MEP15708A - Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primjena - Google Patents

Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primjena

Info

Publication number
MEP15708A
MEP15708A MEP-157/08A MEP15708A MEP15708A ME P15708 A MEP15708 A ME P15708A ME P15708 A MEP15708 A ME P15708A ME P15708 A MEP15708 A ME P15708A
Authority
ME
Montenegro
Prior art keywords
triscarboxymethyl
tetraazacyclododecane
dihydroxypropyl
hydroxymethyl
production
Prior art date
Application number
MEP-157/08A
Other languages
English (en)
Inventor
Johannes Platzek
Peter Blaszkiewicz
Orlin Petrov
Holger Hoffmann
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MEP15708A publication Critical patent/MEP15708A/bs
Publication of ME00157B publication Critical patent/ME00157B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pronalazak se odnosi na kristalne litijumove komplekse N-(1-Hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i dobijanje od soli oslobođenog gadolinijum kompleksa N-(1-Hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tet- raazaciklododekana iz ovoga, bez primjene jonskih izmenjivača.
MEP-2008-157A 2000-12-15 2001-12-05 Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena ME00157B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064467A DE10064467C2 (de) 2000-12-15 2000-12-15 Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (de) 2000-12-15 2001-12-05 Lithium-komplexe von n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren herstellung und verwendung

Publications (2)

Publication Number Publication Date
MEP15708A true MEP15708A (bs) 2010-06-10
ME00157B ME00157B (me) 2010-10-10

Family

ID=7668584

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-157A ME00157B (me) 2000-12-15 2001-12-05 Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena

Country Status (35)

Country Link
US (1) US6894151B2 (bs)
EP (1) EP1343770B1 (bs)
JP (1) JP4399163B2 (bs)
KR (1) KR100869627B1 (bs)
CN (1) CN1229357C (bs)
AR (1) AR035609A1 (bs)
AT (1) ATE430737T1 (bs)
AU (2) AU3165902A (bs)
BG (1) BG66117B1 (bs)
BR (1) BR0116219A (bs)
CA (1) CA2431976C (bs)
CY (1) CY1109280T1 (bs)
CZ (1) CZ304573B6 (bs)
DE (2) DE10064467C2 (bs)
DK (1) DK1343770T3 (bs)
EC (1) ECSP034676A (bs)
EE (1) EE05245B1 (bs)
ES (1) ES2325982T3 (bs)
HK (1) HK1064098A1 (bs)
HR (1) HRP20030576B1 (bs)
HU (1) HU229657B1 (bs)
IL (1) IL156432A0 (bs)
ME (1) ME00157B (bs)
MX (1) MXPA03005240A (bs)
NO (1) NO324864B1 (bs)
NZ (1) NZ526478A (bs)
PL (1) PL204181B1 (bs)
PT (1) PT1343770E (bs)
RS (1) RS51862B (bs)
RU (1) RU2003120513A (bs)
SK (1) SK287424B6 (bs)
TW (1) TWI302531B (bs)
UY (1) UY27056A1 (bs)
WO (1) WO2002048119A2 (bs)
ZA (1) ZA200305421B (bs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1635878B1 (en) * 2003-06-25 2010-12-29 Guerbet Peptide conjugate for magnetic resonance imaging of matrix metalloproteinases
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
CN1993357B (zh) * 2004-07-02 2011-10-19 伯拉考成像股份公司 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
EP1999118B1 (en) 2006-03-14 2012-10-17 Mallinckrodt LLC Metal complexes of tetraazamacrocycle derivatives
US7777029B2 (en) * 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
WO2011054480A1 (de) * 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
PE20141325A1 (es) 2011-04-21 2014-10-08 Bayer Ip Gmbh Preparacion de gadobutrol de alta pureza
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

Also Published As

Publication number Publication date
EP1343770B1 (de) 2009-05-06
EE05245B1 (et) 2009-12-15
HU229657B1 (en) 2014-03-28
BG107901A (bg) 2004-06-30
NO20032523L (no) 2003-06-04
HRP20030576B1 (en) 2011-09-30
NO324864B1 (no) 2007-12-17
MXPA03005240A (es) 2003-09-25
EE200300282A (et) 2003-10-15
ME00157B (me) 2010-10-10
HUP0302563A2 (hu) 2003-12-29
KR20030077555A (ko) 2003-10-01
NZ526478A (en) 2006-04-28
PT1343770E (pt) 2009-07-20
ATE430737T1 (de) 2009-05-15
ZA200305421B (en) 2004-08-27
CY1109280T1 (el) 2014-07-02
SK7292003A3 (en) 2003-11-04
RS51862B (sr) 2012-02-29
HUP0302563A3 (en) 2011-04-28
JP2004515545A (ja) 2004-05-27
DE10064467C2 (de) 2002-10-31
UY27056A1 (es) 2002-07-31
NO20032523D0 (no) 2003-06-04
ES2325982T3 (es) 2009-09-28
US20020128472A1 (en) 2002-09-12
YU48103A (sh) 2006-05-25
KR100869627B1 (ko) 2008-11-21
BR0116219A (pt) 2006-02-21
PL204181B1 (pl) 2009-12-31
PL366141A1 (en) 2005-01-24
AU3165902A (en) 2002-06-24
AR035609A1 (es) 2004-06-16
DE10064467A1 (de) 2002-07-11
WO2002048119A3 (de) 2002-11-07
TWI302531B (en) 2008-11-01
CN1481371A (zh) 2004-03-10
CN1229357C (zh) 2005-11-30
BG66117B1 (bg) 2011-05-31
WO2002048119A2 (de) 2002-06-20
CZ20031641A3 (cs) 2003-09-17
EP1343770A2 (de) 2003-09-17
HK1064098A1 (en) 2005-01-21
CA2431976A1 (en) 2002-06-20
US6894151B2 (en) 2005-05-17
HRP20030576A2 (en) 2005-06-30
ECSP034676A (es) 2003-08-29
AU2002231659B2 (en) 2007-07-05
DE50114889D1 (de) 2009-06-18
DK1343770T3 (da) 2009-08-10
SK287424B6 (sk) 2010-09-07
IL156432A0 (en) 2004-01-04
CZ304573B6 (cs) 2014-07-16
RU2003120513A (ru) 2004-12-27
JP4399163B2 (ja) 2010-01-13
CA2431976C (en) 2010-04-13

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