DE69431359T2 - Prolyl-endopeptidaseinhibitoren - Google Patents

Prolyl-endopeptidaseinhibitoren

Info

Publication number
DE69431359T2
DE69431359T2 DE69431359T DE69431359T DE69431359T2 DE 69431359 T2 DE69431359 T2 DE 69431359T2 DE 69431359 T DE69431359 T DE 69431359T DE 69431359 T DE69431359 T DE 69431359T DE 69431359 T2 DE69431359 T2 DE 69431359T2
Authority
DE
Germany
Prior art keywords
prolyl endopeptidase
compounds
formula
present
memory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431359T
Other languages
English (en)
Other versions
DE69431359D1 (de
Inventor
P Peet
P Burkhart
Shujaath Mehdi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69431359D1 publication Critical patent/DE69431359D1/de
Publication of DE69431359T2 publication Critical patent/DE69431359T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
DE69431359T 1993-12-02 1994-11-08 Prolyl-endopeptidaseinhibitoren Expired - Fee Related DE69431359T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16110693A 1993-12-02 1993-12-02
PCT/US1994/012865 WO1995015310A1 (en) 1993-12-02 1994-11-08 Prolyl endopeptidase inhibitors

Publications (2)

Publication Number Publication Date
DE69431359D1 DE69431359D1 (de) 2002-10-17
DE69431359T2 true DE69431359T2 (de) 2003-07-31

Family

ID=22579844

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431359T Expired - Fee Related DE69431359T2 (de) 1993-12-02 1994-11-08 Prolyl-endopeptidaseinhibitoren

Country Status (19)

Country Link
US (1) US5661167A (de)
EP (1) EP0731788B1 (de)
JP (1) JPH09506090A (de)
KR (1) KR100341982B1 (de)
CN (1) CN1136806A (de)
AT (1) ATE223894T1 (de)
AU (1) AU684861B2 (de)
CA (1) CA2177821C (de)
DE (1) DE69431359T2 (de)
DK (1) DK0731788T3 (de)
ES (1) ES2179093T3 (de)
HU (1) HUT74687A (de)
IL (1) IL111775A (de)
NO (1) NO962238L (de)
NZ (1) NZ276600A (de)
PT (1) PT731788E (de)
TW (1) TW280818B (de)
WO (1) WO1995015310A1 (de)
ZA (1) ZA949302B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
JP2007509898A (ja) 2003-11-03 2007-04-19 プロビオドルグ エージー 神経障害治療に有用な組合せ
EP1824846A2 (de) 2003-11-03 2007-08-29 Probiodrug AG Neue verbindungen zur behandlung neurologischer erkrankungen
EP1713780B1 (de) 2004-02-05 2012-01-18 Probiodrug AG Neue inhibitoren von glutaminylcyclase
EP2089383B1 (de) 2006-11-09 2015-09-16 Probiodrug AG 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
DK2142514T3 (da) 2007-04-18 2015-03-23 Probiodrug Ag Thioureaderivater som glutaminylcyclase-inhibitorer
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
US9771786B2 (en) 2014-01-28 2017-09-26 Spirit Global Energy Solutions, Inc. Down-hole gas and solids separator utilized in production hydrocarbons
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
JPH0662591B2 (ja) * 1988-12-14 1994-08-17 株式会社ヤクルト本社 新規なチオプロリン誘導体
US5118811A (en) * 1989-04-13 1992-06-02 Japan Tobacco Inc. Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities

Also Published As

Publication number Publication date
WO1995015310A1 (en) 1995-06-08
TW280818B (de) 1996-07-11
CA2177821C (en) 2000-03-28
PT731788E (pt) 2003-01-31
EP0731788A1 (de) 1996-09-18
CA2177821A1 (en) 1995-06-08
HUT74687A (en) 1997-01-28
KR100341982B1 (ko) 2002-11-30
DK0731788T3 (da) 2003-01-20
ZA949302B (en) 1995-08-07
ATE223894T1 (de) 2002-09-15
ES2179093T3 (es) 2003-01-16
EP0731788B1 (de) 2002-09-11
DE69431359D1 (de) 2002-10-17
JPH09506090A (ja) 1997-06-17
NZ276600A (en) 1997-09-22
US5661167A (en) 1997-08-26
IL111775A (en) 1998-06-15
IL111775A0 (en) 1995-01-24
NO962238D0 (no) 1996-05-31
AU1091795A (en) 1995-06-19
CN1136806A (zh) 1996-11-27
AU684861B2 (en) 1998-01-08
NO962238L (no) 1996-05-31
HU9601472D0 (en) 1996-07-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee