MX2009008665A - Procedimiento para la sintesis de compuestos de 2-aminotiazol como inhibidores de quinasa. - Google Patents

Procedimiento para la sintesis de compuestos de 2-aminotiazol como inhibidores de quinasa.

Info

Publication number
MX2009008665A
MX2009008665A MX2009008665A MX2009008665A MX2009008665A MX 2009008665 A MX2009008665 A MX 2009008665A MX 2009008665 A MX2009008665 A MX 2009008665A MX 2009008665 A MX2009008665 A MX 2009008665A MX 2009008665 A MX2009008665 A MX 2009008665A
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
synthesis
group
aminothiazole compounds
inhibitors
Prior art date
Application number
MX2009008665A
Other languages
English (en)
Inventor
Alain Moussy
Philippe Reginault
Francois Bellamy
Anne Lermet
Original Assignee
Ab Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Science filed Critical Ab Science
Publication of MX2009008665A publication Critical patent/MX2009008665A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a un procedimiento industrial para preparar compuestos farmacéuticos de formula I: (ver fórmula (I)) que son útiles como determinados inhibidores de tirosina quinasa y más particularmente como inhibidores de c-kit y bcr-abl. Los grupos R1 y R2, idénticos o diferentes, representan cada uno un átomo de hidrógeno o halógeno, un alquilo, un alcoxi, un trifluorometilo, un amino, un alquilamino, un dialquilamino, un grupo solubilizante; m es 0-5 y n es 0-4; el grupo R3 representa un grupo arilo o heteroarilo como se describe en las reivindicaciones de la presente.
MX2009008665A 2007-02-13 2008-02-13 Procedimiento para la sintesis de compuestos de 2-aminotiazol como inhibidores de quinasa. MX2009008665A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88958707P 2007-02-13 2007-02-13
PCT/EP2008/051704 WO2008098949A2 (en) 2007-02-13 2008-02-13 Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009008665A true MX2009008665A (es) 2009-08-21

Family

ID=39332208

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008665A MX2009008665A (es) 2007-02-13 2008-02-13 Procedimiento para la sintesis de compuestos de 2-aminotiazol como inhibidores de quinasa.

Country Status (23)

Country Link
US (3) US8153792B2 (es)
EP (2) EP2118099B1 (es)
JP (2) JP5568312B2 (es)
KR (1) KR20090110851A (es)
CN (2) CN101657446B (es)
AR (1) AR065337A1 (es)
AT (1) ATE515506T1 (es)
AU (1) AU2008214679A1 (es)
BR (1) BRPI0807626B1 (es)
CA (2) CA2970628C (es)
ES (2) ES2369617T3 (es)
HR (2) HRP20110709T1 (es)
IL (1) IL200320A0 (es)
MA (1) MA31180B1 (es)
MX (1) MX2009008665A (es)
NZ (1) NZ578944A (es)
PL (2) PL2118099T3 (es)
RU (2) RU2456285C2 (es)
SI (2) SI2366703T1 (es)
TN (1) TN2009000342A1 (es)
TW (1) TWI406862B (es)
WO (1) WO2008098949A2 (es)
ZA (1) ZA200905981B (es)

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Also Published As

Publication number Publication date
EP2118099A2 (en) 2009-11-18
CA2970628C (en) 2019-08-27
ZA200905981B (en) 2010-11-24
CA2970628A1 (en) 2008-08-21
CN103342701A (zh) 2013-10-09
SI2366703T1 (sl) 2014-10-30
BRPI0807626A2 (pt) 2014-11-25
TWI406862B (zh) 2013-09-01
JP2013177437A (ja) 2013-09-09
AR065337A1 (es) 2009-06-03
PL2118099T3 (pl) 2011-12-30
RU2491286C1 (ru) 2013-08-27
US8940894B2 (en) 2015-01-27
US20130289045A1 (en) 2013-10-31
TN2009000342A1 (en) 2010-12-31
AU2008214679A1 (en) 2008-08-21
WO2008098949A2 (en) 2008-08-21
TW200848419A (en) 2008-12-16
JP2010518141A (ja) 2010-05-27
EP2366703B1 (en) 2014-07-30
US8492545B2 (en) 2013-07-23
CN101657446A (zh) 2010-02-24
HRP20110709T1 (hr) 2011-11-30
ES2522169T3 (es) 2014-11-13
CA2677586C (en) 2017-07-25
MA31180B1 (fr) 2010-02-01
US20100121063A1 (en) 2010-05-13
US20120196871A1 (en) 2012-08-02
ES2369617T3 (es) 2011-12-02
CN103342701B (zh) 2016-09-21
JP5784073B2 (ja) 2015-09-24
SI2118099T1 (sl) 2011-11-30
EP2366703A1 (en) 2011-09-21
PL2366703T3 (pl) 2015-02-27
WO2008098949A3 (en) 2008-10-02
HRP20140986T1 (hr) 2014-11-21
CA2677586A1 (en) 2008-08-21
RU2456285C2 (ru) 2012-07-20
US8153792B2 (en) 2012-04-10
NZ578944A (en) 2011-03-31
KR20090110851A (ko) 2009-10-22
JP5568312B2 (ja) 2014-08-06
IL200320A0 (en) 2010-04-29
CN101657446B (zh) 2013-05-15
EP2118099B1 (en) 2011-07-06
ATE515506T1 (de) 2011-07-15
RU2009132186A (ru) 2011-03-20
BRPI0807626B1 (pt) 2022-03-03

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