cgaaggagcc 840
aaggctggcg tgcaggcgat gatcgacacc gccacggtga atctggaggc caagtga 897
<210> 41
<211> 894
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 41
atgtgcgggg ctttctcatt cctcaaagac ttggagacat tcatggactg gaccaatctg 60
aacgctgacg tgacgaagct gatgggcgtg cacttcaccc ccggacgtga aggcaggacg 120
atcgacaaga tcgtgatcca ccacaacggc ggcaacctga gcatcgacca gatctggaat 180
gtgtggcaga cccgtgaagc ctccgcgcat tatcaggtgg aggcgggtgg ccgtatcggc 240
cagctcgtca acgatttgga caccgcgtgg catgccggcg actgggacgc caacctgacc 300
tcgatcggca tcgagcatgc cgacgactcg accgacccgt ggcatgtgtc tgatgctgcc 360
gtcgatgccg gcgcgcacct ggtggctgca ctgtgtcgcg gctacaacct tggccggccg 420
gagtggatgc gcaacgtctt cccgcactct cagttcacgt ccacgtcgtg cccggcgtcg 480
ctggcccggg accagctcgg cgactacatg gggcgcgcac aagcctactt cgatggcgcg 540
ccggtggctg cggtccatca gtcggtccct gcccccgccc cagcgcccag ccgtcatgtg 600
gacctgcccg cgtggaatct ccccgagggc aacttctacg gcctcgtcag cggcggaaac 660
gactcccacg gcggcttcta tcccgccgag cgtcccgctg tgagggccat ccagctgtgg 720
ctcatccgtc acggctacgc cggcgcggtg cctgacagtt gggcggacgg catctacgag 780
cagccgaccg ccgacgccgt gaccgctttc cagcacgccg agcgccccaa cagcacggac 840
cggtggggcg aggtctgggc cgacgacctg gccaccatgg ccgccaacaa ctga 894
<210> 42
<211> 1065
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 42
atgaaggcgt ctcgcgtgat cgtcgtagca agtgtcgtag cactgatcct tgcgggcctg 60
gcaatgtcgt cagctgccgt gattgtggtg ccactactgt cagtaggcgc cggggccctc 120
gacgacaact ctggcgctgg cggcgtcggt ggggatccct gcataggaac tgtcaccggt 180
ggcgctgtta gtgtcggagg cctcacaacc aggcagaagc aactagtgac caccatcgtc 240
accgtggtcc aacgcgacaa actacctgtc caggctgcgg tcatcgccat catgaccgct 300
aaacaggaat cagacctcgg agccaacccc gccgcaacga aacctaacgg tgacggcgac 360
gccggcccat tccaacagcg cgttctaccg ggctggtacg gcaccttgga ccaagtcaac 420
aatgatgcct acgccacgga gacattcctg aaaggccaca ccatcaccta tgctggcccc 480
acatcggccg gcggccccgg ctaccacatt cccggccttg tcgatgtccc cgactggcag 540
tcgaaatccc cggcccaagc agcccaagcg gttcaggcct cagccctgcc taacgcttac 600
gctaaatggg aggccatcgc caaacagatg gtgggagcca ccaccacagg gcgcctgtcc 660
aacgactgtg tcaccgggac cgctaacgaa accggcgtct caaagaacct gaccaaagcc 720
gtggaatggg ccaaatcgat cgccgccaac aactcctaca cctacgtgtg gggcggtaat 780
ggtgcgagcg atggcggcta cgactgctca ggcctgacct cggcactgta ccgacgtatc 840
ggcatcaacc ttccccgcac cgctgccgaa cagcaaaaag tcggcacccc agtcaaccgc 900
aaccagctca aagtcggcga ccttatcttc tggggcatcc ctgcccacca cgtagccacc 960
tacatcggta gaggccagat gatcagcgcc gacaaccaag cccgcggcat caacgtggag 1020
aagatctacg gcaacccctc gagctaccga aggatcgtca aatga 1065
<210> 43
<211> 843
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 43
atggactgga ccaatctgaa cgctgacgtg accaagctga tgaacgtgca cttcaccccc 60
ggacgtgaag gcaggacgat cgacaagatc gtgatccacc acaacggcgg caacctgtcg 120
atcgaccaga tctggaatgt gtggcaggac cgtgaagcca gcgcgcacta ccaggtggaa 180
tcgagcggcc gcatcggcca gctcgtcaac gactgggaca ccgcctggca tgccggcgac 240
tgggacgcga atctcacgtc gatcggcatc gagcatgctg acgactcgac ggatccgtgg 300
catgtgtcgg atgccgccat cgacagcggc gcccatctgg tggcggccct gtgccgcgcc 360
tacaatcttg gtcggccgga gtggatgcac aacgtgttcc cgcactcgca tttctcggcg 420
acctcgtgcc cggcctcgct ggccgagaat cagcgcgcgg attacatgtc acgggctcag 480
gcctactacg acggcacttc agtggctgcc gcacctgctg ccccgtcggc acctgccggg 540
atccacgtcg atcttccgag ctggaccctc ccgatcgggc attattacgg gctggtcaca 600
gggccgaatg actcgcatgg tggcttctac gagtccgagc gtcccgctgt gagggccatc 660
cagctgtggc tcatccgcca cggctacgcc ggcgcggtgc ctgacagttg ggcggacggc 720
atctacgagc agccgaccgc cgacgccgtg accgctttcc agcatgctga gcgacccaac 780
agcacggacc ggtggggcga ggtctgggcc gacgatctgg ccaccatggc cgccaacaac 840
tga 843
<210> 44
<211> 852
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 44
atggactgga ccaacctcat cgccgacacc acgaagctca tgggcgtgca cttcaccccc 60
gggcgtgaag gccgcaagat cgacaagatc gtgatccacc acaacggcgg caacctgagc 120
atcgaccaga tctggaatgt gtggcagacc cgcgaagcca gcgcgcacta ccaggttgag 180
acgggtggcc gcatcggcca gctcgtcaac gactgggaca ccgcctggca cgccggcgac 240
tgggatgcga atctcacgtc gatcggcatc gagcacgccg acgactccac ggacccgtgg 300
catgtgtcgg atgccgccgt tgacgccggc gcgcaccttg tcgcggccct gtgcaaggcc 360
tacagtcttg gtcgtcctga gtggatgcgc aacgtcttcc cgcactcgca tttctcggcg 420
acctcgtgcc cggcctcgct ggccgagaat cagcgcgcgg attacatgtc acgggctcag 480
gcctactacg acggcgcgcc ggtggctgcg gtccatcagt cggcacctgc ccccgcccca 540
gcgtccagcc gtcacgtgga cctgcccgcg tggaatctcc ccgagggcaa cttctacggc 600
ctggcgagcg gtggcgagga ttcgcacggc ggcttctacg agggtgagcg tcccgcgatc 660
cgccagatcc agctgtggct catccgtcac ggctatgccg gcgcggtgcc tgacagttgg 720
gcggacggga tctacgaaca acccactgcc gacgccgtgg ccgctttcca gcatgctgag 780
cgtcccaact ccacggaccg gtggggcgag gtctgggcag acgatctggc caccatggcc 840
gccaacaact ga 852
<210> 45
<211> 873
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 45
atgatgcgca tgctcaaggc ggcttccccc tggctccttc gagcctgcgt cctgctcgtg 60
gcgctgagct tcgtcatcga ggtccccgtg tggctcgtgt tcgcgccgct gggcctggcg 120
atcgcagtcc cttctccacg tgcagacgac gagtctcccc agaccatgca tgctcccgtg 180
acgggccgct gggtcgccat caacagcccg gcgacgaagg tccccagcca cggcgttcgc 240
acgctcggtc aggcattcgc agtcgacatc ctgcaggcat cagactctcc ccgcgaaagc 300
gcccccggct ggcaatggag acaggccgag ccccaggagt tcccaagctt cggggagcct 360
gtcctggcag cgggctgcgg caccgtgatc gctgcccatg acggcaagcg tgaccatcgc 420
gcccggaaca cctggcccgg cctgatctac atgatgtcgc tcgaggcctt cggtcgagag 480
ttggccgggc accgctccat catcggcaat cacgtgatcc tcgaccatag cgacggcacg 540
ttcagcatgt acgcccacct caagcacgga tctgcagccg tgtgcgtcgg gcagaaagtc 600
cgggccggcg atgtcctggg agcggtcggg aacaccggga ataccagcga accccatctc 660
cacttccagc tgatggaccg gccccaagcg gccatggccg ccggcctgcc gttccggtgg 720
tccccgctca cgatcgagcc ggatcccgat ccccactggg ctccgaagaa acctgtcgca 780
gagacggtcg agggcctgcc cgcgacaggg cagatcttcc gcaccccgga gtccggcgtc 840
atgccccaac ccaagcgcga ggccagttgt tga 873
<210> 46
<211> 759
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 46
atgaggagat ctgtctgcat cagcctacta atcatcacgg tggggatttg cttgctggcc 60
ttcccagctc ccagccacag cattgctgcc gttcccgcgc gaagtgtggc gaatcgtccg 120
actccgccgg tgctaggccc cgtcatcaaa gggtttgcgc cacctgccga aaaatggctg 180
ccgggtagta ggggagtgga atttgcggcc tccgtgggag aaccagtgac gaccgtgacg 240
gctggggtgg tcgtttttgc tggccaggtc gcgggggctg gggtggtgag catcctgctt 300
gctgacggtc gtcggacaac ccacatgccg gttgtgccta gcgttgctgt cggccaggta 360
gtggttcctg gccagcagat cggagttgtc gggatggggc caccatgcac ccgcacttgt 420
ttgcactggg ggttgaagaa gggagatgtt tatcaaaacc ccatgacatt gttgcaactt 480
caggtgcggt tgctgccctt ggacagtcgg cctcattcag cgtcggggca cggatggcct 540
gtgcggcccc tgagcctgcc agggggcagc aggaggaaag ctgcctcaag cggtgccctc 600
atgcctccgt ggcgtggagc tgggcgggac gccgcgttag gcattgatac gacggtgacc 660
gaagccaccc gaggtggctc aggcgcgggg atgagcctgg cgaaacgcag tgcgcaatct 720
ttcggtggaa acgtgggtgt agatctgcgt ggtggctag 759
<210> 47
<211> 651
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 47
atggcaaaga cactctctcg aattgcttcc gttgcggctg cggctgccct cgccggtggc 60
gtctccgtga ctgcggcgca gagcgcgtcg gcagacgatg tcaactggga cgccatcgca 120
aactgcgagt ccggcggtaa ctggagcaca aacaccggca atggctacta cggtggcctt 180
cagttctccc agagcacttg ggccgcctac ggtggctccg gtagcgcctc caatgcctcc 240
cgtgaggagc agatcgccgt ggccgagcgc gtgctcgcgg gccagggcat cggtgcgtgg 300
ccggtctgcg gcgcgtacgc ctactccggt gaaagctaca ccggcaccaa caccgagggt 360
tcctacggct cttcgtacga cacgtcggcc caggacgcct cctacgacgg ctcgtactcg 420
tatgacaact cgtactcgta cgacaacagc gccgggtacg actcgtcctc cgcctactcc 480
ggcggctacc aggccactcg tgaggccact ggcacctacg agatccagcc gggcgacacc 540
ctcaacgcca tcgctgaggc ccatggcacc acctggcagg agctcgcggc cctcaacagc 600
tccatcgtcg acgcgaacct gatctacgcc ggcgaaacca tcaacgtctg a 651
<210> 48
<211> 753
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 48
atggcctatc cctatatcgg ggcattgaag catggcggca agcagggcaa gatccagcgg 60
atcgtcatcc atgccacggt ttcgccctgt gtgcggggcg gtgcccggaa cgtcgcgaag 120
tactttcaga gttcagccgc cggaggcagc gcccactacg tggtggatcc cggtgagatc 180
atccagtgtg tcaaggacga cgtggtggcc taccacgcgc cgcccaacac cggaacgctc 240
gggatcgagc tgtgcgaccc gcaggccgga tcgccgaagc ggtggagcaa cgaggcccac 300
caggcgatgc tcgtgctcgc cgcgaagctc gtcagggaac tcgcggcgaa gcacgacgtg 360
ccgctcgtcc gggtgaccgc cgcgcagctc agggcgggca agcgcggcat ctgctcgcat 420
gtcgcggtca gcgacgcgtt cgggcagtcc gaccacggcg atcccgaggt cgccgggccg 480
ttcccctggg cgaagttcat gcagctcatc aaggaggagg acgacatgcc gtcgcccaag 540
gagatctacg aagccgtctg ggagcaggac gtcatggcgg cccccgacgg ttccaagtcg 600
aacccgacct ggaagcccag cagcgtcctc accgacgtcg acaagaaggt ccgcgccctg 660
cagagccagg tcaccggcct cgagagcgag ctggccgcca ccaacgccaa gctcgaccag 720
gttctcaccc tgctccgcgc ctcggtgtcc tga 753
<210> 49
<211> 849
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 49
atgacattca tccaggccgc ccaccgtggc ggcacttcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgatgtcggc ttcccgtcgg catcgcgggc aggacgagca 120
gtatccacag cggaatattt cgcgtccacg tcgaggtcag cctcggcgca ctacgtatgc 180
gacatctcta ccacggtgca gtgcctgtcc gaggcaacga tcggctatca cgcgccacca 240
aacgcccact ccatcggcat tgaaatctgc gccgacggag gctcgcgcgc ttcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctcagcc cgcaggtatg gcccgccgtg 360
gagcgcgccg cgattctcgc ccgcgacatc tgccaccgac accacatccc catccgccgc 420
ctctccgtcg cgcaggtgcg ggcaggtgag cgcggaatct gcggccacaa cgaggtgagc 480
gaggcgttcc accaatccga ccacgacgac cccggcccct atttcccttg gaatgaattt 540
attgccgccg tccaaggaaa aaccaccaca ccagagggag aactcagcat gtcagacgta 600
aacaccctga ccaagctcat caaggccagc aacgaccagc ttcactacga tattggcgtc 660
gtccagacgc aaaacgggaa catcaagaag aagatcgaca atctgtcgtg ggtgaagaac 720
cccgtcaccg gcaagaagtg gtccactaag gatgccctgt ggtccgtctg gtattacgtg 780
ctggaatgcc gcaaccgcat ccaggctatc gagaaccgta tttacgacct tgagaagaag 840
gtgaagtga 849
<210> 50
<211> 864
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 50
atgagataca ttcctgcggc gcatcattct gccggatcaa ataagccggt gaaccgggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtctg cttcgcgtaa gggtcgggcg 120
gtgtctacag caaactattt tgcttcccca tcgtctggtg gttcggcgca ttatgtgtgt 180
gatattgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcattccgt 300
gttccagggc atgcctatac gcgggagcag tggcttgacc ctcgggtgtg gcccgcggtg 360
gagagggccg ccatcctgtg tcggcagttg tgtgataagc atggtgttcc gaagaggaaa 420
ctgtctgtgg ctgatttgaa ggccggtaaa cggggtgttt gcgggcatgt ggatgttacg 480
gatgcgtggc atcagtcgga tcatgacgat ccggggccgt ggtttccgtg ggacaaattt 540
atggctgtgg tgaatggcca cggcggcggt tcaagtagtg aggagttgag tatggctgat 600
gtacaagcgt tacataatca gattaaacag ttgtcggcac aggtggccca gtcggtgaat 660
aagctgcatc acgatgttgg tgtggttcag gttcagaatg gtgatttggg taaacgtgtt 720
gatgccttgt cgtgggtgaa gaatccggtg acggggaagc tgtggcgcag caaggatgct 780
ttgtggagtg tctggtatta cgtgttggag tgtcgtagcc gtcttgacag gctcgagtct 840
gctgtcaacg atttgaaaaa gtga 864
<210> 51
<211> 846
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 51
atgacattca tccaggcccg ccaccacggc ggcaactcca acgcgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg catcgaaggc cggtagggca 120
gtctcgaccg cgaactactt cgccacgact gatcggcccg cctcggcaca ttacgtatgt 180
gacatcgcca ctacagtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccg 240
aactcgcatt ccatcggcat tgaaatttgc gccgatggcg ggtcgcacgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgaccaa tggttgagcg atgacgtgtg gcccgccgta 360
gagcgcgccg ccattcttgc ccgcgatatt tgccaacgac accgcatccc ggttcgtaaa 420
ctctccaccg cacaggtgaa agccggactg tcgggaattt gcggacacga caatgtatcc 480
ggcgcattcc atcagtccga ccacgacgac ccgggcccct acttcccgtg ggaccagttc 540
atggcactcg tccaaggaaa acccgccaca ccaggagatc tcaccatggc agacatcagc 600
aaactcaccg acgcgatcaa ggcatccaac cggcagctgc accacgacat cggcgtagta 660
cagacccaaa acggaaaatt acgtgagcag atcgaaagga tcacctgggt caaaaatccg 720
gtgacaggaa agaagtggcg catcaccgac gcgctgtggt cgatctggca ctacgtgctg 780
gaatgccgca cccgcatcca gcggctcgac gcccgtctgt ctgaggtcga gaagaaggtg 840
aagtga 846
<210> 52
<211> 849
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 52
atgacattca tccaggccgc ccaccgtggc ggcacttcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgatgtcggc ttcccgtcgg catcgcgggc aggacgagca 120
gtatccacag cggaatattt cgcgtccacg tcgaggtcag cctcggcgca ctacgtatgc 180
gacatctcta ccacggtgca gtgcctgtcc gaggcaacga tcggctatca cgcgccacca 240
aacgcccact ccatcggcat tgaaatctgc gccgccggag gctcgcgcgc ttcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctcagcc cgcaggtatg gcccgccgtg 360
gagcgcgccg cgattctcgc ccgcgacatc tgccaccgac accacatccc catccgccgc 420
ctctccgtcg cgcaggtgcg ggcaggtgag cgcggaatct gcggccacaa cgaggtgagc 480
gaggcgttcc accaatccga ccacgacgac cccggcccct atttcccgtg gaatgaattt 540
attgccgccg tccaaggaaa aaccaccaca ccagagggag aactcagcat gtcagacgta 600
aacaccctga ccaagctcat caaggccagc aacgaccagc ttcactacga cattggcgtc 660
gtccagacgc aaaacgggaa catcaagaag aagatcgaca atctgtcgtg ggtgaagaac 720
cccgtcaccg gcaagaagtg gtccactaag gatgccctgt ggtccgtctg gtattacgtg 780
ctggaatgcc gcaaccgcat ccaggctatc gagaaccgta tttacgacct tgagaagaag 840
gtgaagtga 849
<210> 53
<211> 852
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 53
atgacattca ttcaggccaa gcatcacggc ggccacaaca accctcccgt gactcgtctt 60
gtcattcacg ccacatgccc ggatgtgggc tatccgtctg cgtcgcgcgc tggccgtgcg 120
gtgtcgacgg cccactattt tcaggaaacg acccggccag catccgccca ctacatttgt 180
gacatatcga ccacggtgca gtgtctgtct gaggagacgg tgggctatca cgccccgccg 240
aactcacact ccatcggtat tgagatatgc gctgacggtg ggtcgcatgc ctcgttttcg 300
aaccctgccc acgcctacac ccgcgagcag tggttgagcc ctcaggtgtg gcctgctgtg 360
gagcgtgccg cgatgctggc gcgcggtatc tgtcaacgcc acaacatccc gatccgccgc 420
ctctcgatcg ctgacgtcaa ggccgggaag cgcggcatct gcggccacaa cgaggtgtcc 480
gaggccttcc accaatccga ccatgacgac cccggtcctt atttcccgtg ggacgggttt 540
atcgcgcttg ttaatggcca ttccgcacca tcacgccagg aggaactaac tgtgtcagat 600
gtcaatatgc tcaaaggtct tattcagcaa tcgaacaagc agctgcacca cgatatcggt 660
gttgtgcaga cgcaggcggg taacctccgc cgccagctgg aatccctgtc atgggtgaag 720
aacccggtca gcggcaagct gtggcgcacc aaggacgcct tgtggtcgat ctggtactac 780
gtgctggact gccgatctcg tctcggcaaa ctcgaggccc gcctgtcgac gctggaaaag 840
aaggtgaagt ga 852
<210> 54
<211> 804
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 54
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
gactggcagc gcatggagag gctcgttgac gcgaggctga agtacgctgg tatcgccaag 660
aatgatgacc cggtcttcaa gcccgacaag tcctcgtcgt ggccctggag gaccgcgctg 720
tggagcatct cctactacgc gacccacagc tacaacacga tctgcaatat cgcccgcaag 780
ctcggcgcag aggtgtccaa gtga 804
<210> 55
<211> 855
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 55
atgaaataca ttcccgcgac acatcacgga ggccacacga acaccccctt cacccggatc 60
gtgatccacg ccacctgccc cgaccttggc ttcccccacg catcagctgg tggacaggca 120
aaagccaccg cacgctattt ccaatcagag cagtctgccg gatcagcaca ctatgtgtgc 180
gacatcgccg agactatcca atgcctgccc gatgacgtga tcgcctggca cgccccacca 240
aacagaaggt cgatcggaat cgaaatatgt gccgacggcg gctcccgctc ctcattccag 300
caccccgagc acgcctacac cagatcccaa tggctcagcc cccaagtgtg gcccgccgtc 360
gcccgtgccg ccgcgctcac ccgcgacctc tgccaccgcc acaacattcc gatgcaacaa 420
ctctccgttg ctgatgtgaa agccgggaag cacggaatct gcggccacaa cgacgtatcc 480
gaggcattcc acaagtccga ccatgacgac cccggcccca cattcccgtg ggaccaattc 540
atcaaagagg ttagaacacc aggacaacaa gatacgaaac cttccgtacc aacaccatca 600
ctcacagaaa taggagatca ggacatgaac gggtgctact acaacctcaa ttcgaaaaca 660
cggacgtacc ttatcttcga tagccgttcc ggattttacc acgaattctc ccaaggcaat 720
gggaacggcc ccatgagccc agactatgta aatccgatcg ccaaaggatg ggacaccgga 780
tcatggccgg caatctcccc aggccacgcg aaagtgctca aggccgccct cgataaagtc 840
cggaaaggaa tctga 855
<210> 56
<211> 1470
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 56
atggtggccc actcggtgtg gtcgggcggg caggcccgtg gcgtccacgg caacccgacc 60
ggcggccggc aggtgttcgg ctgggtggcg ccggcctcgg atgagccgaa gacggtaggc 120
caggagcggc tggtggtggg cctgcaggtc acgatcggcg cccagctgct tccgctgatg 180
acccagctgg tgatatgggc caccacgcgg ctggttccca tgctcaagcg caccggcgac 240
tggttgaaga atcaccacag gcagatcgcc gacctggcgc ccaagatcct caaggtggcc 300
ctagcgctgg ccggggtgtt ctcggcgatc aagctagtca acatagcgac ctcgctcacc 360
acgtcgatcc tcgggctggt ggccaccccg gtcggccagg tggtgctcgc cgtcggcgcg 420
gtcgccgccg ctatcgccgg cctcgtggcg gccctcatct acgcctacca ccactgtagg 480
gagttccacg acgggggaac aaggtggtcc acggcatcat gcaggcctgg cgtgggccga 540
tccggctctt cacggtgtgg gtgccgcagg cggcggtggc gggggcgacg gtctgccagc 600
ccgcccctac accccagcct gcaccgaacc ctgaacccac accacgttga ggagaacgac 660
atgcaattca ttcaggccgc gcaccattcg gccgacccta accttccacc aacacgcgtc 720
gtcatccacg ccacctgccc tgacgtcgga ttcccctccg cctcccgggc gggccgggcg 780
gtgggcaccg ccggctactt agcctccatc tcggcgagcg gatccgccca ctatgtgtgc 840
gacgccaccg agacggtcca gtacctgggc gaggacgtca tcggctggct tgccccgccc 900
cacggccact cgatcggcat cgaaatctgc gccgacgggg gctcacgggc ctccttcaac 960
aaccccagcc acgcctactc gcctaagcag tggctgtccc cacaggtgtg gctggcggtg 1020
gagaaggccg cccacctcac ccggcagatc tgccacaggt atgccatccc catgcgcagg 1080
ctcacggtcg ccggcacacc tcgtcgaggg tgcgtgaggt gtcggaggcg gcggtcagtg 1140
tcgagggtgg cagggaaccg ccggtgtcgg tggatgttcc tgacggcccg ccgcggcggg 1200
ccggcgagag tgcaggttcg actgcggtgc cccgcacggt cgcctgagcg tggccccctt 1260
cttggctggc tgccgggagg gggcgctttc gtcatgccca ggcacttgcc gagcccggtt 1320
ggggtaatcg tacccggtac gatctcatct agatctcaac aagaaatccc tagtcagcgc 1380
cgtacccagt tacgatcacc ggactctcca cccgactacc cccagaaccg ccctactcca 1440
tcgcccgagg gtaagaaaaa gaccagctga 1470
<210> 57
<211> 230
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 57
Met Ser Leu Gly Ser Gly Arg Lys Glu Arg Ile His Lys Met Asp Val
1 5 10 15
Asn Thr Leu Arg Glu Val Met Gly Asn Tyr Arg Asn Val Asn Tyr Asp
20 25 30
Ala Met Val Gly Pro Met Asn Glu Ala Met Ile Ala Ala Gly Cys Thr
35 40 45
Asn Leu Arg Arg Ala Ala Met Trp Cys Ala Gln Ile Gly His Glu Ser
50 55 60
Glu Gly Leu Thr Ala Met Glu Glu Tyr Ala Ser Gly Ala Gly Tyr Glu
65 70 75 80
Gly Arg Leu Asp Leu Gly Asn Thr Gln Pro Gly Asp Gly Val Arg Tyr
85 90 95
Lys Gly Arg Gly Pro Ile Gln Leu Thr Gly Arg Ser Asn Tyr Arg Ala
100 105 110
Phe Thr Thr Trp Ala Arg Ser Lys Gly Tyr Thr Thr Ile Asp Phe Glu
115 120 125
Ala Glu Pro His Lys Val Ser Glu Pro Lys Trp Gly Phe Leu Ala Ala
130 135 140
Ser Phe Tyr Trp Thr Val Arg Arg Pro Asp Ile Asn Ser Leu Ala Asp
145 150 155 160
Gln Gly Asp Val Thr Arg Val Thr His Arg Ile Asn Gly Gly Glu Asn
165 170 175
Gly Leu Ser Asp Arg Ile Ala Arg Tyr Asn Arg Ala Met Ala Leu Gly
180 185 190
Asp Arg Ile Leu Pro Ser Ala Ser Glu Thr Gly Thr Gln Thr Ser Lys
195 200 205
Thr Thr Ala Ala Glu Lys Val Leu Asp Tyr Lys Arg Asp Trp Val Lys
210 215 220
Gln Asp Thr Tyr Tyr Asn
225 230
<210> 58
<211> 210
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 58
Asp Arg Ile Leu Pro Ser Ala Ser Glu Thr Gly Thr Gln Thr Ser Lys
1 5 10 15
Thr Thr Ala Ala Glu Lys Val Leu Asp Tyr Lys Arg Asp Trp Val Lys
20 25 30
Gln Asp Thr Tyr Tyr Asn Cys Gly Pro Ala Ser Cys Gln Thr Val Ile
35 40 45
Gly Ala Ala Thr Gly Asn Tyr Pro Gly Glu Val Glu Leu Ala Ala Ala
50 55 60
Leu Lys Thr Thr Ile Asn Gly Thr Asp Trp Ile Gly Val Phe Pro Gly
65 70 75 80
Val Leu Asn Arg Tyr Ile Pro Gly Gly Lys Tyr Ser Ser Arg Glu Ile
85 90 95
Pro Asn Asp Pro Pro Arg Ser Asp Gln Arg Asp Gln Leu Trp Lys Asp
100 105 110
Ile Ile Asn Ser Ile Asn Ser Gly Tyr Gly Val Val Ala Asn Ile Val
115 120 125
Ala Pro Pro Ser Asn Tyr Pro Arg Ala Ser Tyr Lys Ser Thr Gln Ser
130 135 140
Pro Ala Tyr Ala Gly Gly Thr Val Tyr His Tyr Val Ala Val Met Gly
145 150 155 160
Tyr Ala Ile Asp Asp Ser Gly Arg Ser His Val Trp Val Ala Asp Ser
165 170 175
Gly Phe Ala Pro Tyr Gly Tyr Trp Met Thr Leu Gln Gln Leu Ser Thr
180 185 190
Leu Ile Pro Pro Lys Gly Tyr Ala Tyr Ser Thr Asn Ile Pro Gln Glu
195 200 205
Gly Leu
210
<210> 59
<211> 402
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 59
Met Ser Leu Gly Ser Gly Arg Lys Glu Arg Ile His Lys Met Asp Val
1 5 10 15
Asn Thr Leu Arg Glu Val Met Gly Asn Tyr Arg Asn Val Asn Tyr Asp
20 25 30
Ala Met Val Gly Pro Met Asn Glu Ala Met Ile Ala Ala Gly Cys Thr
35 40 45
Asn Leu Arg Arg Ala Ala Met Trp Cys Ala Gln Ile Gly His Glu Ser
50 55 60
Glu Gly Leu Thr Ala Met Glu Glu Tyr Ala Ser Gly Ala Gly Tyr Glu
65 70 75 80
Gly Arg Leu Asp Leu Gly Asn Thr Gln Pro Gly Asp Gly Val Arg Tyr
85 90 95
Lys Gly Arg Gly Pro Ile Gln Leu Thr Gly Arg Ser Asn Tyr Arg Ala
100 105 110
Phe Thr Thr Trp Ala Arg Ser Lys Gly Tyr Thr Thr Ile Asp Phe Glu
115 120 125
Ala Glu Pro His Lys Val Ser Glu Pro Lys Trp Gly Phe Leu Ala Ala
130 135 140
Ser Phe Tyr Trp Thr Val Arg Arg Pro Asp Ile Asn Ser Leu Ala Asp
145 150 155 160
Gln Gly Asp Val Thr Arg Val Thr His Arg Ile Asn Gly Gly Glu Asn
165 170 175
Gly Leu Ser Asp Arg Ile Ala Arg Tyr Asn Arg Ala Met Ala Leu Gly
180 185 190
Asp Arg Ile Leu Pro Ser Ala Ser Glu Thr Gly Thr Gln Thr Ser Lys
195 200 205
Thr Thr Ala Ala Glu Lys Val Leu Asp Tyr Lys Arg Asp Trp Val Lys
210 215 220
Gln Asp Thr Tyr Tyr Asn Cys Gly Pro Ala Ser Cys Gln Thr Val Ile
225 230 235 240
Gly Ala Ala Thr Gly Asn Tyr Pro Gly Glu Val Glu Leu Ala Ala Ala
245 250 255
Leu Lys Thr Thr Ile Asn Gly Thr Asp Trp Ile Gly Val Phe Pro Gly
260 265 270
Val Leu Asn Arg Tyr Ile Pro Gly Gly Lys Tyr Ser Ser Arg Glu Ile
275 280 285
Pro Asn Asp Pro Pro Arg Ser Asp Gln Arg Asp Gln Leu Trp Lys Asp
290 295 300
Ile Ile Asn Ser Ile Asn Ser Gly Tyr Gly Val Val Ala Asn Ile Val
305 310 315 320
Ala Pro Pro Ser Asn Tyr Pro Arg Ala Ser Tyr Lys Ser Thr Gln Ser
325 330 335
Pro Ala Tyr Ala Gly Gly Thr Val Tyr His Tyr Val Ala Val Met Gly
340 345 350
Tyr Ala Ile Asp Asp Ser Gly Arg Ser His Val Trp Val Ala Asp Ser
355 360 365
Gly Phe Ala Pro Tyr Gly Tyr Trp Met Thr Leu Gln Gln Leu Ser Thr
370 375 380
Leu Ile Pro Pro Lys Gly Tyr Ala Tyr Ser Thr Asn Ile Pro Gln Glu
385 390 395 400
Gly Leu
<210> 60
<211> 106
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 60
Ile Pro Gln Glu Gly Leu Asp Met Asp Ala Val Lys Gln Ile Ile Asp
1 5 10 15
Phe Val Lys Gly Trp Thr Gly Pro Met Ile Gln Asp Ile Lys Asp Ile
20 25 30
Arg Gln Gln Leu Thr Gly Gly Arg Asp Thr Val Tyr Arg Glu Asp Gly
35 40 45
Ser Val Asp Leu Val Ala Ser Tyr Pro Gly Trp Arg Gln Leu Gly Thr
50 55 60
Asp Lys Asn Gly Asn Pro Leu Ser Met Val Asp Ser Ile Ala Trp Ser
65 70 75 80
His Val Lys Ser Asp Lys Ile Ile Glu Ile Leu Thr Ala Leu Gln Asp
85 90 95
Arg Ile Thr Glu Leu Glu Lys Lys Val Lys
100 105
<210> 61
<211> 262
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 61
Met Thr Lys Ile Leu Thr Ile Glu Lys Ala Arg Glu Phe Asp Ala Phe
1 5 10 15
Ala Arg Ala Arg Asp Asn Leu Tyr Tyr Gly Tyr Gly Glu Ala Phe Thr
20 25 30
Arg Asn Pro Arg Gln Ser Thr Asp Cys Ser Gly Leu Val Leu Gln Ser
35 40 45
Gly Ala Ile Leu Gly Gly Arg Thr Asp Trp Val Gly Asn Arg Tyr Gly
50 55 60
Ser Thr Glu Ser Phe Arg Leu Asp Tyr Ala Ile Val Tyr Ala Leu Gly
65 70 75 80
Phe Lys Arg Met Pro Arg Gly Gly Leu Pro Phe Val Pro Val Met Lys
85 90 95
Val Gly Leu Gln His Gly Gly Gly Gly Ile Tyr Ser His Thr Ala Cys
100 105 110
Thr Leu Met Phe Leu Asp Lys Pro Gly Gly Pro Ile Lys Glu Ser Ala
115 120 125
Arg Gly Val Asp Trp Glu Ser Gln Gly Ala Gly Val Phe Tyr Tyr Glu
130 135 140
Gly Ala Arg Ala Trp Asn Asp Gly Leu Phe His Asp Phe Trp Tyr Leu
145 150 155 160
Asp Met Arg Leu Gly Glu Leu Ala Pro Pro Val Asn Glu Ile Asn Ala
165 170 175
Glu Phe Glu Arg Ala Lys Gly Trp Ile Gly Lys Arg Ile Asp Val Ala
180 185 190
Glu Lys Pro Cys Pro Asp Gly Glu Gly Lys Tyr Ile Arg Cys Glu Gly
195 200 205
Gly His Ile Tyr Phe His Pro Lys Val Asn Val Gly Ala Lys Pro Gly
210 215 220
Glu Arg Ala Ile Ala Ile Pro Ala Asp Val Phe Glu Val Trp Lys Arg
225 230 235 240
Gln Gly Phe Glu Lys Gly Pro Leu Gly Tyr Pro Thr Arg Arg His Ala
245 250 255
Thr Val Asn Gly Val Gly
260
<210> 62
<211> 102
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 62
Gly Phe Glu Lys Gly Pro Leu Gly Tyr Pro Thr Arg Arg His Ala Thr
1 5 10 15
Val Asn Gly Val Gly Thr Ile Gln Ala Phe Gln Asn Gly Ala Val Tyr
20 25 30
Arg Lys Phe Gly Thr Asp Gly Gly Ile Val Asn Gly Lys Ile Leu Glu
35 40 45
Arg Trp Ala Arg Glu Gly His Glu Lys Gly Arg Leu Gly Trp Pro Leu
50 55 60
Gly Asp Glu Lys Phe Phe Asp Gly Gly Arg Val Gln Ala Phe Glu Asn
65 70 75 80
Gly Asp Ala Tyr Phe His Pro Thr Ala Val Val Glu Phe Leu Asn Asp
85 90 95
Pro Ala Ala Pro Lys Gln
100
<210> 63
<211> 270
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 63
Met Arg Pro Tyr Arg Ala Arg His Leu Ala Thr Pro Pro Thr Pro Asp
1 5 10 15
Ser Thr Pro Asp Thr Ser Ser Gly Ala Ser Arg Arg Ser Val Leu Arg
20 25 30
Gly Gly Val Leu Gly Ala Ala Ala Leu Ser Thr Gly Ala Ala Ala Val
35 40 45
Ala Thr Pro Ala Ala Asn Ala Ala Gly Leu Tyr Gly Gln Asp Val Ser
50 55 60
Gly Trp Gln Gly Glu Ile Asp Trp Ser Ala Gln Ala Asp Leu Gly Ser
65 70 75 80
Arg Phe Ala Tyr Val Lys Ala Thr Glu Gly Arg Ser Tyr Arg Ser Pro
85 90 95
Ala Phe Asn Gln Gln Tyr Arg Gly Ala Gly Asn Ala Gly Leu Val Arg
100 105 110
Gly Gly Tyr His Phe Ala Arg Pro Asp Ser Gly Gly Pro Glu Glu Gln
115 120 125
Val Asp Phe Phe Leu Asn Asn Gly Gly Gly Trp Ser Asp Asp Gly Ile
130 135 140
Thr Leu Pro Gly Met Val Asp Phe Glu Ala Tyr Ser Gly Leu Pro Arg
145 150 155 160
Asp Tyr Gly Leu Ser Gln Gln Glu Met Arg Asn Trp Ile Met Ala Phe
165 170 175
Ser Thr Arg Tyr Arg Asp Ser Val Gly Arg Arg Pro Val Leu Tyr Thr
180 185 190
Asn Leu His Trp Trp Asn Asp Val Val Gly Asp Trp Thr Pro Val Asn
195 200 205
Ser Pro Leu Phe Leu Ala Ser Tyr Ser Ser Ser Ala Pro Thr Thr Leu
210 215 220
Pro Gly Arg Trp Trp Ala Tyr Glu Met Trp Gln Tyr Ser Asp Ser Gly
225 230 235 240
Pro Phe Ala Gly Asp Ser Asn Leu Trp His Gly Ser Glu Ser Gln Phe
245 250 255
Glu Ser Phe Val Ser Asp Gly Asp Tyr His Ala Ile Gly Ile
260 265 270
<210> 64
<211> 143
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 64
Met Arg Phe Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Ser Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ser Gly Gly Ser Ala His Tyr Val Cys Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Gly Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Lys Ala Ala Ile Leu Cys Arg
115 120 125
Arg Leu Cys Asp Lys Tyr Lys Cys Leu His Glu Gly Ala Val Ala
130 135 140
<210> 65
<211> 161
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 65
Met Ala Thr Met Pro Val Lys Lys Gly Phe Tyr Val Thr Ser Gly Phe
1 5 10 15
Gly Pro Arg Trp Gly Thr Thr His Tyr Gly Thr Asp Phe Gly Val Asp
20 25 30
Gly Gly Ser Gly Gly His Pro Ile Phe Ala Ile Lys Ser Gly Thr Val
35 40 45
Thr Ala Ser Gly Pro Ala Ser Gly Phe Gly Gln Trp Ile Asn Val Asp
50 55 60
His Pro Ala Ser Asp Gly Gly Gly Leu Ser Val Tyr Gly His Ile Ile
65 70 75 80
Pro Glu Val Arg Val Gly Asp Gln Val Val Glu Gly Gln Arg Ile Gly
85 90 95
Arg Ile Asn Pro Asp Gln Asn Thr Asn Gly Gly Val Ala Pro His Leu
100 105 110
His Leu Glu Phe His Arg Ser Val Trp Ser Pro Pro Gly Gly Asp Arg
115 120 125
Leu Asp Pro Met Lys Thr Val Leu Ala Gly Ala Asp Trp Pro Gly Asp
130 135 140
Ala Pro Ser Asn Ser Ser Ala Lys Pro Glu Thr Gly Lys Val Lys Asn
145 150 155 160
Ile
<210> 66
<211> 238
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 66
Gly Ala Asp Trp Pro Gly Asp Ala Pro Ser Asn Ser Ser Ala Lys Pro
1 5 10 15
Glu Thr Gly Lys Val Lys Asn Ile Phe Gly Val Asp Ile Ser Asn His
20 25 30
Gln Asn Gly Ile Leu Ala Glu Leu Ile Gly Ala Glu Gly Phe Glu Phe
35 40 45
Cys Ile Ile Lys Ala Thr Glu Gly Thr Trp Lys Asp Pro Ile Leu His
50 55 60
Ser His Leu Ala Asp Val Arg Lys Asn Ser Gly Met Gln Val Gly Ala
65 70 75 80
Tyr Val Tyr Val Arg Gly Glu Thr Ser Pro Glu Ala His Ala Ile Ala
85 90 95
Leu His Glu His Leu Asn Asp Thr Ser Val Pro Val Ala Leu Asp Ile
100 105 110
Glu His Asn Ser Gly Ser Asn Pro Asp His Trp Arg Ala Ile Lys Thr
115 120 125
Ala Ile Glu Ala Arg Gly Tyr Arg Val Ile Leu Thr Tyr Leu Pro Glu
130 135 140
Trp Tyr Trp Ser Gln Val Gly Gln Pro Asn Leu Ala Gly Leu Pro Pro
145 150 155 160
Leu Trp Ala Ser Arg Tyr Val Gly Thr Thr Pro Gly Val Ala Ser Val
165 170 175
Leu Tyr Ser Thr Ala Gly Arg Arg Gly Trp Gln Gly Tyr Gly Gly Leu
180 185 190
Glu Val Ala Met Trp Gln Phe Thr Asp Arg Ala Gln Val Ala Gly Gln
195 200 205
Lys Ile Asp Ala Asn Val Phe Glu Gly Thr Glu Lys Gln Leu Arg Ala
210 215 220
Leu Phe His Gly Asp Thr Pro Glu Ile Glu Glu Glu Phe Asp
225 230 235
<210> 67
<211> 375
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 67
Met Ala Thr Met Pro Val Lys Lys Gly Phe Tyr Val Thr Ser Gly Phe
1 5 10 15
Gly Pro Arg Trp Gly Thr Thr His Tyr Gly Thr Asp Phe Gly Val Asp
20 25 30
Gly Gly Ser Gly Gly His Pro Ile Phe Ala Ile Lys Ser Gly Thr Val
35 40 45
Thr Ala Ser Gly Pro Ala Ser Gly Phe Gly Gln Trp Ile Asn Val Asp
50 55 60
His Pro Ala Ser Asp Gly Gly Gly Leu Ser Val Tyr Gly His Ile Ile
65 70 75 80
Pro Glu Val Arg Val Gly Asp Gln Val Val Glu Gly Gln Arg Ile Gly
85 90 95
Arg Ile Asn Pro Asp Gln Asn Thr Asn Gly Gly Val Ala Pro His Leu
100 105 110
His Leu Glu Phe His Arg Ser Val Trp Ser Pro Pro Gly Gly Asp Arg
115 120 125
Leu Asp Pro Met Lys Thr Val Leu Ala Gly Ala Asp Trp Pro Gly Asp
130 135 140
Ala Pro Ser Asn Ser Ser Ala Lys Pro Glu Thr Gly Lys Val Lys Asn
145 150 155 160
Ile Phe Gly Val Asp Ile Ser Asn His Gln Asn Gly Ile Leu Ala Glu
165 170 175
Leu Ile Gly Ala Glu Gly Phe Glu Phe Cys Ile Ile Lys Ala Thr Glu
180 185 190
Gly Thr Trp Lys Asp Pro Ile Leu His Ser His Leu Ala Asp Val Arg
195 200 205
Lys Asn Ser Gly Met Gln Val Gly Ala Tyr Val Tyr Val Arg Gly Glu
210 215 220
Thr Ser Pro Glu Ala His Ala Ile Ala Leu His Glu His Leu Asn Asp
225 230 235 240
Thr Ser Val Pro Val Ala Leu Asp Ile Glu His Asn Ser Gly Ser Asn
245 250 255
Pro Asp His Trp Arg Ala Ile Lys Thr Ala Ile Glu Ala Arg Gly Tyr
260 265 270
Arg Val Ile Leu Thr Tyr Leu Pro Glu Trp Tyr Trp Ser Gln Val Gly
275 280 285
Gln Pro Asn Leu Ala Gly Leu Pro Pro Leu Trp Ala Ser Arg Tyr Val
290 295 300
Gly Thr Thr Pro Gly Val Ala Ser Val Leu Tyr Ser Thr Ala Gly Arg
305 310 315 320
Arg Gly Trp Gln Gly Tyr Gly Gly Leu Glu Val Ala Met Trp Gln Phe
325 330 335
Thr Asp Arg Ala Gln Val Ala Gly Gln Lys Ile Asp Ala Asn Val Phe
340 345 350
Glu Gly Thr Glu Lys Gln Leu Arg Ala Leu Phe His Gly Asp Thr Pro
355 360 365
Glu Ile Glu Glu Glu Phe Asp
370 375
<210> 68
<211> 110
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 68
His Gly Asp Thr Pro Glu Ile Glu Glu Glu Phe Asp Met Ser Ala Val
1 5 10 15
Gln Glu Ile Lys Asp Tyr Ile Asp Thr Arg Leu Thr Gly Pro Val Gly
20 25 30
Thr Asp Val Lys Asp Ile Arg Gln Gln Ile Thr Gly Gly Arg Asp Ser
35 40 45
Ile Pro Gly Asp Leu Lys Ala Ser Tyr Pro Gly Trp Asp Leu Gly Gln
50 55 60
Leu Val Arg Ala Ala Arg Glu Lys Glu Phe Thr Gly Leu Thr Met Met
65 70 75 80
Glu Ile Leu Ala Val Asn Ile Ala Gly Asn Asp Asp Asp Phe Arg Ala
85 90 95
Ala Arg Val Ala Ala Gly Thr Glu Glu Ala Gly Asn Ala Glu
100 105 110
<210> 69
<211> 185
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 69
Met Ala Asp Tyr Phe Tyr Pro Leu Ser Gln Gly Ala His Val Thr Ser
1 5 10 15
Pro Phe Gly Pro Arg Ala Gly Gly Tyr His Trp Gly Thr Asp Tyr Gly
20 25 30
Arg Ala Gly Gly Ser Gly Gly Asn Ala Val Tyr Ala Pro Gln Ala Gly
35 40 45
Thr Val Ile Met Ala Gly Pro Ala Ser Gly Phe Gly Gly Pro Asp Pro
50 55 60
Ala Gly Trp Ile Val Ile Asp His Pro Thr Ala Ala Gly Gly Gly Val
65 70 75 80
Ser Val Leu Gly His Ile Ile Arg Glu Val Ala Val Gly Asp Thr Val
85 90 95
Arg Ala Gly Gln Arg Ile Gly Arg Val Asn Pro Ser Ser Ala Thr Asn
100 105 110
Gly Gly Val Ala Pro His Val His Phe Glu His His Arg Tyr Val Trp
115 120 125
Ser Pro Pro Gly Pro Asp Arg Leu Asp Pro His Ala Trp Leu Ala Thr
130 135 140
Arg Gly Ala Arg Trp Pro Gly Ala Pro Ala Thr Pro Thr Arg Lys Glu
145 150 155 160
Ser Met Asn Ala Leu Thr Ala Asp Ile Asp Leu Leu Thr Pro Asn Asp
165 170 175
Asp Gly Arg Ala Thr Lys Pro Arg Asn
180 185
<210> 70
<211> 207
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 70
Ile Asp Leu Leu Thr Pro Asn Asp Asp Gly Arg Ala Thr Lys Pro Arg
1 5 10 15
Asn Leu Leu Cys Ile His Thr Phe Glu Asp Asp Gly Thr Trp Ser Ala
20 25 30
Asp Arg Met Ala Lys Tyr Gln Gln Ser Pro Ala Ala Gly Gly Ser Tyr
35 40 45
His Leu Val Ile Asp Leu Asn Gly Arg Ile Ala Arg Glu Asn Asp Asp
50 55 60
Ala Phe Ile Pro Trp Ala Ala Met Phe Thr Gly Asn Arg Val Ala Phe
65 70 75 80
His Phe Ser Leu Ser Gly Lys Ala Ser Trp Thr Arg Gln Gln Trp Leu
85 90 95
Ala Arg Pro Lys Gln Met Asp Ala Leu Ala Lys Val Leu Ala Ala Tyr
100 105 110
Ser Lys Ala Lys Gly Ile Pro Leu Ile Arg Arg Gly Pro Gln Asp Val
115 120 125
Arg Ala Gly Lys Trp Gly Val Cys Gly His Asp Asp Ile Ser Lys Ala
130 135 140
Phe Gly Glu Ser Thr His Trp Asp Pro Gly Pro Asn Phe Pro Phe Asp
145 150 155 160
Val Val Ile Asp Lys Ala Lys Ala Ile Leu Ala Glu Pro Lys Pro Thr
165 170 175
Pro Ala Pro Pro Ser Asp Pro Ala Pro Arg Pro Ile Pro Pro Lys Glu
180 185 190
Thr Leu Val Pro Thr Thr Leu Asp Thr Val Leu Pro Ser Leu Val
195 200 205
<210> 71
<211> 375
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 71
Met Ala Asp Tyr Phe Tyr Pro Leu Ser Gln Gly Ala His Val Thr Ser
1 5 10 15
Pro Phe Gly Pro Arg Ala Gly Gly Tyr His Trp Gly Thr Asp Tyr Gly
20 25 30
Arg Ala Gly Gly Ser Gly Gly Asn Ala Val Tyr Ala Pro Gln Ala Gly
35 40 45
Thr Val Ile Met Ala Gly Pro Ala Ser Gly Phe Gly Gly Pro Asp Pro
50 55 60
Ala Gly Trp Ile Val Ile Asp His Pro Thr Ala Ala Gly Gly Gly Val
65 70 75 80
Ser Val Leu Gly His Ile Ile Arg Glu Val Ala Val Gly Asp Thr Val
85 90 95
Arg Ala Gly Gln Arg Ile Gly Arg Val Asn Pro Ser Ser Ala Thr Asn
100 105 110
Gly Gly Val Ala Pro His Val His Phe Glu His His Arg Tyr Val Trp
115 120 125
Ser Pro Pro Gly Pro Asp Arg Leu Asp Pro His Ala Trp Leu Ala Thr
130 135 140
Arg Gly Ala Arg Trp Pro Gly Ala Pro Ala Thr Pro Thr Arg Lys Glu
145 150 155 160
Ser Met Asn Ala Leu Thr Ala Asp Ile Asp Leu Leu Thr Pro Asn Asp
165 170 175
Asp Gly Arg Ala Thr Lys Pro Arg Asn Leu Leu Cys Ile His Thr Phe
180 185 190
Glu Asp Asp Gly Thr Trp Ser Ala Asp Arg Met Ala Lys Tyr Gln Gln
195 200 205
Ser Pro Ala Ala Gly Gly Ser Tyr His Leu Val Ile Asp Leu Asn Gly
210 215 220
Arg Ile Ala Arg Glu Asn Asp Asp Ala Phe Ile Pro Trp Ala Ala Met
225 230 235 240
Phe Thr Gly Asn Arg Val Ala Phe His Phe Ser Leu Ser Gly Lys Ala
245 250 255
Ser Trp Thr Arg Gln Gln Trp Leu Ala Arg Pro Lys Gln Met Asp Ala
260 265 270
Leu Ala Lys Val Leu Ala Ala Tyr Ser Lys Ala Lys Gly Ile Pro Leu
275 280 285
Ile Arg Arg Gly Pro Gln Asp Val Arg Ala Gly Lys Trp Gly Val Cys
290 295 300
Gly His Asp Asp Ile Ser Lys Ala Phe Gly Glu Ser Thr His Trp Asp
305 310 315 320
Pro Gly Pro Asn Phe Pro Phe Asp Val Val Ile Asp Lys Ala Lys Ala
325 330 335
Ile Leu Ala Glu Pro Lys Pro Thr Pro Ala Pro Pro Ser Asp Pro Ala
340 345 350
Pro Arg Pro Ile Pro Pro Lys Glu Thr Leu Val Pro Thr Thr Leu Asp
355 360 365
Thr Val Leu Pro Ser Leu Val
370 375
<210> 72
<211> 86
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 72
Pro Lys Pro Thr Pro Ala Pro Pro Ser Asp Pro Ala Pro Arg Pro Ile
1 5 10 15
Pro Pro Lys Glu Thr Leu Val Pro Thr Thr Leu Asp Thr Val Leu Pro
20 25 30
Ser Leu Val Asp Gly Ser Thr Phe Glu Ala Pro Leu Ala Thr Phe Ile
35 40 45
Arg Thr Ala Asp Lys Gln Ala Tyr Glu Ala Asn Gln Arg Ile Ala Arg
50 55 60
Leu Glu Ala Lys Phe Asp Arg Leu Leu Asp Ala Met Gly Glu Lys Pro
65 70 75 80
Asp Pro Lys Pro Gly Gln
85
<210> 73
<211> 195
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 73
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Ser Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ala Gly Gly Ser Ala His Tyr Val Cys Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Lys Ala Ala Val Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys Tyr Asn Val Pro Lys Arg Lys Leu Ser Val Ser
130 135 140
Asp Leu Lys Ala Gly Arg Arg Gly Val Cys Gly His Thr Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Arg Phe Met Ala Val Val Asn Gly Gly Ser Gly Glu Ser Gly
180 185 190
Glu Leu Ser
195
<210> 74
<211> 186
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 74
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Ser Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ala Gly Gly Ser Ala His Tyr Val Cys Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Lys Ala Ala Val Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys Tyr Asn Val Pro Lys Arg Lys Leu Ser Val Ser
130 135 140
Asp Leu Lys Ala Gly Arg Arg Gly Val Cys Gly His Thr Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Arg Phe Met Ala Val Val Asn Gly
180 185
<210> 75
<211> 99
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 75
Gly Ser Gly Glu Ser Gly Glu Leu Ser Met Ala Asp Val Lys Ala Leu
1 5 10 15
His Asp Gln Ile Lys Gln Leu Ser Gly Gln Val Ala Gln Ser Val Asn
20 25 30
Lys Leu His His Asp Val Gly Val Val Gln Val Gln Asn Gly Asn Leu
35 40 45
Lys Lys Gln Val Asp Ser Leu Ser Met Val Lys Asn Pro Val Thr Gly
50 55 60
Lys Leu Trp Arg Thr Arg Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val
65 70 75 80
Leu Glu Cys Arg Ser Arg Ile Gly Lys Leu Glu Ala Glu Val Ala Arg
85 90 95
Leu Lys Lys
<210> 76
<211> 90
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 76
Met Ala Asp Val Lys Ala Leu His Asp Gln Ile Lys Gln Leu Ser Gly
1 5 10 15
Gln Val Ala Gln Ser Val Asn Lys Leu His His Asp Val Gly Val Val
20 25 30
Gln Val Gln Asn Gly Asn Leu Lys Lys Gln Val Asp Ser Leu Ser Met
35 40 45
Val Lys Asn Pro Val Thr Gly Lys Leu Trp Arg Thr Arg Asp Ala Ile
50 55 60
Trp Ser Ile Trp Tyr Tyr Val Leu Glu Cys Arg Ser Arg Ile Gly Lys
65 70 75 80
Leu Glu Ala Glu Val Ala Arg Leu Lys Lys
85 90
<210> 77
<211> 164
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 77
Met Ser Thr Ala Asn Tyr Phe Ala Ser Pro Ser Ser Gly Gly Ser Ala
1 5 10 15
His Tyr Val Cys Asp Ile Ser Glu Thr Val Gln Cys Leu Ser Glu Ser
20 25 30
Thr Ile Gly Trp His Ala Pro Pro Asn Pro His Ser Leu Gly Ile Glu
35 40 45
Ile Cys Ala Asp Gly Gly Ser His Ala Ser Phe Arg Val Pro Gly His
50 55 60
Ala Tyr Thr Arg Glu Gln Trp Leu Asp Pro Arg Val Trp Pro Ala Val
65 70 75 80
Glu Lys Ala Ala Ile Leu Cys Arg Arg Leu Cys Asp Lys Tyr Asn Val
85 90 95
Pro Lys Arg Lys Leu Ser Val Ala Asp Leu Lys Ala Gly Arg Arg Gly
100 105 110
Val Cys Gly His Val Asp Val Thr Asp Ala Trp His Gln Ser Asp His
115 120 125
Asp Asp Pro Gly Pro Trp Phe Pro Trp Asp Arg Phe Met Ala Val Val
130 135 140
Asn Gly Gly Ser Gly Asp Ser Gly Glu Leu Thr Val Ala Asp Val Lys
145 150 155 160
Ala Leu His Asp
<210> 78
<211> 101
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 78
Asn Gly Gly Ser Gly Asp Ser Gly Glu Leu Thr Val Ala Asp Val Lys
1 5 10 15
Ala Leu His Asp Gln Ile Lys Gln Leu Ser Ala Gln Leu Thr Gly Ser
20 25 30
Val Asn Lys Leu His His Asp Val Gly Val Val Gln Val Gln Asn Gly
35 40 45
Asp Leu Gly Lys Arg Val Asp Ala Leu Ser Trp Val Lys Asn Pro Val
50 55 60
Thr Gly Lys Leu Trp Arg Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr
65 70 75 80
Tyr Val Leu Glu Cys Arg Ser Arg Ile Asp Arg Leu Glu Ser Ala Val
85 90 95
Asn Gly Leu Lys Lys
100
<210> 79
<211> 90
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 79
Val Ala Asp Val Lys Ala Leu His Asp Gln Ile Lys Gln Leu Ser Ala
1 5 10 15
Gln Leu Thr Gly Ser Val Asn Lys Leu His His Asp Val Gly Val Val
20 25 30
Gln Val Gln Asn Gly Asp Leu Gly Lys Arg Val Asp Ala Leu Ser Trp
35 40 45
Val Lys Asn Pro Val Thr Gly Lys Leu Trp Arg Thr Lys Asp Ala Leu
50 55 60
Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg Ser Arg Ile Asp Arg
65 70 75 80
Leu Glu Ser Ala Val Asn Gly Leu Lys Lys
85 90
<210> 80
<211> 195
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 80
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Lys Asn Thr Asn Lys Gly
180 185 190
Glu Leu Ser
195
<210> 81
<211> 186
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 81
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly
180 185
<210> 82
<211> 95
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 82
Lys Asn Thr Asn Lys Gly Glu Leu Ser Met Ser Asp Val Asn Thr Leu
1 5 10 15
Thr Lys Leu Ile Lys Ala Ser Asn Asn Gln Leu His His Asp Ile Gly
20 25 30
Val Val Gln Thr Gln Asn Gly Thr Leu Lys Ser Lys Ile Asp Asn Leu
35 40 45
Ser Trp Val Lys Asn Pro Val Thr Gly Lys Lys Trp Ser Thr Lys Asp
50 55 60
Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile
65 70 75 80
Gln Ala Ile Glu Asn Arg Leu Ser Asp Ile Glu Lys Lys Val Lys
85 90 95
<210> 83
<211> 86
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 83
Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn Asn
1 5 10 15
Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn Gly Thr Leu
20 25 30
Lys Ser Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr Gly
35 40 45
Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val
50 55 60
Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg Leu Ser Asp
65 70 75 80
Ile Glu Lys Lys Val Lys
85
<210> 84
<211> 90
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 84
Gly Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys
1 5 10 15
Ala Ser Asn Asn Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln
20 25 30
Asn Gly Thr Leu Lys Ser Lys Ile Asp Asn Leu Ser Trp Val Lys Asn
35 40 45
Pro Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val
50 55 60
Trp Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn
65 70 75 80
Arg Leu Ser Asp Ile Glu Lys Lys Val Lys
85 90
<210> 85
<211> 197
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 85
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr
195
<210> 86
<211> 185
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 86
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys
180 185
<210> 87
<211> 191
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 87
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro
180 185 190
<210> 88
<211> 84
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 88
Gly Gly Ala Thr Asn Pro Asp Glu Leu Glu Leu Thr Val Ser Gln Phe
1 5 10 15
Ser Asp Leu Thr Lys Arg Leu Gln Gly Met Gln Glu Gln Thr His His
20 25 30
Asp Leu Gly Val Val Gln Thr Lys Leu Ala Thr Met Asp Thr Val Lys
35 40 45
Asn Pro Arg Thr Gly Ala Lys Trp Ser Leu Lys Asp Ala Ile Trp Ser
50 55 60
Ile Trp Tyr Tyr Val Leu Glu Asn Arg Asp Arg Ile Ala Ala Leu Glu
65 70 75 80
Lys Lys Val Lys
<210> 89
<211> 72
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 89
Val Ser Gln Phe Ser Asp Leu Thr Lys Arg Leu Gln Gly Met Gln Glu
1 5 10 15
Gln Thr His His Asp Leu Gly Val Val Gln Thr Lys Leu Ala Thr Met
20 25 30
Asp Thr Val Lys Asn Pro Arg Thr Gly Ala Lys Trp Ser Leu Lys Asp
35 40 45
Ala Ile Trp Ser Ile Trp Tyr Tyr Val Leu Glu Asn Arg Asp Arg Ile
50 55 60
Ala Ala Leu Glu Lys Lys Val Lys
65 70
<210> 90
<211> 78
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 90
Asp Glu Leu Glu Leu Thr Val Ser Gln Phe Ser Asp Leu Thr Lys Arg
1 5 10 15
Leu Gln Gly Met Gln Glu Gln Thr His His Asp Leu Gly Val Val Gln
20 25 30
Thr Lys Leu Ala Thr Met Asp Thr Val Lys Asn Pro Arg Thr Gly Ala
35 40 45
Lys Trp Ser Leu Lys Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val Leu
50 55 60
Glu Asn Arg Asp Arg Ile Ala Ala Leu Glu Lys Lys Val Lys
65 70 75
<210> 91
<211> 215
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 91
Met Asp Trp Thr Asn Leu Asn Ala Asp Val Thr Lys Leu Met Asn Val
1 5 10 15
His Phe Thr Pro Gly Arg Glu Gly His Thr Ile Asp Lys Ile Val Ile
20 25 30
His His Asn Gly Gly Asn Leu Ser Ile Asp Gln Ile Trp Asn Val Trp
35 40 45
Gln Asp Arg Glu Ala Ser Ala His Tyr Gln Val Gln Ser Asp Gly Arg
50 55 60
Ile Gly Gln Leu Val Asn Asp Trp Asp Thr Ala Trp His Ala Gly Asp
65 70 75 80
Trp Asp Ala Asn Leu Thr Ser Ile Gly Ile Glu His Ala Asp Asp Ser
85 90 95
Thr Asp Pro Trp His Val Ser Asp Ala Ala Val Asp Ala Gly Ala His
100 105 110
Leu Val Ala Ala Leu Cys Arg Gly Tyr Asn Leu Gly Arg Pro Glu Trp
115 120 125
Met Arg Asn Val Phe Pro His Ser His Phe Ser Ala Thr Ser Cys Pro
130 135 140
Ala Ser Leu Ala Glu Asn Gln Arg Ala Asp Tyr Met Ala Arg Ala Gln
145 150 155 160
Ala Tyr Phe Asp Gly Ala Pro Val Thr Gly Arg Ser Ser Val Pro Ala
165 170 175
Pro Ala Pro Ala Pro Ala Gly Ile His Val Asp Leu Pro Ala Trp Thr
180 185 190
Leu Pro Ala Gly Asn Phe Tyr Gly Ser Ile Asp Gly Gly Glu Asp Ser
195 200 205
His Gly Gly Tyr Tyr Glu Gly
210 215
<210> 92
<211> 140
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 92
Ala Ser Leu Ala Glu Asn Gln Arg Ala Asp Tyr Met Ala Arg Ala Gln
1 5 10 15
Ala Tyr Phe Asp Gly Ala Pro Val Thr Gly Arg Ser Ser Val Pro Ala
20 25 30
Pro Ala Pro Ala Pro Ala Gly Ile His Val Asp Leu Pro Ala Trp Thr
35 40 45
Leu Pro Ala Gly Asn Phe Tyr Gly Ser Ile Asp Gly Gly Glu Asp Ser
50 55 60
His Gly Gly Tyr Tyr Glu Gly Glu Arg Pro Ala Ile Ala Ala Ile Gln
65 70 75 80
Arg Trp Leu Ile Arg His Gly Tyr Ala Gly Ala Val Asp Asp Ser Trp
85 90 95
Ala Asp Gly Leu Tyr Glu Gln Pro Thr Val Asp Ala Val Thr Arg Phe
100 105 110
Gln Arg Ala Glu Arg Pro Asn Ser Thr Asp Arg Trp Gly Glu Val Trp
115 120 125
Ala Asp Asp Leu Ala Thr Met Ala Ala Asn Asn Gly
130 135 140
<210> 93
<211> 196
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 93
Met Asp Arg Gly Ile Asp Val Ser Ser Tyr Gln Ala Pro Asp Gly Gly
1 5 10 15
Leu Leu Glu Gly Met Ser Phe Cys Ile Ile Lys Ala Thr Glu Gly Thr
20 25 30
Gly Tyr Val Asn Pro Asn Arg Thr Gln Trp Tyr Lys Val Ala Thr Asp
35 40 45
Arg Gly Val Thr Thr Gly Ala Tyr His Phe Met Arg Gly Gly Asp Pro
50 55 60
Val Ala Gln Ala Asp Tyr Phe Leu Ala His Leu Pro Gly Asp Val Asp
65 70 75 80
Trp Leu Ala Leu Asp Val Glu Asp Pro Ser Asp Gly Leu Ser Trp Ala
85 90 95
Gly Arg Val Ser Phe Ile Leu Ala Trp Thr Asp Arg Val Lys Ala Thr
100 105 110
Gly Lys Pro Thr Leu Val Tyr Cys Ser Arg Ser Trp Ala Asn Ala Leu
115 120 125
Leu Gly Ala Ala Ser Ser Asp Glu Arg Ala Arg Leu Ala Gln Leu Pro
130 135 140
Leu Trp Met Ala Asp Tyr Thr Gln Arg Pro Gly Glu Tyr Ser Gly Pro
145 150 155 160
Trp Pro Gly Gly Trp Pro Ile Ala Ile His Gln Tyr Thr Ser Ala Pro
165 170 175
Ile Asp Lys Asn Val Leu Leu Thr Asp Asp Leu Gln Gly Gly Asp Asp
180 185 190
Met Pro Leu Ser
195
<210> 94
<211> 116
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 94
Leu Thr Asp Asp Leu Gln Gly Gly Asp Asp Met Pro Leu Ser Thr Asp
1 5 10 15
Asp Leu Arg Asn Ile Ala Thr Ala Val Trp Gly Gly Gly Gly Ala Ala
20 25 30
Ser Pro Met Tyr Ala Asp Arg Leu Asp Gly His Gln Glu Tyr Pro Glu
35 40 45
Thr Ala Leu Phe Ser Leu Gln Gln Arg Leu Gly Ala Arg Phe Gly Glu
50 55 60
Leu Ser Gly Lys Ile Asp Gly Leu Ala Glu Ala Leu Lys Gln Val Gln
65 70 75 80
Gly Gly Asn Gly Val Asp Ala Asp Ala Ile Arg Ala Ala Ala Ala Glu
85 90 95
Gly Ala Lys Ala Gly Val Gln Ala Met Ile Asp Thr Ala Thr Val Asn
100 105 110
Leu Glu Ala Lys
115
<210> 95
<211> 229
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 95
Met Cys Gly Ala Phe Ser Phe Leu Lys Asp Leu Glu Thr Phe Met Asp
1 5 10 15
Trp Thr Asn Leu Asn Ala Asp Val Thr Lys Leu Met Gly Val His Phe
20 25 30
Thr Pro Gly Arg Glu Gly Arg Thr Ile Asp Lys Ile Val Ile His His
35 40 45
Asn Gly Gly Asn Leu Ser Ile Asp Gln Ile Trp Asn Val Trp Gln Thr
50 55 60
Arg Glu Ala Ser Ala His Tyr Gln Val Glu Ala Gly Gly Arg Ile Gly
65 70 75 80
Gln Leu Val Asn Asp Leu Asp Thr Ala Trp His Ala Gly Asp Trp Asp
85 90 95
Ala Asn Leu Thr Ser Ile Gly Ile Glu His Ala Asp Asp Ser Thr Asp
100 105 110
Pro Trp His Val Ser Asp Ala Ala Val Asp Ala Gly Ala His Leu Val
115 120 125
Ala Ala Leu Cys Arg Gly Tyr Asn Leu Gly Arg Pro Glu Trp Met Arg
130 135 140
Asn Val Phe Pro His Ser Gln Phe Thr Ser Thr Ser Cys Pro Ala Ser
145 150 155 160
Leu Ala Arg Asp Gln Leu Gly Asp Tyr Met Gly Arg Ala Gln Ala Tyr
165 170 175
Phe Asp Gly Ala Pro Val Ala Ala Val His Gln Ser Val Pro Ala Pro
180 185 190
Ala Pro Ala Pro Ser Arg His Val Asp Leu Pro Ala Trp Asn Leu Pro
195 200 205
Glu Gly Asn Phe Tyr Gly Leu Val Ser Gly Gly Asn Asp Ser His Gly
210 215 220
Gly Phe Tyr Pro Ala
225
<210> 96
<211> 139
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 96
Ala Ser Leu Ala Arg Asp Gln Leu Gly Asp Tyr Met Gly Arg Ala Gln
1 5 10 15
Ala Tyr Phe Asp Gly Ala Pro Val Ala Ala Val His Gln Ser Val Pro
20 25 30
Ala Pro Ala Pro Ala Pro Ser Arg His Val Asp Leu Pro Ala Trp Asn
35 40 45
Leu Pro Glu Gly Asn Phe Tyr Gly Leu Val Ser Gly Gly Asn Asp Ser
50 55 60
His Gly Gly Phe Tyr Pro Ala Glu Arg Pro Ala Val Arg Ala Ile Gln
65 70 75 80
Leu Trp Leu Ile Arg His Gly Tyr Ala Gly Ala Val Pro Asp Ser Trp
85 90 95
Ala Asp Gly Ile Tyr Glu Gln Pro Thr Ala Asp Ala Val Thr Ala Phe
100 105 110
Gln His Ala Glu Arg Pro Asn Ser Thr Asp Arg Trp Gly Glu Val Trp
115 120 125
Ala Asp Asp Leu Ala Thr Met Ala Ala Asn Asn
130 135
<210> 97
<211> 232
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 97
Met Lys Ala Ser Arg Val Ile Val Val Ala Ser Val Val Ala Leu Ile
1 5 10 15
Leu Ala Gly Leu Ala Met Ser Ser Ala Ala Val Ile Val Val Pro Leu
20 25 30
Leu Ser Val Gly Ala Gly Ala Leu Asp Asp Asn Ser Gly Ala Gly Gly
35 40 45
Val Gly Gly Asp Pro Cys Ile Gly Thr Val Thr Gly Gly Ala Val Ser
50 55 60
Val Gly Gly Leu Thr Thr Arg Gln Lys Gln Leu Val Thr Thr Ile Val
65 70 75 80
Thr Val Val Gln Arg Asp Lys Leu Pro Val Gln Ala Ala Val Ile Ala
85 90 95
Ile Met Thr Ala Lys Gln Glu Ser Asp Leu Gly Ala Asn Pro Ala Ala
100 105 110
Thr Lys Pro Asn Gly Asp Gly Asp Ala Gly Pro Phe Gln Gln Arg Val
115 120 125
Leu Pro Gly Trp Tyr Gly Thr Leu Asp Gln Val Asn Asn Asp Ala Tyr
130 135 140
Ala Thr Glu Thr Phe Leu Lys Gly His Thr Ile Thr Tyr Ala Gly Pro
145 150 155 160
Thr Ser Ala Gly Gly Pro Gly Tyr His Ile Pro Gly Leu Val Asp Val
165 170 175
Pro Asp Trp Gln Ser Lys Ser Pro Ala Gln Ala Ala Gln Ala Val Gln
180 185 190
Ala Ser Ala Leu Pro Asn Ala Tyr Ala Lys Trp Glu Ala Ile Ala Lys
195 200 205
Gln Met Val Gly Ala Thr Thr Thr Gly Arg Leu Ser Asn Asp Cys Val
210 215 220
Thr Gly Thr Ala Asn Glu Thr Gly
225 230
<210> 98
<211> 150
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 98
Ala Ile Ala Lys Gln Met Val Gly Ala Thr Thr Thr Gly Arg Leu Ser
1 5 10 15
Asn Asp Cys Val Thr Gly Thr Ala Asn Glu Thr Gly Val Ser Lys Asn
20 25 30
Leu Thr Lys Ala Val Glu Trp Ala Lys Ser Ile Ala Ala Asn Asn Ser
35 40 45
Tyr Thr Tyr Val Trp Gly Gly Asn Gly Ala Ser Asp Gly Gly Tyr Asp
50 55 60
Cys Ser Gly Leu Thr Ser Ala Leu Tyr Arg Arg Ile Gly Ile Asn Leu
65 70 75 80
Pro Arg Thr Ala Ala Glu Gln Gln Lys Val Gly Thr Pro Val Asn Arg
85 90 95
Asn Gln Leu Lys Val Gly Asp Leu Ile Phe Trp Gly Ile Pro Ala His
100 105 110
His Val Ala Thr Tyr Ile Gly Arg Gly Gln Met Ile Ser Ala Asp Asn
115 120 125
Gln Ala Arg Gly Ile Asn Val Glu Lys Ile Tyr Gly Asn Pro Ser Ser
130 135 140
Tyr Arg Arg Ile Val Lys
145 150
<210> 99
<211> 354
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 99
Met Lys Ala Ser Arg Val Ile Val Val Ala Ser Val Val Ala Leu Ile
1 5 10 15
Leu Ala Gly Leu Ala Met Ser Ser Ala Ala Val Ile Val Val Pro Leu
20 25 30
Leu Ser Val Gly Ala Gly Ala Leu Asp Asp Asn Ser Gly Ala Gly Gly
35 40 45
Val Gly Gly Asp Pro Cys Ile Gly Thr Val Thr Gly Gly Ala Val Ser
50 55 60
Val Gly Gly Leu Thr Thr Arg Gln Lys Gln Leu Val Thr Thr Ile Val
65 70 75 80
Thr Val Val Gln Arg Asp Lys Leu Pro Val Gln Ala Ala Val Ile Ala
85 90 95
Ile Met Thr Ala Lys Gln Glu Ser Asp Leu Gly Ala Asn Pro Ala Ala
100 105 110
Thr Lys Pro Asn Gly Asp Gly Asp Ala Gly Pro Phe Gln Gln Arg Val
115 120 125
Leu Pro Gly Trp Tyr Gly Thr Leu Asp Gln Val Asn Asn Asp Ala Tyr
130 135 140
Ala Thr Glu Thr Phe Leu Lys Gly His Thr Ile Thr Tyr Ala Gly Pro
145 150 155 160
Thr Ser Ala Gly Gly Pro Gly Tyr His Ile Pro Gly Leu Val Asp Val
165 170 175
Pro Asp Trp Gln Ser Lys Ser Pro Ala Gln Ala Ala Gln Ala Val Gln
180 185 190
Ala Ser Ala Leu Pro Asn Ala Tyr Ala Lys Trp Glu Ala Ile Ala Lys
195 200 205
Gln Met Val Gly Ala Thr Thr Thr Gly Arg Leu Ser Asn Asp Cys Val
210 215 220
Thr Gly Thr Ala Asn Glu Thr Gly Val Ser Lys Asn Leu Thr Lys Ala
225 230 235 240
Val Glu Trp Ala Lys Ser Ile Ala Ala Asn Asn Ser Tyr Thr Tyr Val
245 250 255
Trp Gly Gly Asn Gly Ala Ser Asp Gly Gly Tyr Asp Cys Ser Gly Leu
260 265 270
Thr Ser Ala Leu Tyr Arg Arg Ile Gly Ile Asn Leu Pro Arg Thr Ala
275 280 285
Ala Glu Gln Gln Lys Val Gly Thr Pro Val Asn Arg Asn Gln Leu Lys
290 295 300
Val Gly Asp Leu Ile Phe Trp Gly Ile Pro Ala His His Val Ala Thr
305 310 315 320
Tyr Ile Gly Arg Gly Gln Met Ile Ser Ala Asp Asn Gln Ala Arg Gly
325 330 335
Ile Asn Val Glu Lys Ile Tyr Gly Asn Pro Ser Ser Tyr Arg Arg Ile
340 345 350
Val Lys
<210> 100
<211> 189
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 100
Met Asp Trp Thr Asn Leu Asn Ala Asp Val Thr Lys Leu Met Asn Val
1 5 10 15
His Phe Thr Pro Gly Arg Glu Gly Arg Thr Ile Asp Lys Ile Val Ile
20 25 30
His His Asn Gly Gly Asn Leu Ser Ile Asp Gln Ile Trp Asn Val Trp
35 40 45
Gln Asp Arg Glu Ala Ser Ala His Tyr Gln Val Glu Ser Ser Gly Arg
50 55 60
Ile Gly Gln Leu Val Asn Asp Trp Asp Thr Ala Trp His Ala Gly Asp
65 70 75 80
Trp Asp Ala Asn Leu Thr Ser Ile Gly Ile Glu His Ala Asp Asp Ser
85 90 95
Thr Asp Pro Trp His Val Ser Asp Ala Ala Ile Asp Ser Gly Ala His
100 105 110
Leu Val Ala Ala Leu Cys Arg Ala Tyr Asn Leu Gly Arg Pro Glu Trp
115 120 125
Met His Asn Val Phe Pro His Ser His Phe Ser Ala Thr Ser Cys Pro
130 135 140
Ala Ser Leu Ala Glu Asn Gln Arg Ala Asp Tyr Met Ser Arg Ala Gln
145 150 155 160
Ala Tyr Tyr Asp Gly Thr Ser Val Ala Ala Ala Pro Ala Ala Pro Ser
165 170 175
Ala Pro Ala Gly Ile His Val Asp Leu Pro Ser Trp Thr
180 185
<210> 101
<211> 123
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 101
Arg Ala Gln Ala Tyr Tyr Asp Gly Thr Ser Val Ala Ala Ala Pro Ala
1 5 10 15
Ala Pro Ser Ala Pro Ala Gly Ile His Val Asp Leu Pro Ser Trp Thr
20 25 30
Leu Pro Ile Gly His Tyr Tyr Gly Leu Val Thr Gly Pro Asn Asp Ser
35 40 45
His Gly Gly Phe Tyr Glu Ser Glu Arg Pro Ala Val Arg Ala Ile Gln
50 55 60
Leu Trp Leu Ile Arg His Gly Tyr Ala Gly Ala Val Pro Asp Ser Trp
65 70 75 80
Ala Asp Gly Ile Tyr Glu Gln Pro Thr Ala Asp Ala Val Thr Ala Phe
85 90 95
Gln His Ala Glu Arg Pro Asn Ser Thr Asp Arg Trp Gly Glu Val Trp
100 105 110
Ala Asp Asp Leu Ala Thr Met Ala Ala Asn Asn
115 120
<210> 102
<211> 204
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 102
Met Asp Trp Thr Asn Leu Ile Ala Asp Thr Thr Lys Leu Met Gly Val
1 5 10 15
His Phe Thr Pro Gly Arg Glu Gly Arg Lys Ile Asp Lys Ile Val Ile
20 25 30
His His Asn Gly Gly Asn Leu Ser Ile Asp Gln Ile Trp Asn Val Trp
35 40 45
Gln Thr Arg Glu Ala Ser Ala His Tyr Gln Val Glu Thr Gly Gly Arg
50 55 60
Ile Gly Gln Leu Val Asn Asp Trp Asp Thr Ala Trp His Ala Gly Asp
65 70 75 80
Trp Asp Ala Asn Leu Thr Ser Ile Gly Ile Glu His Ala Asp Asp Ser
85 90 95
Thr Asp Pro Trp His Val Ser Asp Ala Ala Val Asp Ala Gly Ala His
100 105 110
Leu Val Ala Ala Leu Cys Lys Ala Tyr Ser Leu Gly Arg Pro Glu Trp
115 120 125
Met Arg Asn Val Phe Pro His Ser His Phe Ser Ala Thr Ser Cys Pro
130 135 140
Ala Ser Leu Ala Glu Asn Gln Arg Ala Asp Tyr Met Ser Arg Ala Gln
145 150 155 160
Ala Tyr Tyr Asp Gly Ala Pro Val Ala Ala Val His Gln Ser Ala Pro
165 170 175
Ala Pro Ala Pro Ala Ser Ser Arg His Val Asp Leu Pro Ala Trp Asn
180 185 190
Leu Pro Glu Gly Asn Phe Tyr Gly Leu Ala Ser Gly
195 200
<210> 103
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 103
Arg Ala Gln Ala Tyr Tyr Asp Gly Ala Pro Val Ala Ala Val His Gln
1 5 10 15
Ser Ala Pro Ala Pro Ala Pro Ala Ser Ser Arg His Val Asp Leu Pro
20 25 30
Ala Trp Asn Leu Pro Glu Gly Asn Phe Tyr Gly Leu Ala Ser Gly Gly
35 40 45
Glu Asp Ser His Gly Gly Phe Tyr Glu Gly Glu Arg Pro Ala Ile Arg
50 55 60
Gln Ile Gln Leu Trp Leu Ile Arg His Gly Tyr Ala Gly Ala Val Pro
65 70 75 80
Asp Ser Trp Ala Asp Gly Ile Tyr Glu Gln Pro Thr Ala Asp Ala Val
85 90 95
Ala Ala Phe Gln His Ala Glu Arg Pro Asn Ser Thr Asp Arg Trp Gly
100 105 110
Glu Val Trp Ala Asp Asp Leu Ala Thr Met Ala Ala Asn Asn
115 120 125
<210> 104
<211> 145
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 104
Ala Phe Ala Val Asp Ile Leu Gln Ala Ser Asp Ser Pro Arg Glu Ser
1 5 10 15
Ala Pro Gly Trp Gln Trp Arg Gln Ala Glu Pro Gln Glu Phe Pro Ser
20 25 30
Phe Gly Glu Pro Val Leu Ala Ala Gly Cys Gly Thr Val Ile Ala Ala
35 40 45
His Asp Gly Lys Arg Asp His Arg Ala Arg Asn Thr Trp Pro Gly Leu
50 55 60
Ile Tyr Met Met Ser Leu Glu Ala Phe Gly Arg Glu Leu Ala Gly His
65 70 75 80
Arg Ser Ile Ile Gly Asn His Val Ile Leu Asp His Ser Asp Gly Thr
85 90 95
Phe Ser Met Tyr Ala His Leu Lys His Gly Ser Ala Ala Val Cys Val
100 105 110
Gly Gln Lys Val Arg Ala Gly Asp Val Leu Gly Ala Val Gly Asn Thr
115 120 125
Gly Asn Thr Ser Glu Pro His Leu His Phe Gln Leu Met Asp Arg Pro
130 135 140
Gln
145
<210> 105
<211> 290
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 105
Met Met Arg Met Leu Lys Ala Ala Ser Pro Trp Leu Leu Arg Ala Cys
1 5 10 15
Val Leu Leu Val Ala Leu Ser Phe Val Ile Glu Val Pro Val Trp Leu
20 25 30
Val Phe Ala Pro Leu Gly Leu Ala Ile Ala Val Pro Ser Pro Arg Ala
35 40 45
Asp Asp Glu Ser Pro Gln Thr Met His Ala Pro Val Thr Gly Arg Trp
50 55 60
Val Ala Ile Asn Ser Pro Ala Thr Lys Val Pro Ser His Gly Val Arg
65 70 75 80
Thr Leu Gly Gln Ala Phe Ala Val Asp Ile Leu Gln Ala Ser Asp Ser
85 90 95
Pro Arg Glu Ser Ala Pro Gly Trp Gln Trp Arg Gln Ala Glu Pro Gln
100 105 110
Glu Phe Pro Ser Phe Gly Glu Pro Val Leu Ala Ala Gly Cys Gly Thr
115 120 125
Val Ile Ala Ala His Asp Gly Lys Arg Asp His Arg Ala Arg Asn Thr
130 135 140
Trp Pro Gly Leu Ile Tyr Met Met Ser Leu Glu Ala Phe Gly Arg Glu
145 150 155 160
Leu Ala Gly His Arg Ser Ile Ile Gly Asn His Val Ile Leu Asp His
165 170 175
Ser Asp Gly Thr Phe Ser Met Tyr Ala His Leu Lys His Gly Ser Ala
180 185 190
Ala Val Cys Val Gly Gln Lys Val Arg Ala Gly Asp Val Leu Gly Ala
195 200 205
Val Gly Asn Thr Gly Asn Thr Ser Glu Pro His Leu His Phe Gln Leu
210 215 220
Met Asp Arg Pro Gln Ala Ala Met Ala Ala Gly Leu Pro Phe Arg Trp
225 230 235 240
Ser Pro Leu Thr Ile Glu Pro Asp Pro Asp Pro His Trp Ala Pro Lys
245 250 255
Lys Pro Val Ala Glu Thr Val Glu Gly Leu Pro Ala Thr Gly Gln Ile
260 265 270
Phe Arg Thr Pro Glu Ser Gly Val Met Pro Gln Pro Lys Arg Glu Ala
275 280 285
Ser Cys
290
<210> 106
<211> 93
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 106
Gly Ser Arg Gly Val Glu Phe Ala Ala Ser Val Gly Glu Pro Val Thr
1 5 10 15
Thr Val Thr Ala Gly Val Val Val Phe Ala Gly Gln Val Ala Gly Ala
20 25 30
Gly Val Val Ser Ile Leu Leu Ala Asp Gly Arg Arg Thr Thr His Met
35 40 45
Pro Val Val Pro Ser Val Ala Val Gly Gln Val Val Val Pro Gly Gln
50 55 60
Gln Ile Gly Val Val Gly Met Gly Pro Pro Cys Thr Arg Thr Cys Leu
65 70 75 80
His Trp Gly Leu Lys Lys Gly Asp Val Tyr Gln Asn Pro
85 90
<210> 107
<211> 252
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 107
Met Arg Arg Ser Val Cys Ile Ser Leu Leu Ile Ile Thr Val Gly Ile
1 5 10 15
Cys Leu Leu Ala Phe Pro Ala Pro Ser His Ser Ile Ala Ala Val Pro
20 25 30
Ala Arg Ser Val Ala Asn Arg Pro Thr Pro Pro Val Leu Gly Pro Val
35 40 45
Ile Lys Gly Phe Ala Pro Pro Ala Glu Lys Trp Leu Pro Gly Ser Arg
50 55 60
Gly Val Glu Phe Ala Ala Ser Val Gly Glu Pro Val Thr Thr Val Thr
65 70 75 80
Ala Gly Val Val Val Phe Ala Gly Gln Val Ala Gly Ala Gly Val Val
85 90 95
Ser Ile Leu Leu Ala Asp Gly Arg Arg Thr Thr His Met Pro Val Val
100 105 110
Pro Ser Val Ala Val Gly Gln Val Val Val Pro Gly Gln Gln Ile Gly
115 120 125
Val Val Gly Met Gly Pro Pro Cys Thr Arg Thr Cys Leu His Trp Gly
130 135 140
Leu Lys Lys Gly Asp Val Tyr Gln Asn Pro Met Thr Leu Leu Gln Leu
145 150 155 160
Gln Val Arg Leu Leu Pro Leu Asp Ser Arg Pro His Ser Ala Ser Gly
165 170 175
His Gly Trp Pro Val Arg Pro Leu Ser Leu Pro Gly Gly Ser Arg Arg
180 185 190
Lys Ala Ala Ser Ser Gly Ala Leu Met Pro Pro Trp Arg Gly Ala Gly
195 200 205
Arg Asp Ala Ala Leu Gly Ile Asp Thr Thr Val Thr Glu Ala Thr Arg
210 215 220
Gly Gly Ser Gly Ala Gly Met Ser Leu Ala Lys Arg Ser Ala Gln Ser
225 230 235 240
Phe Gly Gly Asn Val Gly Val Asp Leu Arg Gly Gly
245 250
<210> 108
<211> 171
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 108
Met Ala Lys Thr Leu Ser Arg Ile Ala Ser Val Ala Ala Ala Ala Ala
1 5 10 15
Leu Ala Gly Gly Val Ser Val Thr Ala Ala Gln Ser Ala Ser Ala Asp
20 25 30
Asp Val Asn Trp Asp Ala Ile Ala Asn Cys Glu Ser Gly Gly Asn Trp
35 40 45
Ser Thr Asn Thr Gly Asn Gly Tyr Tyr Gly Gly Leu Gln Phe Ser Gln
50 55 60
Ser Thr Trp Ala Ala Tyr Gly Gly Ser Gly Ser Ala Ser Asn Ala Ser
65 70 75 80
Arg Glu Glu Gln Ile Ala Val Ala Glu Arg Val Leu Ala Gly Gln Gly
85 90 95
Ile Gly Ala Trp Pro Val Cys Gly Ala Tyr Ala Tyr Ser Gly Glu Ser
100 105 110
Tyr Thr Gly Thr Asn Thr Glu Gly Ser Tyr Gly Ser Ser Tyr Asp Thr
115 120 125
Ser Ala Gln Asp Ala Ser Tyr Asp Gly Ser Tyr Ser Tyr Asp Asn Ser
130 135 140
Tyr Ser Tyr Asp Asn Ser Ala Gly Tyr Asp Ser Ser Ser Ala Tyr Ser
145 150 155 160
Gly Gly Tyr Gln Ala Thr Arg Glu Ala Thr Gly
165 170
<210> 109
<211> 113
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 109
Gly Ala Tyr Ala Tyr Ser Gly Glu Ser Tyr Thr Gly Thr Asn Thr Glu
1 5 10 15
Gly Ser Tyr Gly Ser Ser Tyr Asp Thr Ser Ala Gln Asp Ala Ser Tyr
20 25 30
Asp Gly Ser Tyr Ser Tyr Asp Asn Ser Tyr Ser Tyr Asp Asn Ser Ala
35 40 45
Gly Tyr Asp Ser Ser Ser Ala Tyr Ser Gly Gly Tyr Gln Ala Thr Arg
50 55 60
Glu Ala Thr Gly Thr Tyr Glu Ile Gln Pro Gly Asp Thr Leu Asn Ala
65 70 75 80
Ile Ala Glu Ala His Gly Thr Thr Trp Gln Glu Leu Ala Ala Leu Asn
85 90 95
Ser Ser Ile Val Asp Ala Asn Leu Ile Tyr Ala Gly Glu Thr Ile Asn
100 105 110
Val
<210> 110
<211> 176
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 110
Met Ala Tyr Pro Tyr Ile Gly Ala Leu Lys His Gly Gly Lys Gln Gly
1 5 10 15
Lys Ile Gln Arg Ile Val Ile His Ala Thr Val Ser Pro Cys Val Arg
20 25 30
Gly Gly Ala Arg Asn Val Ala Lys Tyr Phe Gln Ser Ser Ala Ala Gly
35 40 45
Gly Ser Ala His Tyr Val Val Asp Pro Gly Glu Ile Ile Gln Cys Val
50 55 60
Lys Asp Asp Val Val Ala Tyr His Ala Pro Pro Asn Thr Gly Thr Leu
65 70 75 80
Gly Ile Glu Leu Cys Asp Pro Gln Ala Gly Ser Pro Lys Arg Trp Ser
85 90 95
Asn Glu Ala His Gln Ala Met Leu Val Leu Ala Ala Lys Leu Val Arg
100 105 110
Glu Leu Ala Ala Lys His Asp Val Pro Leu Val Arg Val Thr Ala Ala
115 120 125
Gln Leu Arg Ala Gly Lys Arg Gly Ile Cys Ser His Val Ala Val Ser
130 135 140
Asp Ala Phe Gly Gln Ser Asp His Gly Asp Pro Glu Val Ala Gly Pro
145 150 155 160
Phe Pro Trp Ala Lys Phe Met Gln Leu Ile Lys Glu Glu Asp Asp Met
165 170 175
<210> 111
<211> 124
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 111
Met Ala Tyr Pro Tyr Ile Gly Ala Leu Lys His Gly Gly Lys Gln Gly
1 5 10 15
Lys Ile Gln Arg Ile Val Ile His Ala Thr Val Ser Pro Cys Val Arg
20 25 30
Gly Gly Ala Arg Asn Val Ala Lys Tyr Phe Gln Ser Ser Ala Ala Gly
35 40 45
Gly Ser Ala His Tyr Val Val Asp Pro Gly Glu Ile Ile Gln Cys Val
50 55 60
Lys Asp Asp Val Val Ala Tyr His Ala Pro Pro Asn Thr Gly Thr Leu
65 70 75 80
Gly Ile Glu Leu Cys Asp Pro Gln Ala Gly Ser Pro Lys Arg Trp Ser
85 90 95
Asn Glu Ala His Gln Ala Met Leu Val Leu Ala Ala Lys Leu Val Arg
100 105 110
Glu Leu Ala Ala Lys His Asp Val Pro Leu Val Arg
115 120
<210> 112
<211> 126
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 112
Val Thr Ala Ala Gln Leu Arg Ala Gly Lys Arg Gly Ile Cys Ser His
1 5 10 15
Val Ala Val Ser Asp Ala Phe Gly Gln Ser Asp His Gly Asp Pro Glu
20 25 30
Val Ala Gly Pro Phe Pro Trp Ala Lys Phe Met Gln Leu Ile Lys Glu
35 40 45
Glu Asp Asp Met Pro Ser Pro Lys Glu Ile Tyr Glu Ala Val Trp Glu
50 55 60
Gln Asp Val Met Ala Ala Pro Asp Gly Ser Lys Ser Asn Pro Thr Trp
65 70 75 80
Lys Pro Ser Ser Val Leu Thr Asp Val Asp Lys Lys Val Arg Ala Leu
85 90 95
Gln Ser Gln Val Thr Gly Leu Glu Ser Glu Leu Ala Ala Thr Asn Ala
100 105 110
Lys Leu Asp Gln Val Leu Thr Leu Leu Arg Ala Ser Val Ser
115 120 125
<210> 113
<211> 193
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 113
Met Thr Phe Ile Gln Ala Ala His Arg Gly Gly Thr Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Ala Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys His Arg His His Ile Pro Ile Arg Arg Leu Ser Val Ala
130 135 140
Gln Val Arg Ala Gly Glu Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr Thr Pro Glu
180 185 190
Gly
<210> 114
<211> 173
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 114
Met Thr Phe Ile Gln Ala Ala His Arg Gly Gly Thr Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Ala Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys His Arg His His Ile Pro Ile Arg Arg Leu Ser Val Ala
130 135 140
Gln Val Arg Ala Gly Glu Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro
165 170
<210> 115
<211> 109
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 115
Tyr Phe Pro Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr
1 5 10 15
Thr Pro Glu Gly Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys
20 25 30
Leu Ile Lys Ala Ser Asn Asp Gln Leu His Tyr Asp Ile Gly Val Val
35 40 45
Gln Thr Gln Asn Gly Asn Ile Lys Lys Lys Ile Asp Asn Leu Ser Trp
50 55 60
Val Lys Asn Pro Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu
65 70 75 80
Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala
85 90 95
Ile Glu Asn Arg Ile Tyr Asp Leu Glu Lys Lys Val Lys
100 105
<210> 116
<211> 90
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 116
Gly Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys
1 5 10 15
Ala Ser Asn Asp Gln Leu His Tyr Asp Ile Gly Val Val Gln Thr Gln
20 25 30
Asn Gly Asn Ile Lys Lys Lys Ile Asp Asn Leu Ser Trp Val Lys Asn
35 40 45
Pro Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val
50 55 60
Trp Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn
65 70 75 80
Arg Ile Tyr Asp Leu Glu Lys Lys Val Lys
85 90
<210> 117
<211> 213
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 117
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Lys Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ser Gly Gly Ser Ala His Tyr Val Cys Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys His Gly Val Pro Lys Arg Lys Leu Ser Val Ala
130 135 140
Asp Leu Lys Ala Gly Lys Arg Gly Val Cys Gly His Val Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly Gly Ser Ser
180 185 190
Ser Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His Asn Gln Ile
195 200 205
Lys Gln Leu Ser Ala
210
<210> 118
<211> 173
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 118
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Lys Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ser Gly Gly Ser Ala His Tyr Val Cys Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys His Gly Val Pro Lys Arg Lys Leu Ser Val Ala
130 135 140
Asp Leu Lys Ala Gly Lys Arg Gly Val Cys Gly His Val Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro
165 170
<210> 119
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 119
Trp Phe Pro Trp Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly
1 5 10 15
Gly Ser Ser Ser Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His
20 25 30
Asn Gln Ile Lys Gln Leu Ser Ala Gln Val Ala Gln Ser Val Asn Lys
35 40 45
Leu His His Asp Val Gly Val Val Gln Val Gln Asn Gly Asp Leu Gly
50 55 60
Lys Arg Val Asp Ala Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys
65 70 75 80
Leu Trp Arg Ser Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu
85 90 95
Glu Cys Arg Ser Arg Leu Asp Arg Leu Glu Ser Ala Val Asn Asp Leu
100 105 110
Lys Lys
<210> 120
<211> 74
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 120
Gln Val Ala Gln Ser Val Asn Lys Leu His His Asp Val Gly Val Val
1 5 10 15
Gln Val Gln Asn Gly Asp Leu Gly Lys Arg Val Asp Ala Leu Ser Trp
20 25 30
Val Lys Asn Pro Val Thr Gly Lys Leu Trp Arg Ser Lys Asp Ala Leu
35 40 45
Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg Ser Arg Leu Asp Arg
50 55 60
Leu Glu Ser Ala Val Asn Asp Leu Lys Lys
65 70
<210> 121
<211> 196
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 121
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Ala Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Thr Thr Asp Arg Pro Ala Ser Ala His Tyr Val Cys Asp Ile Ala Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Asp Gln Trp Leu
100 105 110
Ser Asp Asp Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys Gln Arg His Arg Ile Pro Val Arg Lys Leu Ser Thr Ala
130 135 140
Gln Val Lys Ala Gly Leu Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Gly Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gln Phe Met Ala Leu Val Gln Gly Lys Pro Ala Thr Pro Gly
180 185 190
Asp Leu Thr Met
195
<210> 122
<211> 173
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 122
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Ala Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Thr Thr Asp Arg Pro Ala Ser Ala His Tyr Val Cys Asp Ile Ala Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Asp Gln Trp Leu
100 105 110
Ser Asp Asp Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys Gln Arg His Arg Ile Pro Val Arg Lys Leu Ser Thr Ala
130 135 140
Gln Val Lys Ala Gly Leu Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Gly Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro
165 170
<210> 123
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 123
Tyr Phe Pro Trp Asp Gln Phe Met Ala Leu Val Gln Gly Lys Pro Ala
1 5 10 15
Thr Pro Gly Asp Leu Thr Met Ala Asp Ile Ser Lys Leu Thr Asp Ala
20 25 30
Ile Lys Ala Ser Asn Arg Gln Leu His His Asp Ile Gly Val Val Gln
35 40 45
Thr Gln Asn Gly Lys Leu Arg Glu Gln Ile Glu Arg Ile Thr Trp Val
50 55 60
Lys Asn Pro Val Thr Gly Lys Lys Trp Arg Ile Thr Asp Ala Leu Trp
65 70 75 80
Ser Ile Trp His Tyr Val Leu Glu Cys Arg Thr Arg Ile Gln Arg Leu
85 90 95
Asp Ala Arg Leu Ser Glu Val Glu Lys Lys Val Lys
100 105
<210> 124
<211> 86
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 124
Met Ala Asp Ile Ser Lys Leu Thr Asp Ala Ile Lys Ala Ser Asn Arg
1 5 10 15
Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn Gly Lys Leu
20 25 30
Arg Glu Gln Ile Glu Arg Ile Thr Trp Val Lys Asn Pro Val Thr Gly
35 40 45
Lys Lys Trp Arg Ile Thr Asp Ala Leu Trp Ser Ile Trp His Tyr Val
50 55 60
Leu Glu Cys Arg Thr Arg Ile Gln Arg Leu Asp Ala Arg Leu Ser Glu
65 70 75 80
Val Glu Lys Lys Val Lys
85
<210> 125
<211> 193
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 125
Met Thr Phe Ile Gln Ala Ala His Arg Gly Gly Thr Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Ala Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Ile Gly Ile Glu Ile Cys Ala Ala Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys His Arg His His Ile Pro Ile Arg Arg Leu Ser Val Ala
130 135 140
Gln Val Arg Ala Gly Glu Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr Thr Pro Glu
180 185 190
Gly
<210> 126
<211> 109
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 126
Tyr Phe Pro Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr
1 5 10 15
Thr Pro Glu Gly Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys
20 25 30
Leu Ile Lys Ala Ser Asn Asp Gln Leu His Tyr Asp Ile Gly Val Val
35 40 45
Gln Thr Gln Asn Gly Asn Ile Lys Lys Lys Ile Asp Asn Leu Ser Trp
50 55 60
Val Lys Asn Pro Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu
65 70 75 80
Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala
85 90 95
Ile Glu Asn Arg Ile Tyr Asp Leu Glu Lys Lys Val Lys
100 105
<210> 127
<211> 200
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 127
Met Thr Phe Ile Gln Ala Lys His His Gly Gly His Asn Asn Pro Pro
1 5 10 15
Val Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala His Tyr Phe Gln
35 40 45
Glu Thr Thr Arg Pro Ala Ser Ala His Tyr Ile Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Val Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Ser Asn Pro Ala His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Met Leu Ala Arg
115 120 125
Gly Ile Cys Gln Arg His Asn Ile Pro Ile Arg Arg Leu Ser Ile Ala
130 135 140
Asp Val Lys Ala Gly Lys Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gly Phe Ile Ala Leu Val Asn Gly His Ser Ala Pro Ser Arg
180 185 190
Gln Glu Glu Leu Thr Val Ser Asp
195 200
<210> 128
<211> 173
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 128
Met Thr Phe Ile Gln Ala Lys His His Gly Gly His Asn Asn Pro Pro
1 5 10 15
Val Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala His Tyr Phe Gln
35 40 45
Glu Thr Thr Arg Pro Ala Ser Ala His Tyr Ile Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Val Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Ser Asn Pro Ala His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Met Leu Ala Arg
115 120 125
Gly Ile Cys Gln Arg His Asn Ile Pro Ile Arg Arg Leu Ser Ile Ala
130 135 140
Asp Val Lys Ala Gly Lys Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro
165 170
<210> 129
<211> 110
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 129
Tyr Phe Pro Trp Asp Gly Phe Ile Ala Leu Val Asn Gly His Ser Ala
1 5 10 15
Pro Ser Arg Gln Glu Glu Leu Thr Val Ser Asp Val Asn Met Leu Lys
20 25 30
Gly Leu Ile Gln Gln Ser Asn Lys Gln Leu His His Asp Ile Gly Val
35 40 45
Val Gln Thr Gln Ala Gly Asn Leu Arg Arg Gln Leu Glu Ser Leu Ser
50 55 60
Trp Val Lys Asn Pro Val Ser Gly Lys Leu Trp Arg Thr Lys Asp Ala
65 70 75 80
Leu Trp Ser Ile Trp Tyr Tyr Val Leu Asp Cys Arg Ser Arg Leu Gly
85 90 95
Lys Leu Glu Ala Arg Leu Ser Thr Leu Glu Lys Lys Val Lys
100 105 110
<210> 130
<211> 93
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 130
Ser Arg Gln Glu Glu Leu Thr Val Ser Asp Val Asn Met Leu Lys Gly
1 5 10 15
Leu Ile Gln Gln Ser Asn Lys Gln Leu His His Asp Ile Gly Val Val
20 25 30
Gln Thr Gln Ala Gly Asn Leu Arg Arg Gln Leu Glu Ser Leu Ser Trp
35 40 45
Val Lys Asn Pro Val Ser Gly Lys Leu Trp Arg Thr Lys Asp Ala Leu
50 55 60
Trp Ser Ile Trp Tyr Tyr Val Leu Asp Cys Arg Ser Arg Leu Gly Lys
65 70 75 80
Leu Glu Ala Arg Leu Ser Thr Leu Glu Lys Lys Val Lys
85 90
<210> 131
<211> 200
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 131
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala
195 200
<210> 132
<211> 173
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 132
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro
165 170
<210> 133
<211> 185
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 133
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys
180 185
<210> 134
<211> 94
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 134
Asp Phe Pro Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr
1 5 10 15
Thr Gln Glu Asp Glu Asp Glu Met Lys Glu Ala Asp Trp Gln Arg Met
20 25 30
Glu Arg Leu Val Asp Ala Arg Leu Lys Tyr Ala Gly Ile Ala Lys Asn
35 40 45
Asp Asp Pro Val Phe Lys Pro Asp Lys Ser Ser Ser Trp Pro Trp Arg
50 55 60
Thr Ala Leu Trp Ser Ile Ser Tyr Tyr Ala Thr His Ser Tyr Asn Thr
65 70 75 80
Ile Cys Asn Ile Ala Arg Lys Leu Gly Ala Glu Val Ser Lys
85 90
<210> 135
<211> 186
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 135
Met Lys Tyr Ile Pro Ala Thr His His Gly Gly His Thr Asn Thr Pro
1 5 10 15
Phe Thr Arg Ile Val Ile His Ala Thr Cys Pro Asp Leu Gly Phe Pro
20 25 30
His Ala Ser Ala Gly Gly Gln Ala Lys Ala Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Glu Gln Ser Ala Gly Ser Ala His Tyr Val Cys Asp Ile Ala Glu
50 55 60
Thr Ile Gln Cys Leu Pro Asp Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Arg Arg Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ser Ser Phe Gln His Pro Glu His Ala Tyr Thr Arg Ser Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Ala Arg Ala Ala Ala Leu Thr Arg
115 120 125
Asp Leu Cys His Arg His Asn Ile Pro Met Gln Gln Leu Ser Val Ala
130 135 140
Asp Val Lys Ala Gly Lys His Gly Ile Cys Gly His Asn Asp Val Ser
145 150 155 160
Glu Ala Phe His Lys Ser Asp His Asp Asp Pro Gly Pro Thr Phe Pro
165 170 175
Trp Asp Gln Phe Ile Lys Glu Val Arg Thr
180 185
<210> 136
<211> 173
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 136
Met Lys Tyr Ile Pro Ala Thr His His Gly Gly His Thr Asn Thr Pro
1 5 10 15
Phe Thr Arg Ile Val Ile His Ala Thr Cys Pro Asp Leu Gly Phe Pro
20 25 30
His Ala Ser Ala Gly Gly Gln Ala Lys Ala Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Glu Gln Ser Ala Gly Ser Ala His Tyr Val Cys Asp Ile Ala Glu
50 55 60
Thr Ile Gln Cys Leu Pro Asp Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Arg Arg Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ser Ser Phe Gln His Pro Glu His Ala Tyr Thr Arg Ser Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Ala Arg Ala Ala Ala Leu Thr Arg
115 120 125
Asp Leu Cys His Arg His Asn Ile Pro Met Gln Gln Leu Ser Val Ala
130 135 140
Asp Val Lys Ala Gly Lys His Gly Ile Cys Gly His Asn Asp Val Ser
145 150 155 160
Glu Ala Phe His Lys Ser Asp His Asp Asp Pro Gly Pro
165 170
<210> 137
<211> 111
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 137
Thr Phe Pro Trp Asp Gln Phe Ile Lys Glu Val Arg Thr Pro Gly Gln
1 5 10 15
Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly
20 25 30
Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg
35 40 45
Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser
50 55 60
Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile
65 70 75 80
Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His
85 90 95
Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
100 105 110
<210> 138
<211> 98
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 138
Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr
1 5 10 15
Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser
20 25 30
Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His
35 40 45
Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val
50 55 60
Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser
65 70 75 80
Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys
85 90 95
Gly Ile
<210> 139
<211> 102
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 139
Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr
1 5 10 15
Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr
20 25 30
Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser
35 40 45
Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser
50 55 60
Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp
65 70 75 80
Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp
85 90 95
Lys Val Arg Lys Gly Ile
100
<210> 140
<211> 690
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 140
atgtcacttg ggtctggcag gaaggagaga atacataaga tggatgttaa cacactaagg 60
gaggtgatgg ggaattaccg aaacgttaac tatgacgcta tggtaggccc catgaatgag 120
gcgatgatcg ctgctggatg cactaacctc cggcgagctg ctatgtggtg tgctcagatc 180
ggccacgagt cagaaggcct caccgcgatg gaagagtacg ccagcggagc tggctacgaa 240
ggaaggcttg atctaggcaa tactcagcct ggagacggag tgcgctacaa gggccgaggc 300
cctatccagc tcacgggtag gtccaactat cgagccttta ctacgtgggc tagaagcaag 360
ggctatacaa ctatcgactt tgaggcggaa ccacacaagg tttccgagcc taagtgggga 420
ttccttgcag cgtccttcta ttggacggtg aggaggcctg acattaactc tctggccgac 480
cagggagatg taacgagagt aactcacagg attaacggag gagaaaacgg actcagtgac 540
cgtatagcga gatataatcg cgcgatggca ctcggggacc gaatccttcc ttcagcctct 600
gagacaggca cacagacatc gaaaacgacg gctgcggaga aggtcctgga ttataagcga 660
gactgggtga agcaggacac ctactataac 690
<210> 141
<211> 630
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 141
gaccgaatcc ttccttcagc ctctgagaca ggcacacaga catcgaaaac gacggctgcg 60
gagaaggtcc tggattataa gcgagactgg gtgaagcagg acacctacta taactgcggt 120
cccgcttctt gtcagacagt aatcggcgca gctacaggga attaccctgg agaggttgag 180
ctggcagcag ctctcaagac cacgattaac ggaactgact ggatcggagt cttccctgga 240
gtcctaaaca ggtacattcc cggaggaaag tactcctcca gggagatacc taacgatccg 300
ccaaggagcg accagagaga tcagctctgg aaggacatca taaactccat caactccggt 360
tatggagtcg tggcaaacat tgttgctcct ccaagcaact acccgagagc gagctacaag 420
tccacacagt ccccagccta tgcaggcgga acagtgtatc actacgttgc ggtgatgggt 480
tacgccattg acgacagcgg aagatctcat gtgtgggtcg cagattccgg tttcgcaccc 540
tatggctact ggatgactct ccagcagcta tccacgctta tcccaccaaa gggatatgcg 600
tactccacca acattcctca ggaaggacta 630
<210> 142
<211> 1206
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 142
atgtcacttg ggtctggcag gaaggagaga atacataaga tggatgttaa cacactaagg 60
gaggtgatgg ggaattaccg aaacgttaac tatgacgcta tggtaggccc catgaatgag 120
gcgatgatcg ctgctggatg cactaacctc cggcgagctg ctatgtggtg tgctcagatc 180
ggccacgagt cagaaggcct caccgcgatg gaagagtacg ccagcggagc tggctacgaa 240
ggaaggcttg atctaggcaa tactcagcct ggagacggag tgcgctacaa gggccgaggc 300
cctatccagc tcacgggtag gtccaactat cgagccttta ctacgtgggc tagaagcaag 360
ggctatacaa ctatcgactt tgaggcggaa ccacacaagg tttccgagcc taagtgggga 420
ttccttgcag cgtccttcta ttggacggtg aggaggcctg acattaactc tctggccgac 480
cagggagatg taacgagagt aactcacagg attaacggag gagaaaacgg actcagtgac 540
cgtatagcga gatataatcg cgcgatggca ctcggggacc gaatccttcc ttcagcctct 600
gagacaggca cacagacatc gaaaacgacg gctgcggaga aggtcctgga ttataagcga 660
gactgggtga agcaggacac ctactataac tgcggtcccg cttcttgtca gacagtaatc 720
ggcgcagcta cagggaatta ccctggagag gttgagctgg cagcagctct caagaccacg 780
attaacggaa ctgactggat cggagtcttc cctggagtcc taaacaggta cattcccgga 840
ggaaagtact cctccaggga gatacctaac gatccgccaa ggagcgacca gagagatcag 900
ctctggaagg acatcataaa ctccatcaac tccggttatg gagtcgtggc aaacattgtt 960
gctcctccaa gcaactaccc gagagcgagc tacaagtcca cacagtcccc agcctatgca 1020
ggcggaacag tgtatcacta cgttgcggtg atgggttacg ccattgacga cagcggaaga 1080
tctcatgtgt gggtcgcaga ttccggtttc gcaccctatg gctactggat gactctccag 1140
cagctatcca cgcttatccc accaaaggga tatgcgtact ccaccaacat tcctcaggaa 1200
ggacta 1206
<210> 143
<211> 321
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 143
attcctcagg aaggactaga tatggacgca gtaaagcaaa tcatcgactt tgttaagggc 60
tggacaggcc cgatgatcca ggacatcaag gacatcagac agcagctgac cggaggcagg 120
gatactgtct accgagagga tggctctgtt gaccttgttg ccagctaccc aggctggagg 180
cagctaggaa ccgacaagaa cggaaacccg ctctctatgg tcgatagtat cgcctggagc 240
catgtgaagt cagataagat catcgagatc cttacggctc tccaggatcg tatcaccgaa 300
ctagaaaaga aggttaagta a 321
<210> 144
<211> 786
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 144
atgaccaaga ttctgaccat cgaaaaggca cgcgagttcg acgctttcgc gcgcgcccgc 60
gacaacctgt actacgggta cggcgaggca ttcacccgta accctcgcca gtcgaccgac 120
tgctccgggc tcgtcctgca gtcgggtgcg atcctcggtg gccgcaccga ctgggtggga 180
aaccgctacg gatcgaccga gtcgttccgc ctcgactacg cgatcgtgta cgcgctggga 240
ttcaagcgca tgcctcgagg tgggttgccg ttcgtgccgg tgatgaaggt cggtctgcag 300
cacggtggcg gcgggatcta ctcccacacc gcgtgcacgc tgatgttcct cgacaagccc 360
ggtggcccga tcaaggagtc tgcgcggggc gtcgactggg agtcccaggg cgccggcgtc 420
ttttactacg agggcgcccg tgcctggaat gatggtctgt tccacgattt ctggtacctc 480
gacatgcgcc tcggtgagct cgcgccgccg gtgaacgaga tcaacgccga gttcgagcgg 540
gcgaagggct ggatcggcaa gcgcatcgac gtcgctgaga agccctgccc cgacggcgaa 600
ggcaagtaca tcaggtgcga gggcggccat atctacttcc acccgaaggt caacgtcggc 660
gcgaagccgg gcgagcgtgc gatcgcgatc ccggctgacg tcttcgaggt gtggaagcgc 720
cagggattcg agaagggacc gctcggctac ccgacgcgcc gtcacgccac ggtcaacggt 780
gtcggc 786
<210> 145
<211> 309
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 145
ggattcgaga agggaccgct cggctacccg acgcgccgtc acgccacggt caacggtgtc 60
ggcaccatcc aggcatttca gaacggcgcg gtctatcgca agttcggcac cgacggcggc 120
atcgtcaacg gcaagatcct cgagcgctgg gcgcgcgaag gtcacgagaa gggccgcctc 180
ggttggcctc tcggcgacga gaagttcttc gacggcggtc gcgtccaggc gttcgagaac 240
ggtgacgcct acttccaccc caccgcggtg gtcgagttcc tcaacgatcc cgcagccccc 300
aagcagtaa 309
<210> 146
<211> 810
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 146
atgcgtccct accgtgcacg ccatctcgcc actcctccca cccccgactc gactcccgac 60
acctcatccg gtgcgtcgcg ccgttccgtc ctgcgcgggg gtgtcctcgg tgccgcggca 120
ctgagcaccg gcgccgccgc cgtcgcgacc ccggcggcga acgccgccgg cctctacgga 180
caggacgtct ccggctggca gggagagatc gactggtccg cccaggcgga cctcggctct 240
cgcttcgcct atgtgaaggc caccgagggt cggtcctacc gcagccccgc cttcaaccag 300
cagtaccgcg gcgccggcaa tgccggcctg gtccgcggcg gctaccactt cgcccgcccc 360
gactccggcg gccccgagga gcaggtcgac ttcttcctca acaacggcgg gggatggtcc 420
gacgacggca tcacgctgcc gggcatggtc gacttcgagg cctactccgg actgcctcgc 480
gactacgggc tgagccagca ggagatgcgg aactggatca tggcgttctc cactcgctac 540
cgggacagcg tcgggcgtcg gcccgtcctc tacacgaacc tccactggtg gaacgacgtg 600
gtgggggact ggaccccggt caactccccg ctgttcctcg cgtcctacag cagcagcgcg 660
ccgaccaccc tgccgggccg ctggtgggcc tacgagatgt ggcagtactc ggattcgggt 720
cccttcgccg gtgactcgaa cctctggcac ggctccgagt cccagttcga gagcttcgtc 780
tccgacgggg actaccacgc gatcggcatc 810
<210> 147
<211> 429
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 147
atgaggttta ttcctgcggc gcatcattct gccggctcga atagtccggt gaatagggtt 60
gtgatccatg cgacatgccc tgatgtgggg tttccgtctg cctcacgtaa ggggcgggcg 120
gtgtctacag caaactattt tgcttcccca tcgtcggggg gttcggcgca ttatgtgtgt 180
gatgttgggg agacggtgca gtgcctgtca gaggggacta ttggttggca tgccccgccg 240
aatccgcatt ctttgggtat agagatttgc gcggatgggg gttcgcacgc ctcgttccgt 300
gtgccggggc atgcttacac gagggagcag tggcttgatc ctcgcgtgtg gcctgcggtg 360
gagaaggctg ccatcctgtg tagacgtttg tgtgacaaat ataaatgctt acacgaggga 420
gcagtggct 429
<210> 148
<211> 483
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 148
atggcaacca tgcctgtcaa aaaaggcttt tatgtcactt cggggtttgg cccgcgttgg 60
ggcactacgc attacggcac ggattttggt gttgatggtg gctcaggtgg gcaccctatt 120
ttcgctatca aatctggcac tgtgaccgct tctggcccgg cttctggttt tgggcagtgg 180
atcaatgtgg atcatcctgc aagtgatggc ggtggcttgt cggtgtatgg gcacatcatc 240
ccagaggtgc gcgtaggtga tcaggtggtg gaggggcagc ggatcggacg aatcaacccc 300
gatcaaaaca ctaacggcgg ggttgcgcct catcttcatt tggagtttca ccgctccgtg 360
tggtcaccac ctggtggtga tcgcctcgac cccatgaaaa ctgtgctcgc tggtgcagac 420
tggccgggtg atgcgccctc aaattcgagc gcgaaaccgg aaacggggaa ggtcaaaaac 480
atc 483
<210> 149
<211> 714
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 149
ggtgcagact ggccgggtga tgcgccctca aattcgagcg cgaaaccgga aacggggaag 60
gtcaaaaaca tctttggtgt ggatatttcc aatcatcaaa atggtatttt ggctgaattg 120
atcggtgcgg aaggttttga attctgcatc atcaaagcca ccgagggtac gtggaaagac 180
cctattttgc attcgcattt ggcggatgtt cgcaaaaatt ccggcatgca ggttggcgca 240
tatgtgtatg tgcgtgggga aacctcacca gaagcgcatg ctatcgctct acatgagcat 300
ctgaatgaca cgtcggtgcc ggttgctttg gatattgagc ataattccgg ctctaatcct 360
gatcattggc gggcaattaa aacggcgatc gaggcccgtg gctaccgcgt gatcctaaca 420
tacttgccgg agtggtactg gagccaagtc gggcagccaa acttggcggg gctaccgccg 480
ttgtgggctt cccgttatgt cggcaccaca ccaggggttg ccagcgtctt atattccacg 540
gctggtcggc gtggctggca aggatacggc ggccttgaag ttgcgatgtg gcagttcacc 600
gaccgggcgc aggtcgcagg ccaaaagatc gacgccaatg tttttgaggg cacggagaaa 660
cagcttcgtg cccttttcca tggggacacc ccagaaatag aggaggagtt cgat 714
<210> 150
<211> 1125
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 150
atggcaacca tgcctgtcaa aaaaggcttt tatgtcactt cggggtttgg cccgcgttgg 60
ggcactacgc attacggcac ggattttggt gttgatggtg gctcaggtgg gcaccctatt 120
ttcgctatca aatctggcac tgtgaccgct tctggcccgg cttctggttt tgggcagtgg 180
atcaatgtgg atcatcctgc aagtgatggc ggtggcttgt cggtgtatgg gcacatcatc 240
ccagaggtgc gcgtaggtga tcaggtggtg gaggggcagc ggatcggacg aatcaacccc 300
gatcaaaaca ctaacggcgg ggttgcgcct catcttcatt tggagtttca ccgctccgtg 360
tggtcaccac ctggtggtga tcgcctcgac cccatgaaaa ctgtgctcgc tggtgcagac 420
tggccgggtg atgcgccctc aaattcgagc gcgaaaccgg aaacggggaa ggtcaaaaac 480
atctttggtg tggatatttc caatcatcaa aatggtattt tggctgaatt gatcggtgcg 540
gaaggttttg aattctgcat catcaaagcc accgagggta cgtggaaaga ccctattttg 600
cattcgcatt tggcggatgt tcgcaaaaat tccggcatgc aggttggcgc atatgtgtat 660
gtgcgtgggg aaacctcacc agaagcgcat gctatcgctc tacatgagca tctgaatgac 720
acgtcggtgc cggttgcttt ggatattgag cataattccg gctctaatcc tgatcattgg 780
cgggcaatta aaacggcgat cgaggcccgt ggctaccgcg tgatcctaac atacttgccg 840
gagtggtact ggagccaagt cgggcagcca aacttggcgg ggctaccgcc gttgtgggct 900
tcccgttatg tcggcaccac accaggggtt gccagcgtct tatattccac ggctggtcgg 960
cgtggctggc aaggatacgg cggccttgaa gttgcgatgt ggcagttcac cgaccgggcg 1020
caggtcgcag gccaaaagat cgacgccaat gtttttgagg gcacggagaa acagcttcgt 1080
gcccttttcc atggggacac cccagaaata gaggaggagt tcgat 1125
<210> 151
<211> 333
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 151
catggggaca ccccagaaat agaggaggag ttcgatatga gcgcagtcca ggaaatcaaa 60
gactatattg acacccgact gacaggacct gtcggcaccg atgtcaagga catcaggcag 120
cagatcaccg gagggcgcga ctctatccca ggtgacctca aagcgtctta ccctgggtgg 180
gatttaggtc agctggtgcg tgcggcacgt gaaaaagaat ttactggcct gacgatgatg 240
gaaattcttg cagtcaatat tgctggtaat gatgatgatt tccgtgcagc acgtgttgct 300
gcaggtaccg aggaggctgg caatgctgaa taa 333
<210> 152
<211> 555
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 152
atggccgact acttctaccc actcagccag ggcgctcacg tcaccagccc attcgggccc 60
cgagctggcg gctatcactg gggcaccgac tacggccgcg ccggaggctc cggcggcaac 120
gccgtctacg ccccgcaagc cggaaccgtc atcatggccg gccccgccag cggcttcggc 180
ggccccgacc ccgccggatg gatcgtcatc gaccacccaa ccgccgccgg cggcggagtc 240
agcgtcctcg gccacatcat ccgtgaagtc gccgtcggcg acaccgtccg cgccgggcag 300
cgcatcgggc gggtcaatcc ttcctcggcc accaatggcg gcgtggcgcc gcacgtccac 360
ttcgagcatc accgttacgt ctggtccccg ccgggaccgg accgtctgga cccgcacgct 420
tggctggcca cccgcggcgc ccgatggccg ggagccccgg ccacacctac ccgaaaggaa 480
tccatgaacg cgctcaccgc tgacatcgac ctgctgaccc ccaacgacga tggccgggcg 540
acgaagcccc gcaac 555
<210> 153
<211> 621
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 153
atcgacctgc tgacccccaa cgacgatggc cgggcgacga agccccgcaa ccttttgtgc 60
atccatacct tcgaagacga cggcacgtgg tcggccgaca ggatggcgaa gtaccagcag 120
tcgcccgccg ccggcggctc gtaccacctg gtcattgacc tcaacggccg catcgctcgt 180
gagaacgacg acgcgttcat cccatgggcg gcgatgttca cgggcaaccg ggtggcgttc 240
cacttctcgc tgtcgggcaa ggcgtcctgg acgcgccagc agtggctggc ccgtccgaag 300
cagatggacg ccctggcgaa ggtgctggcg gcgtactcga aggccaaggg catcccgctc 360
atccgccgcg gaccgcagga cgtgcgagcc gggaagtggg gcgtgtgcgg ccacgacgac 420
atttccaagg cattcggtga gtcgacgcac tgggacccgg gcccgaactt cccgttcgac 480
gtcgtcatcg acaaggccaa ggcgatcctc gccgagccga agccgacgcc cgccccgccg 540
tcggatccgg cgccccgtcc gattcccccg aaggagactc tggtgcccac cacgctcgac 600
accgtcctgc cgtcgctcgt c 621
<210> 154
<211> 1125
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 154
atggccgact acttctaccc actcagccag ggcgctcacg tcaccagccc attcgggccc 60
cgagctggcg gctatcactg gggcaccgac tacggccgcg ccggaggctc cggcggcaac 120
gccgtctacg ccccgcaagc cggaaccgtc atcatggccg gccccgccag cggcttcggc 180
ggccccgacc ccgccggatg gatcgtcatc gaccacccaa ccgccgccgg cggcggagtc 240
agcgtcctcg gccacatcat ccgtgaagtc gccgtcggcg acaccgtccg cgccgggcag 300
cgcatcgggc gggtcaatcc ttcctcggcc accaatggcg gcgtggcgcc gcacgtccac 360
ttcgagcatc accgttacgt ctggtccccg ccgggaccgg accgtctgga cccgcacgct 420
tggctggcca cccgcggcgc ccgatggccg ggagccccgg ccacacctac ccgaaaggaa 480
tccatgaacg cgctcaccgc tgacatcgac ctgctgaccc ccaacgacga tggccgggcg 540
acgaagcccc gcaacctttt gtgcatccat accttcgaag acgacggcac gtggtcggcc 600
gacaggatgg cgaagtacca gcagtcgccc gccgccggcg gctcgtacca cctggtcatt 660
gacctcaacg gccgcatcgc tcgtgagaac gacgacgcgt tcatcccatg ggcggcgatg 720
ttcacgggca accgggtggc gttccacttc tcgctgtcgg gcaaggcgtc ctggacgcgc 780
cagcagtggc tggcccgtcc gaagcagatg gacgccctgg cgaaggtgct ggcggcgtac 840
tcgaaggcca agggcatccc gctcatccgc cgcggaccgc aggacgtgcg agccgggaag 900
tggggcgtgt gcggccacga cgacatttcc aaggcattcg gtgagtcgac gcactgggac 960
ccgggcccga acttcccgtt cgacgtcgtc atcgacaagg ccaaggcgat cctcgccgag 1020
ccgaagccga cgcccgcccc gccgtcggat ccggcgcccc gtccgattcc cccgaaggag 1080
actctggtgc ccaccacgct cgacaccgtc ctgccgtcgc tcgtc 1125
<210> 155
<211> 261
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 155
ccgaagccga cgcccgcccc gccgtcggat ccggcgcccc gtccgattcc cccgaaggag 60
actctggtgc ccaccacgct cgacaccgtc ctgccgtcgc tcgtcgacgg ctccacgttc 120
gaggctccgt tggccacgtt catccgcacc gcggacaaac aggcctacga agccaaccag 180
cggatcgccc gcctggaggc gaagttcgat cggctgctcg atgccatggg cgaaaagccc 240
gaccccaagc ccggccagta g 261
<210> 156
<211> 585
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 156
atgagataca ttcctgcggc gcatcactcg gccggctcta atagtccggt gaacagggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtccg cttcccgtaa aggacgggcg 120
gtgtccacgg caaactattt cgcgtcccca tcggcgggcg gttctgccca ttatgtgtgt 180
gatgttgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcgttccgt 300
gtgccggggc atgcttacac tcgtgagcag tggcttgatc cgagggtgtg gcctgcggtg 360
gagaaggcgg ctgtgctgtg tagacagttg tgtgacaaat ataatgttcc gaagaggaaa 420
ctgtctgtat ccgatttgaa ggctggcagg cggggtgtgt gcggccatac ggatgtgacg 480
gatgcgtggc atcagtcgga tcatgatgat ccggggccgt ggtttccgtg ggacaggttt 540
atggccgtcg tcaacggcgg cagtggagag agtggagagt tgagt 585
<210> 157
<211> 558
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 157
atgagataca ttcctgcggc gcatcactcg gccggctcta atagtccggt gaacagggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtccg cttcccgtaa aggacgggcg 120
gtgtccacgg caaactattt cgcgtcccca tcggcgggcg gttctgccca ttatgtgtgt 180
gatgttgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcgttccgt 300
gtgccggggc atgcttacac tcgtgagcag tggcttgatc cgagggtgtg gcctgcggtg 360
gagaaggcgg ctgtgctgtg tagacagttg tgtgacaaat ataatgttcc gaagaggaaa 420
ctgtctgtat ccgatttgaa ggctggcagg cggggtgtgt gcggccatac ggatgtgacg 480
gatgcgtggc atcagtcgga tcatgatgat ccggggccgt ggtttccgtg ggacaggttt 540
atggccgtcg tcaacggc 558
<210> 158
<211> 300
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 158
ggcagtggag agagtggaga gttgagtatg gctgatgtga aagccttgca tgatcagatt 60
aaacagttgt cggggcaggt ggcccagtcg gtgaataagc tgcatcacga tgtgggtgtg 120
gttcaggttc agaatgggaa tcttaaaaag caggttgatt ccctgtctat ggtgaagaat 180
cctgtgacgg ggaagctgtg gcgtaccagg gatgcgatct ggtcgatctg gtattacgtg 240
ttggagtgtc gtagccgtat cggcaagttg gaggccgagg tggcccggtt gaagaagtga 300
<210> 159
<211> 273
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 159
atggctgatg tgaaagcctt gcatgatcag attaaacagt tgtcggggca ggtggcccag 60
tcggtgaata agctgcatca cgatgtgggt gtggttcagg ttcagaatgg gaatcttaaa 120
aagcaggttg attccctgtc tatggtgaag aatcctgtga cggggaagct gtggcgtacc 180
agggatgcga tctggtcgat ctggtattac gtgttggagt gtcgtagccg tatcggcaag 240
ttggaggccg aggtggcccg gttgaagaag tga 273
<210> 160
<211> 492
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 160
atgtccacgg caaactattt tgcttcccca tcgtcgggtg gttcggcgca ttatgtttgc 60
gatattagtg agacggtgca atgcctgtcg gagtctacga tcgggtggca tgccccgccg 120
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcgtttagg 180
gtgccagggc acgcttacac tcgtgagcag tggctggatc ctagggtgtg gcctgccgtg 240
gagaaggctg ccatcctgtg tagacgtttg tgtgacaaat ataatgttcc gaagcggaaa 300
ctgtctgtag ccgatttgaa ggctggcagg cggggtgtgt gcggccacgt ggatgtgacg 360
gatgcgtggc atcagtcgga tcatgacgat ccggggccgt ggtttccgtg ggacaggttt 420
atggccgtcg tcaacggcgg tagtggagat agtggggagt taactgtggc tgatgtgaaa 480
gccttgcatg at 492
<210> 161
<211> 306
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 161
aacggcggta gtggagatag tggggagtta actgtggctg atgtgaaagc cttgcatgat 60
cagattaaac aattgtctgc tcagcttact ggttcggtga ataagctgca ccatgatgtt 120
ggtgtggtac aggtacagaa tggtgatttg ggtaaacgtg ttgatgcctt gtcgtgggtg 180
aagaatccgg tgacggggaa gctgtggcgc accaaagacg ctttgtggag tgtctggtat 240
tacgtgctgg agtgtcgcag ccgcatagac aggctcgagt ctgctgttaa cggtttgaaa 300
aagtga 306
<210> 162
<211> 273
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 162
gtggctgatg tgaaagcctt gcatgatcag attaaacaat tgtctgctca gcttactggt 60
tcggtgaata agctgcacca tgatgttggt gtggtacagg tacagaatgg tgatttgggt 120
aaacgtgttg atgccttgtc gtgggtgaag aatccggtga cggggaagct gtggcgcacc 180
aaagacgctt tgtggagtgt ctggtattac gtgctggagt gtcgcagccg catagacagg 240
ctcgagtctg ctgttaacgg tttgaaaaag tga 273
<210> 163
<211> 585
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 163
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggaaa aaacaccaac aagggagaac tcagc 585
<210> 164
<211> 558
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 164
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaagga 558
<210> 165
<211> 288
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 165
aaaaacacca acaagggaga actcagcatg tccgacgtca acaccctgac caagctcatc 60
aaggccagca acaatcagct ccaccacgac attggcgtcg tccagacaca gaacggcacc 120
ctcaaaagca agatcgacaa cttgtcgtgg gtgaagaatc ccgtcaccgg caagaagtgg 180
tccaccaagg atgcgctgtg gtctgtctgg tactacgtgc tggaatgccg caaccgcatc 240
caggctatcg aaaaccgcct ctctgacatc gaaaagaagg tgaagtga 288
<210> 166
<211> 261
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 166
atgtccgacg tcaacaccct gaccaagctc atcaaggcca gcaacaatca gctccaccac 60
gacattggcg tcgtccagac acagaacggc accctcaaaa gcaagatcga caacttgtcg 120
tgggtgaaga atcccgtcac cggcaagaag tggtccacca aggatgcgct gtggtctgtc 180
tggtactacg tgctggaatg ccgcaaccgc atccaggcta tcgaaaaccg cctctctgac 240
atcgaaaaga aggtgaagtg a 261
<210> 167
<211> 273
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 167
ggagaactca gcatgtccga cgtcaacacc ctgaccaagc tcatcaaggc cagcaacaat 60
cagctccacc acgacattgg cgtcgtccag acacagaacg gcaccctcaa aagcaagatc 120
gacaacttgt cgtgggtgaa gaatcccgtc accggcaaga agtggtccac caaggatgcg 180
ctgtggtctg tctggtacta cgtgctggaa tgccgcaacc gcatccaggc tatcgaaaac 240
cgcctctctg acatcgaaaa gaaggtgaag tga 273
<210> 168
<211> 591
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 168
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac a 591
<210> 169
<211> 555
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 169
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaa 555
<210> 170
<211> 573
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 170
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac ccc 573
<210> 171
<211> 255
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 171
ggcggcgcca ccaaccccga tgaactggag ctcacagtgt ctcaattcag tgacctgacc 60
aagcgcctgc agggcatgca ggagcagacc caccacgacc tcggcgtcgt ccagaccaag 120
ctggccacca tggacaccgt caagaacccc cgcaccggcg ccaagtggag cctcaaggac 180
gccatctggt cgatctggta ctacgtgctg gagaacaggg accggatcgc cgccctcgag 240
aagaaggtga agtga 255
<210> 172
<211> 216
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 172
gtgtctcaat tcagtgacct gaccaagcgc ctgcagggca tgcaggagca gacccaccac 60
gacctcggcg tcgtccagac caagctggcc accatggaca ccgtcaagaa cccccgcacc 120
ggcgccaagt ggagcctcaa ggacgccatc tggtcgatct ggtactacgt gctggagaac 180
agggaccgga tcgccgccct cgagaagaag gtgaag 216
<210> 173
<211> 237
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 173
gatgaactgg agctcacagt gtctcaattc agtgacctga ccaagcgcct gcagggcatg 60
caggagcaga cccaccacga cctcggcgtc gtccagacca agctggccac catggacacc 120
gtcaagaacc cccgcaccgg cgccaagtgg agcctcaagg acgccatctg gtcgatctgg 180
tactacgtgc tggagaacag ggaccggatc gccgccctcg agaagaaggt gaagtga 237
<210> 174
<211> 645
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 174
atggactgga ccaatctgaa cgctgacgtg acgaagctga tgaacgtgca cttcaccccc 60
gggcgtgaag gccacacgat cgacaagatc gtgattcacc acaacggcgg caacctgagc 120
atcgaccaga tctggaatgt gtggcaggac cgtgaagcat cggcccacta tcaggtgcaa 180
tctgatggcc gtatcggcca gctcgtcaac gactgggaca ccgcctggca cgccggcgac 240
tgggacgcca acctgacctc gatcggcatc gagcacgccg acgactcgac cgacccgtgg 300
catgtgtcgg atgccgccgt cgatgccggc gcgcacctgg tggctgcact gtgtcgcggc 360
tacaaccttg gccggccgga gtggatgcgc aacgtcttcc cgcactcgca tttctcggcg 420
acctcgtgcc cggcctcgct tgccgagaat cagcgcgcgg attacatggc gcgcgctcag 480
gcctatttcg atggcgctcc cgtcacaggc cgttcttcgg tccctgcacc ggctccggcg 540
cctgccggga tccatgtgga cctgcctgcc tggactctcc ccgcaggcaa cttttacggg 600
tcgatcgatg gcggcgagga ctcgcatggc ggctactacg agggt 645
<210> 175
<211> 423
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 175
gcctcgcttg ccgagaatca gcgcgcggat tacatggcgc gcgctcaggc ctatttcgat 60
ggcgctcccg tcacaggccg ttcttcggtc cctgcaccgg ctccggcgcc tgccgggatc 120
catgtggacc tgcctgcctg gactctcccc gcaggcaact tttacgggtc gatcgatggc 180
ggcgaggact cgcatggcgg ctactacgag ggtgagcgtc ctgcaatcgc agcgattcag 240
cgctggctta tccgccacgg ctacgcgggt gcagtggacg actcatgggc cgatggtctg 300
tacgagcagc ccaccgtcga cgccgtgacc cgcttccagc gtgccgagcg accaaactcc 360
acggaccggt ggggcgaggt ctgggccgac gatctggcca ccatggccgc caacaacggc 420
tga 423
<210> 176
<211> 588
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 176
atggatcgtg gtattgacgt gtcgtcctat caggcccccg atggtggcct gctggagggc 60
atgtcgtttt gcatcatcaa ggccaccgaa ggcaccggct atgtgaaccc gaaccgtacc 120
cagtggtaca aggtcgccac ggatcgtggg gtgaccaccg gcgcctatca cttcatgcgt 180
ggcggcgatc ccgtggcgca ggccgattac ttcctcgcgc atctgcccgg tgatgtcgat 240
tggctcgccc ttgatgtcga ggatcccagc gacggcctgt catgggccgg gcgcgtcagc 300
ttcatcctcg cctggaccga tcgggtgaag gcgaccggca agcccacctt ggtctattgc 360
tcgcgctcct gggcgaatgc cctgttgggt gcggccagca gcgacgagcg ggcacggctc 420
gcgcaattgc cgctgtggat ggctgattac acccaacgcc ccggcgaata ttcggggccg 480
tggccgggcg gctggccgat tgccatacac cagtacacct cggccccgat cgacaagaac 540
gtcctgctca ccgacgatct ccaaggagga gacgacatgc ccctgtca 588
<210> 177
<211> 351
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 177
ctcaccgacg atctccaagg aggagacgac atgcccctgt caaccgacga ccttcgaaat 60
atcgccactg ccgtgtgggg tggcggcggc gctgcaagcc caatgtatgc cgaccggctc 120
gatgggcatc aagaatatcc ggagacagcc cttttcagcc tgcaacagcg gctgggtgcc 180
cgcttcggtg agctgtcggg caagatcgac ggtctggccg aggcgctcaa gcaggtgcag 240
ggagggaacg gcgtggacgc ggacgccatt agggctgctg ctgccgaagg agccaaggct 300
ggcgtgcagg cgatgatcga caccgccacg gtgaatctgg aggccaagtg a 351
<210> 178
<211> 687
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 178
atgtgcgggg ctttctcatt cctcaaagac ttggagacat tcatggactg gaccaatctg 60
aacgctgacg tgacgaagct gatgggcgtg cacttcaccc ccggacgtga aggcaggacg 120
atcgacaaga tcgtgatcca ccacaacggc ggcaacctga gcatcgacca gatctggaat 180
gtgtggcaga cccgtgaagc ctccgcgcat tatcaggtgg aggcgggtgg ccgtatcggc 240
cagctcgtca acgatttgga caccgcgtgg catgccggcg actgggacgc caacctgacc 300
tcgatcggca tcgagcatgc cgacgactcg accgacccgt ggcatgtgtc tgatgctgcc 360
gtcgatgccg gcgcgcacct ggtggctgca ctgtgtcgcg gctacaacct tggccggccg 420
gagtggatgc gcaacgtctt cccgcactct cagttcacgt ccacgtcgtg cccggcgtcg 480
ctggcccggg accagctcgg cgactacatg gggcgcgcac aagcctactt cgatggcgcg 540
ccggtggctg cggtccatca gtcggtccct gcccccgccc cagcgcccag ccgtcatgtg 600
gacctgcccg cgtggaatct ccccgagggc aacttctacg gcctcgtcag cggcggaaac 660
gactcccacg gcggcttcta tcccgcc 687
<210> 179
<211> 420
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 179
gcgtcgctgg cccgggacca gctcggcgac tacatggggc gcgcacaagc ctacttcgat 60
ggcgcgccgg tggctgcggt ccatcagtcg gtccctgccc ccgccccagc gcccagccgt 120
catgtggacc tgcccgcgtg gaatctcccc gagggcaact tctacggcct cgtcagcggc 180
ggaaacgact cccacggcgg cttctatccc gccgagcgtc ccgctgtgag ggccatccag 240
ctgtggctca tccgtcacgg ctacgccggc gcggtgcctg acagttgggc ggacggcatc 300
tacgagcagc cgaccgccga cgccgtgacc gctttccagc acgccgagcg ccccaacagc 360
acggaccggt ggggcgaggt ctgggccgac gacctggcca ccatggccgc caacaactga 420
<210> 180
<211> 696
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 180
atgaaggcgt ctcgcgtgat cgtcgtagca agtgtcgtag cactgatcct tgcgggcctg 60
gcaatgtcgt cagctgccgt gattgtggtg ccactactgt cagtaggcgc cggggccctc 120
gacgacaact ctggcgctgg cggcgtcggt ggggatccct gcataggaac tgtcaccggt 180
ggcgctgtta gtgtcggagg cctcacaacc aggcagaagc aactagtgac caccatcgtc 240
accgtggtcc aacgcgacaa actacctgtc caggctgcgg tcatcgccat catgaccgct 300
aaacaggaat cagacctcgg agccaacccc gccgcaacga aacctaacgg tgacggcgac 360
gccggcccat tccaacagcg cgttctaccg ggctggtacg gcaccttgga ccaagtcaac 420
aatgatgcct acgccacgga gacattcctg aaaggccaca ccatcaccta tgctggcccc 480
acatcggccg gcggccccgg ctaccacatt cccggccttg tcgatgtccc cgactggcag 540
tcgaaatccc cggcccaagc agcccaagcg gttcaggcct cagccctgcc taacgcttac 600
gctaaatggg aggccatcgc caaacagatg gtgggagcca ccaccacagg gcgcctgtcc 660
aacgactgtg tcaccgggac cgctaacgaa accggc 696
<210> 181
<211> 450
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 181
gccatcgcca aacagatggt gggagccacc accacagggc gcctgtccaa cgactgtgtc 60
accgggaccg ctaacgaaac cggcgtctca aagaacctga ccaaagccgt ggaatgggcc 120
aaatcgatcg ccgccaacaa ctcctacacc tacgtgtggg gcggtaatgg tgcgagcgat 180
ggcggctacg actgctcagg cctgacctcg gcactgtacc gacgtatcgg catcaacctt 240
ccccgcaccg ctgccgaaca gcaaaaagtc ggcaccccag tcaaccgcaa ccagctcaaa 300
gtcggcgacc ttatcttctg gggcatccct gcccaccacg tagccaccta catcggtaga 360
ggccagatga tcagcgccga caaccaagcc cgcggcatca acgtggagaa gatctacggc 420
aacccctcga gctaccgaag gatcgtcaaa 450
<210> 182
<211> 1062
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 182
atgaaggcgt ctcgcgtgat cgtcgtagca agtgtcgtag cactgatcct tgcgggcctg 60
gcaatgtcgt cagctgccgt gattgtggtg ccactactgt cagtaggcgc cggggccctc 120
gacgacaact ctggcgctgg cggcgtcggt ggggatccct gcataggaac tgtcaccggt 180
ggcgctgtta gtgtcggagg cctcacaacc aggcagaagc aactagtgac caccatcgtc 240
accgtggtcc aacgcgacaa actacctgtc caggctgcgg tcatcgccat catgaccgct 300
aaacaggaat cagacctcgg agccaacccc gccgcaacga aacctaacgg tgacggcgac 360
gccggcccat tccaacagcg cgttctaccg ggctggtacg gcaccttgga ccaagtcaac 420
aatgatgcct acgccacgga gacattcctg aaaggccaca ccatcaccta tgctggcccc 480
acatcggccg gcggccccgg ctaccacatt cccggccttg tcgatgtccc cgactggcag 540
tcgaaatccc cggcccaagc agcccaagcg gttcaggcct cagccctgcc taacgcttac 600
gctaaatggg aggccatcgc caaacagatg gtgggagcca ccaccacagg gcgcctgtcc 660
aacgactgtg tcaccgggac cgctaacgaa accggcgtct caaagaacct gaccaaagcc 720
gtggaatggg ccaaatcgat cgccgccaac aactcctaca cctacgtgtg gggcggtaat 780
ggtgcgagcg atggcggcta cgactgctca ggcctgacct cggcactgta ccgacgtatc 840
ggcatcaacc ttccccgcac cgctgccgaa cagcaaaaag tcggcacccc agtcaaccgc 900
aaccagctca aagtcggcga ccttatcttc tggggcatcc ctgcccacca cgtagccacc 960
tacatcggta gaggccagat gatcagcgcc gacaaccaag cccgcggcat caacgtggag 1020
aagatctacg gcaacccctc gagctaccga aggatcgtca aa 1062
<210> 183
<211> 567
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 183
atggactgga ccaatctgaa cgctgacgtg accaagctga tgaacgtgca cttcaccccc 60
ggacgtgaag gcaggacgat cgacaagatc gtgatccacc acaacggcgg caacctgtcg 120
atcgaccaga tctggaatgt gtggcaggac cgtgaagcca gcgcgcacta ccaggtggaa 180
tcgagcggcc gcatcggcca gctcgtcaac gactgggaca ccgcctggca tgccggcgac 240
tgggacgcga atctcacgtc gatcggcatc gagcatgctg acgactcgac ggatccgtgg 300
catgtgtcgg atgccgccat cgacagcggc gcccatctgg tggcggccct gtgccgcgcc 360
tacaatcttg gtcggccgga gtggatgcac aacgtgttcc cgcactcgca tttctcggcg 420
acctcgtgcc cggcctcgct ggccgagaat cagcgcgcgg attacatgtc acgggctcag 480
gcctactacg acggcacttc agtggctgcc gcacctgctg ccccgtcggc acctgccggg 540
atccacgtcg atcttccgag ctggacc 567
<210> 184
<211> 372
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 184
cgggctcagg cctactacga cggcacttca gtggctgccg cacctgctgc cccgtcggca 60
cctgccggga tccacgtcga tcttccgagc tggaccctcc cgatcgggca ttattacggg 120
ctggtcacag ggccgaatga ctcgcatggt ggcttctacg agtccgagcg tcccgctgtg 180
agggccatcc agctgtggct catccgccac ggctacgccg gcgcggtgcc tgacagttgg 240
gcggacggca tctacgagca gccgaccgcc gacgccgtga ccgctttcca gcatgctgag 300
cgacccaaca gcacggaccg gtggggcgag gtctgggccg acgatctggc caccatggcc 360
gccaacaact ga 372
<210> 185
<211> 612
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 185
atggactgga ccaacctcat cgccgacacc acgaagctca tgggcgtgca cttcaccccc 60
gggcgtgaag gccgcaagat cgacaagatc gtgatccacc acaacggcgg caacctgagc 120
atcgaccaga tctggaatgt gtggcagacc cgcgaagcca gcgcgcacta ccaggttgag 180
acgggtggcc gcatcggcca gctcgtcaac gactgggaca ccgcctggca cgccggcgac 240
tgggatgcga atctcacgtc gatcggcatc gagcacgccg acgactccac ggacccgtgg 300
catgtgtcgg atgccgccgt tgacgccggc gcgcaccttg tcgcggccct gtgcaaggcc 360
tacagtcttg gtcgtcctga gtggatgcgc aacgtcttcc cgcactcgca tttctcggcg 420
acctcgtgcc cggcctcgct ggccgagaat cagcgcgcgg attacatgtc acgggctcag 480
gcctactacg acggcgcgcc ggtggctgcg gtccatcagt cggcacctgc ccccgcccca 540
gcgtccagcc gtcacgtgga cctgcccgcg tggaatctcc ccgagggcaa cttctacggc 600
ctggcgagcg gt 612
<210> 186
<211> 381
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 186
cgggctcagg cctactacga cggcgcgccg gtggctgcgg tccatcagtc ggcacctgcc 60
cccgccccag cgtccagccg tcacgtggac ctgcccgcgt ggaatctccc cgagggcaac 120
ttctacggcc tggcgagcgg tggcgaggat tcgcacggcg gcttctacga gggtgagcgt 180
cccgcgatcc gccagatcca gctgtggctc atccgtcacg gctatgccgg cgcggtgcct 240
gacagttggg cggacgggat ctacgaacaa cccactgccg acgccgtggc cgctttccag 300
catgctgagc gtcccaactc cacggaccgg tggggcgagg tctgggcaga cgatctggcc 360
accatggccg ccaacaactg a 381
<210> 187
<211> 435
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 187
gcattcgcag tcgacatcct gcaggcatca gactctcccc gcgaaagcgc ccccggctgg 60
caatggagac aggccgagcc ccaggagttc ccaagcttcg gggagcctgt cctggcagcg 120
ggctgcggca ccgtgatcgc tgcccatgac ggcaagcgtg accatcgcgc ccggaacacc 180
tggcccggcc tgatctacat gatgtcgctc gaggccttcg gtcgagagtt ggccgggcac 240
cgctccatca tcggcaatca cgtgatcctc gaccatagcg acggcacgtt cagcatgtac 300
gcccacctca agcacggatc tgcagccgtg tgcgtcgggc agaaagtccg ggccggcgat 360
gtcctgggag cggtcgggaa caccgggaat accagcgaac cccatctcca cttccagctg 420
atggaccggc cccaa 435
<210> 188
<211> 870
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 188
atgatgcgca tgctcaaggc ggcttccccc tggctccttc gagcctgcgt cctgctcgtg 60
gcgctgagct tcgtcatcga ggtccccgtg tggctcgtgt tcgcgccgct gggcctggcg 120
atcgcagtcc cttctccacg tgcagacgac gagtctcccc agaccatgca tgctcccgtg 180
acgggccgct gggtcgccat caacagcccg gcgacgaagg tccccagcca cggcgttcgc 240
acgctcggtc aggcattcgc agtcgacatc ctgcaggcat cagactctcc ccgcgaaagc 300
gcccccggct ggcaatggag acaggccgag ccccaggagt tcccaagctt cggggagcct 360
gtcctggcag cgggctgcgg caccgtgatc gctgcccatg acggcaagcg tgaccatcgc 420
gcccggaaca cctggcccgg cctgatctac atgatgtcgc tcgaggcctt cggtcgagag 480
ttggccgggc accgctccat catcggcaat cacgtgatcc tcgaccatag cgacggcacg 540
ttcagcatgt acgcccacct caagcacgga tctgcagccg tgtgcgtcgg gcagaaagtc 600
cgggccggcg atgtcctggg agcggtcggg aacaccggga ataccagcga accccatctc 660
cacttccagc tgatggaccg gccccaagcg gccatggccg ccggcctgcc gttccggtgg 720
tccccgctca cgatcgagcc ggatcccgat ccccactggg ctccgaagaa acctgtcgca 780
gagacggtcg agggcctgcc cgcgacaggg cagatcttcc gcaccccgga gtccggcgtc 840
atgccccaac ccaagcgcga ggccagttgt 870
<210> 189
<211> 279
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 189
ggtagtaggg gagtggaatt tgcggcctcc gtgggagaac cagtgacgac cgtgacggct 60
ggggtggtcg tttttgctgg ccaggtcgcg ggggctgggg tggtgagcat cctgcttgct 120
gacggtcgtc ggacaaccca catgccggtt gtgcctagcg ttgctgtcgg ccaggtagtg 180
gttcctggcc agcagatcgg agttgtcggg atggggccac catgcacccg cacttgtttg 240
cactgggggt tgaagaaggg agatgtttat caaaacccc 279
<210> 190
<211> 756
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 190
atgaggagat ctgtctgcat cagcctacta atcatcacgg tggggatttg cttgctggcc 60
ttcccagctc ccagccacag cattgctgcc gttcccgcgc gaagtgtggc gaatcgtccg 120
actccgccgg tgctaggccc cgtcatcaaa gggtttgcgc cacctgccga aaaatggctg 180
ccgggtagta ggggagtgga atttgcggcc tccgtgggag aaccagtgac gaccgtgacg 240
gctggggtgg tcgtttttgc tggccaggtc gcgggggctg gggtggtgag catcctgctt 300
gctgacggtc gtcggacaac ccacatgccg gttgtgccta gcgttgctgt cggccaggta 360
gtggttcctg gccagcagat cggagttgtc gggatggggc caccatgcac ccgcacttgt 420
ttgcactggg ggttgaagaa gggagatgtt tatcaaaacc ccatgacatt gttgcaactt 480
caggtgcggt tgctgccctt ggacagtcgg cctcattcag cgtcggggca cggatggcct 540
gtgcggcccc tgagcctgcc agggggcagc aggaggaaag ctgcctcaag cggtgccctc 600
atgcctccgt ggcgtggagc tgggcgggac gccgcgttag gcattgatac gacggtgacc 660
gaagccaccc gaggtggctc aggcgcgggg atgagcctgg cgaaacgcag tgcgcaatct 720
ttcggtggaa acgtgggtgt agatctgcgt ggtggc 756
<210> 191
<211> 513
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 191
atggcaaaga cactctctcg aattgcttcc gttgcggctg cggctgccct cgccggtggc 60
gtctccgtga ctgcggcgca gagcgcgtcg gcagacgatg tcaactggga cgccatcgca 120
aactgcgagt ccggcggtaa ctggagcaca aacaccggca atggctacta cggtggcctt 180
cagttctccc agagcacttg ggccgcctac ggtggctccg gtagcgcctc caatgcctcc 240
cgtgaggagc agatcgccgt ggccgagcgc gtgctcgcgg gccagggcat cggtgcgtgg 300
ccggtctgcg gcgcgtacgc ctactccggt gaaagctaca ccggcaccaa caccgagggt 360
tcctacggct cttcgtacga cacgtcggcc caggacgcct cctacgacgg ctcgtactcg 420
tatgacaact cgtactcgta cgacaacagc gccgggtacg actcgtcctc cgcctactcc 480
ggcggctacc aggccactcg tgaggccact ggc 513
<210> 192
<211> 342
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 192
ggcgcgtacg cctactccgg tgaaagctac accggcacca acaccgaggg ttcctacggc 60
tcttcgtacg acacgtcggc ccaggacgcc tcctacgacg gctcgtactc gtatgacaac 120
tcgtactcgt acgacaacag cgccgggtac gactcgtcct ccgcctactc cggcggctac 180
caggccactc gtgaggccac tggcacctac gagatccagc cgggcgacac cctcaacgcc 240
atcgctgagg cccatggcac cacctggcag gagctcgcgg ccctcaacag ctccatcgtc 300
gacgcgaacc tgatctacgc cggcgaaacc atcaacgtct ga 342
<210> 193
<211> 528
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 193
atggcctatc cctatatcgg ggcattgaag catggcggca agcagggcaa gatccagcgg 60
atcgtcatcc atgccacggt ttcgccctgt gtgcggggcg gtgcccggaa cgtcgcgaag 120
tactttcaga gttcagccgc cggaggcagc gcccactacg tggtggatcc cggtgagatc 180
atccagtgtg tcaaggacga cgtggtggcc taccacgcgc cgcccaacac cggaacgctc 240
gggatcgagc tgtgcgaccc gcaggccgga tcgccgaagc ggtggagcaa cgaggcccac 300
caggcgatgc tcgtgctcgc cgcgaagctc gtcagggaac tcgcggcgaa gcacgacgtg 360
ccgctcgtcc gggtgaccgc cgcgcagctc agggcgggca agcgcggcat ctgctcgcat 420
gtcgcggtca gcgacgcgtt cgggcagtcc gaccacggcg atcccgaggt cgccgggccg 480
ttcccctggg cgaagttcat gcagctcatc aaggaggagg acgacatg 528
<210> 194
<211> 372
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 194
atggcctatc cctatatcgg ggcattgaag catggcggca agcagggcaa gatccagcgg 60
atcgtcatcc atgccacggt ttcgccctgt gtgcggggcg gtgcccggaa cgtcgcgaag 120
tactttcaga gttcagccgc cggaggcagc gcccactacg tggtggatcc cggtgagatc 180
atccagtgtg tcaaggacga cgtggtggcc taccacgcgc cgcccaacac cggaacgctc 240
gggatcgagc tgtgcgaccc gcaggccgga tcgccgaagc ggtggagcaa cgaggcccac 300
caggcgatgc tcgtgctcgc cgcgaagctc gtcagggaac tcgcggcgaa gcacgacgtg 360
ccgctcgtcc gg 372
<210> 195
<211> 381
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 195
gtgaccgccg cgcagctcag ggcgggcaag cgcggcatct gctcgcatgt cgcggtcagc 60
gacgcgttcg ggcagtccga ccacggcgat cccgaggtcg ccgggccgtt cccctgggcg 120
aagttcatgc agctcatcaa ggaggaggac gacatgccgt cgcccaagga gatctacgaa 180
gccgtctggg agcaggacgt catggcggcc cccgacggtt ccaagtcgaa cccgacctgg 240
aagcccagca gcgtcctcac cgacgtcgac aagaaggtcc gcgccctgca gagccaggtc 300
accggcctcg agagcgagct ggccgccacc aacgccaagc tcgaccaggt tctcaccctg 360
ctccgcgcct cggtgtcctg a 381
<210> 196
<211> 579
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 196
atgacattca tccaggccgc ccaccgtggc ggcacttcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgatgtcggc ttcccgtcgg catcgcgggc aggacgagca 120
gtatccacag cggaatattt cgcgtccacg tcgaggtcag cctcggcgca ctacgtatgc 180
gacatctcta ccacggtgca gtgcctgtcc gaggcaacga tcggctatca cgcgccacca 240
aacgcccact ccatcggcat tgaaatctgc gccgacggag gctcgcgcgc ttcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctcagcc cgcaggtatg gcccgccgtg 360
gagcgcgccg cgattctcgc ccgcgacatc tgccaccgac accacatccc catccgccgc 420
ctctccgtcg cgcaggtgcg ggcaggtgag cgcggaatct gcggccacaa cgaggtgagc 480
gaggcgttcc accaatccga ccacgacgac cccggcccct atttcccttg gaatgaattt 540
attgccgccg tccaaggaaa aaccaccaca ccagaggga 579
<210> 197
<211> 519
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 197
atgacattca tccaggccgc ccaccgtggc ggcacttcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgatgtcggc ttcccgtcgg catcgcgggc aggacgagca 120
gtatccacag cggaatattt cgcgtccacg tcgaggtcag cctcggcgca ctacgtatgc 180
gacatctcta ccacggtgca gtgcctgtcc gaggcaacga tcggctatca cgcgccacca 240
aacgcccact ccatcggcat tgaaatctgc gccgacggag gctcgcgcgc ttcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctcagcc cgcaggtatg gcccgccgtg 360
gagcgcgccg cgattctcgc ccgcgacatc tgccaccgac accacatccc catccgccgc 420
ctctccgtcg cgcaggtgcg ggcaggtgag cgcggaatct gcggccacaa cgaggtgagc 480
gaggcgttcc accaatccga ccacgacgac cccggcccc 519
<210> 198
<211> 330
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 198
tatttccctt ggaatgaatt tattgccgcc gtccaaggaa aaaccaccac accagaggga 60
gaactcagca tgtcagacgt aaacaccctg accaagctca tcaaggccag caacgaccag 120
cttcactacg atattggcgt cgtccagacg caaaacggga acatcaagaa gaagatcgac 180
aatctgtcgt gggtgaagaa ccccgtcacc ggcaagaagt ggtccactaa ggatgccctg 240
tggtccgtct ggtattacgt gctggaatgc cgcaaccgca tccaggctat cgagaaccgt 300
atttacgacc ttgagaagaa ggtgaagtga 330
<210> 199
<211> 273
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 199
ggagaactca gcatgtcaga cgtaaacacc ctgaccaagc tcatcaaggc cagcaacgac 60
cagcttcact acgatattgg cgtcgtccag acgcaaaacg ggaacatcaa gaagaagatc 120
gacaatctgt cgtgggtgaa gaaccccgtc accggcaaga agtggtccac taaggatgcc 180
ctgtggtccg tctggtatta cgtgctggaa tgccgcaacc gcatccaggc tatcgagaac 240
cgtatttacg accttgagaa gaaggtgaag tga 273
<210> 200
<211> 639
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 200
atgagataca ttcctgcggc gcatcattct gccggatcaa ataagccggt gaaccgggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtctg cttcgcgtaa gggtcgggcg 120
gtgtctacag caaactattt tgcttcccca tcgtctggtg gttcggcgca ttatgtgtgt 180
gatattgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcattccgt 300
gttccagggc atgcctatac gcgggagcag tggcttgacc ctcgggtgtg gcccgcggtg 360
gagagggccg ccatcctgtg tcggcagttg tgtgataagc atggtgttcc gaagaggaaa 420
ctgtctgtgg ctgatttgaa ggccggtaaa cggggtgttt gcgggcatgt ggatgttacg 480
gatgcgtggc atcagtcgga tcatgacgat ccggggccgt ggtttccgtg ggacaaattt 540
atggctgtgg tgaatggcca cggcggcggt tcaagtagtg aggagttgag tatggctgat 600
gtacaagcgt tacataatca gattaaacag ttgtcggca 639
<210> 201
<211> 519
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 201
atgagataca ttcctgcggc gcatcattct gccggatcaa ataagccggt gaaccgggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtctg cttcgcgtaa gggtcgggcg 120
gtgtctacag caaactattt tgcttcccca tcgtctggtg gttcggcgca ttatgtgtgt 180
gatattgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcattccgt 300
gttccagggc atgcctatac gcgggagcag tggcttgacc ctcgggtgtg gcccgcggtg 360
gagagggccg ccatcctgtg tcggcagttg tgtgataagc atggtgttcc gaagaggaaa 420
ctgtctgtgg ctgatttgaa ggccggtaaa cggggtgttt gcgggcatgt ggatgttacg 480
gatgcgtggc atcagtcgga tcatgacgat ccggggccg 519
<210> 202
<211> 345
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 202
tggtttccgt gggacaaatt tatggctgtg gtgaatggcc acggcggcgg ttcaagtagt 60
gaggagttga gtatggctga tgtacaagcg ttacataatc agattaaaca gttgtcggca 120
caggtggccc agtcggtgaa taagctgcat cacgatgttg gtgtggttca ggttcagaat 180
ggtgatttgg gtaaacgtgt tgatgccttg tcgtgggtga agaatccggt gacggggaag 240
ctgtggcgca gcaaggatgc tttgtggagt gtctggtatt acgtgttgga gtgtcgtagc 300
cgtcttgaca ggctcgagtc tgctgtcaac gatttgaaaa agtga 345
<210> 203
<211> 225
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 203
caggtggccc agtcggtgaa taagctgcat cacgatgttg gtgtggttca ggttcagaat 60
ggtgatttgg gtaaacgtgt tgatgccttg tcgtgggtga agaatccggt gacggggaag 120
ctgtggcgca gcaaggatgc tttgtggagt gtctggtatt acgtgttgga gtgtcgtagc 180
cgtcttgaca ggctcgagtc tgctgtcaac gatttgaaaa agtga 225
<210> 204
<211> 588
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 204
atgacattca tccaggcccg ccaccacggc ggcaactcca acgcgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg catcgaaggc cggtagggca 120
gtctcgaccg cgaactactt cgccacgact gatcggcccg cctcggcaca ttacgtatgt 180
gacatcgcca ctacagtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccg 240
aactcgcatt ccatcggcat tgaaatttgc gccgatggcg ggtcgcacgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgaccaa tggttgagcg atgacgtgtg gcccgccgta 360
gagcgcgccg ccattcttgc ccgcgatatt tgccaacgac accgcatccc ggttcgtaaa 420
ctctccaccg cacaggtgaa agccggactg tcgggaattt gcggacacga caatgtatcc 480
ggcgcattcc atcagtccga ccacgacgac ccgggcccct acttcccgtg ggaccagttc 540
atggcactcg tccaaggaaa acccgccaca ccaggagatc tcaccatg 588
<210> 205
<211> 519
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 205
atgacattca tccaggcccg ccaccacggc ggcaactcca acgcgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg catcgaaggc cggtagggca 120
gtctcgaccg cgaactactt cgccacgact gatcggcccg cctcggcaca ttacgtatgt 180
gacatcgcca ctacagtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccg 240
aactcgcatt ccatcggcat tgaaatttgc gccgatggcg ggtcgcacgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgaccaa tggttgagcg atgacgtgtg gcccgccgta 360
gagcgcgccg ccattcttgc ccgcgatatt tgccaacgac accgcatccc ggttcgtaaa 420
ctctccaccg cacaggtgaa agccggactg tcgggaattt gcggacacga caatgtatcc 480
ggcgcattcc atcagtccga ccacgacgac ccgggcccc 519
<210> 206
<211> 327
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 206
tacttcccgt gggaccagtt catggcactc gtccaaggaa aacccgccac accaggagat 60
ctcaccatgg cagacatcag caaactcacc gacgcgatca aggcatccaa ccggcagctg 120
caccacgaca tcggcgtagt acagacccaa aacggaaaat tacgtgagca gatcgaaagg 180
atcacctggg tcaaaaatcc ggtgacagga aagaagtggc gcatcaccga cgcgctgtgg 240
tcgatctggc actacgtgct ggaatgccgc acccgcatcc agcggctcga cgcccgtctg 300
tctgaggtcg agaagaaggt gaagtga 327
<210> 207
<211> 261
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 207
atggcagaca tcagcaaact caccgacgcg atcaaggcat ccaaccggca gctgcaccac 60
gacatcggcg tagtacagac ccaaaacgga aaattacgtg agcagatcga aaggatcacc 120
tgggtcaaaa atccggtgac aggaaagaag tggcgcatca ccgacgcgct gtggtcgatc 180
tggcactacg tgctggaatg ccgcacccgc atccagcggc tcgacgcccg tctgtctgag 240
gtcgagaaga aggtgaagtg a 261
<210> 208
<211> 579
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 208
atgacattca tccaggccgc ccaccgtggc ggcacttcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgatgtcggc ttcccgtcgg catcgcgggc aggacgagca 120
gtatccacag cggaatattt cgcgtccacg tcgaggtcag cctcggcgca ctacgtatgc 180
gacatctcta ccacggtgca gtgcctgtcc gaggcaacga tcggctatca cgcgccacca 240
aacgcccact ccatcggcat tgaaatctgc gccgccggag gctcgcgcgc ttcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctcagcc cgcaggtatg gcccgccgtg 360
gagcgcgccg cgattctcgc ccgcgacatc tgccaccgac accacatccc catccgccgc 420
ctctccgtcg cgcaggtgcg ggcaggtgag cgcggaatct gcggccacaa cgaggtgagc 480
gaggcgttcc accaatccga ccacgacgac cccggcccct atttcccgtg gaatgaattt 540
attgccgccg tccaaggaaa aaccaccaca ccagaggga 579
<210> 209
<211> 330
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 209
tatttcccgt ggaatgaatt tattgccgcc gtccaaggaa aaaccaccac accagaggga 60
gaactcagca tgtcagacgt aaacaccctg accaagctca tcaaggccag caacgaccag 120
cttcactacg acattggcgt cgtccagacg caaaacggga acatcaagaa gaagatcgac 180
aatctgtcgt gggtgaagaa ccccgtcacc ggcaagaagt ggtccactaa ggatgccctg 240
tggtccgtct ggtattacgt gctggaatgc cgcaaccgca tccaggctat cgagaaccgt 300
atttacgacc ttgagaagaa ggtgaagtga 330
<210> 210
<211> 600
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 210
atgacattca ttcaggccaa gcatcacggc ggccacaaca accctcccgt gactcgtctt 60
gtcattcacg ccacatgccc ggatgtgggc tatccgtctg cgtcgcgcgc tggccgtgcg 120
gtgtcgacgg cccactattt tcaggaaacg acccggccag catccgccca ctacatttgt 180
gacatatcga ccacggtgca gtgtctgtct gaggagacgg tgggctatca cgccccgccg 240
aactcacact ccatcggtat tgagatatgc gctgacggtg ggtcgcatgc ctcgttttcg 300
aaccctgccc acgcctacac ccgcgagcag tggttgagcc ctcaggtgtg gcctgctgtg 360
gagcgtgccg cgatgctggc gcgcggtatc tgtcaacgcc acaacatccc gatccgccgc 420
ctctcgatcg ctgacgtcaa ggccgggaag cgcggcatct gcggccacaa cgaggtgtcc 480
gaggccttcc accaatccga ccatgacgac cccggtcctt atttcccgtg ggacgggttt 540
atcgcgcttg ttaatggcca ttccgcacca tcacgccagg aggaactaac tgtgtcagat 600
<210> 211
<211> 519
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 211
atgacattca ttcaggccaa gcatcacggc ggccacaaca accctcccgt gactcgtctt 60
gtcattcacg ccacatgccc ggatgtgggc tatccgtctg cgtcgcgcgc tggccgtgcg 120
gtgtcgacgg cccactattt tcaggaaacg acccggccag catccgccca ctacatttgt 180
gacatatcga ccacggtgca gtgtctgtct gaggagacgg tgggctatca cgccccgccg 240
aactcacact ccatcggtat tgagatatgc gctgacggtg ggtcgcatgc ctcgttttcg 300
aaccctgccc acgcctacac ccgcgagcag tggttgagcc ctcaggtgtg gcctgctgtg 360
gagcgtgccg cgatgctggc gcgcggtatc tgtcaacgcc acaacatccc gatccgccgc 420
ctctcgatcg ctgacgtcaa ggccgggaag cgcggcatct gcggccacaa cgaggtgtcc 480
gaggccttcc accaatccga ccatgacgac cccggtcct 519
<210> 212
<211> 333
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 212
tatttcccgt gggacgggtt tatcgcgctt gttaatggcc attccgcacc atcacgccag 60
gaggaactaa ctgtgtcaga tgtcaatatg ctcaaaggtc ttattcagca atcgaacaag 120
cagctgcacc acgatatcgg tgttgtgcag acgcaggcgg gtaacctccg ccgccagctg 180
gaatccctgt catgggtgaa gaacccggtc agcggcaagc tgtggcgcac caaggacgcc 240
ttgtggtcga tctggtacta cgtgctggac tgccgatctc gtctcggcaa actcgaggcc 300
cgcctgtcga cgctggaaaa gaaggtgaag tga 333
<210> 213
<211> 282
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 213
tcacgccagg aggaactaac tgtgtcagat gtcaatatgc tcaaaggtct tattcagcaa 60
tcgaacaagc agctgcacca cgatatcggt gttgtgcaga cgcaggcggg taacctccgc 120
cgccagctgg aatccctgtc atgggtgaag aacccggtca gcggcaagct gtggcgcacc 180
aaggacgcct tgtggtcgat ctggtactac gtgctggact gccgatctcg tctcggcaaa 240
ctcgaggccc gcctgtcgac gctggaaaag aaggtgaagt ga 282
<210> 214
<211> 600
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 214
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
<210> 215
<211> 519
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 215
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggcccc 519
<210> 216
<211> 555
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 216
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaa 555
<210> 217
<211> 285
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 217
gacttcccgt gggccgaatt catggcagcc gtcaaaggcg gcaccaccac acaggaagat 60
gaggatgaaa tgaaggaagc tgactggcag cgcatggaga ggctcgttga cgcgaggctg 120
aagtacgctg gtatcgccaa gaatgatgac ccggtcttca agcccgacaa gtcctcgtcg 180
tggccctgga ggaccgcgct gtggagcatc tcctactacg cgacccacag ctacaacacg 240
atctgcaata tcgcccgcaa gctcggcgca gaggtgtcca agtga 285
<210> 218
<211> 558
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 218
atgaaataca ttcccgcgac acatcacgga ggccacacga acaccccctt cacccggatc 60
gtgatccacg ccacctgccc cgaccttggc ttcccccacg catcagctgg tggacaggca 120
aaagccaccg cacgctattt ccaatcagag cagtctgccg gatcagcaca ctatgtgtgc 180
gacatcgccg agactatcca atgcctgccc gatgacgtga tcgcctggca cgccccacca 240
aacagaaggt cgatcggaat cgaaatatgt gccgacggcg gctcccgctc ctcattccag 300
caccccgagc acgcctacac cagatcccaa tggctcagcc cccaagtgtg gcccgccgtc 360
gcccgtgccg ccgcgctcac ccgcgacctc tgccaccgcc acaacattcc gatgcaacaa 420
ctctccgttg ctgatgtgaa agccgggaag cacggaatct gcggccacaa cgacgtatcc 480
gaggcattcc acaagtccga ccatgacgac cccggcccca cattcccgtg ggaccaattc 540
atcaaagagg ttagaaca 558
<210> 219
<211> 519
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 219
atgaaataca ttcccgcgac acatcacgga ggccacacga acaccccctt cacccggatc 60
gtgatccacg ccacctgccc cgaccttggc ttcccccacg catcagctgg tggacaggca 120
aaagccaccg cacgctattt ccaatcagag cagtctgccg gatcagcaca ctatgtgtgc 180
gacatcgccg agactatcca atgcctgccc gatgacgtga tcgcctggca cgccccacca 240
aacagaaggt cgatcggaat cgaaatatgt gccgacggcg gctcccgctc ctcattccag 300
caccccgagc acgcctacac cagatcccaa tggctcagcc cccaagtgtg gcccgccgtc 360
gcccgtgccg ccgcgctcac ccgcgacctc tgccaccgcc acaacattcc gatgcaacaa 420
ctctccgttg ctgatgtgaa agccgggaag cacggaatct gcggccacaa cgacgtatcc 480
gaggcattcc acaagtccga ccatgacgac cccggcccc 519
<210> 220
<211> 336
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 220
acattcccgt gggaccaatt catcaaagag gttagaacac caggacaaca agatacgaaa 60
ccttccgtac caacaccatc actcacagaa ataggagatc aggacatgaa cgggtgctac 120
tacaacctca attcgaaaac acggacgtac cttatcttcg atagccgttc cggattttac 180
cacgaattct cccaaggcaa tgggaacggc cccatgagcc cagactatgt aaatccgatc 240
gccaaaggat gggacaccgg atcatggccg gcaatctccc caggccacgc gaaagtgctc 300
aaggccgccc tcgataaagt ccggaaagga atctga 336
<210> 221
<211> 297
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 221
ccaggacaac aagatacgaa accttccgta ccaacaccat cactcacaga aataggagat 60
caggacatga acgggtgcta ctacaacctc aattcgaaaa cacggacgta ccttatcttc 120
gatagccgtt ccggatttta ccacgaattc tcccaaggca atgggaacgg ccccatgagc 180
ccagactatg taaatccgat cgccaaagga tgggacaccg gatcatggcc ggcaatctcc 240
ccaggccacg cgaaagtgct caaggccgcc ctcgataaag tccggaaagg aatctga 297
<210> 222
<211> 309
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 222
gaggttagaa caccaggaca acaagatacg aaaccttccg taccaacacc atcactcaca 60
gaaataggag atcaggacat gaacgggtgc tactacaacc tcaattcgaa aacacggacg 120
taccttatct tcgatagccg ttccggattt taccacgaat tctcccaagg caatgggaac 180
ggccccatga gcccagacta tgtaaatccg atcgccaaag gatgggacac cggatcatgg 240
ccggcaatct ccccaggcca cgcgaaagtg ctcaaggccg ccctcgataa agtccggaaa 300
ggaatctga 309
<210> 223
<211> 310
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 223
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Thr Phe Pro Trp Asp Gln Phe Ile Lys
195 200 205
Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr
210 215 220
Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr
225 230 235 240
Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser
245 250 255
Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser
260 265 270
Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp
275 280 285
Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp
290 295 300
Lys Val Arg Lys Gly Ile
305 310
<210> 224
<211> 309
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 224
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Tyr Phe Pro Trp Asp Gly Phe Ile Ala
195 200 205
Leu Val Asn Gly His Ser Ala Pro Ser Arg Gln Glu Glu Leu Thr Val
210 215 220
Ser Asp Val Asn Met Leu Lys Gly Leu Ile Gln Gln Ser Asn Lys Gln
225 230 235 240
Leu His His Asp Ile Gly Val Val Gln Thr Gln Ala Gly Asn Leu Arg
245 250 255
Arg Gln Leu Glu Ser Leu Ser Trp Val Lys Asn Pro Val Ser Gly Lys
260 265 270
Leu Trp Arg Thr Lys Asp Ala Leu Trp Ser Ile Trp Tyr Tyr Val Leu
275 280 285
Asp Cys Arg Ser Arg Leu Gly Lys Leu Glu Ala Arg Leu Ser Thr Leu
290 295 300
Glu Lys Lys Val Lys
305
<210> 225
<211> 313
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 225
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Thr Phe Pro Trp Asp Gln
195 200 205
Phe Ile Lys Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser
210 215 220
Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly
225 230 235 240
Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp
245 250 255
Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly
260 265 270
Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr
275 280 285
Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala
290 295 300
Ala Leu Asp Lys Val Arg Lys Gly Ile
305 310
<210> 226
<211> 298
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 226
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Gly Ser Gly Glu Ser Gly Glu Leu Ser
195 200 205
Met Ala Asp Val Lys Ala Leu His Asp Gln Ile Lys Gln Leu Ser Gly
210 215 220
Gln Val Ala Gln Ser Val Asn Lys Leu His His Asp Val Gly Val Val
225 230 235 240
Gln Val Gln Asn Gly Asn Leu Lys Lys Gln Val Asp Ser Leu Ser Met
245 250 255
Val Lys Asn Pro Val Thr Gly Lys Leu Trp Arg Thr Arg Asp Ala Ile
260 265 270
Trp Ser Ile Trp Tyr Tyr Val Leu Glu Cys Arg Ser Arg Ile Gly Lys
275 280 285
Leu Glu Ala Glu Val Ala Arg Leu Lys Lys
290 295
<210> 227
<211> 294
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 227
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Lys Asn Thr Asn Lys Gly Glu Leu Ser
195 200 205
Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn Asn
210 215 220
Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn Gly Thr Leu
225 230 235 240
Lys Ser Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr Gly
245 250 255
Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val
260 265 270
Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg Leu Ser Asp
275 280 285
Ile Glu Lys Lys Val Lys
290
<210> 228
<211> 308
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 228
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Lys Asn Thr Asn Lys Gly
180 185 190
Glu Leu Ser Gly Gly Thr Phe Pro Trp Asp Gln Phe Ile Lys Glu Val
195 200 205
Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser
210 215 220
Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu
225 230 235 240
Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe
245 250 255
Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp
260 265 270
Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala
275 280 285
Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val
290 295 300
Arg Lys Gly Ile
305
<210> 229
<211> 309
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 229
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Ala Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Thr Thr Asp Arg Pro Ala Ser Ala His Tyr Val Cys Asp Ile Ala Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Asp Gln Trp Leu
100 105 110
Ser Asp Asp Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys Gln Arg His Arg Ile Pro Val Arg Lys Leu Ser Thr Ala
130 135 140
Gln Val Lys Ala Gly Leu Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Gly Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gln Phe Met Ala Leu Val Gln Gly Lys Pro Ala Thr Pro Gly
180 185 190
Asp Leu Thr Met Gly Gly Thr Phe Pro Trp Asp Gln Phe Ile Lys Glu
195 200 205
Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro
210 215 220
Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn
225 230 235 240
Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly
245 250 255
Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro
260 265 270
Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro
275 280 285
Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys
290 295 300
Val Arg Lys Gly Ile
305
<210> 230
<211> 313
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 230
Met Thr Phe Ile Gln Ala Lys His His Gly Gly His Asn Asn Pro Pro
1 5 10 15
Val Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala His Tyr Phe Gln
35 40 45
Glu Thr Thr Arg Pro Ala Ser Ala His Tyr Ile Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Val Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Ser Asn Pro Ala His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Met Leu Ala Arg
115 120 125
Gly Ile Cys Gln Arg His Asn Ile Pro Ile Arg Arg Leu Ser Ile Ala
130 135 140
Asp Val Lys Ala Gly Lys Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gly Phe Ile Ala Leu Val Asn Gly His Ser Ala Pro Ser Arg
180 185 190
Gln Glu Glu Leu Thr Val Ser Asp Gly Gly Thr Phe Pro Trp Asp Gln
195 200 205
Phe Ile Lys Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser
210 215 220
Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly
225 230 235 240
Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp
245 250 255
Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly
260 265 270
Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr
275 280 285
Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala
290 295 300
Ala Leu Asp Lys Val Arg Lys Gly Ile
305 310
<210> 231
<211> 288
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 231
Met Gly Phe Pro Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala
1 5 10 15
Arg Tyr Phe Gln Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val
20 25 30
Asp Ile Gly Glu Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp
35 40 45
His Ala Pro Pro Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp
50 55 60
Gly Gly Ser Ala Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg
65 70 75 80
Ala Gln Trp Leu Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala
85 90 95
Ala Leu Thr Arg Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys
100 105 110
Leu Ser Ala Ser Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His
115 120 125
Val Asp Val Ser Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly
130 135 140
Pro Asp Phe Pro Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr
145 150 155 160
Thr Thr Gln Glu Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Trp Phe
165 170 175
Pro Trp Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly Gly Ser
180 185 190
Ser Ser Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His Asn Gln
195 200 205
Ile Lys Gln Leu Ser Ala Gln Val Ala Gln Ser Val Asn Lys Leu His
210 215 220
His Asp Val Gly Val Val Gln Val Gln Asn Gly Asp Leu Gly Lys Arg
225 230 235 240
Val Asp Ala Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Leu Trp
245 250 255
Arg Ser Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys
260 265 270
Arg Ser Arg Leu Asp Arg Leu Glu Ser Ala Val Asn Asp Leu Lys Lys
275 280 285
<210> 232
<211> 312
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 232
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Tyr Phe Pro Trp Asp Gly
195 200 205
Phe Ile Ala Leu Val Asn Gly His Ser Ala Pro Ser Arg Gln Glu Glu
210 215 220
Leu Thr Val Ser Asp Val Asn Met Leu Lys Gly Leu Ile Gln Gln Ser
225 230 235 240
Asn Lys Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Ala Gly
245 250 255
Asn Leu Arg Arg Gln Leu Glu Ser Leu Ser Trp Val Lys Asn Pro Val
260 265 270
Ser Gly Lys Leu Trp Arg Thr Lys Asp Ala Leu Trp Ser Ile Trp Tyr
275 280 285
Tyr Val Leu Asp Cys Arg Ser Arg Leu Gly Lys Leu Glu Ala Arg Leu
290 295 300
Ser Thr Leu Glu Lys Lys Val Lys
305 310
<210> 233
<211> 292
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 233
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Lys Asn Thr Asn Lys Gly
180 185 190
Glu Leu Ser Gly Gly Lys Asn Thr Asn Lys Gly Glu Leu Ser Met Ser
195 200 205
Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn Asn Gln Leu
210 215 220
His His Asp Ile Gly Val Val Gln Thr Gln Asn Gly Thr Leu Lys Ser
225 230 235 240
Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Lys
245 250 255
Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu
260 265 270
Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg Leu Ser Asp Ile Glu
275 280 285
Lys Lys Val Lys
290
<210> 234
<211> 313
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 234
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Trp Phe Pro Trp Asp Lys Phe Met Ala
195 200 205
Val Val Asn Gly His Gly Gly Gly Ser Ser Ser Glu Glu Leu Ser Met
210 215 220
Ala Asp Val Gln Ala Leu His Asn Gln Ile Lys Gln Leu Ser Ala Gln
225 230 235 240
Val Ala Gln Ser Val Asn Lys Leu His His Asp Val Gly Val Val Gln
245 250 255
Val Gln Asn Gly Asp Leu Gly Lys Arg Val Asp Ala Leu Ser Trp Val
260 265 270
Lys Asn Pro Val Thr Gly Lys Leu Trp Arg Ser Lys Asp Ala Leu Trp
275 280 285
Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg Ser Arg Leu Asp Arg Leu
290 295 300
Glu Ser Ala Val Asn Asp Leu Lys Lys
305 310
<210> 235
<211> 308
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 235
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Ser Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ala Gly Gly Ser Ala His Tyr Val Cys Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Lys Ala Ala Val Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys Tyr Asn Val Pro Lys Arg Lys Leu Ser Val Ser
130 135 140
Asp Leu Lys Ala Gly Arg Arg Gly Val Cys Gly His Thr Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Arg Phe Met Ala Val Val Asn Gly Gly Ser Gly Glu Ser Gly
180 185 190
Glu Leu Ser Gly Gly Thr Phe Pro Trp Asp Gln Phe Ile Lys Glu Val
195 200 205
Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser
210 215 220
Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu
225 230 235 240
Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe
245 250 255
Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp
260 265 270
Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala
275 280 285
Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val
290 295 300
Arg Lys Gly Ile
305
<210> 236
<211> 306
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 236
Met Thr Phe Ile Gln Ala Ala His Arg Gly Gly Thr Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Ala Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys His Arg His His Ile Pro Ile Arg Arg Leu Ser Val Ala
130 135 140
Gln Val Arg Ala Gly Glu Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr Thr Pro Glu
180 185 190
Gly Gly Gly Thr Phe Pro Trp Asp Gln Phe Ile Lys Glu Val Arg Thr
195 200 205
Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr
210 215 220
Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser
225 230 235 240
Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His
245 250 255
Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val
260 265 270
Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser
275 280 285
Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys
290 295 300
Gly Ile
305
<210> 237
<211> 290
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 237
Met Thr Phe Ile Gln Ala Ala His Arg Gly Gly Thr Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Ala Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys His Arg His His Ile Pro Ile Arg Arg Leu Ser Val Ala
130 135 140
Gln Val Arg Ala Gly Glu Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr Thr Pro Glu
180 185 190
Gly Gly Gly Lys Asn Thr Asn Lys Gly Glu Leu Ser Met Ser Asp Val
195 200 205
Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn Asn Gln Leu His His
210 215 220
Asp Ile Gly Val Val Gln Thr Gln Asn Gly Thr Leu Lys Ser Lys Ile
225 230 235 240
Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Lys Trp Ser
245 250 255
Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg
260 265 270
Asn Arg Ile Gln Ala Ile Glu Asn Arg Leu Ser Asp Ile Glu Lys Lys
275 280 285
Val Lys
290
<210> 238
<211> 310
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 238
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Lys Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ser Gly Gly Ser Ala His Tyr Val Cys Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys His Gly Val Pro Lys Arg Lys Leu Ser Val Ala
130 135 140
Asp Leu Lys Ala Gly Lys Arg Gly Val Cys Gly His Val Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly Gly Ser Ser
180 185 190
Ser Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His Asn Gln Ile
195 200 205
Lys Gln Leu Ser Ala Gly Gly Lys Asn Thr Asn Lys Gly Glu Leu Ser
210 215 220
Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn Asn
225 230 235 240
Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn Gly Thr Leu
245 250 255
Lys Ser Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr Gly
260 265 270
Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val
275 280 285
Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg Leu Ser Asp
290 295 300
Ile Glu Lys Lys Val Lys
305 310
<210> 239
<211> 299
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 239
Met Lys Tyr Ile Pro Ala Thr His His Gly Gly His Thr Asn Thr Pro
1 5 10 15
Phe Thr Arg Ile Val Ile His Ala Thr Cys Pro Asp Leu Gly Phe Pro
20 25 30
His Ala Ser Ala Gly Gly Gln Ala Lys Ala Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Glu Gln Ser Ala Gly Ser Ala His Tyr Val Cys Asp Ile Ala Glu
50 55 60
Thr Ile Gln Cys Leu Pro Asp Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Arg Arg Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ser Ser Phe Gln His Pro Glu His Ala Tyr Thr Arg Ser Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Ala Arg Ala Ala Ala Leu Thr Arg
115 120 125
Asp Leu Cys His Arg His Asn Ile Pro Met Gln Gln Leu Ser Val Ala
130 135 140
Asp Val Lys Ala Gly Lys His Gly Ile Cys Gly His Asn Asp Val Ser
145 150 155 160
Glu Ala Phe His Lys Ser Asp His Asp Asp Pro Gly Pro Thr Phe Pro
165 170 175
Trp Asp Gln Phe Ile Lys Glu Val Arg Thr Gly Gly Thr Phe Pro Trp
180 185 190
Asp Gln Phe Ile Lys Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys
195 200 205
Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met
210 215 220
Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile
225 230 235 240
Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly
245 250 255
Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp
260 265 270
Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu
275 280 285
Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295
<210> 240
<211> 293
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 240
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Ala Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Thr Thr Asp Arg Pro Ala Ser Ala His Tyr Val Cys Asp Ile Ala Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Asp Gln Trp Leu
100 105 110
Ser Asp Asp Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys Gln Arg His Arg Ile Pro Val Arg Lys Leu Ser Thr Ala
130 135 140
Gln Val Lys Ala Gly Leu Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Gly Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gln Phe Met Ala Leu Val Gln Gly Lys Pro Ala Thr Pro Gly
180 185 190
Asp Leu Thr Met Gly Gly Lys Asn Thr Asn Lys Gly Glu Leu Ser Met
195 200 205
Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn Asn Gln
210 215 220
Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn Gly Thr Leu Lys
225 230 235 240
Ser Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys
245 250 255
Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu
260 265 270
Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg Leu Ser Asp Ile
275 280 285
Glu Lys Lys Val Lys
290
<210> 241
<211> 289
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 241
Met Ala Tyr Pro Tyr Ile Gly Ala Leu Lys His Gly Gly Lys Gln Gly
1 5 10 15
Lys Ile Gln Arg Ile Val Ile His Ala Thr Val Ser Pro Cys Val Arg
20 25 30
Gly Gly Ala Arg Asn Val Ala Lys Tyr Phe Gln Ser Ser Ala Ala Gly
35 40 45
Gly Ser Ala His Tyr Val Val Asp Pro Gly Glu Ile Ile Gln Cys Val
50 55 60
Lys Asp Asp Val Val Ala Tyr His Ala Pro Pro Asn Thr Gly Thr Leu
65 70 75 80
Gly Ile Glu Leu Cys Asp Pro Gln Ala Gly Ser Pro Lys Arg Trp Ser
85 90 95
Asn Glu Ala His Gln Ala Met Leu Val Leu Ala Ala Lys Leu Val Arg
100 105 110
Glu Leu Ala Ala Lys His Asp Val Pro Leu Val Arg Val Thr Ala Ala
115 120 125
Gln Leu Arg Ala Gly Lys Arg Gly Ile Cys Ser His Val Ala Val Ser
130 135 140
Asp Ala Phe Gly Gln Ser Asp His Gly Asp Pro Glu Val Ala Gly Pro
145 150 155 160
Phe Pro Trp Ala Lys Phe Met Gln Leu Ile Lys Glu Glu Asp Asp Met
165 170 175
Gly Gly Thr Phe Pro Trp Asp Gln Phe Ile Lys Glu Val Arg Thr Pro
180 185 190
Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu
195 200 205
Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys
210 215 220
Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu
225 230 235 240
Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn
245 250 255
Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro
260 265 270
Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly
275 280 285
Ile
<210> 242
<211> 311
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 242
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Tyr Phe Pro Trp Asn Glu
195 200 205
Phe Ile Ala Ala Val Gln Gly Lys Thr Thr Thr Pro Glu Gly Glu Leu
210 215 220
Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn
225 230 235 240
Asp Gln Leu His Tyr Asp Ile Gly Val Val Gln Thr Gln Asn Gly Asn
245 250 255
Ile Lys Lys Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr
260 265 270
Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr
275 280 285
Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg Ile Tyr
290 295 300
Asp Leu Glu Lys Lys Val Lys
305 310
<210> 243
<211> 310
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 243
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Tyr Phe Pro Trp Asp Gln
195 200 205
Phe Met Ala Leu Val Gln Gly Lys Pro Ala Thr Pro Gly Asp Leu Thr
210 215 220
Met Ala Asp Ile Ser Lys Leu Thr Asp Ala Ile Lys Ala Ser Asn Arg
225 230 235 240
Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn Gly Lys Leu
245 250 255
Arg Glu Gln Ile Glu Arg Ile Thr Trp Val Lys Asn Pro Val Thr Gly
260 265 270
Lys Lys Trp Arg Ile Thr Asp Ala Leu Trp Ser Ile Trp His Tyr Val
275 280 285
Leu Glu Cys Arg Thr Arg Ile Gln Arg Leu Asp Ala Arg Leu Ser Glu
290 295 300
Val Glu Lys Lys Val Lys
305 310
<210> 244
<211> 326
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 244
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Lys Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ser Gly Gly Ser Ala His Tyr Val Cys Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys His Gly Val Pro Lys Arg Lys Leu Ser Val Ala
130 135 140
Asp Leu Lys Ala Gly Lys Arg Gly Val Cys Gly His Val Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly Gly Ser Ser
180 185 190
Ser Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His Asn Gln Ile
195 200 205
Lys Gln Leu Ser Ala Gly Gly Thr Phe Pro Trp Asp Gln Phe Ile Lys
210 215 220
Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr
225 230 235 240
Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr
245 250 255
Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser
260 265 270
Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser
275 280 285
Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp
290 295 300
Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp
305 310 315 320
Lys Val Arg Lys Gly Ile
325
<210> 245
<211> 302
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 245
Met Lys Tyr Ile Pro Ala Thr His His Gly Gly His Thr Asn Thr Pro
1 5 10 15
Phe Thr Arg Ile Val Ile His Ala Thr Cys Pro Asp Leu Gly Phe Pro
20 25 30
His Ala Ser Ala Gly Gly Gln Ala Lys Ala Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Glu Gln Ser Ala Gly Ser Ala His Tyr Val Cys Asp Ile Ala Glu
50 55 60
Thr Ile Gln Cys Leu Pro Asp Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Arg Arg Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ser Ser Phe Gln His Pro Glu His Ala Tyr Thr Arg Ser Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Ala Arg Ala Ala Ala Leu Thr Arg
115 120 125
Asp Leu Cys His Arg His Asn Ile Pro Met Gln Gln Leu Ser Val Ala
130 135 140
Asp Val Lys Ala Gly Lys His Gly Ile Cys Gly His Asn Asp Val Ser
145 150 155 160
Glu Ala Phe His Lys Ser Asp His Asp Asp Pro Gly Pro Thr Phe Pro
165 170 175
Trp Asp Gln Phe Ile Lys Glu Val Arg Thr Gly Gly Trp Phe Pro Trp
180 185 190
Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly Gly Ser Ser Ser
195 200 205
Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His Asn Gln Ile Lys
210 215 220
Gln Leu Ser Ala Gln Val Ala Gln Ser Val Asn Lys Leu His His Asp
225 230 235 240
Val Gly Val Val Gln Val Gln Asn Gly Asp Leu Gly Lys Arg Val Asp
245 250 255
Ala Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Leu Trp Arg Ser
260 265 270
Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg Ser
275 280 285
Arg Leu Asp Arg Leu Glu Ser Ala Val Asn Asp Leu Lys Lys
290 295 300
<210> 246
<211> 303
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 246
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Asn Gly Gly Ser Gly Asp
195 200 205
Ser Gly Glu Leu Thr Val Ala Asp Val Lys Ala Leu His Asp Gln Ile
210 215 220
Lys Gln Leu Ser Ala Gln Leu Thr Gly Ser Val Asn Lys Leu His His
225 230 235 240
Asp Val Gly Val Val Gln Val Gln Asn Gly Asp Leu Gly Lys Arg Val
245 250 255
Asp Ala Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Leu Trp Arg
260 265 270
Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg
275 280 285
Ser Arg Ile Asp Arg Leu Glu Ser Ala Val Asn Gly Leu Lys Lys
290 295 300
<210> 247
<211> 308
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 247
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Tyr Phe Pro Trp Asn Glu Phe Ile Ala
195 200 205
Ala Val Gln Gly Lys Thr Thr Thr Pro Glu Gly Glu Leu Ser Met Ser
210 215 220
Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn Asp Gln Leu
225 230 235 240
His Tyr Asp Ile Gly Val Val Gln Thr Gln Asn Gly Asn Ile Lys Lys
245 250 255
Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Lys
260 265 270
Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu
275 280 285
Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg Ile Tyr Asp Leu Glu
290 295 300
Lys Lys Val Lys
305
<210> 248
<211> 306
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 248
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Lys Asn Thr Asn Lys Gly
180 185 190
Glu Leu Ser Gly Gly Tyr Phe Pro Trp Asn Glu Phe Ile Ala Ala Val
195 200 205
Gln Gly Lys Thr Thr Thr Pro Glu Gly Glu Leu Ser Met Ser Asp Val
210 215 220
Asn Thr Leu Thr Lys Leu Ile Lys Ala Ser Asn Asp Gln Leu His Tyr
225 230 235 240
Asp Ile Gly Val Val Gln Thr Gln Asn Gly Asn Ile Lys Lys Lys Ile
245 250 255
Asp Asn Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Lys Trp Ser
260 265 270
Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys Arg
275 280 285
Asn Arg Ile Gln Ala Ile Glu Asn Arg Ile Tyr Asp Leu Glu Lys Lys
290 295 300
Val Lys
305
<210> 249
<211> 297
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 249
Met Thr Phe Ile Gln Ala Lys His His Gly Gly His Asn Asn Pro Pro
1 5 10 15
Val Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala His Tyr Phe Gln
35 40 45
Glu Thr Thr Arg Pro Ala Ser Ala His Tyr Ile Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Val Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Ser Asn Pro Ala His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Met Leu Ala Arg
115 120 125
Gly Ile Cys Gln Arg His Asn Ile Pro Ile Arg Arg Leu Ser Ile Ala
130 135 140
Asp Val Lys Ala Gly Lys Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gly Phe Ile Ala Leu Val Asn Gly His Ser Ala Pro Ser Arg
180 185 190
Gln Glu Glu Leu Thr Val Ser Asp Gly Gly Lys Asn Thr Asn Lys Gly
195 200 205
Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala
210 215 220
Ser Asn Asn Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn
225 230 235 240
Gly Thr Leu Lys Ser Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro
245 250 255
Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp
260 265 270
Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg
275 280 285
Leu Ser Asp Ile Glu Lys Lys Val Lys
290 295
<210> 250
<211> 297
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 250
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Lys Asn Thr Asn Lys Gly
195 200 205
Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile Lys Ala
210 215 220
Ser Asn Asn Gln Leu His His Asp Ile Gly Val Val Gln Thr Gln Asn
225 230 235 240
Gly Thr Leu Lys Ser Lys Ile Asp Asn Leu Ser Trp Val Lys Asn Pro
245 250 255
Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser Val Trp
260 265 270
Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu Asn Arg
275 280 285
Leu Ser Asp Ile Glu Lys Lys Val Lys
290 295
<210> 251
<211> 290
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 251
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Gly Gly Glu Val Arg Thr
180 185 190
Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr
195 200 205
Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser
210 215 220
Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His
225 230 235 240
Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val
245 250 255
Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser
260 265 270
Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys
275 280 285
Gly Ile
290
<210> 252
<211> 286
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 252
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Gly Gly Pro Gly Gln Gln
180 185 190
Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp
195 200 205
Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr
210 215 220
Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln
225 230 235 240
Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala
245 250 255
Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala
260 265 270
Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
275 280 285
<210> 253
<211> 289
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 253
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Glu Val Arg Thr Pro
180 185 190
Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu
195 200 205
Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys
210 215 220
Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu
225 230 235 240
Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn
245 250 255
Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro
260 265 270
Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly
275 280 285
Ile
<210> 254
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 254
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Gly Gly Lys Asn Thr Asn
180 185 190
Lys Gly Glu Leu Ser Met Ser Asp Val Asn Thr Leu Thr Lys Leu Ile
195 200 205
Lys Ala Ser Asn Asn Gln Leu His His Asp Ile Gly Val Val Gln Thr
210 215 220
Gln Asn Gly Thr Leu Lys Ser Lys Ile Asp Asn Leu Ser Trp Val Lys
225 230 235 240
Asn Pro Val Thr Gly Lys Lys Trp Ser Thr Lys Asp Ala Leu Trp Ser
245 250 255
Val Trp Tyr Tyr Val Leu Glu Cys Arg Asn Arg Ile Gln Ala Ile Glu
260 265 270
Asn Arg Leu Ser Asp Ile Glu Lys Lys Val Lys
275 280
<210> 255
<211> 298
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 255
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Phe Pro Trp Asp
180 185 190
Gln Phe Ile Lys Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro
195 200 205
Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn
210 215 220
Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe
225 230 235 240
Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn
245 250 255
Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp
260 265 270
Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys
275 280 285
Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295
<210> 256
<211> 299
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 256
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Gly Gly Thr Phe Pro Trp
180 185 190
Asp Gln Phe Ile Lys Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys
195 200 205
Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met
210 215 220
Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile
225 230 235 240
Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly
245 250 255
Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp
260 265 270
Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu
275 280 285
Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295
<210> 257
<211> 289
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 257
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Glu Val Arg Thr Pro
180 185 190
Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu
195 200 205
Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys
210 215 220
Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu
225 230 235 240
Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn
245 250 255
Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro
260 265 270
Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly
275 280 285
Ile
<210> 258
<211> 285
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 258
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Pro Gly Gln Gln Asp
180 185 190
Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln
195 200 205
Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr
210 215 220
Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly
225 230 235 240
Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys
245 250 255
Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys
260 265 270
Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
275 280 285
<210> 259
<211> 295
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 259
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Gly
180 185 190
Gly Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro
195 200 205
Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr
210 215 220
Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg
225 230 235 240
Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met
245 250 255
Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser
260 265 270
Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu
275 280 285
Asp Lys Val Arg Lys Gly Ile
290 295
<210> 260
<211> 291
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 260
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Gly
180 185 190
Gly Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu
195 200 205
Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn
210 215 220
Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr
225 230 235 240
His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr
245 250 255
Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile
260 265 270
Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg
275 280 285
Lys Gly Ile
290
<210> 261
<211> 288
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 261
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Asn Gly Gly Ser Gly
180 185 190
Asp Ser Gly Glu Leu Thr Val Ala Asp Val Lys Ala Leu His Asp Gln
195 200 205
Ile Lys Gln Leu Ser Ala Gln Leu Thr Gly Ser Val Asn Lys Leu His
210 215 220
His Asp Val Gly Val Val Gln Val Gln Asn Gly Asp Leu Gly Lys Arg
225 230 235 240
Val Asp Ala Leu Ser Trp Val Lys Asn Pro Val Thr Gly Lys Leu Trp
245 250 255
Arg Thr Lys Asp Ala Leu Trp Ser Val Trp Tyr Tyr Val Leu Glu Cys
260 265 270
Arg Ser Arg Ile Asp Arg Leu Glu Ser Ala Val Asn Gly Leu Lys Lys
275 280 285
<210> 262
<211> 298
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 262
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Phe Pro Trp Asp
180 185 190
Gln Phe Ile Lys Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys Pro
195 200 205
Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn
210 215 220
Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe
225 230 235 240
Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn
245 250 255
Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp
260 265 270
Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys
275 280 285
Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295
<210> 263
<211> 301
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 263
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Glu Val Arg Thr Pro Gly Gln Gln Asp
195 200 205
Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln
210 215 220
Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr
225 230 235 240
Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly
245 250 255
Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys
260 265 270
Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys
275 280 285
Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295 300
<210> 264
<211> 299
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 264
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Thr Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Glu Tyr Phe Ala
35 40 45
Ser Thr Ser Arg Ser Ala Ser Ala His Tyr Val Cys Asp Val Ser Ala
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Gly Ile Cys His Arg His His Ile Pro Val Arg Lys Leu Thr Thr Ala
130 135 140
Gln Val Lys Ser Gly Met Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Asp Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asn Glu Phe Ile Ala Ala Ile Gln Gly Lys Asn Thr Asn Lys Gly
180 185 190
Glu Leu Ser Gly Gly Glu Val Arg Thr Pro Gly Gln Gln Asp Thr Lys
195 200 205
Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met
210 215 220
Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile
225 230 235 240
Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly
245 250 255
Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp
260 265 270
Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu
275 280 285
Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295
<210> 265
<211> 297
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 265
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Pro Gly Gln Gln Asp Thr Lys Pro Ser
195 200 205
Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly
210 215 220
Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp
225 230 235 240
Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly
245 250 255
Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr
260 265 270
Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala
275 280 285
Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295
<210> 266
<211> 304
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 266
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Glu Val Arg Thr Pro Gly
195 200 205
Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile
210 215 220
Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr
225 230 235 240
Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe
245 250 255
Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro
260 265 270
Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly
275 280 285
His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295 300
<210> 267
<211> 290
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 267
Met Lys Tyr Ile Pro Ala Thr His His Gly Gly His Thr Asn Thr Pro
1 5 10 15
Phe Thr Arg Ile Val Ile His Ala Thr Cys Pro Asp Leu Gly Phe Pro
20 25 30
His Ala Ser Ala Gly Gly Gln Ala Lys Ala Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Glu Gln Ser Ala Gly Ser Ala His Tyr Val Cys Asp Ile Ala Glu
50 55 60
Thr Ile Gln Cys Leu Pro Asp Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Arg Arg Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ser Ser Phe Gln His Pro Glu His Ala Tyr Thr Arg Ser Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Ala Arg Ala Ala Ala Leu Thr Arg
115 120 125
Asp Leu Cys His Arg His Asn Ile Pro Met Gln Gln Leu Ser Val Ala
130 135 140
Asp Val Lys Ala Gly Lys His Gly Ile Cys Gly His Asn Asp Val Ser
145 150 155 160
Glu Ala Phe His Lys Ser Asp His Asp Asp Pro Gly Pro Thr Phe Pro
165 170 175
Trp Asp Gln Phe Ile Lys Glu Val Arg Thr Gly Gly Glu Val Arg Thr
180 185 190
Pro Gly Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr
195 200 205
Glu Ile Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser
210 215 220
Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His
225 230 235 240
Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val
245 250 255
Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser
260 265 270
Pro Gly His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys
275 280 285
Gly Ile
290
<210> 268
<211> 317
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 268
Met Arg Tyr Ile Pro Ala Ala His His Ser Ala Gly Ser Asn Lys Pro
1 5 10 15
Val Asn Arg Val Val Ile His Ala Thr Cys Pro Asp Val Gly Phe Pro
20 25 30
Ser Ala Ser Arg Lys Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Ser Pro Ser Ser Gly Gly Ser Ala His Tyr Val Cys Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Ser Glu Ser Thr Ile Gly Trp His Ala Pro Pro
65 70 75 80
Asn Pro His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Arg Val Pro Gly His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Asp Pro Arg Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Cys Arg
115 120 125
Gln Leu Cys Asp Lys His Gly Val Pro Lys Arg Lys Leu Ser Val Ala
130 135 140
Asp Leu Lys Ala Gly Lys Arg Gly Val Cys Gly His Val Asp Val Thr
145 150 155 160
Asp Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Trp Phe Pro
165 170 175
Trp Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly Gly Ser Ser
180 185 190
Ser Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His Asn Gln Ile
195 200 205
Lys Gln Leu Ser Ala Gly Gly Glu Val Arg Thr Pro Gly Gln Gln Asp
210 215 220
Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln
225 230 235 240
Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr
245 250 255
Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly
260 265 270
Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys
275 280 285
Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys
290 295 300
Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
305 310 315
<210> 269
<211> 286
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 269
Met Lys Tyr Ile Pro Ala Thr His His Gly Gly His Thr Asn Thr Pro
1 5 10 15
Phe Thr Arg Ile Val Ile His Ala Thr Cys Pro Asp Leu Gly Phe Pro
20 25 30
His Ala Ser Ala Gly Gly Gln Ala Lys Ala Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Glu Gln Ser Ala Gly Ser Ala His Tyr Val Cys Asp Ile Ala Glu
50 55 60
Thr Ile Gln Cys Leu Pro Asp Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Arg Arg Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Arg
85 90 95
Ser Ser Phe Gln His Pro Glu His Ala Tyr Thr Arg Ser Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Ala Arg Ala Ala Ala Leu Thr Arg
115 120 125
Asp Leu Cys His Arg His Asn Ile Pro Met Gln Gln Leu Ser Val Ala
130 135 140
Asp Val Lys Ala Gly Lys His Gly Ile Cys Gly His Asn Asp Val Ser
145 150 155 160
Glu Ala Phe His Lys Ser Asp His Asp Asp Pro Gly Pro Thr Phe Pro
165 170 175
Trp Asp Gln Phe Ile Lys Glu Val Arg Thr Gly Gly Pro Gly Gln Gln
180 185 190
Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp
195 200 205
Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr
210 215 220
Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln
225 230 235 240
Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala
245 250 255
Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala
260 265 270
Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
275 280 285
<210> 270
<211> 296
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 270
Met Thr Phe Ile Gln Ala Arg His His Gly Gly Asn Ser Asn Ala Pro
1 5 10 15
Ile Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Lys Ala Gly Arg Ala Val Ser Thr Ala Asn Tyr Phe Ala
35 40 45
Thr Thr Asp Arg Pro Ala Ser Ala His Tyr Val Cys Asp Ile Ala Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Ile Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Glu Lys Ala Ser His Ala Tyr Thr Arg Asp Gln Trp Leu
100 105 110
Ser Asp Asp Val Trp Pro Ala Val Glu Arg Ala Ala Ile Leu Ala Arg
115 120 125
Asp Ile Cys Gln Arg His Arg Ile Pro Val Arg Lys Leu Ser Thr Ala
130 135 140
Gln Val Lys Ala Gly Leu Ser Gly Ile Cys Gly His Asp Asn Val Ser
145 150 155 160
Gly Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gln Phe Met Ala Leu Val Gln Gly Lys Pro Ala Thr Pro Gly
180 185 190
Asp Leu Thr Met Gly Gly Pro Gly Gln Gln Asp Thr Lys Pro Ser Val
195 200 205
Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp Met Asn Gly Cys
210 215 220
Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu Ile Phe Asp Ser
225 230 235 240
Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn Gly Asn Gly Pro
245 250 255
Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly Trp Asp Thr Gly
260 265 270
Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val Leu Lys Ala Ala
275 280 285
Leu Asp Lys Val Arg Lys Gly Ile
290 295
<210> 271
<211> 304
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 271
Met Thr Phe Ile Gln Ala Lys His His Gly Gly His Asn Asn Pro Pro
1 5 10 15
Val Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala His Tyr Phe Gln
35 40 45
Glu Thr Thr Arg Pro Ala Ser Ala His Tyr Ile Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Val Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Ser Asn Pro Ala His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Met Leu Ala Arg
115 120 125
Gly Ile Cys Gln Arg His Asn Ile Pro Ile Arg Arg Leu Ser Ile Ala
130 135 140
Asp Val Lys Ala Gly Lys Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gly Phe Ile Ala Leu Val Asn Gly His Ser Ala Pro Ser Arg
180 185 190
Gln Glu Glu Leu Thr Val Ser Asp Gly Gly Glu Val Arg Thr Pro Gly
195 200 205
Gln Gln Asp Thr Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile
210 215 220
Gly Asp Gln Asp Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr
225 230 235 240
Arg Thr Tyr Leu Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe
245 250 255
Ser Gln Gly Asn Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro
260 265 270
Ile Ala Lys Gly Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly
275 280 285
His Ala Lys Val Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295 300
<210> 272
<211> 300
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 272
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Met Gly Phe Pro
20 25 30
Lys Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ser Ser Gly Gly Ser Ala His Tyr Val Val Asp Ile Gly Glu
50 55 60
Thr Val Gln Cys Leu Gly Glu Asn Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ala His Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Ser Asn Pro Lys Val Arg Tyr Thr Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Lys Met Cys Ser Lys Tyr Gly Ile Pro Val Val Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr Thr Gln Glu
180 185 190
Asp Glu Asp Glu Met Lys Glu Ala Gly Gly Pro Gly Gln Gln Asp Thr
195 200 205
Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp
210 215 220
Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu
225 230 235 240
Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn
245 250 255
Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly
260 265 270
Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val
275 280 285
Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295 300
<210> 273
<211> 300
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 273
Met Thr Phe Ile Gln Ala Lys His His Gly Gly His Asn Asn Pro Pro
1 5 10 15
Val Thr Arg Leu Val Ile His Ala Thr Cys Pro Asp Val Gly Tyr Pro
20 25 30
Ser Ala Ser Arg Ala Gly Arg Ala Val Ser Thr Ala His Tyr Phe Gln
35 40 45
Glu Thr Thr Arg Pro Ala Ser Ala His Tyr Ile Cys Asp Ile Ser Thr
50 55 60
Thr Val Gln Cys Leu Ser Glu Glu Thr Val Gly Tyr His Ala Pro Pro
65 70 75 80
Asn Ser His Ser Ile Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser His
85 90 95
Ala Ser Phe Ser Asn Pro Ala His Ala Tyr Thr Arg Glu Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Glu Arg Ala Ala Met Leu Ala Arg
115 120 125
Gly Ile Cys Gln Arg His Asn Ile Pro Ile Arg Arg Leu Ser Ile Ala
130 135 140
Asp Val Lys Ala Gly Lys Arg Gly Ile Cys Gly His Asn Glu Val Ser
145 150 155 160
Glu Ala Phe His Gln Ser Asp His Asp Asp Pro Gly Pro Tyr Phe Pro
165 170 175
Trp Asp Gly Phe Ile Ala Leu Val Asn Gly His Ser Ala Pro Ser Arg
180 185 190
Gln Glu Glu Leu Thr Val Ser Asp Gly Gly Pro Gly Gln Gln Asp Thr
195 200 205
Lys Pro Ser Val Pro Thr Pro Ser Leu Thr Glu Ile Gly Asp Gln Asp
210 215 220
Met Asn Gly Cys Tyr Tyr Asn Leu Asn Ser Lys Thr Arg Thr Tyr Leu
225 230 235 240
Ile Phe Asp Ser Arg Ser Gly Phe Tyr His Glu Phe Ser Gln Gly Asn
245 250 255
Gly Asn Gly Pro Met Ser Pro Asp Tyr Val Asn Pro Ile Ala Lys Gly
260 265 270
Trp Asp Thr Gly Ser Trp Pro Ala Ile Ser Pro Gly His Ala Lys Val
275 280 285
Leu Lys Ala Ala Leu Asp Lys Val Arg Lys Gly Ile
290 295 300
<210> 274
<211> 259
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 274
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Val Ser Gln Phe Ser
180 185 190
Asp Leu Thr Lys Arg Leu Gln Gly Met Gln Glu Gln Thr His His Asp
195 200 205
Leu Gly Val Val Gln Thr Lys Leu Ala Thr Met Asp Thr Val Lys Asn
210 215 220
Pro Arg Thr Gly Ala Lys Trp Ser Leu Lys Asp Ala Ile Trp Ser Ile
225 230 235 240
Trp Tyr Tyr Val Leu Glu Asn Arg Asp Arg Ile Ala Ala Leu Glu Lys
245 250 255
Lys Val Lys
<210> 275
<211> 265
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 275
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Asp Glu Leu Glu Leu
180 185 190
Thr Val Ser Gln Phe Ser Asp Leu Thr Lys Arg Leu Gln Gly Met Gln
195 200 205
Glu Gln Thr His His Asp Leu Gly Val Val Gln Thr Lys Leu Ala Thr
210 215 220
Met Asp Thr Val Lys Asn Pro Arg Thr Gly Ala Lys Trp Ser Leu Lys
225 230 235 240
Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val Leu Glu Asn Arg Asp Arg
245 250 255
Ile Ala Ala Leu Glu Lys Lys Val Lys
260 265
<210> 276
<211> 271
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 276
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Gly Gly Ala Thr Asn
180 185 190
Pro Asp Glu Leu Glu Leu Thr Val Ser Gln Phe Ser Asp Leu Thr Lys
195 200 205
Arg Leu Gln Gly Met Gln Glu Gln Thr His His Asp Leu Gly Val Val
210 215 220
Gln Thr Lys Leu Ala Thr Met Asp Thr Val Lys Asn Pro Arg Thr Gly
225 230 235 240
Ala Lys Trp Ser Leu Lys Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val
245 250 255
Leu Glu Asn Arg Asp Arg Ile Ala Ala Leu Glu Lys Lys Val Lys
260 265 270
<210> 277
<211> 265
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 277
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Gly
180 185 190
Gly Val Ser Gln Phe Ser Asp Leu Thr Lys Arg Leu Gln Gly Met Gln
195 200 205
Glu Gln Thr His His Asp Leu Gly Val Val Gln Thr Lys Leu Ala Thr
210 215 220
Met Asp Thr Val Lys Asn Pro Arg Thr Gly Ala Lys Trp Ser Leu Lys
225 230 235 240
Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val Leu Glu Asn Arg Asp Arg
245 250 255
Ile Ala Ala Leu Glu Lys Lys Val Lys
260 265
<210> 278
<211> 271
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 278
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Gly
180 185 190
Gly Asp Glu Leu Glu Leu Thr Val Ser Gln Phe Ser Asp Leu Thr Lys
195 200 205
Arg Leu Gln Gly Met Gln Glu Gln Thr His His Asp Leu Gly Val Val
210 215 220
Gln Thr Lys Leu Ala Thr Met Asp Thr Val Lys Asn Pro Arg Thr Gly
225 230 235 240
Ala Lys Trp Ser Leu Lys Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val
245 250 255
Leu Glu Asn Arg Asp Arg Ile Ala Ala Leu Glu Lys Lys Val Lys
260 265 270
<210> 279
<211> 277
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 279
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Gly
180 185 190
Gly Gly Gly Ala Thr Asn Pro Asp Glu Leu Glu Leu Thr Val Ser Gln
195 200 205
Phe Ser Asp Leu Thr Lys Arg Leu Gln Gly Met Gln Glu Gln Thr His
210 215 220
His Asp Leu Gly Val Val Gln Thr Lys Leu Ala Thr Met Asp Thr Val
225 230 235 240
Lys Asn Pro Arg Thr Gly Ala Lys Trp Ser Leu Lys Asp Ala Ile Trp
245 250 255
Ser Ile Trp Tyr Tyr Val Leu Glu Asn Arg Asp Arg Ile Ala Ala Leu
260 265 270
Glu Lys Lys Val Lys
275
<210> 280
<211> 271
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 280
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Val Ser Gln Phe Ser Asp Leu Thr Lys
195 200 205
Arg Leu Gln Gly Met Gln Glu Gln Thr His His Asp Leu Gly Val Val
210 215 220
Gln Thr Lys Leu Ala Thr Met Asp Thr Val Lys Asn Pro Arg Thr Gly
225 230 235 240
Ala Lys Trp Ser Leu Lys Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val
245 250 255
Leu Glu Asn Arg Asp Arg Ile Ala Ala Leu Glu Lys Lys Val Lys
260 265 270
<210> 281
<211> 277
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 281
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Asp Glu Leu Glu Leu Thr Val Ser Gln
195 200 205
Phe Ser Asp Leu Thr Lys Arg Leu Gln Gly Met Gln Glu Gln Thr His
210 215 220
His Asp Leu Gly Val Val Gln Thr Lys Leu Ala Thr Met Asp Thr Val
225 230 235 240
Lys Asn Pro Arg Thr Gly Ala Lys Trp Ser Leu Lys Asp Ala Ile Trp
245 250 255
Ser Ile Trp Tyr Tyr Val Leu Glu Asn Arg Asp Arg Ile Ala Ala Leu
260 265 270
Glu Lys Lys Val Lys
275
<210> 282
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 282
Met Thr Phe Ile Gln Ala Ala His His Ser Ser Gly Ser Asn Leu Pro
1 5 10 15
Pro Thr Arg Val Val Ile His Ala Thr Cys Pro Glu Leu Gly Phe Pro
20 25 30
Arg Ala Ser Ala Lys Gly Arg Ala Val Ser Thr Ala Arg Tyr Phe Gln
35 40 45
Ser Ala Ile Ser Gly Gly Ser Ala His Tyr Val Val Asp Val Gly Glu
50 55 60
Thr Val Gln Cys Leu Ala Glu Asp Val Ile Ala Trp His Ala Pro Pro
65 70 75 80
Asn Ser Arg Ser Leu Gly Ile Glu Ile Cys Ala Asp Gly Gly Ser Ala
85 90 95
Thr Ser Phe Lys Asn Pro Asn Val Arg Tyr Ser Arg Ala Gln Trp Leu
100 105 110
Ser Pro Gln Val Trp Pro Ala Val Leu Arg Ala Ala Ala Leu Thr Arg
115 120 125
Gln Met Cys Gln Lys Tyr Gly Ile Pro Val Thr Lys Leu Ser Ala Ser
130 135 140
Asp Leu Lys Ala Gly Lys Lys Gly Ile Cys Gly His Val Asp Val Ser
145 150 155 160
Asn Ala Trp His Gln Ser Asp His Asp Asp Pro Gly Pro Asp Phe Pro
165 170 175
Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Ala Thr Asn Pro Asp
180 185 190
Glu Leu Glu Leu Thr Gly Gly Gly Gly Ala Thr Asn Pro Asp Glu Leu
195 200 205
Glu Leu Thr Val Ser Gln Phe Ser Asp Leu Thr Lys Arg Leu Gln Gly
210 215 220
Met Gln Glu Gln Thr His His Asp Leu Gly Val Val Gln Thr Lys Leu
225 230 235 240
Ala Thr Met Asp Thr Val Lys Asn Pro Arg Thr Gly Ala Lys Trp Ser
245 250 255
Leu Lys Asp Ala Ile Trp Ser Ile Trp Tyr Tyr Val Leu Glu Asn Arg
260 265 270
Asp Arg Ile Ala Ala Leu Glu Lys Lys Val Lys
275 280
<210> 284
<211> 933
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 284
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggtaca 600
ttcccgtggg accaattcat caaagaggtt agaacaccag gacaacaaga tacgaaacct 660
tccgtaccaa caccatcact cacagaaata ggagatcagg acatgaacgg gtgctactac 720
aacctcaatt cgaaaacacg gacgtacctt atcttcgata gccgttccgg attttaccac 780
gaattctccc aaggcaatgg gaacggcccc atgagcccag actatgtaaa tccgatcgcc 840
aaaggatggg acaccggatc atggccggca atctccccag gccacgcgaa agtgctcaag 900
gccgccctcg ataaagtccg gaaaggaatc tga 933
<210> 284
<211> 924
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 284
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggttac 600
ttcccgtggg accagttcat ggcactcgtc caaggaaaac ccgccacacc aggagatctc 660
accatggcag acatcagcaa actcaccgac gcgatcaagg catccaaccg gcagctgcac 720
cacgacatcg gcgtagtaca gacccaaaac ggaaaattac gtgagcagat cgaaaggatc 780
acctgggtca aaaatccggt gacaggaaag aagtggcgca tcaccgacgc gctgtggtcg 840
atctggcact acgtgctgga atgccgcacc cgcatccagc ggctcgacgc ccgtctgtct 900
gaggtcgaga agaaggtgaa gtga 924
<210> 285
<211> 942
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 285
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggtacat tcccgtggga ccaattcatc aaagaggtta gaacaccagg acaacaagat 660
acgaaacctt ccgtaccaac accatcactc acagaaatag gagatcagga catgaacggg 720
tgctactaca acctcaattc gaaaacacgg acgtacctta tcttcgatag ccgttccgga 780
ttttaccacg aattctccca aggcaatggg aacggcccca tgagcccaga ctatgtaaat 840
ccgatcgcca aaggatggga caccggatca tggccggcaa tctccccagg ccacgcgaaa 900
gtgctcaagg ccgccctcga taaagtccgg aaaggaatct ga 942
<210> 286
<211> 897
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 286
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggtggc 600
agtggagaga gtggagagtt gagtatggct gatgtgaaag ccttgcatga tcagattaaa 660
cagttgtcgg ggcaggtggc ccagtcggtg aataagctgc atcacgatgt gggtgtggtt 720
caggttcaga atgggaatct taaaaagcag gttgattccc tgtctatggt gaagaatcct 780
gtgacgggga agctgtggcg taccagggat gcgatctggt cgatctggta ttacgtgttg 840
gagtgtcgta gccgtatcgg caagttggag gccgaggtgg cccggttgaa gaagtga 897
<210> 287
<211> 885
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 287
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggtaaa 600
aacaccaaca agggagaact cagcatgtcc gacgtcaaca ccctgaccaa gctcatcaag 660
gccagcaaca atcagctcca ccacgacatt ggcgtcgtcc agacacagaa cggcaccctc 720
aaaagcaaga tcgacaactt gtcgtgggtg aagaatcccg tcaccggcaa gaagtggtcc 780
accaaggatg cgctgtggtc tgtctggtac tacgtgctgg aatgccgcaa ccgcatccag 840
gctatcgaaa accgcctctc tgacatcgaa aagaaggtga agtga 885
<210> 288
<211> 927
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 288
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggaaa aaacaccaac aagggagaac tcagcggcgg tacattcccg 600
tgggaccaat tcatcaaaga ggttagaaca ccaggacaac aagatacgaa accttccgta 660
ccaacaccat cactcacaga aataggagat caggacatga acgggtgcta ctacaacctc 720
aattcgaaaa cacggacgta ccttatcttc gatagccgtt ccggatttta ccacgaattc 780
tcccaaggca atgggaacgg ccccatgagc ccagactatg taaatccgat cgccaaagga 840
tgggacaccg gatcatggcc ggcaatctcc ccaggccacg cgaaagtgct caaggccgcc 900
ctcgataaag tccggaaagg aatctga 927
<210> 289
<211> 930
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 289
atgacattca tccaggcccg ccaccacggc ggcaactcca acgcgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg catcgaaggc cggtagggca 120
gtctcgaccg cgaactactt cgccacgact gatcggcccg cctcggcaca ttacgtatgt 180
gacatcgcca ctacagtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccg 240
aactcgcatt ccatcggcat tgaaatttgc gccgatggcg ggtcgcacgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgaccaa tggttgagcg atgacgtgtg gcccgccgta 360
gagcgcgccg ccattcttgc ccgcgatatt tgccaacgac accgcatccc ggttcgtaaa 420
ctctccaccg cacaggtgaa agccggactg tcgggaattt gcggacacga caatgtatcc 480
ggcgcattcc atcagtccga ccacgacgac ccgggcccct acttcccgtg ggaccagttc 540
atggcactcg tccaaggaaa acccgccaca ccaggagatc tcaccatggg cggtacattc 600
ccgtgggacc aattcatcaa agaggttaga acaccaggac aacaagatac gaaaccttcc 660
gtaccaacac catcactcac agaaatagga gatcaggaca tgaacgggtg ctactacaac 720
ctcaattcga aaacacggac gtaccttatc ttcgatagcc gttccggatt ttaccacgaa 780
ttctcccaag gcaatgggaa cggccccatg agcccagact atgtaaatcc gatcgccaaa 840
ggatgggaca ccggatcatg gccggcaatc tccccaggcc acgcgaaagt gctcaaggcc 900
gccctcgata aagtccggaa aggaatctga 930
<210> 290
<211> 942
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 290
atgacattca ttcaggccaa gcatcacggc ggccacaaca accctcccgt gactcgtctt 60
gtcattcacg ccacatgccc ggatgtgggc tatccgtctg cgtcgcgcgc tggccgtgcg 120
gtgtcgacgg cccactattt tcaggaaacg acccggccag catccgccca ctacatttgt 180
gacatatcga ccacggtgca gtgtctgtct gaggagacgg tgggctatca cgccccgccg 240
aactcacact ccatcggtat tgagatatgc gctgacggtg ggtcgcatgc ctcgttttcg 300
aaccctgccc acgcctacac ccgcgagcag tggttgagcc ctcaggtgtg gcctgctgtg 360
gagcgtgccg cgatgctggc gcgcggtatc tgtcaacgcc acaacatccc gatccgccgc 420
ctctcgatcg ctgacgtcaa ggccgggaag cgcggcatct gcggccacaa cgaggtgtcc 480
gaggccttcc accaatccga ccatgacgac cccggtcctt atttcccgtg ggacgggttt 540
atcgcgcttg ttaatggcca ttccgcacca tcacgccagg aggaactaac tgtgtcagat 600
ggcggtacat tcccgtggga ccaattcatc aaagaggtta gaacaccagg acaacaagat 660
acgaaacctt ccgtaccaac accatcactc acagaaatag gagatcagga catgaacggg 720
tgctactaca acctcaattc gaaaacacgg acgtacctta tcttcgatag ccgttccgga 780
ttttaccacg aattctccca aggcaatggg aacggcccca tgagcccaga ctatgtaaat 840
ccgatcgcca aaggatggga caccggatca tggccggcaa tctccccagg ccacgcgaaa 900
gtgctcaagg ccgccctcga taaagtccgg aaaggaatct ga 942
<210> 291
<211> 951
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 291
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggttggt ttccgtggga caaatttatg gctgtggtga atggccacgg cggcggttca 660
agtagtgagg agttgagtat ggctgatgta caagcgttac ataatcagat taaacagttg 720
tcggcacagg tggcccagtc ggtgaataag ctgcatcacg atgttggtgt ggttcaggtt 780
cagaatggtg atttgggtaa acgtgttgat gccttgtcgt gggtgaagaa tccggtgacg 840
gggaagctgt ggcgcagcaa ggatgctttg tggagtgtct ggtattacgt gttggagtgt 900
cgtagccgtc ttgacaggct cgagtctgct gtcaacgatt tgaaaaagtg a 951
<210> 292
<211> 939
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 292
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggttatt tcccgtggga cgggtttatc gcgcttgtta atggccattc cgcaccatca 660
cgccaggagg aactaactgt gtcagatgtc aatatgctca aaggtcttat tcagcaatcg 720
aacaagcagc tgcaccacga tatcggtgtt gtgcagacgc aggcgggtaa cctccgccgc 780
cagctggaat ccctgtcatg ggtgaagaac ccggtcagcg gcaagctgtg gcgcaccaag 840
gacgccttgt ggtcgatctg gtactacgtg ctggactgcc gatctcgtct cggcaaactc 900
gaggcccgcc tgtcgacgct ggaaaagaag gtgaagtga 939
<210> 293
<211> 942
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 293
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggttgg 600
tttccgtggg acaaatttat ggctgtggtg aatggccacg gcggcggttc aagtagtgag 660
gagttgagta tggctgatgt acaagcgtta cataatcaga ttaaacagtt gtcggcacag 720
gtggcccagt cggtgaataa gctgcatcac gatgttggtg tggttcaggt tcagaatggt 780
gatttgggta aacgtgttga tgccttgtcg tgggtgaaga atccggtgac ggggaagctg 840
tggcgcagca aggatgcttt gtggagtgtc tggtattacg tgttggagtg tcgtagccgt 900
cttgacaggc tcgagtctgc tgtcaacgat ttgaaaaagt ga 942
<210> 294
<211> 927
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 294
atgagataca ttcctgcggc gcatcactcg gccggctcta atagtccggt gaacagggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtccg cttcccgtaa aggacgggcg 120
gtgtccacgg caaactattt cgcgtcccca tcggcgggcg gttctgccca ttatgtgtgt 180
gatgttgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcgttccgt 300
gtgccggggc atgcttacac tcgtgagcag tggcttgatc cgagggtgtg gcctgcggtg 360
gagaaggcgg ctgtgctgtg tagacagttg tgtgacaaat ataatgttcc gaagaggaaa 420
ctgtctgtat ccgatttgaa ggctggcagg cggggtgtgt gcggccatac ggatgtgacg 480
gatgcgtggc atcagtcgga tcatgatgat ccggggccgt ggtttccgtg ggacaggttt 540
atggccgtcg tcaacggcgg cagtggagag agtggagagt tgagtggcgg tacattcccg 600
tgggaccaat tcatcaaaga ggttagaaca ccaggacaac aagatacgaa accttccgta 660
ccaacaccat cactcacaga aataggagat caggacatga acgggtgcta ctacaacctc 720
aattcgaaaa cacggacgta ccttatcttc gatagccgtt ccggatttta ccacgaattc 780
tcccaaggca atgggaacgg ccccatgagc ccagactatg taaatccgat cgccaaagga 840
tgggacaccg gatcatggcc ggcaatctcc ccaggccacg cgaaagtgct caaggccgcc 900
ctcgataaag tccggaaagg aatctga 927
<210> 295
<211> 921
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 295
atgacattca tccaggccgc ccaccgtggc ggcacttcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgatgtcggc ttcccgtcgg catcgcgggc aggacgagca 120
gtatccacag cggaatattt cgcgtccacg tcgaggtcag cctcggcgca ctacgtatgc 180
gacatctcta ccacggtgca gtgcctgtcc gaggcaacga tcggctatca cgcgccacca 240
aacgcccact ccatcggcat tgaaatctgc gccgacggag gctcgcgcgc ttcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctcagcc cgcaggtatg gcccgccgtg 360
gagcgcgccg cgattctcgc ccgcgacatc tgccaccgac accacatccc catccgccgc 420
ctctccgtcg cgcaggtgcg ggcaggtgag cgcggaatct gcggccacaa cgaggtgagc 480
gaggcgttcc accaatccga ccacgacgac cccggcccct atttcccttg gaatgaattt 540
attgccgccg tccaaggaaa aaccaccaca ccagagggag gcggtacatt cccgtgggac 600
caattcatca aagaggttag aacaccagga caacaagata cgaaaccttc cgtaccaaca 660
ccatcactca cagaaatagg agatcaggac atgaacgggt gctactacaa cctcaattcg 720
aaaacacgga cgtaccttat cttcgatagc cgttccggat tttaccacga attctcccaa 780
ggcaatggga acggccccat gagcccagac tatgtaaatc cgatcgccaa aggatgggac 840
accggatcat ggccggcaat ctccccaggc cacgcgaaag tgctcaaggc cgccctcgat 900
aaagtccgga aaggaatctg a 921
<210> 296
<211> 873
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 296
atgacattca tccaggccgc ccaccgtggc ggcacttcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgatgtcggc ttcccgtcgg catcgcgggc aggacgagca 120
gtatccacag cggaatattt cgcgtccacg tcgaggtcag cctcggcgca ctacgtatgc 180
gacatctcta ccacggtgca gtgcctgtcc gaggcaacga tcggctatca cgcgccacca 240
aacgcccact ccatcggcat tgaaatctgc gccgacggag gctcgcgcgc ttcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctcagcc cgcaggtatg gcccgccgtg 360
gagcgcgccg cgattctcgc ccgcgacatc tgccaccgac accacatccc catccgccgc 420
ctctccgtcg cgcaggtgcg ggcaggtgag cgcggaatct gcggccacaa cgaggtgagc 480
gaggcgttcc accaatccga ccacgacgac cccggcccct atttcccttg gaatgaattt 540
attgccgccg tccaaggaaa aaccaccaca ccagagggag gcggtaaaaa caccaacaag 600
ggagaactca gcatgtccga cgtcaacacc ctgaccaagc tcatcaaggc cagcaacaat 660
cagctccacc acgacattgg cgtcgtccag acacagaacg gcaccctcaa aagcaagatc 720
gacaacttgt cgtgggtgaa gaatcccgtc accggcaaga agtggtccac caaggatgcg 780
ctgtggtctg tctggtacta cgtgctggaa tgccgcaacc gcatccaggc tatcgaaaac 840
cgcctctctg acatcgaaaa gaaggtgaag tga 873
<210> 297
<211> 933
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 297
atgagataca ttcctgcggc gcatcattct gccggatcaa ataagccggt gaaccgggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtctg cttcgcgtaa gggtcgggcg 120
gtgtctacag caaactattt tgcttcccca tcgtctggtg gttcggcgca ttatgtgtgt 180
gatattgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcattccgt 300
gttccagggc atgcctatac gcgggagcag tggcttgacc ctcgggtgtg gcccgcggtg 360
gagagggccg ccatcctgtg tcggcagttg tgtgataagc atggtgttcc gaagaggaaa 420
ctgtctgtgg ctgatttgaa ggccggtaaa cggggtgttt gcgggcatgt ggatgttacg 480
gatgcgtggc atcagtcgga tcatgacgat ccggggccgt ggtttccgtg ggacaaattt 540
atggctgtgg tgaatggcca cggcggcggt tcaagtagtg aggagttgag tatggctgat 600
gtacaagcgt tacataatca gattaaacag ttgtcggcag gcggtaaaaa caccaacaag 660
ggagaactca gcatgtccga cgtcaacacc ctgaccaagc tcatcaaggc cagcaacaat 720
cagctccacc acgacattgg cgtcgtccag acacagaacg gcaccctcaa aagcaagatc 780
gacaacttgt cgtgggtgaa gaatcccgtc accggcaaga agtggtccac caaggatgcg 840
ctgtggtctg tctggtacta cgtgctggaa tgccgcaacc gcatccaggc tatcgaaaac 900
cgcctctctg acatcgaaaa gaaggtgaag tga 933
<210> 298
<211> 882
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 298
atgacattca tccaggcccg ccaccacggc ggcaactcca acgcgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg catcgaaggc cggtagggca 120
gtctcgaccg cgaactactt cgccacgact gatcggcccg cctcggcaca ttacgtatgt 180
gacatcgcca ctacagtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccg 240
aactcgcatt ccatcggcat tgaaatttgc gccgatggcg ggtcgcacgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgaccaa tggttgagcg atgacgtgtg gcccgccgta 360
gagcgcgccg ccattcttgc ccgcgatatt tgccaacgac accgcatccc ggttcgtaaa 420
ctctccaccg cacaggtgaa agccggactg tcgggaattt gcggacacga caatgtatcc 480
ggcgcattcc atcagtccga ccacgacgac ccgggcccct acttcccgtg ggaccagttc 540
atggcactcg tccaaggaaa acccgccaca ccaggagatc tcaccatggg cggtaaaaac 600
accaacaagg gagaactcag catgtccgac gtcaacaccc tgaccaagct catcaaggcc 660
agcaacaatc agctccacca cgacattggc gtcgtccaga cacagaacgg caccctcaaa 720
agcaagatcg acaacttgtc gtgggtgaag aatcccgtca ccggcaagaa gtggtccacc 780
aaggatgcgc tgtggtctgt ctggtactac gtgctggaat gccgcaaccg catccaggct 840
atcgaaaacc gcctctctga catcgaaaag aaggtgaagt ga 882
<210> 299
<211> 870
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 299
atggcctatc cctatatcgg ggcattgaag catggcggca agcagggcaa gatccagcgg 60
atcgtcatcc atgccacggt ttcgccctgt gtgcggggcg gtgcccggaa cgtcgcgaag 120
tactttcaga gttcagccgc cggaggcagc gcccactacg tggtggatcc cggtgagatc 180
atccagtgtg tcaaggacga cgtggtggcc taccacgcgc cgcccaacac cggaacgctc 240
gggatcgagc tgtgcgaccc gcaggccgga tcgccgaagc ggtggagcaa cgaggcccac 300
caggcgatgc tcgtgctcgc cgcgaagctc gtcagggaac tcgcggcgaa gcacgacgtg 360
ccgctcgtcc gggtgaccgc cgcgcagctc agggcgggca agcgcggcat ctgctcgcat 420
gtcgcggtca gcgacgcgtt cgggcagtcc gaccacggcg atcccgaggt cgccgggccg 480
ttcccctggg cgaagttcat gcagctcatc aaggaggagg acgacatggg cggtacattc 540
ccgtgggacc aattcatcaa agaggttaga acaccaggac aacaagatac gaaaccttcc 600
gtaccaacac catcactcac agaaatagga gatcaggaca tgaacgggtg ctactacaac 660
ctcaattcga aaacacggac gtaccttatc ttcgatagcc gttccggatt ttaccacgaa 720
ttctcccaag gcaatgggaa cggccccatg agcccagact atgtaaatcc gatcgccaaa 780
ggatgggaca ccggatcatg gccggcaatc tccccaggcc acgcgaaagt gctcaaggcc 840
gccctcgata aagtccggaa aggaatctga 870
<210> 300
<211> 936
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 300
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggttatt tcccttggaa tgaatttatt gccgccgtcc aaggaaaaac caccacacca 660
gagggagaac tcagcatgtc agacgtaaac accctgacca agctcatcaa ggccagcaac 720
gaccagcttc actacgatat tggcgtcgtc cagacgcaaa acgggaacat caagaagaag 780
atcgacaatc tgtcgtgggt gaagaacccc gtcaccggca agaagtggtc cactaaggat 840
gccctgtggt ccgtctggta ttacgtgctg gaatgccgca accgcatcca ggctatcgag 900
aaccgtattt acgaccttga gaagaaggtg aagtga 936
<210> 301
<211> 933
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 301
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggttact tcccgtggga ccagttcatg gcactcgtcc aaggaaaacc cgccacacca 660
ggagatctca ccatggcaga catcagcaaa ctcaccgacg cgatcaaggc atccaaccgg 720
cagctgcacc acgacatcgg cgtagtacag acccaaaacg gaaaattacg tgagcagatc 780
gaaaggatca cctgggtcaa aaatccggtg acaggaaaga agtggcgcat caccgacgcg 840
ctgtggtcga tctggcacta cgtgctggaa tgccgcaccc gcatccagcg gctcgacgcc 900
cgtctgtctg aggtcgagaa gaaggtgaag tga 933
<210> 302
<211> 981
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 302
atgagataca ttcctgcggc gcatcattct gccggatcaa ataagccggt gaaccgggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtctg cttcgcgtaa gggtcgggcg 120
gtgtctacag caaactattt tgcttcccca tcgtctggtg gttcggcgca ttatgtgtgt 180
gatattgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcattccgt 300
gttccagggc atgcctatac gcgggagcag tggcttgacc ctcgggtgtg gcccgcggtg 360
gagagggccg ccatcctgtg tcggcagttg tgtgataagc atggtgttcc gaagaggaaa 420
ctgtctgtgg ctgatttgaa ggccggtaaa cggggtgttt gcgggcatgt ggatgttacg 480
gatgcgtggc atcagtcgga tcatgacgat ccggggccgt ggtttccgtg ggacaaattt 540
atggctgtgg tgaatggcca cggcggcggt tcaagtagtg aggagttgag tatggctgat 600
gtacaagcgt tacataatca gattaaacag ttgtcggcag gcggtacatt cccgtgggac 660
caattcatca aagaggttag aacaccagga caacaagata cgaaaccttc cgtaccaaca 720
ccatcactca cagaaatagg agatcaggac atgaacgggt gctactacaa cctcaattcg 780
aaaacacgga cgtaccttat cttcgatagc cgttccggat tttaccacga attctcccaa 840
ggcaatggga acggccccat gagcccagac tatgtaaatc cgatcgccaa aggatgggac 900
accggatcat ggccggcaat ctccccaggc cacgcgaaag tgctcaaggc cgccctcgat 960
aaagtccgga aaggaatctg a 981
<210> 303
<211> 909
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 303
atgaaataca ttcccgcgac acatcacgga ggccacacga acaccccctt cacccggatc 60
gtgatccacg ccacctgccc cgaccttggc ttcccccacg catcagctgg tggacaggca 120
aaagccaccg cacgctattt ccaatcagag cagtctgccg gatcagcaca ctatgtgtgc 180
gacatcgccg agactatcca atgcctgccc gatgacgtga tcgcctggca cgccccacca 240
aacagaaggt cgatcggaat cgaaatatgt gccgacggcg gctcccgctc ctcattccag 300
caccccgagc acgcctacac cagatcccaa tggctcagcc cccaagtgtg gcccgccgtc 360
gcccgtgccg ccgcgctcac ccgcgacctc tgccaccgcc acaacattcc gatgcaacaa 420
ctctccgttg ctgatgtgaa agccgggaag cacggaatct gcggccacaa cgacgtatcc 480
gaggcattcc acaagtccga ccatgacgac cccggcccca cattcccgtg ggaccaattc 540
atcaaagagg ttagaacagg cggttggttt ccgtgggaca aatttatggc tgtggtgaat 600
ggccacggcg gcggttcaag tagtgaggag ttgagtatgg ctgatgtaca agcgttacat 660
aatcagatta aacagttgtc ggcacaggtg gcccagtcgg tgaataagct gcatcacgat 720
gttggtgtgg ttcaggttca gaatggtgat ttgggtaaac gtgttgatgc cttgtcgtgg 780
gtgaagaatc cggtgacggg gaagctgtgg cgcagcaagg atgctttgtg gagtgtctgg 840
tattacgtgt tggagtgtcg tagccgtctt gacaggctcg agtctgctgt caacgatttg 900
aaaaagtga 909
<210> 304
<211> 912
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 304
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggtaacg gcggtagtgg agatagtggg gagttaactg tggctgatgt gaaagccttg 660
catgatcaga ttaaacaatt gtctgctcag cttactggtt cggtgaataa gctgcaccat 720
gatgttggtg tggtacaggt acagaatggt gatttgggta aacgtgttga tgccttgtcg 780
tgggtgaaga atccggtgac ggggaagctg tggcgcacca aagacgcttt gtggagtgtc 840
tggtattacg tgctggagtg tcgcagccgc atagacaggc tcgagtctgc tgttaacggt 900
ttgaaaaagt ga 912
<210> 305
<211> 927
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 305
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggttat 600
ttcccttgga atgaatttat tgccgccgtc caaggaaaaa ccaccacacc agagggagaa 660
ctcagcatgt cagacgtaaa caccctgacc aagctcatca aggccagcaa cgaccagctt 720
cactacgata ttggcgtcgt ccagacgcaa aacgggaaca tcaagaagaa gatcgacaat 780
ctgtcgtggg tgaagaaccc cgtcaccggc aagaagtggt ccactaagga tgccctgtgg 840
tccgtctggt attacgtgct ggaatgccgc aaccgcatcc aggctatcga gaaccgtatt 900
tacgaccttg agaagaaggt gaagtga 927
<210> 306
<211> 921
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 306
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggaaa aaacaccaac aagggagaac tcagcggcgg ttatttccct 600
tggaatgaat ttattgccgc cgtccaagga aaaaccacca caccagaggg agaactcagc 660
atgtcagacg taaacaccct gaccaagctc atcaaggcca gcaacgacca gcttcactac 720
gatattggcg tcgtccagac gcaaaacggg aacatcaaga agaagatcga caatctgtcg 780
tgggtgaaga accccgtcac cggcaagaag tggtccacta aggatgccct gtggtccgtc 840
tggtattacg tgctggaatg ccgcaaccgc atccaggcta tcgagaaccg tatttacgac 900
cttgagaaga aggtgaagtg a 921
<210> 307
<211> 894
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 307
atgacattca ttcaggccaa gcatcacggc ggccacaaca accctcccgt gactcgtctt 60
gtcattcacg ccacatgccc ggatgtgggc tatccgtctg cgtcgcgcgc tggccgtgcg 120
gtgtcgacgg cccactattt tcaggaaacg acccggccag catccgccca ctacatttgt 180
gacatatcga ccacggtgca gtgtctgtct gaggagacgg tgggctatca cgccccgccg 240
aactcacact ccatcggtat tgagatatgc gctgacggtg ggtcgcatgc ctcgttttcg 300
aaccctgccc acgcctacac ccgcgagcag tggttgagcc ctcaggtgtg gcctgctgtg 360
gagcgtgccg cgatgctggc gcgcggtatc tgtcaacgcc acaacatccc gatccgccgc 420
ctctcgatcg ctgacgtcaa ggccgggaag cgcggcatct gcggccacaa cgaggtgtcc 480
gaggccttcc accaatccga ccatgacgac cccggtcctt atttcccgtg ggacgggttt 540
atcgcgcttg ttaatggcca ttccgcacca tcacgccagg aggaactaac tgtgtcagat 600
ggcggtaaaa acaccaacaa gggagaactc agcatgtccg acgtcaacac cctgaccaag 660
ctcatcaagg ccagcaacaa tcagctccac cacgacattg gcgtcgtcca gacacagaac 720
ggcaccctca aaagcaagat cgacaacttg tcgtgggtga agaatcccgt caccggcaag 780
aagtggtcca ccaaggatgc gctgtggtct gtctggtact acgtgctgga atgccgcaac 840
cgcatccagg ctatcgaaaa ccgcctctct gacatcgaaa agaaggtgaa gtga 894
<210> 308
<211> 894
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 308
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggtaaaa acaccaacaa gggagaactc agcatgtccg acgtcaacac cctgaccaag 660
ctcatcaagg ccagcaacaa tcagctccac cacgacattg gcgtcgtcca gacacagaac 720
ggcaccctca aaagcaagat cgacaacttg tcgtgggtga agaatcccgt caccggcaag 780
aagtggtcca ccaaggatgc gctgtggtct gtctggtact acgtgctgga atgccgcaac 840
cgcatccagg ctatcgaaaa ccgcctctct gacatcgaaa agaaggtgaa gtga 894
<210> 309
<211> 873
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 309
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggagg cggtgaggtt agaacaccag gacaacaaga tacgaaacct 600
tccgtaccaa caccatcact cacagaaata ggagatcagg acatgaacgg gtgctactac 660
aacctcaatt cgaaaacacg gacgtacctt atcttcgata gccgttccgg attttaccac 720
gaattctccc aaggcaatgg gaacggcccc atgagcccag actatgtaaa tccgatcgcc 780
aaaggatggg acaccggatc atggccggca atctccccag gccacgcgaa agtgctcaag 840
gccgccctcg ataaagtccg gaaaggaatc tga 873
<210> 310
<211> 861
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 310
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggagg cggtccagga caacaagata cgaaaccttc cgtaccaaca 600
ccatcactca cagaaatagg agatcaggac atgaacgggt gctactacaa cctcaattcg 660
aaaacacgga cgtaccttat cttcgatagc cgttccggat tttaccacga attctcccaa 720
ggcaatggga acggccccat gagcccagac tatgtaaatc cgatcgccaa aggatgggac 780
accggatcat ggccggcaat ctccccaggc cacgcgaaag tgctcaaggc cgccctcgat 840
aaagtccgga aaggaatctg a 861
<210> 311
<211> 870
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 311
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg tgaggttaga acaccaggac aacaagatac gaaaccttcc 600
gtaccaacac catcactcac agaaatagga gatcaggaca tgaacgggtg ctactacaac 660
ctcaattcga aaacacggac gtaccttatc ttcgatagcc gttccggatt ttaccacgaa 720
ttctcccaag gcaatgggaa cggccccatg agcccagact atgtaaatcc gatcgccaaa 780
ggatgggaca ccggatcatg gccggcaatc tccccaggcc acgcgaaagt gctcaaggcc 840
gccctcgata aagtccggaa aggaatctga 870
<210> 312
<211> 852
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 312
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggagg cggtaaaaac accaacaagg gagaactcag catgtccgac 600
gtcaacaccc tgaccaagct catcaaggcc agcaacaatc agctccacca cgacattggc 660
gtcgtccaga cacagaacgg caccctcaaa agcaagatcg acaacttgtc gtgggtgaag 720
aatcccgtca ccggcaagaa gtggtccacc aaggatgcgc tgtggtctgt ctggtactac 780
gtgctggaat gccgcaaccg catccaggct atcgaaaacc gcctctctga catcgaaaag 840
aaggtgaagt ga 852
<210> 313
<211> 897
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 313
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg tacattcccg tgggaccaat tcatcaaaga ggttagaaca 600
ccaggacaac aagatacgaa accttccgta ccaacaccat cactcacaga aataggagat 660
caggacatga acgggtgcta ctacaacctc aattcgaaaa cacggacgta ccttatcttc 720
gatagccgtt ccggatttta ccacgaattc tcccaaggca atgggaacgg ccccatgagc 780
ccagactatg taaatccgat cgccaaagga tgggacaccg gatcatggcc ggcaatctcc 840
ccaggccacg cgaaagtgct caaggccgcc ctcgataaag tccggaaagg aatctga 897
<210> 314
<211> 900
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 314
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggagg cggtacattc ccgtgggacc aattcatcaa agaggttaga 600
acaccaggac aacaagatac gaaaccttcc gtaccaacac catcactcac agaaatagga 660
gatcaggaca tgaacgggtg ctactacaac ctcaattcga aaacacggac gtaccttatc 720
ttcgatagcc gttccggatt ttaccacgaa ttctcccaag gcaatgggaa cggccccatg 780
agcccagact atgtaaatcc gatcgccaaa ggatgggaca ccggatcatg gccggcaatc 840
tccccaggcc acgcgaaagt gctcaaggcc gccctcgata aagtccggaa aggaatctga 900
<210> 315
<211> 870
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 315
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg tgaggttaga acaccaggac aacaagatac gaaaccttcc 600
gtaccaacac catcactcac agaaatagga gatcaggaca tgaacgggtg ctactacaac 660
ctcaattcga aaacacggac gtaccttatc ttcgatagcc gttccggatt ttaccacgaa 720
ttctcccaag gcaatgggaa cggccccatg agcccagact atgtaaatcc gatcgccaaa 780
ggatgggaca ccggatcatg gccggcaatc tccccaggcc acgcgaaagt gctcaaggcc 840
gccctcgata aagtccggaa aggaatctga 870
<210> 316
<211> 858
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 316
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg tccaggacaa caagatacga aaccttccgt accaacacca 600
tcactcacag aaataggaga tcaggacatg aacgggtgct actacaacct caattcgaaa 660
acacggacgt accttatctt cgatagccgt tccggatttt accacgaatt ctcccaaggc 720
aatgggaacg gccccatgag cccagactat gtaaatccga tcgccaaagg atgggacacc 780
ggatcatggc cggcaatctc cccaggccac gcgaaagtgc tcaaggccgc cctcgataaa 840
gtccggaaag gaatctga 858
<210> 317
<211> 888
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 317
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccggcggtg aggttagaac accaggacaa 600
caagatacga aaccttccgt accaacacca tcactcacag aaataggaga tcaggacatg 660
aacgggtgct actacaacct caattcgaaa acacggacgt accttatctt cgatagccgt 720
tccggatttt accacgaatt ctcccaaggc aatgggaacg gccccatgag cccagactat 780
gtaaatccga tcgccaaagg atgggacacc ggatcatggc cggcaatctc cccaggccac 840
gcgaaagtgc tcaaggccgc cctcgataaa gtccggaaag gaatctga 888
<210> 318
<211> 876
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 318
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccggcggtc caggacaaca agatacgaaa 600
ccttccgtac caacaccatc actcacagaa ataggagatc aggacatgaa cgggtgctac 660
tacaacctca attcgaaaac acggacgtac cttatcttcg atagccgttc cggattttac 720
cacgaattct cccaaggcaa tgggaacggc cccatgagcc cagactatgt aaatccgatc 780
gccaaaggat gggacaccgg atcatggccg gcaatctccc caggccacgc gaaagtgctc 840
aaggccgccc tcgataaagt ccggaaagga atctga 876
<210> 319
<211> 867
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 319
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg taacggcggt agtggagata gtggggagtt aactgtggct 600
gatgtgaaag ccttgcatga tcagattaaa caattgtctg ctcagcttac tggttcggtg 660
aataagctgc accatgatgt tggtgtggta caggtacaga atggtgattt gggtaaacgt 720
gttgatgcct tgtcgtgggt gaagaatccg gtgacgggga agctgtggcg caccaaagac 780
gctttgtgga gtgtctggta ttacgtgctg gagtgtcgca gccgcataga caggctcgag 840
tctgctgtta acggtttgaa aaagtga 867
<210> 320
<211> 897
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 320
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg tacattcccg tgggaccaat tcatcaaaga ggttagaaca 600
ccaggacaac aagatacgaa accttccgta ccaacaccat cactcacaga aataggagat 660
caggacatga acgggtgcta ctacaacctc aattcgaaaa cacggacgta ccttatcttc 720
gatagccgtt ccggatttta ccacgaattc tcccaaggca atgggaacgg ccccatgagc 780
ccagactatg taaatccgat cgccaaagga tgggacaccg gatcatggcc ggcaatctcc 840
ccaggccacg cgaaagtgct caaggccgcc ctcgataaag tccggaaagg aatctga 897
<210> 321
<211> 906
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 321
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggtgag 600
gttagaacac caggacaaca agatacgaaa ccttccgtac caacaccatc actcacagaa 660
ataggagatc aggacatgaa cgggtgctac tacaacctca attcgaaaac acggacgtac 720
cttatcttcg atagccgttc cggattttac cacgaattct cccaaggcaa tgggaacggc 780
cccatgagcc cagactatgt aaatccgatc gccaaaggat gggacaccgg atcatggccg 840
gcaatctccc caggccacgc gaaagtgctc aaggccgccc tcgataaagt ccggaaagga 900
atctga 906
<210> 322
<211> 900
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 322
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggaaa aaacaccaac aagggagaac tcagcggcgg tgaggttaga 600
acaccaggac aacaagatac gaaaccttcc gtaccaacac catcactcac agaaatagga 660
gatcaggaca tgaacgggtg ctactacaac ctcaattcga aaacacggac gtaccttatc 720
ttcgatagcc gttccggatt ttaccacgaa ttctcccaag gcaatgggaa cggccccatg 780
agcccagact atgtaaatcc gatcgccaaa ggatgggaca ccggatcatg gccggcaatc 840
tccccaggcc acgcgaaagt gctcaaggcc gccctcgata aagtccggaa aggaatctga 900
<210> 323
<211> 894
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 323
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggtcca 600
ggacaacaag atacgaaacc ttccgtacca acaccatcac tcacagaaat aggagatcag 660
gacatgaacg ggtgctacta caacctcaat tcgaaaacac ggacgtacct tatcttcgat 720
agccgttccg gattttacca cgaattctcc caaggcaatg ggaacggccc catgagccca 780
gactatgtaa atccgatcgc caaaggatgg gacaccggat catggccggc aatctcccca 840
ggccacgcga aagtgctcaa ggccgccctc gataaagtcc ggaaaggaat ctga 894
<210> 324
<211> 915
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 324
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggtgagg ttagaacacc aggacaacaa gatacgaaac cttccgtacc aacaccatca 660
ctcacagaaa taggagatca ggacatgaac gggtgctact acaacctcaa ttcgaaaaca 720
cggacgtacc ttatcttcga tagccgttcc ggattttacc acgaattctc ccaaggcaat 780
gggaacggcc ccatgagccc agactatgta aatccgatcg ccaaaggatg ggacaccgga 840
tcatggccgg caatctcccc aggccacgcg aaagtgctca aggccgccct cgataaagtc 900
cggaaaggaa tctga 915
<210> 325
<211> 873
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 325
atgaaataca ttcccgcgac acatcacgga ggccacacga acaccccctt cacccggatc 60
gtgatccacg ccacctgccc cgaccttggc ttcccccacg catcagctgg tggacaggca 120
aaagccaccg cacgctattt ccaatcagag cagtctgccg gatcagcaca ctatgtgtgc 180
gacatcgccg agactatcca atgcctgccc gatgacgtga tcgcctggca cgccccacca 240
aacagaaggt cgatcggaat cgaaatatgt gccgacggcg gctcccgctc ctcattccag 300
caccccgagc acgcctacac cagatcccaa tggctcagcc cccaagtgtg gcccgccgtc 360
gcccgtgccg ccgcgctcac ccgcgacctc tgccaccgcc acaacattcc gatgcaacaa 420
ctctccgttg ctgatgtgaa agccgggaag cacggaatct gcggccacaa cgacgtatcc 480
gaggcattcc acaagtccga ccatgacgac cccggcccca cattcccgtg ggaccaattc 540
atcaaagagg ttagaacagg cggtgaggtt agaacaccag gacaacaaga tacgaaacct 600
tccgtaccaa caccatcact cacagaaata ggagatcagg acatgaacgg gtgctactac 660
aacctcaatt cgaaaacacg gacgtacctt atcttcgata gccgttccgg attttaccac 720
gaattctccc aaggcaatgg gaacggcccc atgagcccag actatgtaaa tccgatcgcc 780
aaaggatggg acaccggatc atggccggca atctccccag gccacgcgaa agtgctcaag 840
gccgccctcg ataaagtccg gaaaggaatc tga 873
<210> 326
<211> 954
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 326
atgagataca ttcctgcggc gcatcattct gccggatcaa ataagccggt gaaccgggtt 60
gtgattcatg caacatgccc ggatgtgggg tttccgtctg cttcgcgtaa gggtcgggcg 120
gtgtctacag caaactattt tgcttcccca tcgtctggtg gttcggcgca ttatgtgtgt 180
gatattgggg agacggtgca gtgcttgtcg gagtctacga ttggttggca tgccccgccg 240
aatccgcata gtttgggtat agagatttgc gcggatgggg gttcgcacgc ctcattccgt 300
gttccagggc atgcctatac gcgggagcag tggcttgacc ctcgggtgtg gcccgcggtg 360
gagagggccg ccatcctgtg tcggcagttg tgtgataagc atggtgttcc gaagaggaaa 420
ctgtctgtgg ctgatttgaa ggccggtaaa cggggtgttt gcgggcatgt ggatgttacg 480
gatgcgtggc atcagtcgga tcatgacgat ccggggccgt ggtttccgtg ggacaaattt 540
atggctgtgg tgaatggcca cggcggcggt tcaagtagtg aggagttgag tatggctgat 600
gtacaagcgt tacataatca gattaaacag ttgtcggcag gcggtgaggt tagaacacca 660
ggacaacaag atacgaaacc ttccgtacca acaccatcac tcacagaaat aggagatcag 720
gacatgaacg ggtgctacta caacctcaat tcgaaaacac ggacgtacct tatcttcgat 780
agccgttccg gattttacca cgaattctcc caaggcaatg ggaacggccc catgagccca 840
gactatgtaa atccgatcgc caaaggatgg gacaccggat catggccggc aatctcccca 900
ggccacgcga aagtgctcaa ggccgccctc gataaagtcc ggaaaggaat ctga 954
<210> 327
<211> 861
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 327
atgaaataca ttcccgcgac acatcacgga ggccacacga acaccccctt cacccggatc 60
gtgatccacg ccacctgccc cgaccttggc ttcccccacg catcagctgg tggacaggca 120
aaagccaccg cacgctattt ccaatcagag cagtctgccg gatcagcaca ctatgtgtgc 180
gacatcgccg agactatcca atgcctgccc gatgacgtga tcgcctggca cgccccacca 240
aacagaaggt cgatcggaat cgaaatatgt gccgacggcg gctcccgctc ctcattccag 300
caccccgagc acgcctacac cagatcccaa tggctcagcc cccaagtgtg gcccgccgtc 360
gcccgtgccg ccgcgctcac ccgcgacctc tgccaccgcc acaacattcc gatgcaacaa 420
ctctccgttg ctgatgtgaa agccgggaag cacggaatct gcggccacaa cgacgtatcc 480
gaggcattcc acaagtccga ccatgacgac cccggcccca cattcccgtg ggaccaattc 540
atcaaagagg ttagaacagg cggtccagga caacaagata cgaaaccttc cgtaccaaca 600
ccatcactca cagaaatagg agatcaggac atgaacgggt gctactacaa cctcaattcg 660
aaaacacgga cgtaccttat cttcgatagc cgttccggat tttaccacga attctcccaa 720
ggcaatggga acggccccat gagcccagac tatgtaaatc cgatcgccaa aggatgggac 780
accggatcat ggccggcaat ctccccaggc cacgcgaaag tgctcaaggc cgccctcgat 840
aaagtccgga aaggaatctg a 861
<210> 328
<211> 891
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 328
atgacattca tccaggcccg ccaccacggc ggcaactcca acgcgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg catcgaaggc cggtagggca 120
gtctcgaccg cgaactactt cgccacgact gatcggcccg cctcggcaca ttacgtatgt 180
gacatcgcca ctacagtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccg 240
aactcgcatt ccatcggcat tgaaatttgc gccgatggcg ggtcgcacgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgaccaa tggttgagcg atgacgtgtg gcccgccgta 360
gagcgcgccg ccattcttgc ccgcgatatt tgccaacgac accgcatccc ggttcgtaaa 420
ctctccaccg cacaggtgaa agccggactg tcgggaattt gcggacacga caatgtatcc 480
ggcgcattcc atcagtccga ccacgacgac ccgggcccct acttcccgtg ggaccagttc 540
atggcactcg tccaaggaaa acccgccaca ccaggagatc tcaccatggg cggtccagga 600
caacaagata cgaaaccttc cgtaccaaca ccatcactca cagaaatagg agatcaggac 660
atgaacgggt gctactacaa cctcaattcg aaaacacgga cgtaccttat cttcgatagc 720
cgttccggat tttaccacga attctcccaa ggcaatggga acggccccat gagcccagac 780
tatgtaaatc cgatcgccaa aggatgggac accggatcat ggccggcaat ctccccaggc 840
cacgcgaaag tgctcaaggc cgccctcgat aaagtccgga aaggaatctg a 891
<210> 329
<211> 915
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 329
atgacattca ttcaggccaa gcatcacggc ggccacaaca accctcccgt gactcgtctt 60
gtcattcacg ccacatgccc ggatgtgggc tatccgtctg cgtcgcgcgc tggccgtgcg 120
gtgtcgacgg cccactattt tcaggaaacg acccggccag catccgccca ctacatttgt 180
gacatatcga ccacggtgca gtgtctgtct gaggagacgg tgggctatca cgccccgccg 240
aactcacact ccatcggtat tgagatatgc gctgacggtg ggtcgcatgc ctcgttttcg 300
aaccctgccc acgcctacac ccgcgagcag tggttgagcc ctcaggtgtg gcctgctgtg 360
gagcgtgccg cgatgctggc gcgcggtatc tgtcaacgcc acaacatccc gatccgccgc 420
ctctcgatcg ctgacgtcaa ggccgggaag cgcggcatct gcggccacaa cgaggtgtcc 480
gaggccttcc accaatccga ccatgacgac cccggtcctt atttcccgtg ggacgggttt 540
atcgcgcttg ttaatggcca ttccgcacca tcacgccagg aggaactaac tgtgtcagat 600
ggcggtgagg ttagaacacc aggacaacaa gatacgaaac cttccgtacc aacaccatca 660
ctcacagaaa taggagatca ggacatgaac gggtgctact acaacctcaa ttcgaaaaca 720
cggacgtacc ttatcttcga tagccgttcc ggattttacc acgaattctc ccaaggcaat 780
gggaacggcc ccatgagccc agactatgta aatccgatcg ccaaaggatg ggacaccgga 840
tcatggccgg caatctcccc aggccacgcg aaagtgctca aggccgccct cgataaagtc 900
cggaaaggaa tctga 915
<210> 330
<211> 903
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 330
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccacc cacgagggtg 60
gtgatccatg cgacatgccc cgagatggga ttcccgaagg ccagtgcgaa gggcagggct 120
gtctcgacgg cccgatactt ccagtctgcg agctcgggcg gtagcgccca ctatgttgtc 180
gacatcggcg agacggtgca gtgtctcggt gagaacgtga tcgcgtggca cgccccgccc 240
aatgcccaca gtctcggcat cgagatctgc gcggacgggg gatcggccac ctccttctcc 300
aatcccaagg tgcgctacac gcgggcgcag tggctgagcc cgcaggtgtg gcccgccgtg 360
ctccgtgccg cagcactcac ccggaagatg tgcagcaagt acggcatccc cgtcgtcaag 420
ctgtccgcgt cggacctcaa ggccggaaag aagggcatct gcggccacgt ggatgtcagc 480
aatgctttcc accagtccga ccacgacgac cccggccccg acttcccgtg ggccgaattc 540
atggcagccg tcaaaggcgg caccaccaca caggaagatg aggatgaaat gaaggaagct 600
ggcggtccag gacaacaaga tacgaaacct tccgtaccaa caccatcact cacagaaata 660
ggagatcagg acatgaacgg gtgctactac aacctcaatt cgaaaacacg gacgtacctt 720
atcttcgata gccgttccgg attttaccac gaattctccc aaggcaatgg gaacggcccc 780
atgagcccag actatgtaaa tccgatcgcc aaaggatggg acaccggatc atggccggca 840
atctccccag gccacgcgaa agtgctcaag gccgccctcg ataaagtccg gaaaggaatc 900
tga 903
<210> 331
<211> 903
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 331
atgacattca ttcaggccaa gcatcacggc ggccacaaca accctcccgt gactcgtctt 60
gtcattcacg ccacatgccc ggatgtgggc tatccgtctg cgtcgcgcgc tggccgtgcg 120
gtgtcgacgg cccactattt tcaggaaacg acccggccag catccgccca ctacatttgt 180
gacatatcga ccacggtgca gtgtctgtct gaggagacgg tgggctatca cgccccgccg 240
aactcacact ccatcggtat tgagatatgc gctgacggtg ggtcgcatgc ctcgttttcg 300
aaccctgccc acgcctacac ccgcgagcag tggttgagcc ctcaggtgtg gcctgctgtg 360
gagcgtgccg cgatgctggc gcgcggtatc tgtcaacgcc acaacatccc gatccgccgc 420
ctctcgatcg ctgacgtcaa ggccgggaag cgcggcatct gcggccacaa cgaggtgtcc 480
gaggccttcc accaatccga ccatgacgac cccggtcctt atttcccgtg ggacgggttt 540
atcgcgcttg ttaatggcca ttccgcacca tcacgccagg aggaactaac tgtgtcagat 600
ggcggtccag gacaacaaga tacgaaacct tccgtaccaa caccatcact cacagaaata 660
ggagatcagg acatgaacgg gtgctactac aacctcaatt cgaaaacacg gacgtacctt 720
atcttcgata gccgttccgg attttaccac gaattctccc aaggcaatgg gaacggcccc 780
atgagcccag actatgtaaa tccgatcgcc aaaggatggg acaccggatc atggccggca 840
atctccccag gccacgcgaa agtgctcaag gccgccctcg ataaagtccg gaaaggaatc 900
tga 903
<210> 332
<211> 780
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 332
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg tgtgtctcaa ttcagtgacc tgaccaagcg cctgcagggc 600
atgcaggagc agacccacca cgacctcggc gtcgtccaga ccaagctggc caccatggac 660
accgtcaaga acccccgcac cggcgccaag tggagcctca aggacgccat ctggtcgatc 720
tggtactacg tgctggagaa cagggaccgg atcgccgccc tcgagaagaa ggtgaagtga 780
<210> 333
<211> 798
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 333
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg tgatgaactg gagctcacag tgtctcaatt cagtgacctg 600
accaagcgcc tgcagggcat gcaggagcag acccaccacg acctcggcgt cgtccagacc 660
aagctggcca ccatggacac cgtcaagaac ccccgcaccg gcgccaagtg gagcctcaag 720
gacgccatct ggtcgatctg gtactacgtg ctggagaaca gggaccggat cgccgccctc 780
gagaagaagg tgaagtga 798
<210> 334
<211> 816
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 334
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg tggcggcgcc accaaccccg atgaactgga gctcacagtg 600
tctcaattca gtgacctgac caagcgcctg cagggcatgc aggagcagac ccaccacgac 660
ctcggcgtcg tccagaccaa gctggccacc atggacaccg tcaagaaccc ccgcaccggc 720
gccaagtgga gcctcaagga cgccatctgg tcgatctggt actacgtgct ggagaacagg 780
gaccggatcg ccgccctcga gaagaaggtg aagtga 816
<210> 335
<211> 798
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 335
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccggcggtg tgtctcaatt cagtgacctg 600
accaagcgcc tgcagggcat gcaggagcag acccaccacg acctcggcgt cgtccagacc 660
aagctggcca ccatggacac cgtcaagaac ccccgcaccg gcgccaagtg gagcctcaag 720
gacgccatct ggtcgatctg gtactacgtg ctggagaaca gggaccggat cgccgccctc 780
gagaagaagg tgaagtga 798
<210> 336
<211> 816
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 336
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccggcggtg atgaactgga gctcacagtg 600
tctcaattca gtgacctgac caagcgcctg cagggcatgc aggagcagac ccaccacgac 660
ctcggcgtcg tccagaccaa gctggccacc atggacaccg tcaagaaccc ccgcaccggc 720
gccaagtgga gcctcaagga cgccatctgg tcgatctggt actacgtgct ggagaacagg 780
gaccggatcg ccgccctcga gaagaaggtg aagtga 816
<210> 337
<211> 834
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 337
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccggcggtg gcggcgccac caaccccgat 600
gaactggagc tcacagtgtc tcaattcagt gacctgacca agcgcctgca gggcatgcag 660
gagcagaccc accacgacct cggcgtcgtc cagaccaagc tggccaccat ggacaccgtc 720
aagaaccccc gcaccggcgc caagtggagc ctcaaggacg ccatctggtc gatctggtac 780
tacgtgctgg agaacaggga ccggatcgcc gccctcgaga agaaggtgaa gtga 834
<210> 338
<211> 816
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 338
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggtgtg 600
tctcaattca gtgacctgac caagcgcctg cagggcatgc aggagcagac ccaccacgac 660
ctcggcgtcg tccagaccaa gctggccacc atggacaccg tcaagaaccc ccgcaccggc 720
gccaagtgga gcctcaagga cgccatctgg tcgatctggt actacgtgct ggagaacagg 780
gaccggatcg ccgccctcga gaagaaggtg aagtga 816
<210> 339
<211> 834
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 339
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggtgat 600
gaactggagc tcacagtgtc tcaattcagt gacctgacca agcgcctgca gggcatgcag 660
gagcagaccc accacgacct cggcgtcgtc cagaccaagc tggccaccat ggacaccgtc 720
aagaaccccc gcaccggcgc caagtggagc ctcaaggacg ccatctggtc gatctggtac 780
tacgtgctgg agaacaggga ccggatcgcc gccctcgaga agaaggtgaa gtga 834
<210> 340
<211> 852
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 340
atgacgttca ttcaggccgc gcatcacagc agcggctcca atctgccgcc cacgagggtg 60
gtgatccacg cgacatgccc cgaactcggc ttcccgaggg ccagtgcgaa gggccgagct 120
gtctcgacag cccgctactt ccagtctgcg atctcgggcg gctcggcgca ctatgttgtc 180
gatgtcggcg aaaccgtgca gtgtctggca gaggatgtga tcgcctggca cgccccgccc 240
aacagccgca gcctggggat cgagatctgc gctgacggcg gctcggcgac cagcttcaag 300
aaccccaacg tgcgctacag ccgcgcccag tggctcagcc cgcaggtctg gcccgccgtg 360
ctccgtgccg cagcactcac ccggcagatg tgccagaagt acggcatacc ggtcaccaag 420
ctcagcgcgt cggacctcaa ggccgggaag aagggcatct gcggacacgt cgatgtcagc 480
aatgcgtggc atcagtccga ccacgacgac cccggcccgg acttcccctg ggccgaattc 540
atggcagccg tcaaaggcgg cgccaccaac cccgatgaac tggagctcac aggcggtggc 600
ggcgccacca accccgatga actggagctc acagtgtctc aattcagtga cctgaccaag 660
cgcctgcagg gcatgcagga gcagacccac cacgacctcg gcgtcgtcca gaccaagctg 720
gccaccatgg acaccgtcaa gaacccccgc accggcgcca agtggagcct caaggacgcc 780
atctggtcga tctggtacta cgtgctggag aacagggacc ggatcgccgc cctcgagaag 840
aaggtgaagt ga 852
<210> 342
<211> 879
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 342
atgacattca tccaggcccg ccatcacggc ggcaactcca acacgccgat cacccggctg 60
gtcatccacg ccacctgccc cgacgtgggc tacccgtcgg cgtcgaaggc cggtagggca 120
gtctccacgg cggagtattt cgcgtccacg tcgcggtctg cctcggctca ctacgtctgt 180
gacgtatcgg caacggtgca gtgcctctcc gaggaaacca tcggctacca cgcgccgccc 240
aacagtcatt ccatcggcat tgagatttgc gccgacggcg ggtcccgcgc ctcatttgag 300
aaggcttctc acgcatacac ccgcgagcaa tggctctcgc ctcaagtgtg gcccgccgtg 360
gagcgcgccg ccattctcgc ccgcggcatc tgccaccgcc accacatccc ggttcgcaaa 420
ctcaccaccg cacaggtcaa atcggggatg tcgggtattt gcggacacga caacgtatcc 480
gatgcattcc accaatccga ccacgacgac cctggcccct acttcccgtg gaacgaattt 540
atcgccgcca tccaaggaaa aaacaccaac aagggagaac tcagcggcgg taaaaacacc 600
aacaagggag aactcagcat gtccgacgtc aacaccctga ccaagctcat caaggccagc 660
aacaatcagc tccaccacga cattggcgtc gtccagacac agaacggcac cctcaaaagc 720
aagatcgaca acttgtcgtg ggtgaagaat cccgtcaccg gcaagaagtg gtccaccaag 780
gatgcgctgt ggtctgtctg gtactacgtg ctggaatgcc gcaaccgcat ccaggctatc 840
gaaaaccgcc tctctgacat cgaaaagaag gtgaagtga 879
<210> 342
<211> 900
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 342
atgaaataca ttcccgcgac acatcacgga ggccacacga acaccccctt cacccggatc 60
gtgatccacg ccacctgccc cgaccttggc ttcccccacg catcagctgg tggacaggca 120
aaagccaccg cacgctattt ccaatcagag cagtctgccg gatcagcaca ctatgtgtgc 180
gacatcgccg agactatcca atgcctgccc gatgacgtga tcgcctggca cgccccacca 240
aacagaaggt cgatcggaat cgaaatatgt gccgacggcg gctcccgctc ctcattccag 300
caccccgagc acgcctacac cagatcccaa tggctcagcc cccaagtgtg gcccgccgtc 360
gcccgtgccg ccgcgctcac ccgcgacctc tgccaccgcc acaacattcc gatgcaacaa 420
ctctccgttg ctgatgtgaa agccgggaag cacggaatct gcggccacaa cgacgtatcc 480
gaggcattcc acaagtccga ccatgacgac cccggcccca cattcccgtg ggaccaattc 540
atcaaagagg ttagaacagg cggtacattc ccgtgggacc aattcatcaa agaggttaga 600
acaccaggac aacaagatac gaaaccttcc gtaccaacac catcactcac agaaatagga 660
gatcaggaca tgaacgggtg ctactacaac ctcaattcga aaacacggac gtaccttatc 720
ttcgatagcc gttccggatt ttaccacgaa ttctcccaag gcaatgggaa cggccccatg 780
agcccagact atgtaaatcc gatcgccaaa ggatgggaca ccggatcatg gccggcaatc 840
tccccaggcc acgcgaaagt gctcaaggcc gccctcgata aagtccggaa aggaatctga 900
<210> 343
<211> 38
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 343
Asp Arg Ile Leu Pro Ser Ala Ser Glu Thr Gly Thr Gln Thr Ser Lys
1 5 10 15
Thr Thr Ala Ala Glu Lys Val Leu Asp Tyr Lys Arg Asp Trp Val Lys
20 25 30
Gln Asp Thr Tyr Tyr Asn
35
<210> 344
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 344
Ile Pro Gln Glu Gly Leu
1 5
<210> 345
<211> 21
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 345
Gly Phe Glu Lys Gly Pro Leu Gly Tyr Pro Thr Arg Arg His Ala Thr
1 5 10 15
Val Asn Gly Val Gly
20
<210> 346
<211> 24
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 346
Gly Ala Asp Trp Pro Gly Asp Ala Pro Ser Asn Ser Ser Ala Lys Pro
1 5 10 15
Glu Thr Gly Lys Val Lys Asn Ile
20
<210> 347
<211> 12
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 347
His Gly Asp Thr Pro Glu Ile Glu Glu Glu Phe Asp
1 5 10
<210> 348
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 348
Ile Asp Leu Leu Thr Pro Asn Asp Asp Gly Arg Ala Thr Lys Pro Arg
1 5 10 15
Asn
<210> 349
<211> 35
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 349
Pro Lys Pro Thr Pro Ala Pro Pro Ser Asp Pro Ala Pro Arg Pro Ile
1 5 10 15
Pro Pro Lys Glu Thr Leu Val Pro Thr Thr Leu Asp Thr Val Leu Pro
20 25 30
Ser Leu Val
35
<210> 350
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 350
Gly Ser Gly Glu Ser Gly Glu Leu Ser
1 5
<210> 351
<211> 20
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 351
Asn Gly Gly Ser Gly Asp Ser Gly Glu Leu Thr Val Ala Asp Val Lys
1 5 10 15
Ala Leu His Asp
20
<210> 352
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 352
Lys Asn Thr Asn Lys Gly Glu Leu Ser
1 5
<210> 353
<211> 12
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 353
Gly Gly Ala Thr Asn Pro Asp Glu Leu Glu Leu Thr
1 5 10
<210> 354
<211> 71
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 354
Ala Ser Leu Ala Glu Asn Gln Arg Ala Asp Tyr Met Ala Arg Ala Gln
1 5 10 15
Ala Tyr Phe Asp Gly Ala Pro Val Thr Gly Arg Ser Ser Val Pro Ala
20 25 30
Pro Ala Pro Ala Pro Ala Gly Ile His Val Asp Leu Pro Ala Trp Thr
35 40 45
Leu Pro Ala Gly Asn Phe Tyr Gly Ser Ile Asp Gly Gly Glu Asp Ser
50 55 60
His Gly Gly Tyr Tyr Glu Gly
65 70
<210> 355
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 355
Leu Thr Asp Asp Leu Gln Gly Gly Asp Asp Met Pro Leu Ser
1 5 10
<210> 356
<211> 71
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 356
Ala Ser Leu Ala Arg Asp Gln Leu Gly Asp Tyr Met Gly Arg Ala Gln
1 5 10 15
Ala Tyr Phe Asp Gly Ala Pro Val Ala Ala Val His Gln Ser Val Pro
20 25 30
Ala Pro Ala Pro Ala Pro Ser Arg His Val Asp Leu Pro Ala Trp Asn
35 40 45
Leu Pro Glu Gly Asn Phe Tyr Gly Leu Val Ser Gly Gly Asn Asp Ser
50 55 60
His Gly Gly Phe Tyr Pro Ala
65 70
<210> 357
<211> 28
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 357
Ala Ile Ala Lys Gln Met Val Gly Ala Thr Thr Thr Gly Arg Leu Ser
1 5 10 15
Asn Asp Cys Val Thr Gly Thr Ala Asn Glu Thr Gly
20 25
<210> 358
<211> 32
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 358
Arg Ala Gln Ala Tyr Tyr Asp Gly Thr Ser Val Ala Ala Ala Pro Ala
1 5 10 15
Ala Pro Ser Ala Pro Ala Gly Ile His Val Asp Leu Pro Ser Trp Thr
20 25 30
<210> 359
<211> 47
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 359
Arg Ala Gln Ala Tyr Tyr Asp Gly Ala Pro Val Ala Ala Val His Gln
1 5 10 15
Ser Ala Pro Ala Pro Ala Pro Ala Ser Ser Arg His Val Asp Leu Pro
20 25 30
Ala Trp Asn Leu Pro Glu Gly Asn Phe Tyr Gly Leu Ala Ser Gly
35 40 45
<210> 360
<211> 68
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 360
Gly Ala Tyr Ala Tyr Ser Gly Glu Ser Tyr Thr Gly Thr Asn Thr Glu
1 5 10 15
Gly Ser Tyr Gly Ser Ser Tyr Asp Thr Ser Ala Gln Asp Ala Ser Tyr
20 25 30
Asp Gly Ser Tyr Ser Tyr Asp Asn Ser Tyr Ser Tyr Asp Asn Ser Ala
35 40 45
Gly Tyr Asp Ser Ser Ser Ala Tyr Ser Gly Gly Tyr Gln Ala Thr Arg
50 55 60
Glu Ala Thr Gly
65
<210> 361
<211> 52
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 361
Val Thr Ala Ala Gln Leu Arg Ala Gly Lys Arg Gly Ile Cys Ser His
1 5 10 15
Val Ala Val Ser Asp Ala Phe Gly Gln Ser Asp His Gly Asp Pro Glu
20 25 30
Val Ala Gly Pro Phe Pro Trp Ala Lys Phe Met Gln Leu Ile Lys Glu
35 40 45
Glu Asp Asp Met
50
<210> 362
<211> 20
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 362
Tyr Phe Pro Trp Asn Glu Phe Ile Ala Ala Val Gln Gly Lys Thr Thr
1 5 10 15
Thr Pro Glu Gly
20
<210> 363
<211> 40
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 363
Trp Phe Pro Trp Asp Lys Phe Met Ala Val Val Asn Gly His Gly Gly
1 5 10 15
Gly Ser Ser Ser Glu Glu Leu Ser Met Ala Asp Val Gln Ala Leu His
20 25 30
Asn Gln Ile Lys Gln Leu Ser Ala
35 40
<210> 364
<211> 23
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 364
Tyr Phe Pro Trp Asp Gln Phe Met Ala Leu Val Gln Gly Lys Pro Ala
1 5 10 15
Thr Pro Gly Asp Leu Thr Met
20
<210> 365
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 365
Tyr Phe Pro Trp Asp Gly Phe Ile Ala Leu Val Asn Gly His Ser Ala
1 5 10 15
Pro Ser Arg Gln Glu Glu Leu Thr Val Ser Asp
20 25
<210> 366
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 366
Asp Phe Pro Trp Ala Glu Phe Met Ala Ala Val Lys Gly Gly Thr Thr
1 5 10 15
Thr Gln Glu Asp Glu Asp Glu Met Lys Glu Ala
20 25
<210> 367
<211> 13
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 367
Thr Phe Pro Trp Asp Gln Phe Ile Lys Glu Val Arg Thr
1 5 10
<210> 369
<211> 114
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 369
gaccgaatcc ttccttcagc ctctgagaca ggcacacaga catcgaaaac gacggctgcg 60
gagaaggtcc tggattataa gcgagactgg gtgaagcagg acacctacta taac 114
<210> 369
<211> 18
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 369
attcctcagg aaggacta 18
<210> 370
<211> 63
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 370
ggattcgaga agggaccgct cggctacccg acgcgccgtc acgccacggt caacggtgtc 60
ggc 63
<210> 371
<211> 72
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 371
ggtgcagact ggccgggtga tgcgccctca aattcgagcg cgaaaccgga aacggggaag 60
gtcaaaaaca tc 72
<210> 372
<211> 36
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 372
catggggaca ccccagaaat agaggaggag ttcgat 36
<210> 373
<211> 51
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 373
atcgacctgc tgacccccaa cgacgatggc cgggcgacga agccccgcaa c 51
<210> 374
<211> 105
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 374
ccgaagccga cgcccgcccc gccgtcggat ccggcgcccc gtccgattcc cccgaaggag 60
actctggtgc ccaccacgct cgacaccgtc ctgccgtcgc tcgtc 105
<210> 375
<211> 27
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 375
ggcagtggag agagtggaga gttgagt 27
<210> 377
<211> 60
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 377
aacggcggta gtggagatag tggggagtta actgtggctg atgtgaaagc cttgcatgat 60
<210> 378
<211> 27
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 378
aaaaacacca acaagggaga actcagc 27
<210> 378
<211> 36
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 378
ggcggcgcca ccaaccccga tgaactggag ctcaca 36
<210> 379
<211> 213
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 379
gcctcgcttg ccgagaatca gcgcgcggat tacatggcgc gcgctcaggc ctatttcgat 60
ggcgctcccg tcacaggccg ttcttcggtc cctgcaccgg ctccggcgcc tgccgggatc 120
catgtggacc tgcctgcctg gactctcccc gcaggcaact tttacgggtc gatcgatggc 180
ggcgaggact cgcatggcgg ctactacgag ggt 213
<210> 380
<211> 42
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 380
ctcaccgacg atctccaagg aggagacgac atgcccctgt ca 42
<210> 381
<211> 213
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 381
gcgtcgctgg cccgggacca gctcggcgac tacatggggc gcgcacaagc ctacttcgat 60
ggcgcgccgg tggctgcggt ccatcagtcg gtccctgccc ccgccccagc gcccagccgt 120
catgtggacc tgcccgcgtg gaatctcccc gagggcaact tctacggcct cgtcagcggc 180
ggaaacgact cccacggcgg cttctatccc gcc 213
<210> 382
<211> 84
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 382
gccatcgcca aacagatggt gggagccacc accacagggc gcctgtccaa cgactgtgtc 60
accgggaccg ctaacgaaac cggc 84
<210> 383
<211> 96
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 383
cgggctcagg cctactacga cggcacttca gtggctgccg cacctgctgc cccgtcggca 60
cctgccggga tccacgtcga tcttccgagc tggacc 96
<210> 384
<211> 141
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 384
cgggctcagg cctactacga cggcgcgccg gtggctgcgg tccatcagtc ggcacctgcc 60
cccgccccag cgtccagccg tcacgtggac ctgcccgcgt ggaatctccc cgagggcaac 120
ttctacggcc tggcgagcgg t 141
<210> 385
<211> 204
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 385
ggcgcgtacg cctactccgg tgaaagctac accggcacca acaccgaggg ttcctacggc 60
tcttcgtacg acacgtcggc ccaggacgcc tcctacgacg gctcgtactc gtatgacaac 120
tcgtactcgt acgacaacag cgccgggtac gactcgtcct ccgcctactc cggcggctac 180
caggccactc gtgaggccac tggc 204
<210> 386
<211> 156
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 386
gtgaccgccg cgcagctcag ggcgggcaag cgcggcatct gctcgcatgt cgcggtcagc 60
gacgcgttcg ggcagtccga ccacggcgat cccgaggtcg ccgggccgtt cccctgggcg 120
aagttcatgc agctcatcaa ggaggaggac gacatg 156
<210> 387
<211> 60
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 387
tatttccctt ggaatgaatt tattgccgcc gtccaaggaa aaaccaccac accagaggga 60
<210> 388
<211> 120
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 388
tggtttccgt gggacaaatt tatggctgtg gtgaatggcc acggcggcgg ttcaagtagt 60
gaggagttga gtatggctga tgtacaagcg ttacataatc agattaaaca gttgtcggca 120
<210> 389
<211> 69
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 389
tacttcccgt gggaccagtt catggcactc gtccaaggaa aacccgccac accaggagat 60
ctcaccatg 69
<210> 390
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 390
tatttcccgt gggacgggtt tatcgcgctt gttaatggcc attccgcacc atcacgccag 60
gaggaactaa ctgtgtcaga t 81
<210> 391
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 391
gacttcccgt gggccgaatt catggcagcc gtcaaaggcg gcaccaccac acaggaagat 60
gaggatgaaa tgaaggaagc t 81
<210> 392
<211> 39
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 392
acattcccgt gggaccaatt catcaaagag gttagaaca 39
<210> 394
<211> 5
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 394
Pro Ala Pro Ala Pro
1 5
<210> 394
<211> 12
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 394
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala
1 5 10
<210> 395
<211> 17
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 395
Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp
1 5 10 15
Val
<210> 396
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 396
Pro Leu Gly Leu Trp Ala
1 5
<210> 397
<211> 6
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 397
Arg Val Leu Ala Glu Ala
1 5
<210> 398
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 398
Glu Asp Val Val Cys Cys Ser Met Ser Tyr
1 5 10
<210> 399
<211> 8
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 399
Gly Gly Ile Glu Gly Arg Gly Ser
1 5
<210> 400
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 400
Thr Arg His Arg Gln Pro Arg Gly Trp Glu
1 5 10
<210> 401
<211> 10
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 401
Ala Gly Asn Arg Val Arg Arg Ser Val Gly
1 5 10
<210> 402
<211> 9
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 402
Arg Arg Arg Arg Arg Arg Arg Arg Arg
1 5
<210> 403
<211> 4
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 403
Gly Phe Leu Gly
1
<210> 404
<211> 18
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 404
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser
1 5 10 15
Leu Asp
<210> 405
<211> 14
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 405
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr
1 5 10
<210> 406
<211> 12
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 406
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe
1 5 10
Claims (38)
1.一种噬菌体裂解酶或其嵌合物在制备预防、治疗或改善痤疮或由痤疮丙酸杆菌引起的感染或与痤疮丙酸杆菌有关的病症的药物、化妆品或医疗设备中的应用，其特征在于，所述噬菌体裂解酶包括来源于类诺卡氏菌科(Nocardioidaceae)或丙酸杆菌科(Propionibacteriaceae)细菌的噬菌体裂解酶。
2.根据权利要求1所述的应用，其特征在于，所述类诺卡氏菌科(Nocardioidaceae)细菌包括微白霜菌属(Micropruina)、产丙酸单孢菌属(Propionicimonas)、产丙酸细胞菌属(Propionicicella)、弗莱德门氏菌属(Friedmanniella)细菌；所述丙酸杆菌科(Propionibacteriaceae)细菌包括产丙酸菌属(Propioniferax)、海马球菌属(Mariniluteicoccus)、颗粒球菌属(Granulicoccus)、瑙曼氏菌属(Naumannella)、棒状丙酸菌属(Propioniciclava)、光球菌属(Auraticoccus)、小月菌属(Microlunatus)、河口微菌属(Aestuariimicrobium)、黄球菌属(Luteococcus)、四合球菌属(Tessaracoccus)、布克劳氏菌属(Brooklawnia)、产丙酸微球菌属(Propionimicrobium)、丙酸杆菌属(Propionibacterium)、痤疮丙酸杆菌属(Cutibacterium)、酸性丙酸杆菌属(Acidipropionibacterium)、或假丙酸杆菌属(Pseudopropionibacterium)细菌；
优选丙酸杆菌属(Propionibacterium)、痤疮丙酸杆菌属(Cutibacterium)、酸性丙酸杆菌属(Acidipropionibacterium)、或假丙酸杆菌属(Pseudopropionibacterium)细菌。
3.根据权利要求1所述的应用，其特征在于，所述噬菌体裂解酶包括来源于痤疮丙酸杆菌(Cutibacterium acnes)、肱丙酸杆菌(Propionibacterium humerusii)、贪婪丙酸杆菌(Cutibacterium avidum)、颗粒丙酸杆菌(Cutibacterium granulosum)、特氏丙酸杆菌(Acidipropionibacterium thoenii)、詹氏丙酸杆菌(Acidipropionibacteriumjensenii)、产丙酸丙酸杆菌(Acidipropionibacterium acidipropionici)、潮汐滩菌(Aestuariimicrobium kwangyangense)、细粒球菌(Granulicoccus phenolivorans)、积磷小月菌(Microlunatus phosphovorus)、丙酸丙酸杆菌(Pseudopropionibacteriumpropionicum)、四合球菌(Tessaracoccus sp.)、极底产丙酸细胞菌(Propionicicellasuperfundia)、费氏丙酸杆菌(Propionibacterium freudenreichii)、费氏丙酸杆菌费氏亚种(Propionibacterium freudenreichii subsp.freudenreichii)、费氏丙酸杆菌舍氏亚种(Propionibacterium freudenreichii subsp.shermanii)、产酸丙酸杆菌(Propionibacterium acidifaciens)、嗜淋巴丙酸杆菌(Propionibacteriumlymphophilum)、丙酸杆菌属细菌(Propionibacteriaceae bacterium)、丙酸杆菌分类群192(Propionibacterium sp.oral taxon 192)、无毒产丙酸菌(Propioniferax innocua)、盐藻瑙曼氏菌(Naumannella halotolerans)、慢生棒状丙酸菌(Propioniciclava tarda)、糖原微白霜菌(Micropruina glycogenica)、淡水产丙酸单孢菌(Propionicimonaspaludicola)、纪念性光球菌(Auraticoccus monumenti)、日本黄球菌(Luteococcusjaponicus)、油田四合球菌(Tessaracoccus oleiagri)、本迪戈四合球菌(Tessaracoccusbendigoensis)、拉帕迪卡四合球菌(Tessaracoccus lapidicaptus)、微嗜气丙酸杆菌(Acidipropionibacterium microaerophilum)、橄榄体丙酸杆菌(Acidipropionibacterium olivae)、或丹诺氏丙酸杆菌(Acidipropionibacteriumdamnosum)细菌的噬菌体裂解酶。
4.根据权利要求1所述的应用，其特征在于，所述噬菌体裂解酶包括来源于詹氏丙酸杆菌(Acidipropionibacterium jensenii)、特氏丙酸杆菌(Acidipropionibacteriumthoenii)、产丙酸丙酸杆菌(Acidipropionibacterium acidipropionici)、微嗜气丙酸杆菌(Acidipropionibacterium microaerophilum)、橄榄体丙酸杆菌(Acidipropionibacterium olivae)、丹诺氏丙酸杆菌(Acidipropionibacteriumdamnosum)、痤疮丙酸杆菌(Cutibacterium acnes)、贪婪丙酸杆菌(Cutibacteriumavidum)、颗粒丙酸杆菌(Cutibacterium granulosum)、或丙酸丙酸杆菌(Pseudopropionibacterium propionicum)细菌的噬菌体裂解酶。
5.根据权利要求1所述的应用，其特征在于，所述噬菌体裂解酶具有SEQ ID NO:1～SEQID NO:28任一所示的氨基酸序列。
6.根据权利要求1所述的应用，其特征在于，所述噬菌体裂解酶具有SEQ ID NO:10所示的氨基酸序列。
7.根据权利要求1所述的应用，其特征在于，所述噬菌体裂解酶具有SEQ ID NO:29～SEQ ID NO:56任一所示的核苷酸序列。
8.根据权利要求1所述的应用，其特征在于，所述噬菌体裂解酶具有SEQ ID NO:38所示的核苷酸序列。
9.根据权利要求1所述的应用，其特征在于，所述嵌合物包含噬菌体裂解酶的催化结构域，或包含噬菌体裂解酶的催化结构域和结合结构域的组合。
10.根据权利要求9所述的应用，其特征在于，所述催化结构域具有全C-末端接头、半C-末端接头、无C-末端接头、或所述接头的任何部分；所述结合结构域具有全N-末端接头、半N-末端接头、无N-末端接头、或所述接头的任何部分。
11.根据权利要求9所述的应用，其特征在于，所述催化结构域包括一个、两个或两个以上的催化结构域。
12.根据权利要求9所述的应用，其特征在于，所述结合结构域包括一个、两个或两个以上的结合结构域。
13.根据权利要求9所述的应用，其特征在于，所述嵌合物进一步包含催化结构域和结合结构域之间的接头，所述接头包括：
1)SEQ ID NO:343～SEQ ID NO:367任一所示的氨基酸序列；
2)SEQ ID NO:368～SEQ ID NO:392任一所示的氨基酸序列；
3)SEQ ID NO:393～SEQ ID NO:406任一所示的氨基酸序列；或
4)(GGGS)n、(GGGGS)n、(GGGGGS)n、(Gly)3-8、(EAAAK)n、(Ala-Pro)n、或A(EAAAK)nALEA(EAAAK)nA，其中1≤n≤15，n为整数。
14.根据权利要求9所述的应用，其特征在于，所述嵌合物包括所述催化结构域具有SEQID NO:57、SEQ ID NO:58、SEQ ID NO:59、SEQ ID NO:61、SEQ ID NO:62、SEQ ID NO:63、SEQID NO:64、SEQ ID NO:65、SEQ ID NO:66、SEQ ID NO:67、SEQ ID NO:69、SEQ ID NO:70、SEQID NO:71、SEQ ID NO:73、SEQ ID NO:74、SEQ ID NO:77、SEQ ID NO:80、SEQ ID NO:81、SEQID NO:85、SEQ ID NO:86、SEQ ID NO:87、SEQ ID NO:91、SEQ ID NO:93、SEQ ID NO:95、SEQID NO:97、SEQ ID NO:98、SEQ ID NO:99、SEQ ID NO:100、SEQ ID NO:102、SEQ ID NO:104、SEQ ID NO:105、SEQ ID NO:106、SEQ ID NO:107、SEQ ID NO:108、SEQ ID NO:110、SEQ IDNO:111、SEQ ID NO:113、SEQ ID NO:114、SEQ ID NO:117、SEQ ID NO:118、SEQ ID NO:121、SEQ ID NO:122、SEQ ID NO:125、SEQ ID NO:127、SEQ ID NO:128、SEQ ID NO:131、SEQ IDNO:132、SEQ ID NO:133、SEQ ID NO:135、或SEQ ID NO:136中所示的氨基酸序列；
所述结合结构域具有SEQ ID NO:60、SEQ ID NO:62、SEQ ID NO:68、SEQ ID NO:72、SEQID NO:75、SEQ ID NO:76、SEQ ID NO:78、SEQ ID NO:79、SEQ ID NO:82、SEQ ID NO:83、SEQID NO:84、SEQ ID NO:88、SEQ ID NO:89、SEQ ID NO:90、SEQ ID NO:92、SEQ ID NO:94、SEQID NO:96、SEQ ID NO:101、SEQ ID NO:103、SEQ ID NO:109、SEQ ID NO:112、SEQ ID NO:115、SEQ ID NO:116、SEQ ID NO:119、SEQ ID NO:120、SEQ ID NO:123、SEQ ID NO:124、SEQID NO:126、SEQ ID NO:129、SEQ ID NO:130、SEQ ID NO:134、SEQ ID NO:137、SEQ ID NO:138、或SEQ ID NO:139所示的氨基酸序列。
15.根据权利要求9所述的应用，其特征在于，所述催化结构域具有SEQ ID NO:140、SEQID NO:141、SEQ ID NO:142、SEQ ID NO:144、SEQ ID NO:146、SEQ ID NO:147、SEQ ID NO:148、SEQ ID NO:149、SEQ ID NO:150、SEQ ID NO:152、SEQ ID NO:153、SEQ ID NO:154、SEQID NO:156、SEQ ID NO:157、SEQ ID NO:160、SEQ ID NO:163、SEQ ID NO:164、SEQ ID NO:168、SEQ ID NO:169、SEQ ID NO:170、SEQ ID NO:174、SEQ ID NO:176、SEQ ID NO:178、SEQID NO:180、SEQ ID NO:181、SEQ ID NO:182、SEQ ID NO:183、SEQ ID NO:185、SEQ ID NO:187、SEQ ID NO:188、SEQ ID NO:189、SEQ ID NO:190、SEQ ID NO:191、SEQ ID NO:193、SEQID NO:194、SEQ ID NO:196、SEQ ID NO:197、SEQ ID NO:200、SEQ ID NO:201、SEQ ID NO:204、SEQ ID NO:205、SEQ ID NO:208、SEQ ID NO:210、SEQ ID NO:211、SEQ ID NO:214、SEQID NO:215、SEQ ID NO:216、SEQ ID NO:218、SEQ ID NO:219所示的核苷酸序列；
所述结合结构域具有SEQ ID NO:143、SEQ ID NO:145、SEQ ID NO:151、SEQ ID NO:155、SEQ ID NO:158、SEQ ID NO:159、SEQ ID NO:161、SEQ ID NO:162、SEQ ID NO:165、SEQID NO:166、SEQ ID NO:167、SEQ ID NO:171、SEQ ID NO:172、SEQ ID NO:173、SEQ ID NO:175、SEQ ID NO:177、SEQ ID NO:179、SEQ ID NO:184、SEQ ID NO:186、SEQ ID NO:192、SEQID NO:195、SEQ ID NO:198、SEQ ID NO:199、SEQ ID NO:202、SEQ ID NO:203、SEQ ID NO:206、SEQ ID NO:207、SEQ ID NO:209、SEQ ID NO:212、SEQ ID NO:213、SEQ ID NO:217、SEQID NO:220、SEQ ID NO:221、或SEQ ID NO:222所示的核苷酸序列。
16.根据权利要求9所述的应用，其特征在于，所述嵌合物具有SEQ ID NO:223～SEQ IDNO:282中任一所示的氨基酸序列；优选SEQ ID NO:258、SEQ ID NO:259、SEQ ID NO:260、SEQ ID NO:271或SEQ ID NO:272所示的氨基酸序列；更优选SEQ ID NO:260或SEQ ID NO:271所示的氨基酸序列。
17.根据权利要求9所述的应用，其特征在于，所述嵌合物具有SEQ ID NO:283～SEQ IDNO:342中任一所示的核苷酸序列；优选SEQ ID NO:316、SEQ ID NO:317、SEQ ID NO:318、SEQ ID NO:329或SEQ ID NO:330所示的核苷酸序列；更优选SEQ ID NO:318或SEQ ID NO:329所示的核苷酸序列。
18.根据权利要求1所述的应用，其特征在于，所述由痤疮丙酸杆菌引起的感染包括侵入性感染、术后感染和/或器械相关的感染。
19.根据权利要求18所述的应用，其特征在于，所述器械相关的感染包括关节假体、分流管和人工心脏瓣膜相关的感染。
20.根据权利要求18所述的应用，其特征在于，所述感染包括骨骼和/或关节的感染，尤其是术后肩部感染，以及口腔、眼、椎间盘和脑部的感染。
21.根据权利要求1所述的应用，其特征在于，所述与痤疮丙酸杆菌有关的病症包括导致癌症的前列腺炎、SAPHO(滑膜炎、痤疮、脓疱病、肥大、骨炎)综合征、结节病、或坐骨神经痛。
22.根据权利要求1所述的应用，其特征在于，所述医疗设备包括用于将裂解酶或其嵌合物释放到受影响区域的任何设备，优选施加至皮肤表面的夹具或贴剂或喷雾剂，使用微针增强裂解酶或其嵌合物的皮肤渗透性的设备，美容专业人员使用的将裂解酶或其嵌合物专门施加至受痤疮影响的毛囊上的细针，或其他类似的设备。
23.根据权利要求1所述的应用，其特征在于，所述医疗设备包括将将裂解酶或其嵌合物固定在易于感染痤疮丙酸杆菌的位置中的假体装置上，优选用于特别容易感染痤疮丙酸杆菌的肩部手术中的假体植入物。
24.一种权利要求1～23任一所述应用中的噬菌体裂解酶嵌合物，所述嵌合物具有SEQID NO:223～SEQ ID NO:282中任一所示的氨基酸序列；优选SEQ ID NO:258、SEQ ID NO:259、SEQ ID NO:260、SEQ ID NO:271或SEQ ID NO:272所示的氨基酸序列，更优选SEQ IDNO:260或SEQ ID NO:271所示的氨基酸序列。
25.根据权利要求24所述的嵌合物，其特征在于，所述嵌合物具有SEQ ID NO:283～SEQID NO:342中任一所示的核苷酸序列，优选SEQ ID NO:316、SEQ ID NO:317、SEQ ID NO:318、SEQ ID NO:329或SEQ ID NO:330所示的核苷酸序列，更优选SEQ ID NO:318或SEQ IDNO:329所示的核苷酸序列。
26.一种权利要求1～23任一所述应用中的或权利要求24～25任一所述的嵌合物的制备方法，其特征在于，所述方法包括：
(1)合成结构域序列及扩增结构域序列的引物；
(2)采用Taq DNA聚合酶PCR扩增结构域序列；
(3)PCR产物凝胶纯化，与表达质粒pET28连接；
(4)重组质粒转移到大肠杆菌BL21(DE3)；
(5)培养含有重组质粒的大肠杆菌BL21(DE3)，诱导表达，离心收集细胞，裂解，纯化得到所述嵌合物。
27.根据权利要求26所述的制备方法，其特征在于，所述方法进一步包括：
将含有重组嵌合裂解酶表达质粒的大肠杆菌BL21(DE3)置于自诱导培养基中在37℃、300rpm下培养至OD600达到0.6-0.8，随后在18℃、300rpm下，持续培养16-18小时；离心收集细胞，重悬于50mM pH 7.4的磷酸钠中，高压均质裂解；裂解液再次离心以收集可溶性粗裂解液。将可溶性组分与等体积的5M NaCl混合，混合物上样到疏水柱中；上样后，用5倍柱体积的20mM磷酸钠(pH 7.4)、2.5M NaCl洗涤柱子；然后用10mM磷酸钠(pH 7.4)洗脱重组嵌合裂解酶。
28.含有权利要求1～23任一所述应用中的噬菌体裂解酶或其嵌合物，或权利要求24～25任一所述的嵌合物的制剂，其特征在于，所述制剂进一步包含抗生素、其他裂解酶、或非活性赋形剂。
29.编码权利要求1～23任一所述应用中的噬菌体裂解酶或其嵌合物，或权利要求24～25任一所述的嵌合物，或权利要求26制备的嵌合物的氨基酸序列，或与前述序列相似度80％及以上、85％及以上、90％及以上、95％及以上或99％及以上的氨基酸序列，或具有相同官能团的替代氨基酸序列。
30.根据权利要求29所述的氨基酸序列，其特征在于，所述替代氨基酸序列为使用同一组氨基酸中的氨基酸的保守替换，所述氨基酸组包括：
脂肪族的：甘氨酸、丙氨酸、缬氨酸、亮氨酸或异亮氨酸；
含羟基或硫/硒的：丝氨酸、半胱氨酸、苏氨酸或甲硫氨酸；
环状的：脯氨酸；
芳族的：苯基丙氨酸、酪氨酸或色氨酸；
碱性的：组氨酸、赖氨酸或精氨酸；或
酸性的以及它们的酰胺：天冬氨酸、谷氨酸、天冬酰胺、谷氨酰胺。
31.编码权利要求1～23任一所述应用中的噬菌体裂解酶或其嵌合物，或权利要求24～25任一所述的嵌合物，或权利要求26制备的嵌合物的核苷酸序列，或其同义密码子序列。
32.权利要求1～23任一所述应用中的噬菌体裂解酶或其嵌合物，或权利要求24～25任一所述的嵌合物，或权利要求26制备的嵌合物用作细菌裂解的试剂的应用，其特征在于，所述细菌裂解用于使用基于PCR的试剂盒进行DNA提取和分型。
33.权利要求1～23任一所述应用中的噬菌体裂解酶或其嵌合物，或权利要求24～25任一所述的嵌合物，或权利要求26制备的嵌合物用作非生物表面上的消毒剂或灭菌剂的应用，其特征在于，所述消毒剂或灭菌剂通过去除浮游形式或生物膜中的痤疮丙酸杆菌以防止感染，优选在手术过程中对手术设备或假体植入装置进行消毒。
34.权利要求1～23任一所述应用中的噬菌体裂解酶或其嵌合物，或权利要求24～25任一所述的嵌合物，或权利要求26制备的嵌合物，或上述分子中的单个结合结构域，或上述分子中的相似或不同的结合结构域串联的组合，在制备用于痤疮丙酸杆菌的诊断工具中的应用，其特征在于，所述裂解酶、嵌合物或结合结构域与信号分子联合使用。
35.根据权利要求34所述的应用，其特征在于，所述裂解酶、嵌合物或结合结构域与信号分子通过基因融合或化学偶联形成融合物。
36.根据权利要求35所述的应用，其特征在于，所述融合物用于通过荧光或其他手段直接检测显微镜载玻片上的痤疮丙酸杆菌，用于通过免疫组织化学标记痤疮丙酸杆菌，用作ELISA测定中的检测试剂，用作Western blot上的检测试剂，用于与在MACS或其他pull-down测定中的磁珠连接，或用于抗体作为检测试剂的测定中的检测试剂。
37.根据权利要求34所述的应用，其特征在于，所述信号分子包括蛋白质或化学荧光染料、蛋白质标签、酶、抗生物素蛋白、链霉亲和素、卵清蛋白、生物素、对点击化学标记敏感的标签、内含肽、或能够引起产生信号的二级蛋白质或分子募集的其他分子，
所述荧光染料包括GFP、RFP、mCherry、FITC、TRITC、Alexafluor 488、Cy3或Cy5；
所述蛋白质标签包括Flag-标签、myc-标签、halo-标签、his-标签、或能够与抗体或其他高亲和力分子结合产生信号的任何其他标签；
所述酶包括萤火虫荧光素酶、β-内酰胺酶、碱性磷酸酶、辣根过氧化物酶、或引起诸如光、颜色变化、底物沉积或其他能够在试验中检测到的反应的任何其他的酶。
38.权利要求1～23任一所述应用中的噬菌体裂解酶或其嵌合物，或权利要求24～25任一所述的嵌合物，或权利要求26制备的嵌合物中的催化结构域在制备治疗痤疮丙酸杆菌感染的药物中的应用，其特征在于，所述催化结构域与寻靶模块结合。
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