BR112018008068A2 - moléculas de ligação que inibem o crescimento do câncer - Google Patents
moléculas de ligação que inibem o crescimento do câncerInfo
- Publication number
- BR112018008068A2 BR112018008068A2 BR112018008068A BR112018008068A BR112018008068A2 BR 112018008068 A2 BR112018008068 A2 BR 112018008068A2 BR 112018008068 A BR112018008068 A BR 112018008068A BR 112018008068 A BR112018008068 A BR 112018008068A BR 112018008068 A2 BR112018008068 A2 BR 112018008068A2
- Authority
- BR
- Brazil
- Prior art keywords
- binding molecules
- cancer growth
- inhibit cancer
- antibodies
- membrane associated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15191343 | 2015-10-23 | ||
EP16168647 | 2016-05-06 | ||
PCT/NL2016/050726 WO2017069628A2 (en) | 2015-10-23 | 2016-10-21 | Binding molecules that inhibit cancer growth |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018008068A2 true BR112018008068A2 (pt) | 2018-11-13 |
Family
ID=57190021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018008068A BR112018008068A2 (pt) | 2015-10-23 | 2016-10-21 | moléculas de ligação que inibem o crescimento do câncer |
Country Status (26)
Country | Link |
---|---|
US (1) | US11939394B2 (pt) |
EP (2) | EP3365373B1 (pt) |
JP (3) | JP7296728B2 (pt) |
KR (1) | KR20180100305A (pt) |
CN (2) | CN108602888B (pt) |
AU (2) | AU2016340764B2 (pt) |
BR (1) | BR112018008068A2 (pt) |
CA (1) | CA3002957A1 (pt) |
CY (1) | CY1124108T1 (pt) |
DK (1) | DK3365373T3 (pt) |
EA (1) | EA201890866A1 (pt) |
ES (1) | ES2865482T3 (pt) |
HK (1) | HK1253914A1 (pt) |
HR (1) | HRP20210483T1 (pt) |
HU (1) | HUE055222T2 (pt) |
LT (1) | LT3365373T (pt) |
MA (2) | MA45517B1 (pt) |
MD (1) | MD3365373T2 (pt) |
MX (2) | MX2018004988A (pt) |
NZ (1) | NZ742290A (pt) |
PL (1) | PL3365373T3 (pt) |
RS (1) | RS61800B1 (pt) |
SG (1) | SG11201803359VA (pt) |
SI (1) | SI3365373T1 (pt) |
WO (1) | WO2017069628A2 (pt) |
ZA (1) | ZA201802758B (pt) |
Families Citing this family (31)
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US10844127B2 (en) | 2014-02-28 | 2020-11-24 | Merus N.V. | Antibodies that bind EGFR and ErbB3 |
KR102352573B1 (ko) * | 2014-04-04 | 2022-01-18 | 바이오노믹스 인코포레이티드 | Lgr5에 결합하는 인간화된 항체들 |
LT3365373T (lt) | 2015-10-23 | 2021-05-25 | Merus N.V. | Surišančios molekulės, kurios inhibuoja vėžio augimą |
CN108697799A (zh) | 2016-03-22 | 2018-10-23 | 生态学有限公司 | 抗lgr5单克隆抗体的施用 |
AU2018207440B2 (en) * | 2017-01-11 | 2022-06-02 | The Board Of Trustees Of The Leland Stanford Junior University | R-spondin (RSPO) surrogate molecules |
CA3050133A1 (en) * | 2017-01-26 | 2018-08-02 | Surrozen, Inc. | Tissue-specific wnt signal enhancing molecules and uses thereof |
WO2018182422A1 (en) | 2017-03-31 | 2018-10-04 | Merus N.V. | Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene |
US11732043B2 (en) * | 2017-07-06 | 2023-08-22 | Merus N.V. | Antibodies that modulate a biological activity expressed by a cell |
KR20200042467A (ko) * | 2017-07-06 | 2020-04-23 | 메뤼스 엔.페. | 이중특이적 항pd-1 tim3 항체 |
TW201910354A (zh) | 2017-08-09 | 2019-03-16 | 荷蘭商美勒斯公司 | 結合表皮生長因子受體(EGFR)及cMET的抗體 |
AU2019243665B2 (en) * | 2018-03-30 | 2023-06-01 | Merus N.V. | Multivalent antibody |
EP3820499A4 (en) * | 2018-07-09 | 2022-07-13 | Surrozen Operating, Inc. | TISSUE-SPECIFIC WNT SIGNAL ENHANCING MOLECULES AND THEIR USES |
EP3886905A4 (en) * | 2018-12-27 | 2022-08-24 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | BISPECIFIC ANTIBODY FOR MEMBRANE REMOVAL OF TARGET RECEPTORS |
JP7440516B2 (ja) | 2018-12-31 | 2024-02-28 | メルス ナムローゼ フェンノートシャップ | 切断多価多量体 |
AU2019418280B2 (en) | 2018-12-31 | 2023-01-05 | Merus N.V. | Mixed binding domains |
CN114426578A (zh) * | 2019-02-14 | 2022-05-03 | 美勒斯公司 | 结合egfr、her2及her3的结合部分的组合 |
SG11202108311RA (en) | 2019-02-26 | 2021-09-29 | Janssen Biotech Inc | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies |
TW202102544A (zh) * | 2019-04-04 | 2021-01-16 | 日商小野藥品工業股份有限公司 | 雙特異性抗體 |
US11879013B2 (en) | 2019-05-14 | 2024-01-23 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors |
AU2020331879A1 (en) * | 2019-08-19 | 2022-02-24 | Merus N.V. | Treatment of cancer with a combination of an antibody that binds LGR5 and EGFR and a topoisomerase I inhibitor. |
BR112022008201A2 (pt) * | 2019-11-01 | 2022-07-12 | Univ California | Degradação de proteínas de superfície usando agente de ligação biespecífico |
EP4114854A1 (en) * | 2020-03-05 | 2023-01-11 | UMC Utrecht Holding B.V. | Membrane ubiquitin ligases to target protein degradation |
KR20230005281A (ko) | 2020-04-24 | 2023-01-09 | 메뤼스 엔.페. | Lgr5 및 egfr에 결합하는 항체를 사용하는 암의 치료 |
CA3178265A1 (en) * | 2020-06-18 | 2021-12-23 | Umc Utrecht Holding B.V. | Screening method for effective target - e3 ligase combinations |
CN113862326A (zh) * | 2020-09-08 | 2021-12-31 | 复旦大学 | KREMEN1和/或ASGR1作为药物靶点在治疗SARS-CoV-2感染中的应用 |
IL303633A (en) | 2020-12-15 | 2023-08-01 | Merus Nv | Cancer treatment with an antibody that binds LGR5 and EGFR |
WO2022131918A1 (en) * | 2020-12-18 | 2022-06-23 | Merus N.V. | Antibody composition |
CN114853889B (zh) * | 2021-02-03 | 2024-03-01 | 中国科学院动物研究所 | 针对人gpr48的单克隆抗体及其应用 |
CN113307882B (zh) * | 2021-05-12 | 2022-12-20 | 东北大学 | 靶向治疗Rspo过度激活导致的结直肠癌的融合蛋白SZ1及其偶联纳米药物 |
TW202321309A (zh) | 2021-10-06 | 2023-06-01 | 荷蘭商美勒斯公司 | 使用至少結合egfr之抗體治療免疫檢查點抑制劑治療之具高egfr表現的癌症 |
CN116082510B (zh) * | 2023-03-07 | 2023-12-05 | 四川尚锐生物医药有限公司 | 一种单克隆抗体或其抗原结合片段及其抗肿瘤的用途 |
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