MX2022000302A - Moleculas de union que inhiben el crecimiento del cancer. - Google Patents
Moleculas de union que inhiben el crecimiento del cancer.Info
- Publication number
- MX2022000302A MX2022000302A MX2022000302A MX2022000302A MX2022000302A MX 2022000302 A MX2022000302 A MX 2022000302A MX 2022000302 A MX2022000302 A MX 2022000302A MX 2022000302 A MX2022000302 A MX 2022000302A MX 2022000302 A MX2022000302 A MX 2022000302A
- Authority
- MX
- Mexico
- Prior art keywords
- binding molecules
- cancer growth
- inhibit cancer
- antibodies
- membrane associated
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La invención proporciona medios y métodos para inhibir el crecimiento de un cáncer. Los medios, en algunas modalidades, comprenden proteínas y anticuerpos que unen una parte extracelular de un miembro asociado a la membrana de la familia del receptor de factor de crecimiento epidérmico (EGF) y una parte extracelular de un miembro asociado a la membrana de una ruta de señalización de WNT. Además, se proporcionan diversas células y ensayos que son útiles para la producción de las proteínas, anticuerpos y células.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15191343 | 2015-10-23 | ||
EP16168647 | 2016-05-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022000302A true MX2022000302A (es) | 2022-02-03 |
Family
ID=57190021
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018004988A MX2018004988A (es) | 2015-10-23 | 2016-10-21 | Moleculas de union que inhibe el crecimiento de cancer. |
MX2022000302A MX2022000302A (es) | 2015-10-23 | 2018-04-23 | Moleculas de union que inhiben el crecimiento del cancer. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018004988A MX2018004988A (es) | 2015-10-23 | 2016-10-21 | Moleculas de union que inhibe el crecimiento de cancer. |
Country Status (26)
Country | Link |
---|---|
US (1) | US11939394B2 (es) |
EP (2) | EP3365373B1 (es) |
JP (3) | JP7296728B2 (es) |
KR (1) | KR20180100305A (es) |
CN (2) | CN115925944A (es) |
AU (2) | AU2016340764B2 (es) |
BR (1) | BR112018008068A2 (es) |
CA (1) | CA3002957A1 (es) |
CY (1) | CY1124108T1 (es) |
DK (1) | DK3365373T3 (es) |
EA (1) | EA201890866A1 (es) |
ES (1) | ES2865482T3 (es) |
HK (1) | HK1253914A1 (es) |
HR (1) | HRP20210483T1 (es) |
HU (1) | HUE055222T2 (es) |
LT (1) | LT3365373T (es) |
MA (2) | MA45517B1 (es) |
MD (1) | MD3365373T2 (es) |
MX (2) | MX2018004988A (es) |
NZ (1) | NZ742290A (es) |
PL (1) | PL3365373T3 (es) |
RS (1) | RS61800B1 (es) |
SG (1) | SG11201803359VA (es) |
SI (1) | SI3365373T1 (es) |
WO (1) | WO2017069628A2 (es) |
ZA (1) | ZA201802758B (es) |
Families Citing this family (31)
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ES2816624T3 (es) | 2014-02-28 | 2021-04-05 | Merus Nv | Anticuerpos que se unen a EGFR y ERBB3 |
EP3126397B1 (en) * | 2014-04-04 | 2020-01-29 | Bionomics, Inc. | Humanized antibodies that bind lgr5 |
ES2865482T3 (es) | 2015-10-23 | 2021-10-15 | Merus Nv | Moléculas de unión que inhiben el crecimiento del cáncer |
AU2017239038A1 (en) | 2016-03-22 | 2018-10-04 | Bionomics Inc | Administration of an anti-LGR5 monoclonal antibody |
CN110325210A (zh) * | 2017-01-11 | 2019-10-11 | 小利兰·斯坦福大学托管委员会 | Rspo替代物分子 |
AU2018211985A1 (en) * | 2017-01-26 | 2019-07-18 | Surrozen Operating, Inc. | Tissue-specific Wnt signal enhancing molecules and uses thereof |
EA201992063A1 (ru) | 2017-03-31 | 2020-03-26 | Мерус Н.В. | СВЯЗЫВАЮЩИЕ ErbB-2 И ErbB-3 БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА ДЛЯ ПРИМЕНЕНИЯ ДЛЯ ЛЕЧЕНИЯ КЛЕТОК, КОТОРЫЕ СОДЕРЖАТ СЛИТЫЙ ГЕН NRG-1 |
CN111094350A (zh) * | 2017-07-06 | 2020-05-01 | 美勒斯公司 | 调节由细胞表达的生物活性的抗体 |
WO2019009727A1 (en) * | 2017-07-06 | 2019-01-10 | Merus N.V. | ANTI-PD1 ANTI-TIM3 BISPECIFIC ANTIBODIES |
CN111094351A (zh) | 2017-08-09 | 2020-05-01 | 美勒斯公司 | 结合EGFR和cMET的抗体 |
CA3094318A1 (en) * | 2018-03-30 | 2019-10-03 | Merus N.V. | Multivalent antibody |
JP2021530223A (ja) * | 2018-07-09 | 2021-11-11 | スロゼン, インコーポレイテッド | 組織特異性Wntシグナル増強分子及びその使用 |
EP3886905A4 (en) * | 2018-12-27 | 2022-08-24 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | BISPECIFIC ANTIBODY FOR MEMBRANE REMOVAL OF TARGET RECEPTORS |
US20220380440A1 (en) | 2018-12-31 | 2022-12-01 | Merus N.V. | Truncated multivalent multimers |
CA3124768A1 (en) * | 2018-12-31 | 2020-07-09 | Merus N.V. | Mixed binding domains |
CN114426578A (zh) * | 2019-02-14 | 2022-05-03 | 美勒斯公司 | 结合egfr、her2及her3的结合部分的组合 |
CN113840842A (zh) | 2019-02-26 | 2021-12-24 | 詹森生物科技公司 | 利用双特异性抗EGFR/c-Met抗体的联合疗法和患者分层 |
TW202102544A (zh) * | 2019-04-04 | 2021-01-16 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
JOP20210304A1 (ar) | 2019-05-14 | 2023-01-30 | Janssen Biotech Inc | علاجات مركبة باستخدام الأجسام المضادة ثنائية النوعية المضادة لمستقبل عامل نمو البشرة (EGFR)/ مستقبل عامل نمو خلايا الكبد (c-Met) ومثبطات كيناز التيروسين الخاصة بمستقبل عامل نمو البشرة (EGFR) من الجيل الثالث |
EP4017879A2 (en) | 2019-08-19 | 2022-06-29 | Merus N.V. | Treatment of cancer with a combination of an antibody that binds lgr5 and egfr and a topoisomerase i inhibitor |
MX2022005241A (es) * | 2019-11-01 | 2022-07-27 | Univ California | Degradacion de proteinas de superficie usando agente de union biespecifico. |
EP4114854A1 (en) * | 2020-03-05 | 2023-01-11 | UMC Utrecht Holding B.V. | Membrane ubiquitin ligases to target protein degradation |
EP4139357A1 (en) * | 2020-04-24 | 2023-03-01 | Merus N.V. | Treatment of cancers with an antibody that binds lgr5 and egfr |
AU2021291235A1 (en) * | 2020-06-18 | 2022-12-22 | Umc Utrecht Holding B.V. | Screening method for effective target - E3 ligase combinations |
CN113862326A (zh) * | 2020-09-08 | 2021-12-31 | 复旦大学 | KREMEN1和/或ASGR1作为药物靶点在治疗SARS-CoV-2感染中的应用 |
IL303633A (en) | 2020-12-15 | 2023-08-01 | Merus Nv | Cancer treatment with an antibody that binds LGR5 and EGFR |
CN116801907A (zh) * | 2020-12-18 | 2023-09-22 | 美勒斯公司 | 抗体组合物 |
CN114853889B (zh) * | 2021-02-03 | 2024-03-01 | 中国科学院动物研究所 | 针对人gpr48的单克隆抗体及其应用 |
CN113307882B (zh) * | 2021-05-12 | 2022-12-20 | 东北大学 | 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物 |
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