MA31180B1 - Procede de synthese de composes 2-aminothiazole comme inhibiteurs de kinase - Google Patents

Procede de synthese de composes 2-aminothiazole comme inhibiteurs de kinase

Info

Publication number
MA31180B1
MA31180B1 MA32161A MA32161A MA31180B1 MA 31180 B1 MA31180 B1 MA 31180B1 MA 32161 A MA32161 A MA 32161A MA 32161 A MA32161 A MA 32161A MA 31180 B1 MA31180 B1 MA 31180B1
Authority
MA
Morocco
Prior art keywords
synthesis
kinase inhibitors
group
inhibitors
aminothiazole compounds
Prior art date
Application number
MA32161A
Other languages
Arabic (ar)
English (en)
Inventor
Alain Moussy
Philippe Reginault
François Bellamy
Anne Lermet
Original Assignee
Ab Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Science filed Critical Ab Science
Publication of MA31180B1 publication Critical patent/MA31180B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention se rapporte à un procédé industriel permettant de préparer des composés pharmaceutiques de formule (i) qui sont utilisés comme inhibiteurs de certaines tyrosine kinases et plus particulièrement comme inhibiteurs de c-kit et de bcr-abl. Les groupes r1 et r2, identiques ou différents, représentent chacun un atome d'hydrogène, un atome d'halogène, un groupe alkyle, alcoxy, trifluorométhyle, amino, alkylamino, dialkylamino, un groupe de solubilisation; m vaut de 0 à 5 et n vaut de 0 à 4; le groupe r3 représente un groupe aryle ou hétéroaryle comme décrit dans les revendications.
MA32161A 2007-02-13 2009-08-11 Procede de synthese de composes 2-aminothiazole comme inhibiteurs de kinase MA31180B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88958707P 2007-02-13 2007-02-13
PCT/EP2008/051704 WO2008098949A2 (fr) 2007-02-13 2008-02-13 Procédé de synthèse de composés 2-aminothiazole comme inhibiteurs de kinase

Publications (1)

Publication Number Publication Date
MA31180B1 true MA31180B1 (fr) 2010-02-01

Family

ID=39332208

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32161A MA31180B1 (fr) 2007-02-13 2009-08-11 Procede de synthese de composes 2-aminothiazole comme inhibiteurs de kinase

Country Status (23)

Country Link
US (3) US8153792B2 (fr)
EP (2) EP2366703B1 (fr)
JP (2) JP5568312B2 (fr)
KR (1) KR20090110851A (fr)
CN (2) CN101657446B (fr)
AR (1) AR065337A1 (fr)
AT (1) ATE515506T1 (fr)
AU (1) AU2008214679A1 (fr)
BR (1) BRPI0807626B1 (fr)
CA (2) CA2677586C (fr)
ES (2) ES2522169T3 (fr)
HR (2) HRP20110709T1 (fr)
IL (1) IL200320A0 (fr)
MA (1) MA31180B1 (fr)
MX (1) MX2009008665A (fr)
NZ (1) NZ578944A (fr)
PL (2) PL2118099T3 (fr)
RU (2) RU2456285C2 (fr)
SI (2) SI2366703T1 (fr)
TN (1) TN2009000342A1 (fr)
TW (1) TWI406862B (fr)
WO (1) WO2008098949A2 (fr)
ZA (1) ZA200905981B (fr)

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ATE375342T1 (de) 2002-08-02 2007-10-15 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren
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US20230000838A1 (en) 2019-11-22 2023-01-05 Ab Science Masitinib for the treatment of sickle cell disease
EP3831384A1 (fr) 2019-12-02 2021-06-09 AB Science Utilisation de masitinib pour le traitement de l'asthme éosinophile
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WO2022129410A1 (fr) 2020-12-16 2022-06-23 Ab Science Masitinib pour le traitement de la maladie d'alzheimer
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Also Published As

Publication number Publication date
EP2118099B1 (fr) 2011-07-06
CN101657446B (zh) 2013-05-15
CN101657446A (zh) 2010-02-24
US8153792B2 (en) 2012-04-10
TN2009000342A1 (en) 2010-12-31
PL2118099T3 (pl) 2011-12-30
ZA200905981B (en) 2010-11-24
CN103342701A (zh) 2013-10-09
RU2491286C1 (ru) 2013-08-27
CA2677586A1 (fr) 2008-08-21
PL2366703T3 (pl) 2015-02-27
CA2970628C (fr) 2019-08-27
MX2009008665A (es) 2009-08-21
IL200320A0 (en) 2010-04-29
US8492545B2 (en) 2013-07-23
HRP20110709T1 (hr) 2011-11-30
US20130289045A1 (en) 2013-10-31
US8940894B2 (en) 2015-01-27
JP5784073B2 (ja) 2015-09-24
TW200848419A (en) 2008-12-16
RU2009132186A (ru) 2011-03-20
NZ578944A (en) 2011-03-31
HRP20140986T1 (hr) 2014-11-21
ES2369617T3 (es) 2011-12-02
TWI406862B (zh) 2013-09-01
KR20090110851A (ko) 2009-10-22
CN103342701B (zh) 2016-09-21
US20100121063A1 (en) 2010-05-13
SI2118099T1 (sl) 2011-11-30
ATE515506T1 (de) 2011-07-15
EP2118099A2 (fr) 2009-11-18
EP2366703B1 (fr) 2014-07-30
SI2366703T1 (sl) 2014-10-30
US20120196871A1 (en) 2012-08-02
CA2677586C (fr) 2017-07-25
AR065337A1 (es) 2009-06-03
JP5568312B2 (ja) 2014-08-06
JP2010518141A (ja) 2010-05-27
WO2008098949A2 (fr) 2008-08-21
BRPI0807626A2 (pt) 2014-11-25
ES2522169T3 (es) 2014-11-13
RU2456285C2 (ru) 2012-07-20
WO2008098949A3 (fr) 2008-10-02
EP2366703A1 (fr) 2011-09-21
BRPI0807626B1 (pt) 2022-03-03
JP2013177437A (ja) 2013-09-09
CA2970628A1 (fr) 2008-08-21
AU2008214679A1 (en) 2008-08-21

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