BR112012026880A2 - método de redução de biofilmes - Google Patents
método de redução de biofilmesInfo
- Publication number
- BR112012026880A2 BR112012026880A2 BR112012026880A BR112012026880A BR112012026880A2 BR 112012026880 A2 BR112012026880 A2 BR 112012026880A2 BR 112012026880 A BR112012026880 A BR 112012026880A BR 112012026880 A BR112012026880 A BR 112012026880A BR 112012026880 A2 BR112012026880 A2 BR 112012026880A2
- Authority
- BR
- Brazil
- Prior art keywords
- food
- gram
- present
- relates
- biofilm
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 5
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 108010062877 Bacteriocins Proteins 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000000645 desinfectant Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
método de redução de biofilmes a presente invenção refere-se a métodos de eliminação , redução ou prevenção de biofilmes bacterianos através de uma proteína de fusão que compreende uma endolisina, uma endolisina, uma entolisina ou uma bacteriocina à qual um peptídeo com membrana ou lps que interrompe atividade é fundido. ainda, a presente invenção refere-se a proteínas de fusão para uso como um medicamento , em paricular para o tratamento ou para a prevenção de infecções causadas por bactérias gram-popsitivas e/ou gram-negativas associadas ao biofilme bacteriano, como um meio para diagnóstico, desinfetante ou como substância cosmética. a presente invenção refere-se ainda à remoção ou à redução ou à prevenção de contaminação por bactérias gram-negativa e/ou gram-positiva associadas ao biofilme bacteriano de matéria alimentícia, de equipamento para processamento de alimentos, de plantas de processamento de alimentos, de superfície que entram em contato com matéria alimentícia , de dispositivos médicos, de superfície em hospitais e cirurgia. além disso , a presente invenção refere-se ao uso da dita proteína de fusão como um meio para diagnóstico em diagnósticos médicos, de alimentos ou produtos alimentícios ou ambientais associados ao biofilme bacteriano.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10161170.5 | 2010-04-27 | ||
| EP10161170 | 2010-04-27 | ||
| PCT/EP2011/056657 WO2011134998A1 (en) | 2010-04-27 | 2011-04-27 | Method of reducing biofilms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012026880A2 true BR112012026880A2 (pt) | 2015-09-22 |
| BR112012026880B1 BR112012026880B1 (pt) | 2021-03-16 |
Family
ID=44201821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012026880-5A BR112012026880B1 (pt) | 2010-04-27 | 2011-04-27 | método para eliminação ou redução de um biofilme bacteriano, variante de endolisina ou variante de bacteriocina e seus usos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9534223B2 (pt) |
| EP (1) | EP2563916B1 (pt) |
| JP (2) | JP2013532955A (pt) |
| KR (1) | KR20130100062A (pt) |
| CN (1) | CN103119158B (pt) |
| AU (1) | AU2011247584B2 (pt) |
| BR (1) | BR112012026880B1 (pt) |
| CA (1) | CA2794603C (pt) |
| DK (1) | DK2563916T3 (pt) |
| EA (1) | EA037276B1 (pt) |
| HK (1) | HK1183687A1 (pt) |
| IL (1) | IL222713A (pt) |
| MX (1) | MX340520B (pt) |
| SG (1) | SG184836A1 (pt) |
| TW (1) | TWI527521B (pt) |
| WO (1) | WO2011134998A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| WO2010149795A1 (en) | 2009-06-26 | 2010-12-29 | Lysando Holding Establishment | Antimicrobial agents |
| EA037202B1 (ru) | 2009-06-26 | 2021-02-18 | Катхолике Университейт Лёвен, К.У. Лёвен Р Энд Д | Слитые белки для лечения инфекций, вызванных грамотрицательными бактериями |
| US8846865B2 (en) * | 2009-08-24 | 2014-09-30 | Lysando Ag | Endolysin OBPgpLYS |
| US9534223B2 (en) * | 2010-04-27 | 2017-01-03 | Lysando Ag | Method of reducing biofilms |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| PL2705144T3 (pl) * | 2011-05-04 | 2016-12-30 | Polipeptyd | |
| KR102141254B1 (ko) * | 2012-03-23 | 2020-08-04 | 아미크로베, 인코포레이티드. | 조직-적합성 특성을 갖는 항균물질의 조성물 및 용도 |
| CA3187222A1 (en) * | 2012-05-09 | 2013-11-14 | Contrafect Corporation | Biofilm prevention, disruption and treatment with bacteriophage lysin |
| EP2679677A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria therapy |
| WO2014001571A1 (en) * | 2012-06-29 | 2014-01-03 | Lysando Ag | Composition for use in mycobacteria diagnosis |
| CN102949750B (zh) * | 2012-11-15 | 2014-11-05 | 中国人民解放军第三军医大学 | 双层电纺仿生骨膜及其制备 |
| DE102013106455A1 (de) * | 2013-06-20 | 2014-12-24 | Airbus Defence and Space GmbH | Verfahren zur Dekontamination von bakteriologischen Verunreinigungen |
| US10203329B2 (en) | 2013-09-12 | 2019-02-12 | The Johns Hopkins University | Biofilm formation to define risk for colon cancer |
| WO2015070912A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| WO2015070911A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| US10329550B2 (en) | 2014-02-14 | 2019-06-25 | Lysando Ag | Antimicrobial agents |
| WO2015155244A1 (en) * | 2014-04-08 | 2015-10-15 | Lysando Ag | Pharmaceutical composition against chronic bacterial infections |
| GB2543453A (en) | 2014-06-26 | 2017-04-19 | Univ Rockefeller | Acinetobacter lysins |
| CN114605507A (zh) * | 2014-09-01 | 2022-06-10 | 弗拉芒区生物技术研究所 | 突变csgg孔 |
| WO2016130024A1 (en) * | 2015-02-13 | 2016-08-18 | Supreme Biotechnologies Limited | Endolysin expression platform |
| TW201710282A (zh) * | 2015-09-04 | 2017-03-16 | 佛教慈濟醫療財團法人 | 衍生自鮑氏不動桿菌噬菌體之新穎抗菌胜肽及其用途 |
| CN117224709A (zh) * | 2016-05-12 | 2023-12-15 | 宾夕法尼亚州立大学托管会 | 用于抑制生物膜沉积和产生的组合物和方法 |
| CN106854247A (zh) * | 2016-12-12 | 2017-06-16 | 华南农业大学 | 一种可以裂解大肠杆菌及沙门氏菌的噬菌体裂解酶的制备方法 |
| KR102503567B1 (ko) * | 2016-12-16 | 2023-02-24 | 유니베르시다데 도 미노 | 신규한 엔돌리신 |
| EP3378485A1 (en) * | 2017-03-24 | 2018-09-26 | Nomad Bioscience GmbH | Bacteriocins for control of salmonella enterica |
| AU2018249552A1 (en) | 2017-04-06 | 2019-10-31 | Amicrobe, Inc. | Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety |
| JP2020528898A (ja) | 2017-07-27 | 2020-10-01 | ローカス アイピー カンパニー、エルエルシー | 医薬品、サプリメント及び摂取物質のバイオアベイラビリティを増進する組成物 |
| CN111212569A (zh) | 2017-08-31 | 2020-05-29 | 辛格隆股份公司 | 用于制备细菌素和抗微生物肽的方法和组合物 |
| CN107723280B (zh) * | 2017-11-10 | 2019-09-17 | 扬州大学 | 波罗的海希瓦氏菌噬菌体SppYZU01及其用途 |
| EP3723789A4 (en) * | 2017-12-12 | 2021-12-01 | Contrafect Corporation | LYSINES AND THEIR BACTERICIDAL DERIVATIVES AGAINST PSEUDOMONAS AERUGINOSA, IN THE PRESENCE OF HUMAN SERUM |
| CA3086033A1 (en) | 2017-12-26 | 2019-07-04 | Locus Ip Company, Llc | Organic food preservative compositions |
| CN108251330B (zh) * | 2017-12-28 | 2021-03-23 | 江苏世邦生物工程科技有限公司 | 用于治理土壤污染的复合微生物菌剂及其制备方法和应用 |
| CA3085343A1 (en) | 2017-12-28 | 2019-07-04 | Locus Ip Company, Llc | Oral health composition comprising purified biosurfactants and/or their derivatives |
| AU2019276253A1 (en) | 2018-05-30 | 2020-11-26 | Lysando Ag | Novel antimicrobial proteins |
| EP3802620A1 (en) | 2018-05-30 | 2021-04-14 | Lysando AG | Novel antimicrobial fusion proteins |
| CN113795577A (zh) * | 2019-05-08 | 2021-12-14 | 法戈梅德生物制药有限公司 | 新的加德纳菌内溶素及其用途 |
| WO2020231786A1 (en) * | 2019-05-10 | 2020-11-19 | Locus Ip Company, Llc | Compositions and methods for treating biofilm-related lung conditions |
| ES2895800B2 (es) * | 2019-10-10 | 2024-01-22 | Univ Alicante | USOS DE PROTEINAS VIRICAS CON ACTIVIDAD ANTIBACTERIANA FRENTE A Escherichia coli |
| CN115942932A (zh) | 2020-03-19 | 2023-04-07 | 迈克瑞欧斯人体健康有限公司 | 感兴趣的稳定蛋白 |
| CN111876400B (zh) * | 2020-08-06 | 2022-05-24 | 昆明理工大学 | 一种常温裂解酶Sly和编码此酶的多核苷酸 |
| WO2022166736A1 (zh) * | 2021-02-08 | 2022-08-11 | 武汉乐斯吉生物科技有限公司 | 噬菌体裂解酶、其嵌合物及应用 |
| US11541106B2 (en) * | 2021-03-19 | 2023-01-03 | Eligo Bioscience | Method for killing bacteria with an engineered postbiotic |
| US11633348B2 (en) | 2021-03-19 | 2023-04-25 | Eligo Bioscience | Cosmetic use of engineered postbiotics comprising bacteriocins and/or endolysins |
| WO2023089544A1 (en) * | 2021-11-18 | 2023-05-25 | Sasinapas Co., Ltd. | Pharmaceutical composition comprising an endolysin or an artilysin and an anti-cancer agent |
| KR102551061B1 (ko) * | 2022-05-26 | 2023-07-03 | 중앙대학교 산학협력단 | Saha를 유효성분으로 포함하는 살모넬라 속 균주에 의한 바이오필름 생성 저해용 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8816693D0 (en) | 1988-07-13 | 1988-08-17 | Agricultural & Food Res | Viral enzyme & gene |
| US20020037260A1 (en) * | 1997-10-16 | 2002-03-28 | Budny John A. | Compositions for treating biofilm |
| WO2008030988A2 (en) | 2006-09-06 | 2008-03-13 | The Regents Of The University Of California | Selectively targeted antimicrobial peptides and the use thereof |
| WO2009041832A2 (en) * | 2007-09-25 | 2009-04-02 | Pastoral Greenhouse Gas Research Ltd | Vaccines and vaccine components for inhibition of microbial cells |
| GB0815484D0 (en) * | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| GB0905451D0 (en) | 2009-03-31 | 2009-05-13 | Novabiotics Ltd | Biofilms |
| EA037202B1 (ru) * | 2009-06-26 | 2021-02-18 | Катхолике Университейт Лёвен, К.У. Лёвен Р Энд Д | Слитые белки для лечения инфекций, вызванных грамотрицательными бактериями |
| US9534223B2 (en) * | 2010-04-27 | 2017-01-03 | Lysando Ag | Method of reducing biofilms |
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2011
- 2011-04-27 US US13/643,900 patent/US9534223B2/en active Active
- 2011-04-27 MX MX2012012345A patent/MX340520B/es active IP Right Grant
- 2011-04-27 TW TW100114595A patent/TWI527521B/zh active
- 2011-04-27 BR BR112012026880-5A patent/BR112012026880B1/pt active IP Right Grant
- 2011-04-27 KR KR1020127031100A patent/KR20130100062A/ko not_active Application Discontinuation
- 2011-04-27 DK DK11718001.8T patent/DK2563916T3/en active
- 2011-04-27 JP JP2013506649A patent/JP2013532955A/ja active Pending
- 2011-04-27 WO PCT/EP2011/056657 patent/WO2011134998A1/en active Application Filing
- 2011-04-27 CA CA2794603A patent/CA2794603C/en active Active
- 2011-04-27 AU AU2011247584A patent/AU2011247584B2/en active Active
- 2011-04-27 EP EP11718001.8A patent/EP2563916B1/en active Active
- 2011-04-27 CN CN201180032048.5A patent/CN103119158B/zh active Active
- 2011-04-27 SG SG2012075933A patent/SG184836A1/en unknown
- 2011-04-27 EA EA201270774A patent/EA037276B1/ru not_active IP Right Cessation
-
2012
- 2012-10-25 IL IL222713A patent/IL222713A/en active IP Right Grant
-
2013
- 2013-08-15 HK HK13109541.0A patent/HK1183687A1/xx unknown
-
2016
- 2016-07-19 JP JP2016141499A patent/JP2016208985A/ja active Pending
- 2016-12-20 US US15/384,564 patent/US10485854B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130100062A (ko) | 2013-09-09 |
| WO2011134998A1 (en) | 2011-11-03 |
| EA037276B1 (ru) | 2021-03-03 |
| JP2013532955A (ja) | 2013-08-22 |
| MX340520B (es) | 2016-07-12 |
| AU2011247584B2 (en) | 2016-01-14 |
| BR112012026880B1 (pt) | 2021-03-16 |
| DK2563916T3 (en) | 2015-10-05 |
| US20170173121A1 (en) | 2017-06-22 |
| US10485854B2 (en) | 2019-11-26 |
| CN103119158A (zh) | 2013-05-22 |
| EP2563916A1 (en) | 2013-03-06 |
| CN103119158B (zh) | 2015-04-08 |
| CA2794603C (en) | 2019-05-21 |
| AU2011247584A1 (en) | 2012-10-11 |
| HK1183687A1 (en) | 2014-01-03 |
| US20130052182A1 (en) | 2013-02-28 |
| IL222713A0 (en) | 2012-12-31 |
| EP2563916B1 (en) | 2015-07-08 |
| TW201204262A (en) | 2012-02-01 |
| EA201270774A1 (ru) | 2013-04-30 |
| WO2011134998A8 (en) | 2011-12-15 |
| SG184836A1 (en) | 2012-11-29 |
| IL222713A (en) | 2017-08-31 |
| CA2794603A1 (en) | 2011-11-03 |
| TWI527521B (zh) | 2016-04-01 |
| JP2016208985A (ja) | 2016-12-15 |
| US9534223B2 (en) | 2017-01-03 |
| MX2012012345A (es) | 2013-05-20 |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/04/2011, OBSERVADAS AS CONDICOES LEGAIS. |