FR2663027B1 - Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. - Google Patents

Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.

Info

Publication number
FR2663027B1
FR2663027B1 FR9007136A FR9007136A FR2663027B1 FR 2663027 B1 FR2663027 B1 FR 2663027B1 FR 9007136 A FR9007136 A FR 9007136A FR 9007136 A FR9007136 A FR 9007136A FR 2663027 B1 FR2663027 B1 FR 2663027B1
Authority
FR
France
Prior art keywords
new
medicaments
application
pharmaceutical compositions
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9007136A
Other languages
English (en)
Other versions
FR2663027A1 (fr
Inventor
Michel Fortin
Daniel Frechet
Gilles Hamon
Simone Jouquey
Jean-Paul Vevert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR9007136A priority Critical patent/FR2663027B1/fr
Priority to AU78201/91A priority patent/AU653524B2/en
Priority to JP3160798A priority patent/JPH04235974A/ja
Priority to EP91401481A priority patent/EP0461040A1/fr
Priority to PT97899A priority patent/PT97899B/pt
Priority to ZA914377A priority patent/ZA914377B/xx
Priority to MX2616091A priority patent/MX26160A/es
Priority to IE194991A priority patent/IE911949A1/en
Priority to HU911915A priority patent/HUT61285A/hu
Priority to CA002044087A priority patent/CA2044087A1/fr
Priority to KR1019910009419A priority patent/KR920000731A/ko
Priority to SU914895865A priority patent/RU2099342C1/ru
Priority to US07/712,247 priority patent/US5338756A/en
Priority to CN91103855A priority patent/CN1057257A/zh
Publication of FR2663027A1 publication Critical patent/FR2663027A1/fr
Priority to US08/074,106 priority patent/US5389634A/en
Priority to US08/324,772 priority patent/US5470867A/en
Application granted granted Critical
Publication of FR2663027B1 publication Critical patent/FR2663027B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9007136A 1990-06-08 1990-06-08 Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. Expired - Lifetime FR2663027B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR9007136A FR2663027B1 (fr) 1990-06-08 1990-06-08 Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
JP3160798A JPH04235974A (ja) 1990-06-08 1991-06-06 新規なイミダゾール誘導体、それらの製造法、得られる新規な中間体、それらの薬剤としての使用及びそれらを含有する製薬組成物
EP91401481A EP0461040A1 (fr) 1990-06-08 1991-06-06 Dérivés de l'imidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
AU78201/91A AU653524B2 (en) 1990-06-08 1991-06-06 New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
HU911915A HUT61285A (en) 1990-06-08 1991-06-07 Process for producing new condensed imidazole derivatives and pharmaceutical compositions comprising such compounds
ZA914377A ZA914377B (en) 1990-06-08 1991-06-07 Imidazole derivatives,their preparation process,the intermediates obtained,their use as medicaments and the pharmaceutical compositions containing them
MX2616091A MX26160A (es) 1990-06-08 1991-06-07 Nuevos derivados del imidazol y procedimiento para su preparacion.
IE194991A IE911949A1 (en) 1990-06-08 1991-06-07 New imidazole derivatives, their preparation process, the¹new intermediates obtained, their use as medicaments and the¹pharmaceutical compositions containing them
PT97899A PT97899B (pt) 1990-06-08 1991-06-07 Processo para a preparacao de novos derivados de imidazol e de composicoes farmaceuticas que os contem
CA002044087A CA2044087A1 (fr) 1990-06-08 1991-06-07 Derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
KR1019910009419A KR920000731A (ko) 1990-06-08 1991-06-07 신규 이미다졸 유도체, 그의 제조 방법, 그로부터 얻어진 신규 중간체, 의약으로서의 용도 및 그를 함유하는 제약 조성물
SU914895865A RU2099342C1 (ru) 1990-06-08 1991-06-07 Производные имидазола, способы их получения и фармацевтическая композиция на их основе
US07/712,247 US5338756A (en) 1990-06-08 1991-06-07 Benzimidazole compounds
CN91103855A CN1057257A (zh) 1990-06-08 1991-06-08 新的咪唑衍生物及其制法、所得的新中间体、作为药物的应用和含有它们的药物组合物
US08/074,106 US5389634A (en) 1990-06-08 1993-06-09 Imidazole derivatives having angiotensin II receptor antagonistic activity
US08/324,772 US5470867A (en) 1990-06-08 1994-10-17 Imidazoles and their salts having antagonistic activity to angiotesin II recetors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9007136A FR2663027B1 (fr) 1990-06-08 1990-06-08 Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.

Publications (2)

Publication Number Publication Date
FR2663027A1 FR2663027A1 (fr) 1991-12-13
FR2663027B1 true FR2663027B1 (fr) 1994-12-02

Family

ID=9397405

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9007136A Expired - Lifetime FR2663027B1 (fr) 1990-06-08 1990-06-08 Nouveaux derives de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.

Country Status (4)

Country Link
FR (1) FR2663027B1 (fr)
MX (1) MX26160A (fr)
RU (1) RU2099342C1 (fr)
ZA (1) ZA914377B (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3465990D1 (en) * 1983-08-12 1987-10-15 Ciba Geigy Ag Process for the production of substituted benzimidazoles
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (fr) * 1989-05-15 1990-12-05 Merck & Co. Inc. Benzimidazoles substitués comme antagoniste d'angiotensine II
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds

Also Published As

Publication number Publication date
RU2099342C1 (ru) 1997-12-20
MX26160A (es) 1993-10-01
ZA914377B (en) 1992-11-25
FR2663027A1 (fr) 1991-12-13

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