IN2014DN06567A - - Google Patents

Info

Publication number
IN2014DN06567A
IN2014DN06567A IN6567DEN2014A IN2014DN06567A IN 2014DN06567 A IN2014DN06567 A IN 2014DN06567A IN 6567DEN2014 A IN6567DEN2014 A IN 6567DEN2014A IN 2014DN06567 A IN2014DN06567 A IN 2014DN06567A
Authority
IN
India
Prior art keywords
kinase
inhibitors
compounds
heteroaryl
aryl
Prior art date
Application number
Other languages
English (en)
Inventor
Bang-Chi Chen
Roberto Droghini
Jean Lajeunesse
John D Dimarco
Michael Galella
Ramakrishnan Chidambaram
Original Assignee
Bristol Myers Squibb Holdings Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34864498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN06567(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Holdings Ireland filed Critical Bristol Myers Squibb Holdings Ireland
Publication of IN2014DN06567A publication Critical patent/IN2014DN06567A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IN6567DEN2014 2004-02-06 2005-02-04 IN2014DN06567A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54249004P 2004-02-06 2004-02-06
US62493704P 2004-11-04 2004-11-04
PCT/US2005/003728 WO2005077945A2 (fr) 2004-02-06 2005-02-04 Procede de preparation de carboxamides 2-aminothiazole-5-aromatiques utiles comme inhibiteurs de kinases

Publications (1)

Publication Number Publication Date
IN2014DN06567A true IN2014DN06567A (fr) 2015-07-10

Family

ID=34864498

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6567DEN2014 IN2014DN06567A (fr) 2004-02-06 2005-02-04

Country Status (27)

Country Link
EP (1) EP1711481B2 (fr)
JP (2) JP5148115B2 (fr)
KR (2) KR101310427B1 (fr)
AR (1) AR047533A1 (fr)
AT (1) ATE453630T1 (fr)
AU (1) AU2005212405B2 (fr)
BR (1) BRPI0507476B8 (fr)
CA (1) CA2555291C (fr)
CY (1) CY1109907T1 (fr)
DE (1) DE602005018601D1 (fr)
DK (1) DK1711481T4 (fr)
ES (1) ES2337272T5 (fr)
GE (1) GEP20094804B (fr)
HK (1) HK1091835A1 (fr)
HR (1) HRP20100166T4 (fr)
IL (1) IL177280A (fr)
IN (1) IN2014DN06567A (fr)
NO (1) NO338049B1 (fr)
NZ (1) NZ548613A (fr)
PE (1) PE20050691A1 (fr)
PL (1) PL1711481T5 (fr)
PT (1) PT1711481E (fr)
RU (1) RU2382039C2 (fr)
SI (1) SI1711481T2 (fr)
TW (1) TWI338004B (fr)
WO (1) WO2005077945A2 (fr)
ZA (1) ZA200606242B (fr)

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EP2258371A1 (fr) 2001-08-10 2010-12-08 Novartis AG Utilisation d'inhibiteurs c-Src seuls ou en combinaison avec STI571 pour le traitement de leucemies
ES2386784T3 (es) 2003-05-01 2012-08-30 Bristol-Myers Squibb Company Compuestos de pirazol-amina útiles como inhibidores de quinasas
US7652146B2 (en) 2004-02-06 2010-01-26 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors
TWI338004B (en) * 2004-02-06 2011-03-01 Bristol Myers Squibb Co Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
TW200600513A (en) 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
SI1885339T1 (sl) * 2005-05-05 2015-10-30 Bristol-Myers Squibb Holdings Ireland Formulacije inhibitorja src/abl
ATE466003T1 (de) 2005-08-05 2010-05-15 Bristol Myers Squibb Co Herstellung von 2-aminothiazol-5- carbonsäurederivaten
EP1937270A1 (fr) * 2005-09-21 2008-07-02 Brystol-Myers Squibb Company Administration par voie orale de n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1,3-thiazole-5-carboxamide et sels de celui-ci
US20070219370A1 (en) * 2006-03-15 2007-09-20 Bristol-Myers Squibb Company Process for preparing n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino] -5-thiazolecarboxamide and related metabolites thereof
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AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
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CN103319476B (zh) * 2013-06-13 2015-12-02 济南德爱医药技术有限公司 一种激酶抑制剂
EP3024830A2 (fr) * 2013-07-25 2016-06-01 Basf Se Sels de dasatinib se présentant sous forme cristalline
MX2016001096A (es) 2013-07-25 2016-04-25 Basf Se Sales de dasatinib en forma amorfa.
CN104341410A (zh) * 2013-08-09 2015-02-11 上海科胜药物研发有限公司 一种达沙替尼新晶型及其制备方法
CN103483289B (zh) * 2013-09-06 2016-01-27 浙江科源化工有限公司 一种2-氨基-n-(2-氯-6-甲基苯基)噻唑-5-甲酰胺的合成方法
WO2015107545A1 (fr) 2013-12-18 2015-07-23 Dharmesh Mahendrabhai Shah Sels solubles dans l'eau d'hydrate de dasatinib
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WO2017098391A1 (fr) * 2015-12-11 2017-06-15 Shilpa Medicare Limited Procédé de préparation du dasatinib
CN105474831B (zh) * 2015-12-16 2017-11-17 湖南省西瓜甜瓜研究所 一种白芨裸种消毒方法
WO2017108605A1 (fr) 2015-12-22 2017-06-29 Synthon B.V. Composition pharmaceutique comprenant du dasatinib amorphe
CN105503854A (zh) * 2015-12-31 2016-04-20 哈药集团技术中心 一种达沙替尼无水合物的新晶型物及其制备方法
US10464933B2 (en) 2016-02-03 2019-11-05 Dr. Reddy's Laboratories Limited Solid state forms of dasatinib and processes for their preparation
EP3419605A1 (fr) 2016-02-25 2019-01-02 Remedica Ltd Composition de dasatinib
CN105830582B (zh) * 2016-04-15 2018-05-01 成都大学 一种白及种子的快速回土培育方法
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CN106117195A (zh) * 2016-06-09 2016-11-16 青岛辰达生物科技有限公司 一种用于治疗白血病的药物达沙替尼的合成方法
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CN109369638B (zh) * 2018-11-21 2020-07-07 山东罗欣药业集团股份有限公司 一种达沙替尼的制备工艺
CN109503568B (zh) * 2018-12-29 2020-08-07 山东罗欣药业集团股份有限公司 一种达沙替尼的制备方法
CN112409349A (zh) * 2019-08-20 2021-02-26 湖南华纳大药厂股份有限公司 激酶抑制剂及其制备、药物组合物和用途
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EP4071248A1 (fr) 2021-04-07 2022-10-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Moyens et procédés pour améliorer le transfert de gènes ciblé par des récepteurs
US11980619B2 (en) 2021-07-28 2024-05-14 Nanocopoeia, Llc Pharmaceutical compositions and crushable tablets including amorphous solid dispersions of dasatinib and uses
CN114634421A (zh) * 2022-02-24 2022-06-17 济宁晟泰药业有限公司 一种达沙替尼中间体的制备方法

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Also Published As

Publication number Publication date
CA2555291C (fr) 2017-01-17
RU2006131591A (ru) 2008-03-20
HRP20100166T1 (hr) 2010-05-31
HRP20100166T4 (en) 2013-09-30
TWI338004B (en) 2011-03-01
BRPI0507476A (pt) 2007-07-17
NO338049B1 (no) 2016-07-25
EP1711481B1 (fr) 2009-12-30
JP2007521340A (ja) 2007-08-02
JP5148115B2 (ja) 2013-02-20
WO2005077945A3 (fr) 2006-05-18
CY1109907T1 (el) 2014-09-10
ES2337272T3 (es) 2010-04-22
ES2337272T5 (es) 2013-09-30
ATE453630T1 (de) 2010-01-15
SI1711481T1 (sl) 2010-03-31
AR047533A1 (es) 2006-01-25
RU2382039C2 (ru) 2010-02-20
PE20050691A1 (es) 2005-09-25
NZ548613A (en) 2010-05-28
DK1711481T4 (da) 2013-08-26
HK1091835A1 (en) 2007-01-26
NO20063780L (no) 2006-10-27
BRPI0507476B8 (pt) 2021-05-25
AU2005212405B2 (en) 2010-08-12
KR20060124692A (ko) 2006-12-05
BRPI0507476B1 (pt) 2020-12-08
ZA200606242B (en) 2008-01-08
WO2005077945A2 (fr) 2005-08-25
IL177280A0 (en) 2006-12-10
TW200530205A (en) 2005-09-16
PL1711481T3 (pl) 2010-05-31
KR101310427B1 (ko) 2013-09-24
GEP20094804B (en) 2009-10-26
EP1711481A2 (fr) 2006-10-18
EP1711481B2 (fr) 2013-05-22
AU2005212405A1 (en) 2005-08-25
DE602005018601D1 (de) 2010-02-11
KR20120097424A (ko) 2012-09-03
SI1711481T2 (sl) 2013-10-30
PL1711481T5 (pl) 2013-10-31
CA2555291A1 (fr) 2005-08-25
JP2012188446A (ja) 2012-10-04
IL177280A (en) 2013-09-30
PT1711481E (pt) 2010-02-25
DK1711481T3 (da) 2010-04-19

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