BR112015028082A2 - ensaio de internalização de receptor de sabor - Google Patents
ensaio de internalização de receptor de saborInfo
- Publication number
- BR112015028082A2 BR112015028082A2 BR112015028082A BR112015028082A BR112015028082A2 BR 112015028082 A2 BR112015028082 A2 BR 112015028082A2 BR 112015028082 A BR112015028082 A BR 112015028082A BR 112015028082 A BR112015028082 A BR 112015028082A BR 112015028082 A2 BR112015028082 A2 BR 112015028082A2
- Authority
- BR
- Brazil
- Prior art keywords
- taste receptor
- receptor internalization
- internalization test
- test
- taste
- Prior art date
Links
- 108091005708 gustatory receptors Proteins 0.000 title abstract 3
- 230000033300 receptor internalization Effects 0.000 title abstract 3
- 238000003556 assay Methods 0.000 abstract 2
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
resumo patente de invenção: "ensaio de internalização de receptor de sabor". a invenção fornece um ensaio de internalização de receptor de sabor útil para identificar os moduladores de sabor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361821978P | 2013-05-10 | 2013-05-10 | |
PCT/US2014/037507 WO2014183041A1 (en) | 2013-05-10 | 2014-05-09 | Taste receptor internalization assay |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015028082A2 true BR112015028082A2 (pt) | 2017-07-25 |
Family
ID=51867771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015028082A BR112015028082A2 (pt) | 2013-05-10 | 2014-05-09 | ensaio de internalização de receptor de sabor |
Country Status (13)
Country | Link |
---|---|
US (1) | US9766236B2 (pt) |
EP (1) | EP2994482B1 (pt) |
JP (1) | JP6211685B2 (pt) |
CN (1) | CN105377885B (pt) |
AU (1) | AU2014262540B2 (pt) |
BR (1) | BR112015028082A2 (pt) |
CA (1) | CA2911189A1 (pt) |
ES (1) | ES2776159T3 (pt) |
HK (1) | HK1218302A1 (pt) |
MX (1) | MX2015015448A (pt) |
PL (1) | PL2994482T3 (pt) |
RU (1) | RU2665812C2 (pt) |
WO (1) | WO2014183041A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2644222C2 (ru) | 2013-05-10 | 2018-02-08 | Пепсико, Инк. | Клетки в качестве модели для идентификации возможных модуляторов вкусовых ощущений |
CN109890217A (zh) | 2016-09-16 | 2019-06-14 | 百事可乐公司 | 用于改善非营养性甜味剂的味道的组合物和方法 |
WO2022236274A1 (en) * | 2021-05-07 | 2022-11-10 | Firmenich Incorporated | Cells expressing bitter taste receptors and uses thereof |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4115038A1 (de) * | 1991-05-08 | 1992-11-12 | Genentech Inc | Neue konjugate, bestehend aus einem glykoprotein und einer nukleinsaeure-bindenden substanz |
US6759206B1 (en) | 1997-02-27 | 2004-07-06 | Cellomics, Inc. | System for cell-based screening |
CA2328194C (en) * | 1998-07-13 | 2003-01-21 | Cellomics, Inc. | A system for cell-based screening |
US7402400B2 (en) | 2001-07-03 | 2008-07-22 | Regents Of The University Of California | Mammalian sweet taste receptors |
JP4339542B2 (ja) * | 1999-09-10 | 2009-10-07 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニア | T2r、すなわち味覚受容体の新規ファミリー |
US6955887B2 (en) | 2001-03-30 | 2005-10-18 | Senomyx, Inc. | Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling |
US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
US20080244761A1 (en) * | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
WO2003025137A2 (en) | 2001-09-18 | 2003-03-27 | Irm, Llc | Sweet taste receptors |
WO2004011617A2 (en) | 2002-07-29 | 2004-02-05 | Senomyx, Inc. | Identification of a novel bitter taste receptor, t2r76 |
AU2003286069A1 (en) | 2002-12-18 | 2004-07-09 | Givaudan Sa | Chimeric alpha q-gustducin g-proteins |
WO2004069191A2 (en) | 2003-02-03 | 2004-08-19 | Senomyx Inc. | Identification of t1r and t2r modulators |
US20050244810A1 (en) * | 2003-09-29 | 2005-11-03 | Egan Josephine M | Taste signaling in gastrointestinal cells |
US20050106571A1 (en) | 2003-10-02 | 2005-05-19 | The Regents Of The University Of California | Mammalian T1R3 sweet taste receptors |
WO2006040337A1 (en) * | 2004-10-13 | 2006-04-20 | Evotec Technologies Gmbh | Method for identifying compounds that affect a transport of a protein through a membrane trafficking pathway |
EP1833961B1 (en) * | 2004-10-15 | 2011-07-20 | Monell Chemical Senses Center | Methods for culturing mammalian taste cells |
US7799538B2 (en) | 2005-03-09 | 2010-09-21 | Trustees Of Dartmouth College | Method for identifying agents which modulate GTPase activity involved in insulin-stimulated GLUT4 translocation |
CN101605810B (zh) | 2005-10-20 | 2013-07-17 | 塞诺米克斯公司 | 嵌合的人甜味-鲜味和鲜味-甜味受体 |
US20070218456A1 (en) | 2006-02-08 | 2007-09-20 | Invitrogen Corporation | Cellular assays for signaling receptors |
WO2007121604A2 (en) | 2006-04-20 | 2007-11-01 | Givaudan Sa | Method relating to sweetness enhancement |
KR101440639B1 (ko) | 2006-06-19 | 2014-09-22 | 지보당 에스아 | 핵산, 폴리펩타이드 및 이의 용도 |
CN101495648A (zh) * | 2006-07-26 | 2009-07-29 | 可口可乐公司 | 用于鉴定rgs21活性调节子的方法、包含rgs21调节子的组合物以及用其调节味觉的方法 |
EP2137322B1 (en) * | 2007-03-30 | 2013-02-27 | Givaudan SA | Methods to identify tas2r modulators |
US20090117563A1 (en) | 2007-06-08 | 2009-05-07 | Bryan Moyer | Identification of TRPML3 (MCOLN3) as a Salty Taste Receptor and Use in Assays for Identifying Taste (Salty) Modulators and/or Therapeutics that Modulate Sodium Transport, Absorption or Excretion and/or Aldosterone and/or Vasopressin Production or Release |
CN104130247B (zh) | 2007-08-21 | 2018-06-01 | 塞诺米克斯公司 | 人t2r苦味受体及其用途 |
NZ603996A (en) | 2009-02-02 | 2014-03-28 | Chromocell Corp | Cells or cell lines that stably express a bitter taste receptor and methods of making them |
US8795977B2 (en) * | 2009-12-02 | 2014-08-05 | Conopco, Inc. | Method for screening a potential modulator compound of a taste receptor |
EP2667885B1 (en) * | 2011-01-25 | 2018-08-08 | Monell Chemical Senses Center | Compositions and methods for providing or modulating sweet taste and methods of screening therefor |
WO2013022948A1 (en) * | 2011-08-08 | 2013-02-14 | The Coca-Cola Company | Cell lines comprising endogenous taste receptors and their uses |
RU2644222C2 (ru) | 2013-05-10 | 2018-02-08 | Пепсико, Инк. | Клетки в качестве модели для идентификации возможных модуляторов вкусовых ощущений |
-
2014
- 2014-05-09 CA CA2911189A patent/CA2911189A1/en not_active Abandoned
- 2014-05-09 EP EP14794217.1A patent/EP2994482B1/en active Active
- 2014-05-09 ES ES14794217T patent/ES2776159T3/es active Active
- 2014-05-09 MX MX2015015448A patent/MX2015015448A/es unknown
- 2014-05-09 BR BR112015028082A patent/BR112015028082A2/pt not_active Application Discontinuation
- 2014-05-09 PL PL14794217T patent/PL2994482T3/pl unknown
- 2014-05-09 US US14/890,054 patent/US9766236B2/en active Active
- 2014-05-09 RU RU2015152792A patent/RU2665812C2/ru active
- 2014-05-09 WO PCT/US2014/037507 patent/WO2014183041A1/en active Application Filing
- 2014-05-09 AU AU2014262540A patent/AU2014262540B2/en active Active
- 2014-05-09 JP JP2016513122A patent/JP6211685B2/ja active Active
- 2014-05-09 CN CN201480026696.3A patent/CN105377885B/zh active Active
-
2016
- 2016-06-03 HK HK16106346.0A patent/HK1218302A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2015152792A (ru) | 2017-06-20 |
JP6211685B2 (ja) | 2017-10-11 |
ES2776159T3 (es) | 2020-07-29 |
MX2015015448A (es) | 2016-03-15 |
RU2665812C2 (ru) | 2018-09-04 |
CA2911189A1 (en) | 2014-11-13 |
WO2014183041A1 (en) | 2014-11-13 |
EP2994482B1 (en) | 2020-01-01 |
AU2014262540B2 (en) | 2016-10-27 |
CN105377885A (zh) | 2016-03-02 |
AU2014262540A1 (en) | 2015-11-12 |
EP2994482A4 (en) | 2016-11-30 |
JP2016519313A (ja) | 2016-06-30 |
CN105377885B (zh) | 2019-11-05 |
PL2994482T3 (pl) | 2020-06-01 |
EP2994482A1 (en) | 2016-03-16 |
US20160084834A1 (en) | 2016-03-24 |
US9766236B2 (en) | 2017-09-19 |
HK1218302A1 (zh) | 2017-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
|
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |