DK0986548T3 - Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser - Google Patents

Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser

Info

Publication number
DK0986548T3
DK0986548T3 DK98934857T DK98934857T DK0986548T3 DK 0986548 T3 DK0986548 T3 DK 0986548T3 DK 98934857 T DK98934857 T DK 98934857T DK 98934857 T DK98934857 T DK 98934857T DK 0986548 T3 DK0986548 T3 DK 0986548T3
Authority
DK
Denmark
Prior art keywords
bis
mono
hydroxyalkyl
cycle
preparation
Prior art date
Application number
DK98934857T
Other languages
English (en)
Inventor
Orlin Petrov
Peter Blaszkiewicz
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7831875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0986548(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0986548T3 publication Critical patent/DK0986548T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98934857T 1997-06-02 1998-05-28 Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser DK0986548T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19724186A DE19724186C2 (de) 1997-06-02 1997-06-02 Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
PCT/DE1998/001523 WO1998055467A1 (de) 1997-06-02 1998-05-28 Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen

Publications (1)

Publication Number Publication Date
DK0986548T3 true DK0986548T3 (da) 2003-11-17

Family

ID=7831875

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98934857T DK0986548T3 (da) 1997-06-02 1998-05-28 Fremstilling af mono- og 1,7-bis-N-hydroxyalkyl-cyklen og lithiumsalt-komplekser

Country Status (15)

Country Link
US (1) US5994536A (da)
EP (1) EP0986548B1 (da)
JP (1) JP4503709B2 (da)
AT (1) ATE246178T1 (da)
AU (1) AU8432798A (da)
CA (1) CA2291782C (da)
DE (2) DE19724186C2 (da)
DK (1) DK0986548T3 (da)
ES (1) ES2205523T3 (da)
NO (1) NO313459B1 (da)
PT (1) PT986548E (da)
SI (1) SI0986548T1 (da)
TW (1) TW450965B (da)
WO (1) WO1998055467A1 (da)
ZA (1) ZA984734B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271325B1 (en) 1999-05-17 2001-08-07 Univation Technologies, Llc Method of polymerization
US6265505B1 (en) 1999-11-18 2001-07-24 Univation Technologies, Llc Catalyst system and its use in a polymerization process
US6300438B1 (en) 1999-10-22 2001-10-09 Univation Technolgies, Llc Hafnium transition metal catalyst compounds, catalyst systems and their use in a polymerization process
US6624107B2 (en) 1999-10-22 2003-09-23 Univation Technologies, Llc Transition metal catalyst compounds having deuterium substituted ligand and catalyst systems thereof
US6300439B1 (en) 1999-11-08 2001-10-09 Univation Technologies, Llc Group 15 containing transition metal catalyst compounds, catalyst systems and their use in a polymerization process
US6271323B1 (en) 1999-10-28 2001-08-07 Univation Technologies, Llc Mixed catalyst compounds, catalyst systems and their use in a polymerization process
US6417304B1 (en) 1999-11-18 2002-07-09 Univation Technologies, Llc Method of polymerization and polymer produced therefrom
US6274684B1 (en) 1999-10-22 2001-08-14 Univation Technologies, Llc Catalyst composition, method of polymerization, and polymer therefrom
US6380328B1 (en) 1999-12-10 2002-04-30 Univation Technologies, Llc Catalyst systems and their use in a polymerization process
US6281306B1 (en) * 1999-12-16 2001-08-28 Univation Technologies, Llc Method of polymerization
EP1322626B1 (en) 2000-09-29 2008-11-05 Anormed Inc. Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof
DE10064467C2 (de) * 2000-12-15 2002-10-31 Schering Ag Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
CN101400661A (zh) 2006-03-14 2009-04-01 马林克罗特公司 四氮杂大环衍生物的金属络合物
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) * 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
US9233971B2 (en) 2010-08-26 2016-01-12 Kunyuan Cui Lipomacrocycles and uses thereof
ES2780599T3 (es) 2011-04-21 2020-08-26 Bayer Ip Gmbh Preparación de gadobutrol de alta pureza
BR112019006066A2 (pt) 2016-09-27 2019-06-18 Bayer Pharma AG método para produzir a forma cristalina de modificação a de calcobutrol
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden

Also Published As

Publication number Publication date
JP4503709B2 (ja) 2010-07-14
NO995870D0 (no) 1999-12-01
ATE246178T1 (de) 2003-08-15
PT986548E (pt) 2003-12-31
CA2291782A1 (en) 1998-12-10
JP2002508755A (ja) 2002-03-19
DE59809163D1 (de) 2003-09-04
AU8432798A (en) 1998-12-21
EP0986548A1 (de) 2000-03-22
DE19724186A1 (de) 1998-12-03
SI0986548T1 (en) 2003-12-31
DE19724186C2 (de) 2002-07-18
CA2291782C (en) 2009-05-26
WO1998055467A1 (de) 1998-12-10
EP0986548B1 (de) 2003-07-30
ES2205523T3 (es) 2004-05-01
NO995870L (no) 2000-02-01
NO313459B1 (no) 2002-10-07
TW450965B (en) 2001-08-21
US5994536A (en) 1999-11-30
ZA984734B (en) 1998-12-29

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