MX2009003145A - Dextrano funcionalizado con aminoacidos hidrofobicos. - Google Patents
Dextrano funcionalizado con aminoacidos hidrofobicos.Info
- Publication number
- MX2009003145A MX2009003145A MX2009003145A MX2009003145A MX2009003145A MX 2009003145 A MX2009003145 A MX 2009003145A MX 2009003145 A MX2009003145 A MX 2009003145A MX 2009003145 A MX2009003145 A MX 2009003145A MX 2009003145 A MX2009003145 A MX 2009003145A
- Authority
- MX
- Mexico
- Prior art keywords
- amino acid
- dextran
- hydrophobic amino
- amino acids
- hydrophobic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
Abstract
La invención se relaciona con un dextrano funcionalizado con por lo menos un residuo de aminoácido alfa hidrofóbico, siendo el aminoácido alfa injertado o unido al dextrano por un brazo de unión y una función. Se entiende por un residuo de aminoácido hidrofóbico el producto de acoplamiento entre la amina del aminoácido y un ácido portado por el brazo de unión, siendo el dextrano anfífilo a pH neutro. En una modalidad, el aminoácido hidrofóbico se elige entre los derivados de triptófano, tal como triptófano, triptofanol, triptofanamida, 2-indol etilamina y sus sales de catión alcalino. La presente invención se relaciona igualmente con una composición farmacéutica que contiene uno de los dextranos de acuerdo con la invención.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2006/002666 WO2007034320A2 (fr) | 2005-09-26 | 2006-09-26 | Complexe polymere amphiphile-pdgf |
FR0702316A FR2914305B1 (fr) | 2007-03-29 | 2007-03-29 | Dextran fonctionnalise par des amino-acides hydrophobes. |
PCT/IB2007/002807 WO2008038111A1 (fr) | 2006-09-26 | 2007-09-26 | Dextran fonctionnalise par des amino-acides hydrophobes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003145A true MX2009003145A (es) | 2009-04-02 |
Family
ID=38654534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003145A MX2009003145A (es) | 2006-09-26 | 2007-09-26 | Dextrano funcionalizado con aminoacidos hidrofobicos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US8629124B2 (es) |
EP (1) | EP2066700B1 (es) |
JP (2) | JP5486925B2 (es) |
KR (2) | KR101502528B1 (es) |
AU (1) | AU2007301670B2 (es) |
BR (1) | BRPI0717110A2 (es) |
CA (1) | CA2664650C (es) |
DK (1) | DK2066700T3 (es) |
ES (1) | ES2562711T3 (es) |
FR (1) | FR2914305B1 (es) |
IL (1) | IL197681A (es) |
MX (1) | MX2009003145A (es) |
PL (1) | PL2066700T3 (es) |
RU (1) | RU2476437C2 (es) |
SG (1) | SG177172A1 (es) |
WO (1) | WO2008038111A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2919188B1 (fr) * | 2007-07-27 | 2010-02-26 | Proteins & Peptides Man | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
FR2937863B1 (fr) * | 2008-11-06 | 2012-05-18 | Adocia | Composition osteogenique comprenant un complexe facteur de croissance polysaccharide anionique, un sel soluble de cation et un gel |
WO2009127939A1 (fr) * | 2008-04-14 | 2009-10-22 | Adocia | Composition osteogenique comprenant un facteur de croissance un sel soluble de cation et un support organique |
FR2933306B1 (fr) * | 2008-07-07 | 2010-09-10 | Adocia | Composition osteogenique comprenant un complexe facteur de croissance polysaccharide anionique, un sel soluble de cation et une matrice organique |
CA2720203A1 (fr) * | 2008-04-14 | 2009-10-22 | Adocia | Composition osteogenique comprenant un complexe facteur de croissance/polymere amphiphile un sel soluble de cation et un support organique |
FR2933304A1 (fr) * | 2008-07-07 | 2010-01-08 | Adocia | Composition synergique osteogenique |
FR2934999B1 (fr) * | 2008-08-13 | 2011-07-29 | Adocia | Polysaccharides fonctionnalises par des derives du tryptophane |
FR2940802A1 (fr) * | 2008-10-10 | 2010-07-09 | Adocia | Complexe entre l'insuline humaine et un polymere amphiphile et utilisation de ce complexe pour la preparation d'une formulation d'insuline humaine rapide. |
RU2498820C2 (ru) * | 2008-09-26 | 2013-11-20 | Адосиа | Комплекс, образованный полисахаридом и нвр |
US8426382B2 (en) | 2008-10-06 | 2013-04-23 | Adocia | Polysaccharides comprising carboxyl functional groups substituted by a hydrophobic alcohol derivative |
FR2936800B1 (fr) * | 2008-10-06 | 2010-12-31 | Adocia | Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe |
FR2948573B1 (fr) | 2009-07-31 | 2011-11-18 | Adocia | Nouvelle forme d'administration de complexes de proteines osteogeniques |
FR2944448B1 (fr) * | 2008-12-23 | 2012-01-13 | Adocia | Composition pharmaceutique stable comprenant au moins un anticorps monodonal et au moins un polysacharide amphiphile comprenant des substituants derives d'alcools hydrofobes ou d'amines hydrophobes. |
US8685458B2 (en) | 2009-03-05 | 2014-04-01 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
US9018190B2 (en) | 2009-03-27 | 2015-04-28 | Adocia | Functionalized oligosaccharides |
FR2980796B1 (fr) * | 2011-09-30 | 2014-07-04 | Adocia | Oligosaccharides fonctionnalises |
FR2943538B1 (fr) * | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
WO2011060250A1 (en) * | 2009-11-13 | 2011-05-19 | Bend Research, Inc. | Cationic dextran polymer derivatives |
FR2956116A1 (fr) * | 2010-02-09 | 2011-08-12 | Adocia | Complexes polysaccharide/bmp-7 solubles a ph physiologique |
FR2958646B1 (fr) | 2010-04-07 | 2012-05-18 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'acide hydrophobe. |
FR2958647B1 (fr) | 2010-04-08 | 2013-08-23 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent. |
US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
US9084727B2 (en) | 2011-05-10 | 2015-07-21 | Bend Research, Inc. | Methods and compositions for maintaining active agents in intra-articular spaces |
EP2828297A1 (fr) * | 2011-05-10 | 2015-01-28 | Adocia | Oligosaccharides fonctionnalisés |
US20120295833A1 (en) | 2011-05-10 | 2012-11-22 | Adocia | Polysaccharides having an adjustable degree of functionalization |
US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
KR101466511B1 (ko) * | 2012-11-12 | 2014-11-27 | 성균관대학교산학협력단 | 저산소증 관련 질환의 진단 및 치료용 저산소 감응형 나노입자 |
EP2920200A1 (fr) | 2012-11-13 | 2015-09-23 | Adocia | Composes anioniques substitues constitues d'un squelette forme d'un nombre discret d'unites saccharidiques |
US9700599B2 (en) * | 2012-11-13 | 2017-07-11 | Adocia | Rapid-acting insulin formulation comprising a substituted anionic compound |
FR2997952B1 (fr) * | 2012-11-13 | 2014-11-21 | Adocia | Composes anioniques substitues constitues d'un squelette forme d'un nombre discret d'unites saccharidiques |
US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
DE102014016901B4 (de) * | 2014-09-17 | 2021-08-12 | Friedrich-Schiller-Universität Jena | Verfahren zur Herstellung für neue Dextranderivate als Wirkstoffträgersystem und deren Verwendung |
FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2808405A (en) * | 1955-03-11 | 1957-10-01 | Ohio Commw Eng Co | Acylated amino acid esters of dextran products and method of making same |
US4006059A (en) * | 1974-07-29 | 1977-02-01 | Purdue Research Foundation | Hydrophobic noncovalent binding of proteins to support materials |
FR2555589B1 (fr) * | 1983-11-30 | 1986-05-16 | Choay Sa | Nouveaux derives du dextrane a activites anticoagulante en anti-inflammatoire, leur procede de preparation et utilisation de ces derives en tant qu'anticoagulants et en tant que substituts du plasma sanguin |
FR2635019B1 (fr) * | 1988-08-02 | 1992-06-12 | Centre Nat Rech Scient | Materiau capable de fixer les substances biologiques, et ses applications notamment comme support de chromatographie d'affinite |
US5693625A (en) * | 1989-03-09 | 1997-12-02 | Therapeutiques Substitutives | Method of regenerating cells and tissues using functionalized dextrans |
DE4136324A1 (de) * | 1991-11-05 | 1993-05-13 | Hoechst Ag | Dextranderivate als adsorptionsmittel fuer gallensaeuren, mit gallensaeuren beladene dextranderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel |
DE69425464T2 (de) * | 1993-02-26 | 2001-05-23 | Drug Delivery System Inst Ltd | Polysaccharidderivat und wirkstoffträger |
DE4433101A1 (de) * | 1994-09-16 | 1996-03-21 | Bauer Kurt Heinz Prof Dr | Wasserlösliche Dextranfettsäureester und ihre Verwendung als Solubilisatoren |
CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
AU7466998A (en) * | 1997-04-14 | 1998-11-11 | Byron E. Anderson | Method and material for inhibiting complement |
FR2772382B1 (fr) * | 1997-12-11 | 2000-03-03 | Solutions | Derives de dextrane, leur procede de preparation et leurs applications comme medicaments a action biologique specifique |
FR2781485B1 (fr) * | 1998-07-21 | 2003-08-08 | Denis Barritault | Polymeres biocompatibles leur procede de preparation et les compositions les contenant |
AU3631999A (en) * | 1998-12-04 | 2000-06-26 | Iliya Yakovlevich Ashkinazi | Biologically active carboxymethyldextran n-arylamides |
TWI313609B (en) | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
FR2891149B1 (fr) * | 2005-09-26 | 2007-11-30 | Biodex Sarl | Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes. |
FR2919188B1 (fr) * | 2007-07-27 | 2010-02-26 | Proteins & Peptides Man | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
RU2498820C2 (ru) * | 2008-09-26 | 2013-11-20 | Адосиа | Комплекс, образованный полисахаридом и нвр |
-
2007
- 2007-03-29 FR FR0702316A patent/FR2914305B1/fr active Active
- 2007-09-26 ES ES07825188.1T patent/ES2562711T3/es active Active
- 2007-09-26 EP EP07825188.1A patent/EP2066700B1/fr not_active Not-in-force
- 2007-09-26 MX MX2009003145A patent/MX2009003145A/es active IP Right Grant
- 2007-09-26 RU RU2009115681/04A patent/RU2476437C2/ru not_active IP Right Cessation
- 2007-09-26 DK DK07825188.1T patent/DK2066700T3/en active
- 2007-09-26 SG SG2011089125A patent/SG177172A1/en unknown
- 2007-09-26 PL PL07825188T patent/PL2066700T3/pl unknown
- 2007-09-26 BR BRPI0717110-2A patent/BRPI0717110A2/pt not_active Application Discontinuation
- 2007-09-26 KR KR1020097006007A patent/KR101502528B1/ko not_active IP Right Cessation
- 2007-09-26 WO PCT/IB2007/002807 patent/WO2008038111A1/fr active Application Filing
- 2007-09-26 CA CA2664650A patent/CA2664650C/fr not_active Expired - Fee Related
- 2007-09-26 AU AU2007301670A patent/AU2007301670B2/en not_active Ceased
- 2007-09-26 JP JP2009528809A patent/JP5486925B2/ja not_active Expired - Fee Related
- 2007-09-26 KR KR1020147036602A patent/KR20150006086A/ko not_active Application Discontinuation
-
2008
- 2008-03-31 US US12/078,441 patent/US8629124B2/en not_active Expired - Fee Related
-
2009
- 2009-03-19 IL IL197681A patent/IL197681A/en active IP Right Grant
-
2013
- 2013-12-16 JP JP2013259110A patent/JP2014088568A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BRPI0717110A2 (pt) | 2013-10-08 |
EP2066700A1 (fr) | 2009-06-10 |
WO2008038111A1 (fr) | 2008-04-03 |
PL2066700T3 (pl) | 2016-05-31 |
FR2914305B1 (fr) | 2009-07-03 |
AU2007301670A1 (en) | 2008-04-03 |
JP2014088568A (ja) | 2014-05-15 |
KR20090060419A (ko) | 2009-06-12 |
DK2066700T3 (en) | 2016-02-08 |
KR101502528B1 (ko) | 2015-03-13 |
JP5486925B2 (ja) | 2014-05-07 |
FR2914305A1 (fr) | 2008-10-03 |
JP2010505008A (ja) | 2010-02-18 |
AU2007301670B2 (en) | 2012-06-07 |
US8629124B2 (en) | 2014-01-14 |
SG177172A1 (en) | 2012-01-30 |
IL197681A0 (en) | 2009-12-24 |
RU2009115681A (ru) | 2010-11-10 |
IL197681A (en) | 2014-12-31 |
US20080234227A1 (en) | 2008-09-25 |
CA2664650C (fr) | 2016-02-09 |
KR20150006086A (ko) | 2015-01-15 |
RU2476437C2 (ru) | 2013-02-27 |
CA2664650A1 (fr) | 2008-04-03 |
ES2562711T3 (es) | 2016-03-07 |
EP2066700B1 (fr) | 2015-11-11 |
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Legal Events
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FG | Grant or registration |