MA45517A - Molécules de liaison inhibant la croissance de cancer - Google Patents

Molécules de liaison inhibant la croissance de cancer

Info

Publication number
MA45517A
MA45517A MA045517A MA45517A MA45517A MA 45517 A MA45517 A MA 45517A MA 045517 A MA045517 A MA 045517A MA 45517 A MA45517 A MA 45517A MA 45517 A MA45517 A MA 45517A
Authority
MA
Morocco
Prior art keywords
binding molecules
cancer growth
inhibit cancer
membrane
molecules inhibit
Prior art date
Application number
MA045517A
Other languages
English (en)
Other versions
MA45517B1 (fr
Inventor
Eduard Batlle
Johannes Carolus Clevers
Bram Herpers
Ton Logtenberg
Mark Throsby
Robert Gerhardus Jacob Vries
Original Assignee
Fundacio Inst De Recerca Biomedica Irb Barcelona
Inst Catalana Recerca Estudis Avancats
Koninklijke Nederlandse Akademie Van Wetenschappen
Merus Nv
Ocello B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacio Inst De Recerca Biomedica Irb Barcelona, Inst Catalana Recerca Estudis Avancats, Koninklijke Nederlandse Akademie Van Wetenschappen, Merus Nv, Ocello B V filed Critical Fundacio Inst De Recerca Biomedica Irb Barcelona
Publication of MA45517A publication Critical patent/MA45517A/fr
Publication of MA45517B1 publication Critical patent/MA45517B1/fr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046Stomach, Intestines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des moyens et des procédés pour inhiber la croissance d'un cancer. Les moyens, dans certains modes de réalisation, comprennent des protéines et des anticorps qui se lient à une partie extracellulaire d'un membre de la famille du récepteur du facteur de croissance épidermique (egf) associé à la membrane et à une partie extracellulaire d'un élément d'une voie de signalisation wnt associé à la membrane. L'invention concerne en outre diverses cellules et tests qui sont utiles pour produire des protéines, des anticorps et des cellules.
MA45517A 2015-10-23 2016-10-21 Molécules de liaison inhibant la croissance de cancer MA45517B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15191343 2015-10-23
EP16168647 2016-05-06
PCT/NL2016/050726 WO2017069628A2 (fr) 2015-10-23 2016-10-21 Molécules de liaison inhibant la croissance de cancer

Publications (2)

Publication Number Publication Date
MA45517A true MA45517A (fr) 2018-08-29
MA45517B1 MA45517B1 (fr) 2021-04-30

Family

ID=57190021

Family Applications (2)

Application Number Title Priority Date Filing Date
MA054760A MA54760A (fr) 2015-10-23 2016-10-21 Molécules de liaison qui inhibent la croissance d'un cancer
MA45517A MA45517B1 (fr) 2015-10-23 2016-10-21 Molécules de liaison inhibant la croissance de cancer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA054760A MA54760A (fr) 2015-10-23 2016-10-21 Molécules de liaison qui inhibent la croissance d'un cancer

Country Status (26)

Country Link
US (2) US11939394B2 (fr)
EP (2) EP3912998A3 (fr)
JP (3) JP7296728B2 (fr)
KR (1) KR20180100305A (fr)
CN (2) CN108602888B (fr)
AU (2) AU2016340764B2 (fr)
BR (1) BR112018008068A2 (fr)
CA (1) CA3002957A1 (fr)
CY (1) CY1124108T1 (fr)
DK (1) DK3365373T3 (fr)
EA (1) EA201890866A1 (fr)
ES (1) ES2865482T3 (fr)
HK (1) HK1253914A1 (fr)
HR (1) HRP20210483T1 (fr)
HU (1) HUE055222T2 (fr)
LT (1) LT3365373T (fr)
MA (2) MA54760A (fr)
MD (1) MD3365373T2 (fr)
MX (2) MX2018004988A (fr)
NZ (1) NZ742290A (fr)
PL (1) PL3365373T3 (fr)
RS (1) RS61800B1 (fr)
SG (1) SG11201803359VA (fr)
SI (1) SI3365373T1 (fr)
WO (1) WO2017069628A2 (fr)
ZA (1) ZA201802758B (fr)

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US20180312604A1 (en) 2018-11-01
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