BR112015028082A2 - ensaio de internalização de receptor de sabor - Google Patents

ensaio de internalização de receptor de sabor

Info

Publication number
BR112015028082A2
BR112015028082A2 BR112015028082A BR112015028082A BR112015028082A2 BR 112015028082 A2 BR112015028082 A2 BR 112015028082A2 BR 112015028082 A BR112015028082 A BR 112015028082A BR 112015028082 A BR112015028082 A BR 112015028082A BR 112015028082 A2 BR112015028082 A2 BR 112015028082A2
Authority
BR
Brazil
Prior art keywords
taste receptor
receptor internalization
internalization test
test
taste
Prior art date
Application number
BR112015028082A
Other languages
English (en)
Inventor
Gravina Stephen
Kurash Yuliya
Original Assignee
Pepsico Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pepsico Inc filed Critical Pepsico Inc
Publication of BR112015028082A2 publication Critical patent/BR112015028082A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

resumo patente de invenção: "ensaio de internalização de receptor de sabor". a invenção fornece um ensaio de internalização de receptor de sabor útil para identificar os moduladores de sabor.
BR112015028082A 2013-05-10 2014-05-09 ensaio de internalização de receptor de sabor BR112015028082A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361821978P 2013-05-10 2013-05-10
PCT/US2014/037507 WO2014183041A1 (en) 2013-05-10 2014-05-09 Taste receptor internalization assay

Publications (1)

Publication Number Publication Date
BR112015028082A2 true BR112015028082A2 (pt) 2017-07-25

Family

ID=51867771

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015028082A BR112015028082A2 (pt) 2013-05-10 2014-05-09 ensaio de internalização de receptor de sabor

Country Status (13)

Country Link
US (1) US9766236B2 (pt)
EP (1) EP2994482B1 (pt)
JP (1) JP6211685B2 (pt)
CN (1) CN105377885B (pt)
AU (1) AU2014262540B2 (pt)
BR (1) BR112015028082A2 (pt)
CA (1) CA2911189A1 (pt)
ES (1) ES2776159T3 (pt)
HK (1) HK1218302A1 (pt)
MX (1) MX2015015448A (pt)
PL (1) PL2994482T3 (pt)
RU (1) RU2665812C2 (pt)
WO (1) WO2014183041A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2994477A4 (en) 2013-05-10 2017-03-22 Pepsico, Inc. Cells as a model to identify potential taste modulators
MX2019003086A (es) 2016-09-16 2019-11-18 Pepsico Inc Composiciones y metodos para mejorar el sabor de edulcorantes no nutritivos.
EP4298209A1 (en) * 2021-05-07 2024-01-03 Firmenich Incorporated Cells expressing bitter taste receptors and uses thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115038A1 (de) * 1991-05-08 1992-11-12 Genentech Inc Neue konjugate, bestehend aus einem glykoprotein und einer nukleinsaeure-bindenden substanz
US6759206B1 (en) * 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
AU4992599A (en) 1998-07-13 2000-02-01 Cellomics, Inc. A system for cell-based screening
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
CN1289525C (zh) * 1999-09-10 2006-12-13 加利福尼亚大学董事会 T2r,一类味觉受体
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US20080244761A1 (en) * 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
WO2003025137A2 (en) 2001-09-18 2003-03-27 Irm, Llc Sweet taste receptors
IL165669A0 (en) 2002-07-29 2006-01-15 Senomyx Inc Identification of a novel bitter taste receptor t2r76
CN1726224A (zh) 2002-12-18 2006-01-25 吉万奥丹股份有限公司 嵌合αQ－Gustducin G－蛋白
WO2004069191A2 (en) 2003-02-03 2004-08-19 Senomyx Inc. Identification of t1r and t2r modulators
US20050244810A1 (en) * 2003-09-29 2005-11-03 Egan Josephine M Taste signaling in gastrointestinal cells
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
WO2006040337A1 (en) 2004-10-13 2006-04-20 Evotec Technologies Gmbh Method for identifying compounds that affect a transport of a protein through a membrane trafficking pathway
CN101065479A (zh) * 2004-10-15 2007-10-31 蒙奈尔化学感觉中心 培养哺乳动物味细胞的方法
US7799538B2 (en) 2005-03-09 2010-09-21 Trustees Of Dartmouth College Method for identifying agents which modulate GTPase activity involved in insulin-stimulated GLUT4 translocation
ES2658859T3 (es) 2005-10-20 2018-03-12 Senomyx, Inc. Receptores del sabor dulce-umami y umami-dulce humanos quiméricos
WO2007092938A2 (en) 2006-02-08 2007-08-16 Invitrogen Corporation Cellular assays for signaling receptors
WO2007121604A2 (en) 2006-04-20 2007-11-01 Givaudan Sa Method relating to sweetness enhancement
EP2035827B1 (en) 2006-06-19 2012-10-17 Givaudan S.A. Nucleic acid, polypeptide and its use
AU2007279276A1 (en) 2006-07-26 2008-01-31 The Coca-Cola Company Methods for identifying modulators of RGS21 activity, compositions comprising an RGS21 modulator, and methods of use thereof to modulate taste sensation
WO2008119195A1 (en) 2007-03-30 2008-10-09 Givaudan Sa Methods to identify modulators
WO2009008950A2 (en) 2007-06-08 2009-01-15 Senomyx, Inc. Identification of trpml3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release
KR101599715B1 (ko) 2007-08-21 2016-03-08 세노믹스, 인코포레이티드 인간 ｔ2ｒ 쓴맛 수용체 및 이의 용도
EP2391711B1 (en) 2009-02-02 2015-04-08 Chromocell Corporation Novel cell lines and methods
JP2013512664A (ja) * 2009-12-02 2013-04-18 ユニリーバー・ナームローゼ・ベンノートシヤープ 味覚受容体の潜在的モジュレーター化合物をスクリーニングする改善された方法
US9012161B2 (en) 2011-01-25 2015-04-21 Monell Chemical Senses Center Methods of identifying molecules that provide or enhance sweet taste
US9128079B2 (en) * 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
EP2994477A4 (en) 2013-05-10 2017-03-22 Pepsico, Inc. Cells as a model to identify potential taste modulators

Also Published As

Publication number Publication date
ES2776159T3 (es) 2020-07-29
CN105377885B (zh) 2019-11-05
JP6211685B2 (ja) 2017-10-11
EP2994482A4 (en) 2016-11-30
EP2994482A1 (en) 2016-03-16
JP2016519313A (ja) 2016-06-30
AU2014262540B2 (en) 2016-10-27
US9766236B2 (en) 2017-09-19
US20160084834A1 (en) 2016-03-24
CN105377885A (zh) 2016-03-02
EP2994482B1 (en) 2020-01-01
RU2665812C2 (ru) 2018-09-04
RU2015152792A (ru) 2017-06-20
AU2014262540A1 (en) 2015-11-12
PL2994482T3 (pl) 2020-06-01
HK1218302A1 (zh) 2017-02-10
WO2014183041A1 (en) 2014-11-13
MX2015015448A (es) 2016-03-15
CA2911189A1 (en) 2014-11-13

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]