PT986548E - Producao de complexos de mono- e 1,7-bis-n-hidroxialquilcicleno e de sal de litio - Google Patents
Producao de complexos de mono- e 1,7-bis-n-hidroxialquilcicleno e de sal de litioInfo
- Publication number
- PT986548E PT986548E PT98934857T PT98934857T PT986548E PT 986548 E PT986548 E PT 986548E PT 98934857 T PT98934857 T PT 98934857T PT 98934857 T PT98934857 T PT 98934857T PT 986548 E PT986548 E PT 986548E
- Authority
- PT
- Portugal
- Prior art keywords
- bis
- mono
- production
- hydroxyloquicylcylene
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229910003002 lithium salt Inorganic materials 0.000 title 1
- 159000000002 lithium salts Chemical class 0.000 title 1
- ZPDFIIGFYAHNSK-CTHHTMFSSA-K 2-[4,10-bis(carboxylatomethyl)-7-[(2r,3s)-1,3,4-trihydroxybutan-2-yl]-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+) Chemical compound [Gd+3].OC[C@@H](O)[C@@H](CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 ZPDFIIGFYAHNSK-CTHHTMFSSA-K 0.000 abstract 1
- 229960003411 gadobutrol Drugs 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Inorganic materials [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 abstract 1
- RRBYUSWBLVXTQN-UHFFFAOYSA-N tricyclene Chemical compound C12CC3CC2C1(C)C3(C)C RRBYUSWBLVXTQN-UHFFFAOYSA-N 0.000 abstract 1
- RRBYUSWBLVXTQN-VZCHMASFSA-N tricyclene Natural products C([C@@H]12)C3C[C@H]1C2(C)C3(C)C RRBYUSWBLVXTQN-VZCHMASFSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19724186A DE19724186C2 (de) | 1997-06-02 | 1997-06-02 | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT986548E true PT986548E (pt) | 2003-12-31 |
Family
ID=7831875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98934857T PT986548E (pt) | 1997-06-02 | 1998-05-28 | Producao de complexos de mono- e 1,7-bis-n-hidroxialquilcicleno e de sal de litio |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5994536A (pt) |
| EP (1) | EP0986548B1 (pt) |
| JP (1) | JP4503709B2 (pt) |
| AT (1) | ATE246178T1 (pt) |
| AU (1) | AU8432798A (pt) |
| CA (1) | CA2291782C (pt) |
| DE (2) | DE19724186C2 (pt) |
| DK (1) | DK0986548T3 (pt) |
| ES (1) | ES2205523T3 (pt) |
| NO (1) | NO313459B1 (pt) |
| PT (1) | PT986548E (pt) |
| SI (1) | SI0986548T1 (pt) |
| TW (1) | TW450965B (pt) |
| WO (1) | WO1998055467A1 (pt) |
| ZA (1) | ZA984734B (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6271325B1 (en) | 1999-05-17 | 2001-08-07 | Univation Technologies, Llc | Method of polymerization |
| US6274684B1 (en) | 1999-10-22 | 2001-08-14 | Univation Technologies, Llc | Catalyst composition, method of polymerization, and polymer therefrom |
| US6265505B1 (en) | 1999-11-18 | 2001-07-24 | Univation Technologies, Llc | Catalyst system and its use in a polymerization process |
| US6300439B1 (en) | 1999-11-08 | 2001-10-09 | Univation Technologies, Llc | Group 15 containing transition metal catalyst compounds, catalyst systems and their use in a polymerization process |
| US6271323B1 (en) | 1999-10-28 | 2001-08-07 | Univation Technologies, Llc | Mixed catalyst compounds, catalyst systems and their use in a polymerization process |
| US6380328B1 (en) | 1999-12-10 | 2002-04-30 | Univation Technologies, Llc | Catalyst systems and their use in a polymerization process |
| US6300438B1 (en) | 1999-10-22 | 2001-10-09 | Univation Technolgies, Llc | Hafnium transition metal catalyst compounds, catalyst systems and their use in a polymerization process |
| US6624107B2 (en) | 1999-10-22 | 2003-09-23 | Univation Technologies, Llc | Transition metal catalyst compounds having deuterium substituted ligand and catalyst systems thereof |
| US6417304B1 (en) | 1999-11-18 | 2002-07-09 | Univation Technologies, Llc | Method of polymerization and polymer produced therefrom |
| US6281306B1 (en) * | 1999-12-16 | 2001-08-28 | Univation Technologies, Llc | Method of polymerization |
| EP1322626B1 (en) | 2000-09-29 | 2008-11-05 | Anormed Inc. | Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof |
| DE10064467C2 (de) * | 2000-12-15 | 2002-10-31 | Schering Ag | Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung |
| EP1999118B1 (en) | 2006-03-14 | 2012-10-17 | Mallinckrodt LLC | Metal complexes of tetraazamacrocycle derivatives |
| DE102009053171B4 (de) | 2009-11-04 | 2011-07-21 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol) |
| DE102009057274B4 (de) | 2009-12-02 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels Trioxobicyclo-octan |
| DE102009053252B3 (de) * | 2009-11-09 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer Membran |
| WO2011054480A1 (de) | 2009-11-09 | 2011-05-12 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer membran |
| DE102010013833A1 (de) | 2010-03-29 | 2011-09-29 | Bayer Schering Pharma Aktiengesellschaft | Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal |
| DE102010023105A1 (de) | 2010-06-04 | 2011-12-08 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol |
| CN103189057B (zh) * | 2010-08-26 | 2015-02-18 | 崔坤元 | 大环脂类化合物及其应用 |
| PE20141325A1 (es) * | 2011-04-21 | 2014-10-08 | Bayer Ip Gmbh | Preparacion de gadobutrol de alta pureza |
| IL265536B (en) | 2016-09-27 | 2022-07-01 | Bayer Pharma AG | A method for the production of a crystalline form of the a modification of calcobuterol |
| CN106543094A (zh) * | 2016-11-04 | 2017-03-29 | 嘉实（湖南）医药科技有限公司 | 高纯度钆布醇的制备方法 |
| KR101971435B1 (ko) * | 2017-08-29 | 2019-04-24 | 주식회사 엔지켐생명과학 | 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법 |
| KR102033964B1 (ko) * | 2018-01-19 | 2019-10-18 | 주식회사 엔지켐생명과학 | 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법 |
| EP3820853A4 (en) * | 2018-07-10 | 2022-08-17 | Biophore India Pharmaceuticals Pvt. Ltd. | PROCESS FOR THE PREPARATION OF 2,2',2''-( 10-((2R,3S)-1,3,4-TRIHYDROXY BUTAN-2-YL)-1,4,7,10-TETRAAZACYCLODODECAN-1,4 ,7-TRIYL)-TRIACETIC ACID AND THEIR COMPLEXES |
| KR20210112910A (ko) * | 2020-03-06 | 2021-09-15 | 주식회사 엔지켐생명과학 | 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5064633A (en) * | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
| DE4009119A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
| DE4140779A1 (de) * | 1991-12-06 | 1993-06-09 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen |
| DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
| DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
| DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
-
1997
- 1997-06-02 DE DE19724186A patent/DE19724186C2/de not_active Expired - Lifetime
-
1998
- 1998-05-28 WO PCT/DE1998/001523 patent/WO1998055467A1/de active IP Right Grant
- 1998-05-28 CA CA002291782A patent/CA2291782C/en not_active Expired - Lifetime
- 1998-05-28 EP EP98934857A patent/EP0986548B1/de not_active Expired - Lifetime
- 1998-05-28 AT AT98934857T patent/ATE246178T1/de active
- 1998-05-28 JP JP50129999A patent/JP4503709B2/ja not_active Expired - Lifetime
- 1998-05-28 PT PT98934857T patent/PT986548E/pt unknown
- 1998-05-28 ES ES98934857T patent/ES2205523T3/es not_active Expired - Lifetime
- 1998-05-28 DK DK98934857T patent/DK0986548T3/da active
- 1998-05-28 AU AU84327/98A patent/AU8432798A/en not_active Abandoned
- 1998-05-28 DE DE59809163T patent/DE59809163D1/de not_active Expired - Lifetime
- 1998-05-28 SI SI9830534T patent/SI0986548T1/xx unknown
- 1998-06-01 TW TW087108521A patent/TW450965B/zh not_active IP Right Cessation
- 1998-06-02 US US09/088,700 patent/US5994536A/en not_active Expired - Lifetime
- 1998-06-02 ZA ZA984734A patent/ZA984734B/xx unknown
-
1999
- 1999-12-01 NO NO19995870A patent/NO313459B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0986548A1 (de) | 2000-03-22 |
| ES2205523T3 (es) | 2004-05-01 |
| DE19724186A1 (de) | 1998-12-03 |
| NO995870L (no) | 2000-02-01 |
| ATE246178T1 (de) | 2003-08-15 |
| DE19724186C2 (de) | 2002-07-18 |
| CA2291782A1 (en) | 1998-12-10 |
| DE59809163D1 (de) | 2003-09-04 |
| US5994536A (en) | 1999-11-30 |
| EP0986548B1 (de) | 2003-07-30 |
| ZA984734B (en) | 1998-12-29 |
| JP2002508755A (ja) | 2002-03-19 |
| AU8432798A (en) | 1998-12-21 |
| CA2291782C (en) | 2009-05-26 |
| JP4503709B2 (ja) | 2010-07-14 |
| NO313459B1 (no) | 2002-10-07 |
| DK0986548T3 (da) | 2003-11-17 |
| TW450965B (en) | 2001-08-21 |
| WO1998055467A1 (de) | 1998-12-10 |
| SI0986548T1 (en) | 2003-12-31 |
| NO995870D0 (no) | 1999-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT986548E (pt) | Producao de complexos de mono- e 1,7-bis-n-hidroxialquilcicleno e de sal de litio | |
| IL86456A (en) | Tetrazole derivatives useful as intermediates for preparing antihypertensive compounds | |
| MX9800867A (es) | Halogenobencimidazoles y su empleo como microbicidas. | |
| ATE227297T1 (de) | 2-pyridylmethylen-polyazamacrocyclophosphonsäur n,ihre komplexe und derivate zur verwendung als kontrastmittel | |
| MX9700430A (es) | El uso de compuestos heterociclicos. | |
| IN2012DE00109A (pt) | ||
| PL338339A1 (en) | Novel derivatives of tetrazole | |
| ATE240336T1 (de) | Metallierung von makrozyklen mit 2,4-dicarbonyl- metallkomplexen | |
| IE883844L (en) | Macrocyclic chelating agents and chelates thereof | |
| MEP15708A (en) | Lithium complexes of n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof | |
| CA2356985A1 (en) | 5ht1 antagonists for antidepressant therapy | |
| MX9702203A (es) | Derivados de pirazolil-pirazol substituidos, procedimientos para su preparacion y su uso como agentes con accion herbicida. | |
| BR9408244A (pt) | Derivados de azabiciclo[3.2.0]heptano N-substituídos | |
| ES2143224T3 (es) | Derivados naftamida de 3-beta-amino azabiciclo octano o nonano, como agentes antipsicoticos. | |
| BG101328A (en) | New derivatives of imidazoloquinaxalon with heterocyclic substituents, their preparation and use | |
| AU2595384A (en) | Tetrazole substituted tetrazolo 1,5-a -quinolines | |
| DE59605148D1 (de) | Dithiazoldioxide und ihre verwendung als mikrobizide | |
| DE69527630D1 (de) | Wasserlösliche glykolisierte derivate von 1,2-dithiinverbindungen | |
| WO1999006838A3 (en) | Novel method of detecting amyloid-like fibrils or protein aggregates | |
| ATE263139T1 (de) | 3-alkoxylbenzylaminderivate und ihre verwendung als arzneimittel zur behandlung von schizophrenie | |
| ZA9510198B (en) | Novel, multiply, substituted dtpa derivatives and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents |