NO962238L - Prolylendopeptidaseinhibitorer - Google Patents

Prolylendopeptidaseinhibitorer

Info

Publication number
NO962238L
NO962238L NO962238A NO962238A NO962238L NO 962238 L NO962238 L NO 962238L NO 962238 A NO962238 A NO 962238A NO 962238 A NO962238 A NO 962238A NO 962238 L NO962238 L NO 962238L
Authority
NO
Norway
Prior art keywords
compounds
formula
present
prolylendopeptidaseinhibitorer
memory
Prior art date
Application number
NO962238A
Other languages
English (en)
Other versions
NO962238D0 (no
Inventor
Norton Paul Peet
Joseph Paul Burkhart
Shujaath Mehdi
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO962238L publication Critical patent/NO962238L/no
Publication of NO962238D0 publication Critical patent/NO962238D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser av formel (l) innbefattende alle deres stereoisomerer, preparater og fremgangsmåter for fremstilling av disse. Forbindelsene ifølge foreliggende oppfinnelse er også anvendbare i deres farmakologiske akti- viteter, da de direkte virker som inhibitorer av prolylendopeptidase og derved tilveiebringer en metode for hukommelsesforøkning, forhindring eller nedsettelse av effekter av amnesi eller hukommelsessvekkelser.
NO962238A 1993-12-02 1996-05-31 Prolylendopeptidaseinhibitorer NO962238D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16110693A 1993-12-02 1993-12-02
PCT/US1994/012865 WO1995015310A1 (en) 1993-12-02 1994-11-08 Prolyl endopeptidase inhibitors

Publications (2)

Publication Number Publication Date
NO962238L true NO962238L (no) 1996-05-31
NO962238D0 NO962238D0 (no) 1996-05-31

Family

ID=22579844

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962238A NO962238D0 (no) 1993-12-02 1996-05-31 Prolylendopeptidaseinhibitorer

Country Status (19)

Country Link
US (1) US5661167A (no)
EP (1) EP0731788B1 (no)
JP (1) JPH09506090A (no)
KR (1) KR100341982B1 (no)
CN (1) CN1136806A (no)
AT (1) ATE223894T1 (no)
AU (1) AU684861B2 (no)
CA (1) CA2177821C (no)
DE (1) DE69431359T2 (no)
DK (1) DK0731788T3 (no)
ES (1) ES2179093T3 (no)
HU (1) HUT74687A (no)
IL (1) IL111775A (no)
NO (1) NO962238D0 (no)
NZ (1) NZ276600A (no)
PT (1) PT731788E (no)
TW (1) TW280818B (no)
WO (1) WO1995015310A1 (no)
ZA (1) ZA949302B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
ZA200603165B (en) 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
WO2006058720A2 (en) 2003-11-03 2006-06-08 Probiodrug Ag Novel compounds for the treatment of neurological disorders
KR101099206B1 (ko) 2004-02-05 2011-12-27 프로비오드룩 아게 신규한 글루타미닐 시클라제 저해제
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
MX2009009234A (es) 2007-03-01 2009-12-01 Probiodrug Ag Uso nuevo de inhibidores de ciclasa de glutaminilo.
EP2865670B1 (en) 2007-04-18 2017-01-11 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
ES2548913T3 (es) 2009-09-11 2015-10-21 Probiodrug Ag Derivados heterocíclicos como inhibidores de glutaminil ciclasa
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
WO2015116590A1 (en) 2014-01-28 2015-08-06 Spirit Global Energy Solutions, Inc. Down-hole gas and solids separator utilized in production hydrocarbons
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
JPH0662591B2 (ja) * 1988-12-14 1994-08-17 株式会社ヤクルト本社 新規なチオプロリン誘導体
US5118811A (en) * 1989-04-13 1992-06-02 Japan Tobacco Inc. Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities

Also Published As

Publication number Publication date
HU9601472D0 (en) 1996-07-29
AU1091795A (en) 1995-06-19
PT731788E (pt) 2003-01-31
IL111775A (en) 1998-06-15
CA2177821C (en) 2000-03-28
IL111775A0 (en) 1995-01-24
EP0731788A1 (en) 1996-09-18
DK0731788T3 (da) 2003-01-20
EP0731788B1 (en) 2002-09-11
JPH09506090A (ja) 1997-06-17
CA2177821A1 (en) 1995-06-08
US5661167A (en) 1997-08-26
ATE223894T1 (de) 2002-09-15
DE69431359D1 (de) 2002-10-17
NZ276600A (en) 1997-09-22
HUT74687A (en) 1997-01-28
ZA949302B (en) 1995-08-07
TW280818B (no) 1996-07-11
WO1995015310A1 (en) 1995-06-08
AU684861B2 (en) 1998-01-08
CN1136806A (zh) 1996-11-27
DE69431359T2 (de) 2003-07-31
ES2179093T3 (es) 2003-01-16
KR100341982B1 (ko) 2002-11-30
NO962238D0 (no) 1996-05-31

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FC2A Withdrawal, rejection or dismissal of laid open patent application