ES2179093T3 - Inhibidores de la prolilendopeptidasa. - Google Patents

Inhibidores de la prolilendopeptidasa.

Info

Publication number
ES2179093T3
ES2179093T3 ES95901820T ES95901820T ES2179093T3 ES 2179093 T3 ES2179093 T3 ES 2179093T3 ES 95901820 T ES95901820 T ES 95901820T ES 95901820 T ES95901820 T ES 95901820T ES 2179093 T3 ES2179093 T3 ES 2179093T3
Authority
ES
Spain
Prior art keywords
inhibitors
compounds
formula
present
prolilendopeptidasa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95901820T
Other languages
English (en)
Inventor
Norton P Peet
Joseph P Burkhart
Shujaath Mehdi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2179093T3 publication Critical patent/ES2179093T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), QUE COMPRENDE TODOS SUS ESTEREOISOMEROS, COMPOSICIONES Y PROCESOS PARA SU PREPARACION. LOS COMPUESTOS DE LA PRESENTE INVENCION TAMBIEN SON UTILES EN SUS ACTIVIDADES FARMACOLOGICAS YA QUE ACTUAN DIRECTAMENTE COMO INHIBIDORES DE PROPIL ENDOPEPTIDASA Y COMO TAL PREVEN UN METODO PARA MEJORAR LA MEMORIA, PREVENIR O REDUCIR LOS EFECTOS DE LA AMNESIA O LOS DEFICITS DE MEMORIA.
ES95901820T 1993-12-02 1994-11-08 Inhibidores de la prolilendopeptidasa. Expired - Lifetime ES2179093T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16110693A 1993-12-02 1993-12-02

Publications (1)

Publication Number Publication Date
ES2179093T3 true ES2179093T3 (es) 2003-01-16

Family

ID=22579844

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95901820T Expired - Lifetime ES2179093T3 (es) 1993-12-02 1994-11-08 Inhibidores de la prolilendopeptidasa.

Country Status (19)

Country Link
US (1) US5661167A (es)
EP (1) EP0731788B1 (es)
JP (1) JPH09506090A (es)
KR (1) KR100341982B1 (es)
CN (1) CN1136806A (es)
AT (1) ATE223894T1 (es)
AU (1) AU684861B2 (es)
CA (1) CA2177821C (es)
DE (1) DE69431359T2 (es)
DK (1) DK0731788T3 (es)
ES (1) ES2179093T3 (es)
HU (1) HUT74687A (es)
IL (1) IL111775A (es)
NO (1) NO962238D0 (es)
NZ (1) NZ276600A (es)
PT (1) PT731788E (es)
TW (1) TW280818B (es)
WO (1) WO1995015310A1 (es)
ZA (1) ZA949302B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
EP1824846A2 (en) 2003-11-03 2007-08-29 Probiodrug AG Novel compounds for the treatment of neurological disorders
ZA200603165B (en) 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1713780B1 (en) 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
SG178953A1 (en) 2009-09-11 2012-04-27 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
US9771786B2 (en) 2014-01-28 2017-09-26 Spirit Global Energy Solutions, Inc. Down-hole gas and solids separator utilized in production hydrocarbons
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
JPH0662591B2 (ja) * 1988-12-14 1994-08-17 株式会社ヤクルト本社 新規なチオプロリン誘導体
US5118811A (en) * 1989-04-13 1992-06-02 Japan Tobacco Inc. Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities

Also Published As

Publication number Publication date
IL111775A0 (en) 1995-01-24
DK0731788T3 (da) 2003-01-20
KR100341982B1 (ko) 2002-11-30
PT731788E (pt) 2003-01-31
HUT74687A (en) 1997-01-28
IL111775A (en) 1998-06-15
AU1091795A (en) 1995-06-19
DE69431359D1 (de) 2002-10-17
NZ276600A (en) 1997-09-22
JPH09506090A (ja) 1997-06-17
ZA949302B (en) 1995-08-07
US5661167A (en) 1997-08-26
ATE223894T1 (de) 2002-09-15
TW280818B (es) 1996-07-11
CA2177821C (en) 2000-03-28
CA2177821A1 (en) 1995-06-08
HU9601472D0 (en) 1996-07-29
WO1995015310A1 (en) 1995-06-08
NO962238L (no) 1996-05-31
EP0731788A1 (en) 1996-09-18
EP0731788B1 (en) 2002-09-11
NO962238D0 (no) 1996-05-31
AU684861B2 (en) 1998-01-08
CN1136806A (zh) 1996-11-27
DE69431359T2 (de) 2003-07-31

Similar Documents

Publication Publication Date Title
ES2179093T3 (es) Inhibidores de la prolilendopeptidasa.
BG103485A (en) Ketobanzamides as calpain inhibitors
ES2092113T3 (es) Derivados fluoroalcoxibencilamino de heterociclos que contienen nitrogeno.
TR199802767T2 (xx) Trombin �nleyiciler olarak yeni amidino t�revleri.
BR9408246A (pt) Composto derivado de 3-azabicicloalcano N-substituído
ATE148130T1 (de) Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
CA2244785A1 (en) Pentafluorobenzenesulfonamides and analogs
TR199700844T1 (xx) Pirazolil-Benzoil T�revleri.
DE69705300T2 (de) Cyclopropylalkansäurederivate
ES2132415T3 (es) Nuevos derivados de 5-pirrolil-2-piridilmetilsulfinilbencimidazol.
DK0830350T3 (da) Hidtil ukendte N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[B][1,5]diazepin-3-yl)acetamider
DE69516128T2 (de) Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren
EA200200510A1 (ru) 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
TR199801935T2 (xx) N�trofil elastaz inhibit�rleri olarak pirolopirolon t�revleri.
CA2266759A1 (en) 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
CA2356985A1 (en) 5ht1 antagonists for antidepressant therapy
MY120550A (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions.
FI962323A0 (fi) N-substituoidut atsabisykloheptaanijohdannaiset, kuten esim. neuroleptit
PT96849A (pt) Processo de preparacao de novos derivados da beta-fenil-iso-serina e de beta-fenil-iso-serina-(2r,2s)
TR199901416T2 (xx) Heterosiklik karbonikasit t�revleri.
TR199800210T2 (xx) Didepsipeptid temelli endoparazitisid kompozisyonlar, yeni didepsipeptidler ve bunlar�n �retimi i�in i�lemler.
ES2128031T3 (es) Forma cristalina y polimorfica de (s,s,s)-n-(1-(2-carboxi-3-(n2-mesilisilamino)propil)-1-ciclopentilcarbonil)tirosina.
PL322969A1 (en) Substituted phenylamidines, pharmaceutic compositions containing theses compounds and method of obtaining them
BR9407232A (pt) Compostos de tiocarbamoíla
KR960700223A (ko) C-치환 디에틸렌 트리아민의 제조 방법(Process for the Production of C-Substituted Diethylenetriamines)