ES2061552T3 - Productos intermedios de tetrazol para compuestos antihipertensores. - Google Patents

Productos intermedios de tetrazol para compuestos antihipertensores.

Info

Publication number
ES2061552T3
ES2061552T3 ES88108005T ES88108005T ES2061552T3 ES 2061552 T3 ES2061552 T3 ES 2061552T3 ES 88108005 T ES88108005 T ES 88108005T ES 88108005 T ES88108005 T ES 88108005T ES 2061552 T3 ES2061552 T3 ES 2061552T3
Authority
ES
Spain
Prior art keywords
products
hypertension
compounds
hypertension compounds
tetrazole products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88108005T
Other languages
English (en)
Inventor
Paul Edward Aldrich
Michael Ernest Pierce
John Jonas Vytautas Duncia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of ES2061552T3 publication Critical patent/ES2061552T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/22—Tin compounds
    • C07F7/2284—Compounds with one or more Sn-N linkages

Abstract

SE DESCRIBEN PRODUCTOS INTERMEDIOS DE TETRAZOL UTILES PARA OBTENER COMPUESTOS ANTIHIPERTENSION DESCRITOS EN LA SOLICITUD ASIGNADA U.S. SER. NO. 884.920 REGISTRADA EL 11 DE JULIO DE 1986. ESTOS TETRAZOLES TIENEN LA FORMULA (I) DONDE X1 Y X2 SON COMO SE DESCRIBEN EN LA ESPECIFICACION.
ES88108005T 1987-05-22 1988-05-19 Productos intermedios de tetrazol para compuestos antihipertensores. Expired - Lifetime ES2061552T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/053,198 US4820843A (en) 1987-05-22 1987-05-22 Tetrazole intermediates to antihypertensive compounds

Publications (1)

Publication Number Publication Date
ES2061552T3 true ES2061552T3 (es) 1994-12-16

Family

ID=21982564

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88108005T Expired - Lifetime ES2061552T3 (es) 1987-05-22 1988-05-19 Productos intermedios de tetrazol para compuestos antihipertensores.

Country Status (20)

Country Link
US (1) US4820843A (es)
EP (1) EP0291969B1 (es)
JP (1) JPH0774207B2 (es)
KR (1) KR960009571B1 (es)
AT (1) ATE101603T1 (es)
AU (1) AU603525B2 (es)
CA (1) CA1340325C (es)
DE (1) DE3887772T2 (es)
DK (1) DK274788A (es)
ES (1) ES2061552T3 (es)
FI (1) FI93831C (es)
HU (1) HU198698B (es)
IE (1) IE63204B1 (es)
IL (1) IL86456A (es)
MY (1) MY101284A (es)
NO (1) NO178189C (es)
NZ (1) NZ224741A (es)
PT (1) PT87552B (es)
RU (1) RU2091376C1 (es)
ZA (1) ZA883528B (es)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
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CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
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CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
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EP0412848B1 (en) * 1989-08-11 1995-01-18 Zeneca Limited Quinoline derivatives, process for their preparation and their use as medicaments
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IE903911A1 (en) * 1989-11-20 1991-05-22 Ici Plc Diazine derivatives
EP0442473B1 (en) * 1990-02-15 1998-08-19 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
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US5284661A (en) * 1990-02-22 1994-02-08 Takeda Chemical Industries, Ltd. Fused thiophene derivatives, their production and use
CA2037630C (en) * 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2665702B1 (fr) * 1990-08-08 1994-02-25 Sanofi Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
FR2659967B1 (fr) * 1990-03-20 1992-07-24 Sanofi Sa Derives d'imidazolinone n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
NZ237476A (en) * 1990-03-20 1994-01-26 Sanofi Sa N-substituted heterocyclic compounds and pharmaceutical compositions.
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
EP0453210A3 (en) * 1990-04-19 1993-01-13 Imperial Chemical Industries Plc Pyridine derivatives
US5198439A (en) * 1990-04-19 1993-03-30 Imperial Chemical Industries Plc Angiotension II antagonizing pyridine derivatives
ZA912983B (en) 1990-04-27 1992-01-29 Takeda Chemical Industries Ltd Benzimidazole derivatives,their production and use
US6004989A (en) 1990-04-27 1999-12-21 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
US5703110A (en) * 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
CA2041763A1 (en) 1990-05-11 1991-11-12 Sheih-Shung T. Chen Microbial transformation process for antihypertensive products
FR2663027B1 (fr) * 1990-06-08 1994-12-02 Roussel Uclaf Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
AU653524B2 (en) * 1990-06-08 1994-10-06 Roussel-Uclaf New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
FR2673943B1 (fr) * 1991-03-13 1994-02-18 Roussel Uclaf Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
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DE4023369A1 (de) * 1990-07-23 1992-01-30 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
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US5284954A (en) * 1990-09-10 1994-02-08 Abbott Laboratories Process for the preparation of tetrazoles
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
JP3214856B2 (ja) * 1990-12-14 2001-10-02 スミスクライン・ビーチャム・コーポレイション イミダゾリル−アルケン酸
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
IE914572A1 (en) * 1991-01-17 1992-07-29 Zeneca Ltd Chemical process
US5153347A (en) * 1991-01-31 1992-10-06 E. R. Squibb & Sons, Inc. Phosphonate, phosphinate derivatives useful as antihypertensive agents
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IE920175A1 (en) * 1991-02-11 1992-08-12 Zeneca Ltd Nitrogen heterocycles
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US5472967A (en) * 1991-02-20 1995-12-05 Synthelabo 4-pyrimidinone derivatives their preparation and their application in therapy
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US5191086A (en) * 1991-03-19 1993-03-02 E.R. Squibb & Sons, Inc. Imidazole and benzimidazole derivatives
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US5177074A (en) 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
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US5190942A (en) * 1991-04-22 1993-03-02 E. R. Squibb & Sons, Inc. Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
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FR2677984B1 (fr) * 1991-06-21 1994-02-25 Elf Sanofi Derives d'imidazoline n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
US5177097A (en) * 1991-07-24 1993-01-05 E. R. Squibb & Sons, Inc. Acyl amidine and acyl, guanidine substituted biphenyl derivatives
US5256695A (en) * 1991-07-24 1993-10-26 E. R. Squibb & Sons, Inc. Acyl amidine and acyl guanidine substituted biphenyl derivatives
AU2494792A (en) * 1991-08-19 1993-03-16 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
AU2496492A (en) * 1991-08-19 1993-03-16 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
IL103020A (en) * 1991-09-10 1998-10-30 Tanabe Seiyaku Co History of acid 3) 1, '1 in biphenyl 4 Methyl (4,5,6,7 tetrahydro H3 imidazo] C 4,5 [pyridine 4 carboxylic acid, preparation and pharmaceutical preparations containing them
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
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US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
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Also Published As

Publication number Publication date
NO178189C (no) 1996-02-07
KR880013909A (ko) 1988-12-22
PT87552A (pt) 1989-05-31
HU198698B (en) 1989-11-28
DK274788A (da) 1988-11-23
PT87552B (pt) 1992-09-30
MY101284A (en) 1991-08-17
IE63204B1 (en) 1995-04-05
NO882241D0 (no) 1988-05-20
IL86456A0 (en) 1988-11-15
US4820843A (en) 1989-04-11
NO882241L (no) 1988-11-23
ATE101603T1 (de) 1994-03-15
DE3887772T2 (de) 1994-06-23
AU1650388A (en) 1988-11-24
FI93831B (fi) 1995-02-28
JPH01117876A (ja) 1989-05-10
IE881515L (en) 1988-11-22
RU2091376C1 (ru) 1997-09-27
DK274788D0 (da) 1988-05-19
FI93831C (fi) 1995-06-12
AU603525B2 (en) 1990-11-15
JPH0774207B2 (ja) 1995-08-09
DE3887772D1 (de) 1994-03-24
CA1340325C (en) 1999-01-19
ZA883528B (en) 1990-01-31
EP0291969B1 (en) 1994-02-16
KR960009571B1 (ko) 1996-07-20
EP0291969A2 (en) 1988-11-23
HUT47550A (en) 1989-03-28
EP0291969A3 (en) 1990-10-31
NO178189B (no) 1995-10-30
FI882390A (fi) 1988-11-23
FI882390A0 (fi) 1988-05-20
IL86456A (en) 1992-12-01
NZ224741A (en) 1990-12-21

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