TW280818B - - Google Patents

Info

Publication number
TW280818B
TW280818B TW083110932A TW83110932A TW280818B TW 280818 B TW280818 B TW 280818B TW 083110932 A TW083110932 A TW 083110932A TW 83110932 A TW83110932 A TW 83110932A TW 280818 B TW280818 B TW 280818B
Authority
TW
Taiwan
Prior art keywords
compounds
formula
present
memory
amnesia
Prior art date
Application number
TW083110932A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of TW280818B publication Critical patent/TW280818B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
TW083110932A 1993-12-02 1994-11-24 TW280818B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16110693A 1993-12-02 1993-12-02

Publications (1)

Publication Number Publication Date
TW280818B true TW280818B (zh) 1996-07-11

Family

ID=22579844

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083110932A TW280818B (zh) 1993-12-02 1994-11-24

Country Status (19)

Country Link
US (1) US5661167A (zh)
EP (1) EP0731788B1 (zh)
JP (1) JPH09506090A (zh)
KR (1) KR100341982B1 (zh)
CN (1) CN1136806A (zh)
AT (1) ATE223894T1 (zh)
AU (1) AU684861B2 (zh)
CA (1) CA2177821C (zh)
DE (1) DE69431359T2 (zh)
DK (1) DK0731788T3 (zh)
ES (1) ES2179093T3 (zh)
HU (1) HUT74687A (zh)
IL (1) IL111775A (zh)
NO (1) NO962238L (zh)
NZ (1) NZ276600A (zh)
PT (1) PT731788E (zh)
TW (1) TW280818B (zh)
WO (1) WO1995015310A1 (zh)
ZA (1) ZA949302B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
JP4806628B2 (ja) 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
WO2006058720A2 (en) 2003-11-03 2006-06-08 Probiodrug Ag Novel compounds for the treatment of neurological disorders
JP2007509898A (ja) 2003-11-03 2007-04-19 プロビオドルグ エージー 神経障害治療に有用な組合せ
EP1713780B1 (en) 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
DK2142514T3 (da) 2007-04-18 2015-03-23 Probiodrug Ag Thioureaderivater som glutaminylcyclase-inhibitorer
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
CN102791704B (zh) 2010-03-10 2015-11-25 前体生物药物股份公司 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
JP6050264B2 (ja) 2011-03-16 2016-12-21 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
CA2938369C (en) 2014-01-28 2019-08-06 Spirit Global Energy Solutions, Inc. Down-hole gas and solids separator utilized in production hydrocarbons
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
JPH0662591B2 (ja) * 1988-12-14 1994-08-17 株式会社ヤクルト本社 新規なチオプロリン誘導体
EP0419683A4 (en) * 1989-04-13 1992-03-11 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity

Also Published As

Publication number Publication date
CA2177821C (en) 2000-03-28
IL111775A0 (en) 1995-01-24
HU9601472D0 (en) 1996-07-29
ZA949302B (en) 1995-08-07
HUT74687A (en) 1997-01-28
IL111775A (en) 1998-06-15
DE69431359T2 (de) 2003-07-31
KR100341982B1 (ko) 2002-11-30
EP0731788A1 (en) 1996-09-18
CN1136806A (zh) 1996-11-27
ES2179093T3 (es) 2003-01-16
CA2177821A1 (en) 1995-06-08
WO1995015310A1 (en) 1995-06-08
NO962238D0 (no) 1996-05-31
US5661167A (en) 1997-08-26
NZ276600A (en) 1997-09-22
DK0731788T3 (da) 2003-01-20
ATE223894T1 (de) 2002-09-15
JPH09506090A (ja) 1997-06-17
NO962238L (no) 1996-05-31
AU684861B2 (en) 1998-01-08
EP0731788B1 (en) 2002-09-11
AU1091795A (en) 1995-06-19
DE69431359D1 (de) 2002-10-17
PT731788E (pt) 2003-01-31

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