ME01072B - Derivati purina kao agonisti receptora adenozina a1 i postupci za njihovu upotrebu - Google Patents
Derivati purina kao agonisti receptora adenozina a1 i postupci za njihovu upotrebuInfo
- Publication number
- ME01072B ME01072B MEP-2010-87A MEP8710A ME01072B ME 01072 B ME01072 B ME 01072B ME P8710 A MEP8710 A ME P8710A ME 01072 B ME01072 B ME 01072B
- Authority
- ME
- Montenegro
- Prior art keywords
- monocyclic
- cycloalkyl
- bicyclic
- aryl
- cycloalkenyl
- Prior art date
Links
- 239000002582 adenosine A1 receptor agonist Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract 9
- 230000004060 metabolic process Effects 0.000 claims abstract 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract 3
- 208000012902 Nervous system disease Diseases 0.000 claims abstract 3
- 208000008589 Obesity Diseases 0.000 claims abstract 3
- 206010063837 Reperfusion injury Diseases 0.000 claims abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 3
- 230000003680 myocardial damage Effects 0.000 claims abstract 3
- 235000020824 obesity Nutrition 0.000 claims abstract 3
- 230000000302 ischemic effect Effects 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims 61
- 150000003839 salts Chemical class 0.000 claims 35
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 24
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 23
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000001475 halogen functional group Chemical group 0.000 claims 7
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 6
- -1 neoheptyl Chemical group 0.000 claims 6
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 6
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 4
- RGPUSZZTRKTMNA-UHFFFAOYSA-N 1-benzofuran-7-carbaldehyde Chemical compound O=CC1=CC=CC2=C1OC=C2 RGPUSZZTRKTMNA-UHFFFAOYSA-N 0.000 claims 3
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 3
- IVVNZDGDKPTYHK-JTQLQIEISA-N 1-cyano-2-[(2s)-3,3-dimethylbutan-2-yl]-3-pyridin-4-ylguanidine Chemical compound CC(C)(C)[C@H](C)N=C(NC#N)NC1=CC=NC=C1 IVVNZDGDKPTYHK-JTQLQIEISA-N 0.000 claims 3
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 3
- 208000001871 Tachycardia Diseases 0.000 claims 3
- 229960003150 bupivacaine Drugs 0.000 claims 3
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 claims 3
- 229960003132 halothane Drugs 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 229960004194 lidocaine Drugs 0.000 claims 3
- LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 claims 3
- 229960002497 nicorandil Drugs 0.000 claims 3
- 229940053973 novocaine Drugs 0.000 claims 3
- 229960002310 pinacidil Drugs 0.000 claims 3
- 235000011164 potassium chloride Nutrition 0.000 claims 3
- 239000001103 potassium chloride Substances 0.000 claims 3
- 229960002816 potassium chloride Drugs 0.000 claims 3
- 229960004919 procaine Drugs 0.000 claims 3
- 230000006794 tachycardia Effects 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000000372 cardioplegic agent Substances 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000003229 2-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 208000003734 Supraventricular Tachycardia Diseases 0.000 claims 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 claims 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000037323 metabolic rate Effects 0.000 claims 1
- 125000005244 neohexyl group Chemical group [H]C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000036284 oxygen consumption Effects 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 230000002861 ventricular Effects 0.000 claims 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 3
- 208000010399 Wasting Syndrome Diseases 0.000 abstract 1
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Epidemiology (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57480504P | 2004-05-26 | 2004-05-26 | |
| US58826304P | 2004-07-15 | 2004-07-15 | |
| PCT/US2005/018381 WO2005117910A2 (en) | 2004-05-26 | 2005-05-25 | Purine derivatives as adenosine a1 receptor agonists and methods of use thereof |
| EP05757108A EP1758596B9 (en) | 2004-05-26 | 2005-05-25 | Purine derivatives as adenosine a1 receptor agonists and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01072B true ME01072B (me) | 2012-10-20 |
Family
ID=35463332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2010-87A ME01072B (me) | 2004-05-26 | 2005-05-25 | Derivati purina kao agonisti receptora adenozina a1 i postupci za njihovu upotrebu |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7423144B2 (enExample) |
| EP (2) | EP1758596B9 (enExample) |
| JP (3) | JP4484928B2 (enExample) |
| KR (2) | KR101267202B1 (enExample) |
| CN (1) | CN103087133B (enExample) |
| AT (1) | ATE462704T1 (enExample) |
| AU (1) | AU2005249430B2 (enExample) |
| BR (1) | BRPI0510406A (enExample) |
| CA (1) | CA2567289C (enExample) |
| CY (1) | CY1110159T1 (enExample) |
| DE (1) | DE602005020286D1 (enExample) |
| DK (1) | DK1758596T3 (enExample) |
| EA (1) | EA011826B1 (enExample) |
| ES (1) | ES2343421T3 (enExample) |
| HR (1) | HRP20100344T2 (enExample) |
| IL (1) | IL179400A (enExample) |
| ME (1) | ME01072B (enExample) |
| MX (1) | MXPA06013560A (enExample) |
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| DE602005020286D1 (de) * | 2004-05-26 | 2010-05-12 | Inotek Pharmaceuticals Corp | Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür |
| NZ554506A (en) * | 2004-09-20 | 2011-01-28 | Inotek Pharmaceuticals Corp | Purine derivatives and methods of use thereof |
| EA015683B1 (ru) * | 2005-11-30 | 2011-10-31 | Инотек Фармасьютикалз Корпорейшн | Производные пурина и способы их применения |
| CA2643503A1 (en) * | 2006-03-23 | 2007-10-04 | Inotek Pharmaceuticals Corporation | Purine compounds and methods of use thereof |
| CA2646899C (en) * | 2006-04-04 | 2014-05-06 | Holger Lars Hermann | Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders |
| EA024042B1 (ru) | 2009-05-01 | 2016-08-31 | Инотек Фармасьютикалз Корпорейшн | Способ снижения внутриглазного давления у людей |
| JP2012532140A (ja) | 2009-06-30 | 2012-12-13 | フォレスト・ラボラトリーズ・ホールディングス・リミテッド | Ａ２ａｒ作動薬としてのアルコキシ−カルボニル−アミノ−アルキニル−アデノシン化合物及びその誘導体 |
| MX2012004225A (es) * | 2009-10-26 | 2012-06-08 | Inotek Pharmaceuticals Corp | Formulacion oftalmica y metodo de fabricacion de la misma. |
| EP2523669B1 (en) | 2010-01-11 | 2016-12-07 | Inotek Pharmaceuticals Corporation | Combination, kit and method of reducing intraocular pressure |
| JP2013522322A (ja) | 2010-03-19 | 2013-06-13 | イノテック ファーマシューティカルズ コーポレイション | 眼内圧を下げるためのアデノシンａ１受容体アゴニストと炭酸脱水酵素阻害剤との組合せ組成物 |
| SMT201700020T1 (it) * | 2010-03-19 | 2017-03-08 | Inotek Pharmaceuticals Corp | Combinazione di composizioni di antagonisti di adenosina a1 e bloccanti di recettori non selettivi beta-adrenergici per ridurre la pressione intraoculare |
| SG184223A1 (en) | 2010-03-26 | 2012-10-30 | Inotek Pharmaceuticals Corp | Adenosine compounds and their use thereof |
| CA2792266A1 (en) | 2010-03-26 | 2011-09-29 | Inotek Pharmaceuticals Corporation | Method of reducing intraocular pressure in humans using n6-cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof |
| CA2861009A1 (en) * | 2012-01-26 | 2013-08-01 | Inotek Pharmaceuticals Corporation | Anhydrous polymorphs of [(2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof |
| EP2968389A4 (en) | 2013-03-15 | 2016-08-24 | Inotek Pharmaceuticals Corp | OPHTHALMIC FORMULATIONS |
| GB2582361A (en) * | 2019-03-21 | 2020-09-23 | Univ Warwick | Adenosine receptor agonists |
| EP3988550A4 (en) * | 2019-06-21 | 2023-07-05 | Academy of Military Medical Sciences | 6-hydrazinoadenosine compound having a2a adenosine receptor agonist activity |
| DE102021120112A1 (de) | 2021-08-03 | 2023-02-09 | Bayerische Motoren Werke Aktiengesellschaft | Schnittwerkzeug für ein Metallblech und ein Verfahren zum Betreiben eines Schnittwerkzeugs für ein Metallblech |
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- 2005-05-25 WO PCT/US2005/018381 patent/WO2005117910A2/en not_active Ceased
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