MX2015015448A - Ensayo de internalizacion del receptor del gusto. - Google Patents

Ensayo de internalizacion del receptor del gusto.

Info

Publication number
MX2015015448A
MX2015015448A MX2015015448A MX2015015448A MX2015015448A MX 2015015448 A MX2015015448 A MX 2015015448A MX 2015015448 A MX2015015448 A MX 2015015448A MX 2015015448 A MX2015015448 A MX 2015015448A MX 2015015448 A MX2015015448 A MX 2015015448A
Authority
MX
Mexico
Prior art keywords
taste receptor
receptor internalization
internalization assay
taste
assay
Prior art date
Application number
MX2015015448A
Other languages
English (en)
Inventor
Yuliya Kurash
Stephen Gravina
Original Assignee
Pepsico Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pepsico Inc filed Critical Pepsico Inc
Publication of MX2015015448A publication Critical patent/MX2015015448A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Esta descripción proporciona un ensayo de internalización del receptor del gusto útil para identificar moduladores del gusto.
MX2015015448A 2013-05-10 2014-05-09 Ensayo de internalizacion del receptor del gusto. MX2015015448A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361821978P 2013-05-10 2013-05-10
PCT/US2014/037507 WO2014183041A1 (en) 2013-05-10 2014-05-09 Taste receptor internalization assay

Publications (1)

Publication Number Publication Date
MX2015015448A true MX2015015448A (es) 2016-03-15

Family

ID=51867771

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015448A MX2015015448A (es) 2013-05-10 2014-05-09 Ensayo de internalizacion del receptor del gusto.

Country Status (13)

Country Link
US (1) US9766236B2 (es)
EP (1) EP2994482B1 (es)
JP (1) JP6211685B2 (es)
CN (1) CN105377885B (es)
AU (1) AU2014262540B2 (es)
BR (1) BR112015028082A2 (es)
CA (1) CA2911189A1 (es)
ES (1) ES2776159T3 (es)
HK (1) HK1218302A1 (es)
MX (1) MX2015015448A (es)
PL (1) PL2994482T3 (es)
RU (1) RU2665812C2 (es)
WO (1) WO2014183041A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2690456C2 (ru) 2013-05-10 2019-06-03 Пепсико, Инк. Клетки в качестве модели для идентификации возможных модуляторов вкусовых ощущений
US11102995B2 (en) 2016-09-16 2021-08-31 Pepsico, Inc. Compositions and methods for improving taste of non-nutritive sweeteners
WO2022236274A1 (en) * 2021-05-07 2022-11-10 Firmenich Incorporated Cells expressing bitter taste receptors and uses thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115038A1 (de) * 1991-05-08 1992-11-12 Genentech Inc Neue konjugate, bestehend aus einem glykoprotein und einer nukleinsaeure-bindenden substanz
US6759206B1 (en) * 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
DK1095277T3 (da) 1998-07-13 2003-04-22 Cellomics Inc System til cellebaseret screening
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
JP4339542B2 (ja) * 1999-09-10 2009-10-07 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニア Ｔ２ｒ、すなわち味覚受容体の新規ファミリー
US20080244761A1 (en) * 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7763431B1 (en) * 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7022488B2 (en) 2003-02-03 2006-04-04 Senomyx, Inc. Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators
AU2002336571A1 (en) 2001-09-18 2003-04-01 Irm, Llc Sweet taste receptors
IL165669A0 (en) 2002-07-29 2006-01-15 Senomyx Inc Identification of a novel bitter taste receptor t2r76
WO2004055048A2 (en) 2002-12-18 2004-07-01 Givaudan Sa Chimeric alpha q-gustducin g-proteins
US20050244810A1 (en) * 2003-09-29 2005-11-03 Egan Josephine M Taste signaling in gastrointestinal cells
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
EP1802975B1 (en) 2004-10-13 2012-05-16 Evotec Technologies GmbH Method for identifying compounds that affect a transport of a protein through a membrane trafficking pathway
CN101065479A (zh) * 2004-10-15 2007-10-31 蒙奈尔化学感觉中心 培养哺乳动物味细胞的方法
WO2006099005A1 (en) 2005-03-09 2006-09-21 Trustees Of Dartmouth College Method for identifying agents which modulate gtpase activity involved in insulin-stimulated glut4 translocation
EP1937718B1 (en) 2005-10-20 2017-12-06 Senomyx, Inc. Chimeric human sweet-umami and umami-sweet taste receptors
WO2007092938A2 (en) 2006-02-08 2007-08-16 Invitrogen Corporation Cellular assays for signaling receptors
JP6095881B2 (ja) 2006-04-20 2017-03-15 ジボダン エス エー 甘味増強に関する方法
US7964376B2 (en) 2006-06-19 2011-06-21 Givaudan Sa Chimeric proteins and their use in methods to screen for sweet taste modulators
EP2054523B1 (en) 2006-07-26 2015-11-18 The Coca-Cola Company Methods for identifying modulators of rgs21 activity, compositions comprising an rgs21 modulator, and methods of use thereof to modulate taste sensation
WO2008119195A1 (en) 2007-03-30 2008-10-09 Givaudan Sa Methods to identify modulators
US20090117563A1 (en) 2007-06-08 2009-05-07 Bryan Moyer Identification of TRPML3 (MCOLN3) as a Salty Taste Receptor and Use in Assays for Identifying Taste (Salty) Modulators and/or Therapeutics that Modulate Sodium Transport, Absorption or Excretion and/or Aldosterone and/or Vasopressin Production or Release
KR101599715B1 (ko) 2007-08-21 2016-03-08 세노믹스, 인코포레이티드 인간 ｔ2ｒ 쓴맛 수용체 및 이의 용도
CA2751223A1 (en) 2009-02-02 2010-08-05 Chromocell Corporation Novel cell lines and methods
US8795977B2 (en) * 2009-12-02 2014-08-05 Conopco, Inc. Method for screening a potential modulator compound of a taste receptor
AU2012209455B2 (en) 2011-01-25 2017-05-04 Monell Chemical Senses Center Compositions and methods for providing or modulating sweet taste and methods of screening therefor
US9128079B2 (en) * 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
RU2690456C2 (ru) 2013-05-10 2019-06-03 Пепсико, Инк. Клетки в качестве модели для идентификации возможных модуляторов вкусовых ощущений

Also Published As

Publication number Publication date
BR112015028082A2 (pt) 2017-07-25
WO2014183041A1 (en) 2014-11-13
JP6211685B2 (ja) 2017-10-11
PL2994482T3 (pl) 2020-06-01
CN105377885A (zh) 2016-03-02
JP2016519313A (ja) 2016-06-30
ES2776159T3 (es) 2020-07-29
EP2994482B1 (en) 2020-01-01
RU2665812C2 (ru) 2018-09-04
CN105377885B (zh) 2019-11-05
US9766236B2 (en) 2017-09-19
EP2994482A4 (en) 2016-11-30
CA2911189A1 (en) 2014-11-13
HK1218302A1 (zh) 2017-02-10
US20160084834A1 (en) 2016-03-24
EP2994482A1 (en) 2016-03-16
AU2014262540A1 (en) 2015-11-12
AU2014262540B2 (en) 2016-10-27
RU2015152792A (ru) 2017-06-20

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