IL179400A - Purine derivatives as adenosine a1 receptor agonists and compositions comprising them - Google Patents

Purine derivatives as adenosine a1 receptor agonists and compositions comprising them

Info

Publication number
IL179400A
IL179400A IL179400A IL17940006A IL179400A IL 179400 A IL179400 A IL 179400A IL 179400 A IL179400 A IL 179400A IL 17940006 A IL17940006 A IL 17940006A IL 179400 A IL179400 A IL 179400A
Authority
IL
Israel
Prior art keywords
compositions
animal
adenosine
purine derivatives
receptor agonists
Prior art date
Application number
IL179400A
Other languages
English (en)
Other versions
IL179400A0 (en
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Publication of IL179400A0 publication Critical patent/IL179400A0/en
Publication of IL179400A publication Critical patent/IL179400A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

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  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
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  • Communicable Diseases (AREA)
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  • Virology (AREA)
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IL179400A 2004-05-26 2006-11-20 Purine derivatives as adenosine a1 receptor agonists and compositions comprising them IL179400A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57480504P 2004-05-26 2004-05-26
US58826304P 2004-07-15 2004-07-15
PCT/US2005/018381 WO2005117910A2 (en) 2004-05-26 2005-05-25 Purine derivatives as adenosine a1 receptor agonists and methods of use thereof

Publications (2)

Publication Number Publication Date
IL179400A0 IL179400A0 (en) 2007-05-15
IL179400A true IL179400A (en) 2010-12-30

Family

ID=35463332

Family Applications (1)

Application Number Title Priority Date Filing Date
IL179400A IL179400A (en) 2004-05-26 2006-11-20 Purine derivatives as adenosine a1 receptor agonists and compositions comprising them

Country Status (24)

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US (3) US7423144B2 (enExample)
EP (2) EP1758596B9 (enExample)
JP (3) JP4484928B2 (enExample)
KR (2) KR101267202B1 (enExample)
CN (1) CN103087133B (enExample)
AT (1) ATE462704T1 (enExample)
AU (1) AU2005249430B2 (enExample)
BR (1) BRPI0510406A (enExample)
CA (1) CA2567289C (enExample)
CY (1) CY1110159T1 (enExample)
DE (1) DE602005020286D1 (enExample)
DK (1) DK1758596T3 (enExample)
EA (1) EA011826B1 (enExample)
ES (1) ES2343421T3 (enExample)
HR (1) HRP20100344T2 (enExample)
IL (1) IL179400A (enExample)
ME (1) ME01072B (enExample)
MX (1) MXPA06013560A (enExample)
NO (1) NO339450B1 (enExample)
NZ (1) NZ551951A (enExample)
PL (1) PL1758596T3 (enExample)
PT (1) PT1758596E (enExample)
RS (1) RS51261B (enExample)
WO (1) WO2005117910A2 (enExample)

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DE602005020286D1 (de) * 2004-05-26 2010-05-12 Inotek Pharmaceuticals Corp Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür
NZ554506A (en) * 2004-09-20 2011-01-28 Inotek Pharmaceuticals Corp Purine derivatives and methods of use thereof
EA015683B1 (ru) * 2005-11-30 2011-10-31 Инотек Фармасьютикалз Корпорейшн Производные пурина и способы их применения
CA2643503A1 (en) * 2006-03-23 2007-10-04 Inotek Pharmaceuticals Corporation Purine compounds and methods of use thereof
CA2646899C (en) * 2006-04-04 2014-05-06 Holger Lars Hermann Use of compositions containing kappa-opioid receptor antagonists for the treatment of dissociative disorders
EA024042B1 (ru) 2009-05-01 2016-08-31 Инотек Фармасьютикалз Корпорейшн Способ снижения внутриглазного давления у людей
JP2012532140A (ja) 2009-06-30 2012-12-13 フォレスト・ラボラトリーズ・ホールディングス・リミテッド Ａ２ａｒ作動薬としてのアルコキシ−カルボニル−アミノ−アルキニル−アデノシン化合物及びその誘導体
MX2012004225A (es) * 2009-10-26 2012-06-08 Inotek Pharmaceuticals Corp Formulacion oftalmica y metodo de fabricacion de la misma.
EP2523669B1 (en) 2010-01-11 2016-12-07 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
JP2013522322A (ja) 2010-03-19 2013-06-13 イノテック ファーマシューティカルズ コーポレイション 眼内圧を下げるためのアデノシンａ１受容体アゴニストと炭酸脱水酵素阻害剤との組合せ組成物
SMT201700020T1 (it) * 2010-03-19 2017-03-08 Inotek Pharmaceuticals Corp Combinazione di composizioni di antagonisti di adenosina a1 e bloccanti di recettori non selettivi beta-adrenergici per ridurre la pressione intraoculare
SG184223A1 (en) 2010-03-26 2012-10-30 Inotek Pharmaceuticals Corp Adenosine compounds and their use thereof
CA2792266A1 (en) 2010-03-26 2011-09-29 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using n6-cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
CA2861009A1 (en) * 2012-01-26 2013-08-01 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of [(2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
EP2968389A4 (en) 2013-03-15 2016-08-24 Inotek Pharmaceuticals Corp OPHTHALMIC FORMULATIONS
GB2582361A (en) * 2019-03-21 2020-09-23 Univ Warwick Adenosine receptor agonists
EP3988550A4 (en) * 2019-06-21 2023-07-05 Academy of Military Medical Sciences 6-hydrazinoadenosine compound having a2a adenosine receptor agonist activity
DE102021120112A1 (de) 2021-08-03 2023-02-09 Bayerische Motoren Werke Aktiengesellschaft Schnittwerkzeug für ein Metallblech und ein Verfahren zum Betreiben eines Schnittwerkzeugs für ein Metallblech

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US20120264706A1 (en) 2012-10-18
PL1758596T3 (pl) 2011-01-31
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JP2008500361A (ja) 2008-01-10
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