TN2009000342A1 - Process for the synthesis of 2- aminothiazole compounds as kinase inhibitors - Google Patents

Process for the synthesis of 2- aminothiazole compounds as kinase inhibitors

Info

Publication number
TN2009000342A1
TN2009000342A1 TNP2009000342A TN2009000342A TN2009000342A1 TN 2009000342 A1 TN2009000342 A1 TN 2009000342A1 TN P2009000342 A TNP2009000342 A TN P2009000342A TN 2009000342 A TN2009000342 A TN 2009000342A TN 2009000342 A1 TN2009000342 A1 TN 2009000342A1
Authority
TN
Tunisia
Prior art keywords
kinase inhibitors
synthesis
group
aminothiazole compounds
inhibitors
Prior art date
Application number
TNP2009000342A
Other languages
English (en)
Inventor
Alain Moussy
Philippe Reginault
Francois Bellamy
Anne Lermet
Original Assignee
Ab Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Science filed Critical Ab Science
Publication of TN2009000342A1 publication Critical patent/TN2009000342A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TNP2009000342A 2007-02-13 2009-08-11 Process for the synthesis of 2- aminothiazole compounds as kinase inhibitors TN2009000342A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88958707P 2007-02-13 2007-02-13
PCT/EP2008/051704 WO2008098949A2 (fr) 2007-02-13 2008-02-13 Procédé de synthèse de composés 2-aminothiazole comme inhibiteurs de kinase

Publications (1)

Publication Number Publication Date
TN2009000342A1 true TN2009000342A1 (en) 2010-12-31

Family

ID=39332208

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000342A TN2009000342A1 (en) 2007-02-13 2009-08-11 Process for the synthesis of 2- aminothiazole compounds as kinase inhibitors

Country Status (23)

Country Link
US (3) US8153792B2 (fr)
EP (2) EP2366703B1 (fr)
JP (2) JP5568312B2 (fr)
KR (1) KR20090110851A (fr)
CN (2) CN101657446B (fr)
AR (1) AR065337A1 (fr)
AT (1) ATE515506T1 (fr)
AU (1) AU2008214679A1 (fr)
BR (1) BRPI0807626B1 (fr)
CA (2) CA2970628C (fr)
ES (2) ES2522169T3 (fr)
HR (2) HRP20110709T1 (fr)
IL (1) IL200320A0 (fr)
MA (1) MA31180B1 (fr)
MX (1) MX2009008665A (fr)
NZ (1) NZ578944A (fr)
PL (2) PL2366703T3 (fr)
RU (2) RU2456285C2 (fr)
SI (2) SI2118099T1 (fr)
TN (1) TN2009000342A1 (fr)
TW (1) TWI406862B (fr)
WO (1) WO2008098949A2 (fr)
ZA (1) ZA200905981B (fr)

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US8450302B2 (en) 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
WO2011092273A1 (fr) 2010-01-28 2011-08-04 Ab Science Traitement des tumeurs stromales gastro-intestinales (gist) à base de masitinib
WO2011092338A1 (fr) 2010-02-01 2011-08-04 Ab Science Polythérapie d'un cancer pancréatique à base de gemcitabine et de masitinib
AR080380A1 (es) 2010-03-09 2012-04-04 Ab Science Tratamiento de la demencia tipo alzheimer con masitinib
TW201204360A (en) 2010-04-20 2012-02-01 Ab Science Treatment of multiple sclerosis with MASITINIB
TW201204719A (en) 2010-06-02 2012-02-01 Ab Science Treatment of rheumatoid arthritis with masitinib
WO2012059526A1 (fr) 2010-11-05 2012-05-10 Ab Science Traitement de la mastocytose par le masitinib
US10045978B2 (en) 2010-11-05 2018-08-14 Ab Science Treatment of mastocytosis with masitinib
US9078894B2 (en) 2011-02-04 2015-07-14 Ab Science Treatment of severe persistant asthma with masitinib
AR085934A1 (es) 2011-04-08 2013-11-06 Ab Science Tratamiento de mieloma multiple con masitinib
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US20170196853A1 (en) 2014-06-02 2017-07-13 Ab Science Use of an inhibitor of kinase activity, particularly masitinib, for treatment of prostate cancer
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EP3831384A1 (fr) 2019-12-02 2021-06-09 AB Science Utilisation de masitinib pour le traitement de l'asthme éosinophile
CN115515590A (zh) 2020-02-20 2022-12-23 Ab科学有限公司 马赛替尼用于治疗多发性硬化患者亚群
KR20230014681A (ko) 2020-04-10 2023-01-30 에이비 사이언스 코로나바이러스 질환 2019(covid-19)의 치료를 위한 마시티닙의 용도
CA3201259A1 (fr) 2020-12-16 2022-06-23 Alain Moussy Masitinib pour le traitement de la maladie d'alzheimer
US20230321081A1 (en) 2021-05-17 2023-10-12 Ab Science Masitinib for the treatment of castrate-resistant prostate cancer
CN115850258B (zh) * 2022-12-27 2024-09-24 东北林业大学 一种马赛替尼的合成方法

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Also Published As

Publication number Publication date
US8940894B2 (en) 2015-01-27
US8492545B2 (en) 2013-07-23
AU2008214679A1 (en) 2008-08-21
CN101657446B (zh) 2013-05-15
CN101657446A (zh) 2010-02-24
PL2366703T3 (pl) 2015-02-27
CA2970628C (fr) 2019-08-27
JP2013177437A (ja) 2013-09-09
IL200320A0 (en) 2010-04-29
AR065337A1 (es) 2009-06-03
CA2970628A1 (fr) 2008-08-21
MX2009008665A (es) 2009-08-21
EP2366703B1 (fr) 2014-07-30
BRPI0807626B1 (pt) 2022-03-03
US8153792B2 (en) 2012-04-10
CN103342701B (zh) 2016-09-21
ATE515506T1 (de) 2011-07-15
NZ578944A (en) 2011-03-31
WO2008098949A2 (fr) 2008-08-21
RU2009132186A (ru) 2011-03-20
JP2010518141A (ja) 2010-05-27
HRP20140986T1 (hr) 2014-11-21
MA31180B1 (fr) 2010-02-01
US20100121063A1 (en) 2010-05-13
JP5568312B2 (ja) 2014-08-06
RU2456285C2 (ru) 2012-07-20
RU2491286C1 (ru) 2013-08-27
CN103342701A (zh) 2013-10-09
HRP20110709T1 (hr) 2011-11-30
SI2366703T1 (sl) 2014-10-30
ZA200905981B (en) 2010-11-24
SI2118099T1 (sl) 2011-11-30
EP2118099A2 (fr) 2009-11-18
KR20090110851A (ko) 2009-10-22
JP5784073B2 (ja) 2015-09-24
ES2522169T3 (es) 2014-11-13
CA2677586A1 (fr) 2008-08-21
TW200848419A (en) 2008-12-16
TWI406862B (zh) 2013-09-01
WO2008098949A3 (fr) 2008-10-02
PL2118099T3 (pl) 2011-12-30
ES2369617T3 (es) 2011-12-02
CA2677586C (fr) 2017-07-25
BRPI0807626A2 (pt) 2014-11-25
US20130289045A1 (en) 2013-10-31
EP2366703A1 (fr) 2011-09-21
EP2118099B1 (fr) 2011-07-06
US20120196871A1 (en) 2012-08-02

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