NO20063780L - Fremgangsmate for fremstilling av 2-aminitiazol-5-aromatisk karboksamid som kinase inhibitorer. - Google Patents
Fremgangsmate for fremstilling av 2-aminitiazol-5-aromatisk karboksamid som kinase inhibitorer.Info
- Publication number
- NO20063780L NO20063780L NO20063780A NO20063780A NO20063780L NO 20063780 L NO20063780 L NO 20063780L NO 20063780 A NO20063780 A NO 20063780A NO 20063780 A NO20063780 A NO 20063780A NO 20063780 L NO20063780 L NO 20063780L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- aminithiazole
- kinase inhibitors
- aromatic carboxamide
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Oppfinnelsen angår fremgangsmåter for fremstilling av forbindelser som har formel (I) og krystallinske former derav, hvor Ar er aryl eller heteroaryl, L er en eventuell alkylen-linker og R2, R3, R4 og R5 er som definert i beskrivelsen her, hvilke forbindelser er anvendelige som kinase-inhibitorer, spesielt inhibitorer av proteintyrosinkinase og p38 kinase.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54249004P | 2004-02-06 | 2004-02-06 | |
US62493704P | 2004-11-04 | 2004-11-04 | |
PCT/US2005/003728 WO2005077945A2 (en) | 2004-02-06 | 2005-02-04 | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20063780L true NO20063780L (no) | 2006-10-27 |
NO338049B1 NO338049B1 (no) | 2016-07-25 |
Family
ID=34864498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20063780A NO338049B1 (no) | 2004-02-06 | 2006-08-24 | Krystallinsk monohydrat av 2-aminotiazol-5-aromatisk karboksamid, fremstilling av denne, farmasøytisk preparat omfattende denne samt anvendelse av denne for behandling av kreft |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP1711481B2 (no) |
JP (2) | JP5148115B2 (no) |
KR (2) | KR20120097424A (no) |
AR (1) | AR047533A1 (no) |
AT (1) | ATE453630T1 (no) |
AU (1) | AU2005212405B2 (no) |
BR (1) | BRPI0507476B8 (no) |
CA (1) | CA2555291C (no) |
CY (1) | CY1109907T1 (no) |
DE (1) | DE602005018601D1 (no) |
DK (1) | DK1711481T4 (no) |
ES (1) | ES2337272T5 (no) |
GE (1) | GEP20094804B (no) |
HK (1) | HK1091835A1 (no) |
HR (1) | HRP20100166T4 (no) |
IL (1) | IL177280A (no) |
IN (1) | IN2014DN06567A (no) |
NO (1) | NO338049B1 (no) |
NZ (1) | NZ548613A (no) |
PE (1) | PE20050691A1 (no) |
PL (1) | PL1711481T5 (no) |
PT (1) | PT1711481E (no) |
RU (1) | RU2382039C2 (no) |
SI (1) | SI1711481T2 (no) |
TW (1) | TWI338004B (no) |
WO (1) | WO2005077945A2 (no) |
ZA (1) | ZA200606242B (no) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO343939B1 (no) * | 2005-05-05 | 2019-07-15 | Bristol Myers Squibb Holdings Ireland | Formuleringer av en src/abl-inhibitor |
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EP1418917A1 (en) | 2001-08-10 | 2004-05-19 | Novartis AG | Use of c-src inhibitors alone or in combination with sti571 for the treatment of leukaemia |
RU2342365C2 (ru) | 2003-05-01 | 2008-12-27 | Бристол-Маерс Сквибб Компани | Арилзамещенные пиразоламиды в качестве ингибиторов киназ |
TWI338004B (en) * | 2004-02-06 | 2011-03-01 | Bristol Myers Squibb Co | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
US7652146B2 (en) | 2004-02-06 | 2010-01-26 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors |
TW200600513A (en) | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
DE602006014001D1 (de) | 2005-08-05 | 2010-06-10 | Bristol Myers Squibb Co | Herstellung von 2-aminothiazol-5-carbonsäurederivaten |
EP1937270A1 (en) * | 2005-09-21 | 2008-07-02 | Brystol-Myers Squibb Company | Oral administration of n-(2-chloro-6-methylphenyl)-2-[[6-4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1,3-thiazole-5-carboxamide and salts thereof |
US20070219370A1 (en) * | 2006-03-15 | 2007-09-20 | Bristol-Myers Squibb Company | Process for preparing n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino] -5-thiazolecarboxamide and related metabolites thereof |
KR101433629B1 (ko) | 2006-09-11 | 2014-08-27 | 쿠리스 인코퍼레이션 | 아연 결합 부분을 함유한 티로신 키나아제 억제제 |
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WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
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EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
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US8513289B2 (en) * | 2009-05-05 | 2013-08-20 | Merck Sharp & Dohme Corp. | P38 kinase inhibiting agents |
CN101812060B (zh) * | 2010-02-02 | 2011-08-17 | 南京卡文迪许生物工程技术有限公司 | 一种简捷制备高纯度达沙替尼的新方法以及中间体化合物 |
EP2359813A1 (en) | 2010-02-04 | 2011-08-24 | Ratiopharm GmbH | Pharmaceutical composition comprising N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamid |
CN102250084A (zh) * | 2010-02-08 | 2011-11-23 | 南京卡文迪许生物工程技术有限公司 | 达沙替尼多晶型物及其制备方法和药用组合物 |
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RU2567537C1 (ru) * | 2014-04-23 | 2015-11-10 | Олег Ростиславович Михайлов | Кристаллическая безводная дельта-модификация n-(2-хлор-6-метилфенил)-2-[[6-[4-(2-гидроксиэтил)-1-пиперазинил]-2-метил-4-пиримидинил]амино]-5-тиазолкарбоксамида, способ ее получения и фармацевтическая композиция на ее основе |
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CN109369638B (zh) * | 2018-11-21 | 2020-07-07 | 山东罗欣药业集团股份有限公司 | 一种达沙替尼的制备工艺 |
CN109503568B (zh) * | 2018-12-29 | 2020-08-07 | 山东罗欣药业集团股份有限公司 | 一种达沙替尼的制备方法 |
CN112409349A (zh) * | 2019-08-20 | 2021-02-26 | 湖南华纳大药厂股份有限公司 | 激酶抑制剂及其制备、药物组合物和用途 |
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2005
- 2005-02-01 TW TW094103090A patent/TWI338004B/zh active
- 2005-02-04 WO PCT/US2005/003728 patent/WO2005077945A2/en active Application Filing
- 2005-02-04 DK DK05722772.0T patent/DK1711481T4/da active
- 2005-02-04 SI SI200530905T patent/SI1711481T2/sl unknown
- 2005-02-04 CA CA2555291A patent/CA2555291C/en active Active
- 2005-02-04 IN IN6567DEN2014 patent/IN2014DN06567A/en unknown
- 2005-02-04 PT PT05722772T patent/PT1711481E/pt unknown
- 2005-02-04 PE PE2005000128A patent/PE20050691A1/es active IP Right Grant
- 2005-02-04 ES ES05722772T patent/ES2337272T5/es active Active
- 2005-02-04 NZ NZ548613A patent/NZ548613A/en unknown
- 2005-02-04 EP EP05722772.0A patent/EP1711481B2/en active Active
- 2005-02-04 KR KR1020127021611A patent/KR20120097424A/ko not_active Application Discontinuation
- 2005-02-04 AU AU2005212405A patent/AU2005212405B2/en active Active
- 2005-02-04 AT AT05722772T patent/ATE453630T1/de active
- 2005-02-04 GE GEAP20059607A patent/GEP20094804B/en unknown
- 2005-02-04 JP JP2006552303A patent/JP5148115B2/ja active Active
- 2005-02-04 AR ARP050100427A patent/AR047533A1/es not_active Application Discontinuation
- 2005-02-04 BR BRPI0507476A patent/BRPI0507476B8/pt active IP Right Grant
- 2005-02-04 DE DE602005018601T patent/DE602005018601D1/de active Active
- 2005-02-04 PL PL05722772T patent/PL1711481T5/pl unknown
- 2005-02-04 RU RU2006131591/04A patent/RU2382039C2/ru active
- 2005-02-04 KR KR1020067015839A patent/KR101310427B1/ko active IP Right Review Request
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2006
- 2006-07-27 ZA ZA2006/06242A patent/ZA200606242B/en unknown
- 2006-08-03 IL IL177280A patent/IL177280A/en active IP Right Grant
- 2006-08-24 NO NO20063780A patent/NO338049B1/no unknown
- 2006-11-23 HK HK06112879.5A patent/HK1091835A1/xx active IP Right Maintenance
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2010
- 2010-03-19 CY CY20101100253T patent/CY1109907T1/el unknown
- 2010-03-22 HR HRP20100166TT patent/HRP20100166T4/hr unknown
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2012
- 2012-06-06 JP JP2012129253A patent/JP2012188446A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO343939B1 (no) * | 2005-05-05 | 2019-07-15 | Bristol Myers Squibb Holdings Ireland | Formuleringer av en src/abl-inhibitor |
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CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH |
|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH |
|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMI, CH |