MA31037B1 - Composes et compositions en tant qu'inhibiteurs de proteases activatrices de canaux - Google Patents
Composes et compositions en tant qu'inhibiteurs de proteases activatrices de canauxInfo
- Publication number
- MA31037B1 MA31037B1 MA32060A MA32060A MA31037B1 MA 31037 B1 MA31037 B1 MA 31037B1 MA 32060 A MA32060 A MA 32060A MA 32060 A MA32060 A MA 32060A MA 31037 B1 MA31037 B1 MA 31037B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- channel
- proteases
- compositions
- activasting
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
L'INVENTION CONCERNE DES COMPOSÉS ET LEURS COMPOSITIONS PHARMACEUTIQUES, QUI SONT UTILES POUR MODULER DES PROTÉASES ACTIVATRICES DE CANAUX ET DES PROCÉDÉS D'UTILISATION DE TELS COMPOSÉS POUR TRAITER, AMÉLIORER OU PRÉVENIR UNE AFFECTION ASSOCIÉE À UNE PROTÉASE ACTIVATRICE DE CANAUX Y COMPRIS, MAIS SANS LIMITATION, LA PROSTASINE, LA PRSS22, LES TMPRSS11 (PAR EXEMPLE, LA TMPRSS11B, LA TMPRSS11E), LA TMPRSS2, LA TMPRSS3, LA TMPRSS4 (MTSP-2), LA MATRIPTASE (MTSP-1), LA CAP2, LA CAP3, LA TRYPSINE, LA CATHEPSINE A OU L'ÉLASTASE NEUTROPHILE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88433407P | 2007-01-10 | 2007-01-10 | |
US89147407P | 2007-02-23 | 2007-02-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31037B1 true MA31037B1 (fr) | 2009-12-01 |
Family
ID=39148650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32060A MA31037B1 (fr) | 2007-01-10 | 2009-06-30 | Composes et compositions en tant qu'inhibiteurs de proteases activatrices de canaux |
Country Status (33)
Country | Link |
---|---|
US (1) | US20080176901A1 (fr) |
EP (2) | EP2279777A2 (fr) |
JP (1) | JP2010515729A (fr) |
KR (1) | KR101084787B1 (fr) |
AR (1) | AR064841A1 (fr) |
AT (1) | ATE493174T1 (fr) |
AU (1) | AU2007342223B2 (fr) |
BR (1) | BRPI0720799A2 (fr) |
CA (1) | CA2673803A1 (fr) |
CL (1) | CL2008000060A1 (fr) |
CO (1) | CO6190626A2 (fr) |
CU (1) | CU23762B7 (fr) |
CY (1) | CY1111340T1 (fr) |
DE (1) | DE602007011670D1 (fr) |
DK (1) | DK2104535T3 (fr) |
EA (1) | EA016199B1 (fr) |
EC (1) | ECSP099517A (fr) |
GT (1) | GT200900196A (fr) |
HK (1) | HK1129860A1 (fr) |
HN (1) | HN2009001282A (fr) |
HR (1) | HRP20110201T1 (fr) |
MA (1) | MA31037B1 (fr) |
MX (1) | MX2009007476A (fr) |
NO (1) | NO20092817L (fr) |
NZ (1) | NZ577939A (fr) |
PE (1) | PE20081566A1 (fr) |
PL (1) | PL2104535T3 (fr) |
PT (1) | PT2104535E (fr) |
RS (1) | RS51644B (fr) |
SV (1) | SV2009003330A (fr) |
TN (1) | TN2009000294A1 (fr) |
TW (1) | TW200845981A (fr) |
WO (1) | WO2008085608A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0712021A2 (pt) | 2006-05-23 | 2012-01-03 | Irm Llc | composto e composiÇÕes como inibidores da protease ativadora de canal |
JP5208963B2 (ja) | 2007-01-10 | 2013-06-12 | エフ.ホフマン−ラ ロシュ アーゲー | キマーゼ阻害剤としてのスルホンアミド誘導体 |
MX2009008518A (es) | 2007-02-09 | 2009-08-20 | Irm Llc | Compuestos y composiciones como inhibidores de la proteasa activadora de canal. |
KR20120058468A (ko) | 2009-05-18 | 2012-06-07 | 오리온 코포레이션 | 프로테아제 억제제 |
GB201805174D0 (en) * | 2018-03-29 | 2018-05-16 | Univ Leeds Innovations Ltd | Compounds |
US11584714B2 (en) | 2018-05-29 | 2023-02-21 | Omeros Corporation | MASP-2 inhibitors and methods of use |
JP2022519924A (ja) * | 2019-03-22 | 2022-03-25 | アキリオン ファーマシューティカルズ, インコーポレーテッド | 補体媒介性障害の治療のための医薬化合物 |
JP2023500182A (ja) | 2019-09-17 | 2023-01-05 | メレオ バイオファーマ 4 リミテッド | 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット |
AU2020395306A1 (en) * | 2019-12-04 | 2022-06-30 | Omeros Corporation | MASP-2 inhibitors and methods of use |
EP4069678A1 (fr) | 2019-12-04 | 2022-10-12 | Omeros Corporation | Inhibiteurs de masp-2 et procédés d'utilisation |
CA3159172A1 (fr) | 2019-12-04 | 2021-06-10 | Michael Cicirelli | Inhibiteurs de masp-2 et procedes d'utilisation |
ES2962498T3 (es) | 2020-04-16 | 2024-03-19 | Mereo Biopharma 4 Ltd | Métodos que implican el inhibidor de elastasa de neutrófilos alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina |
TW202325294A (zh) | 2021-10-20 | 2023-07-01 | 英商梅瑞奧生物製藥4有限公司 | 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑 |
WO2023183405A2 (fr) * | 2022-03-22 | 2023-09-28 | Alexion Pharmaceuticals, Inc. | Composés pharmaceutiques pour le traitement de troubles médiés par le complément |
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GB0015876D0 (en) | 2000-06-28 | 2000-08-23 | Novartis Ag | Organic compounds |
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DZ3468A1 (fr) | 2000-08-05 | 2002-02-14 | Glaxo Group Ltd | 6.alpha., 9.alpha.-difluoro-17.alpha.-`(2-furanylcarboxyle) oxy!-11.beta.-hydroxy-16.alpha.-methyle-3-oxo-androst-1,4,-diene-17-acide carbothioique s-fluoromethyle ester utilise comme agent anti inflammatoire |
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EP1556369A1 (fr) | 2002-08-10 | 2005-07-27 | ALTANA Pharma AG | Derives de pyridazinone utilises comme inhibiteurs de pde4 |
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GB0507577D0 (en) * | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
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2007
- 2007-11-21 PL PL07854747T patent/PL2104535T3/pl unknown
- 2007-11-21 DK DK07854747.8T patent/DK2104535T3/da active
- 2007-11-21 EP EP10013675A patent/EP2279777A2/fr not_active Withdrawn
- 2007-11-21 BR BRPI0720799-9A patent/BRPI0720799A2/pt not_active IP Right Cessation
- 2007-11-21 NZ NZ577939A patent/NZ577939A/en not_active IP Right Cessation
- 2007-11-21 DE DE602007011670T patent/DE602007011670D1/de active Active
- 2007-11-21 MX MX2009007476A patent/MX2009007476A/es active IP Right Grant
- 2007-11-21 CA CA002673803A patent/CA2673803A1/fr not_active Abandoned
- 2007-11-21 KR KR1020097014455A patent/KR101084787B1/ko not_active IP Right Cessation
- 2007-11-21 RS RS20110129A patent/RS51644B/en unknown
- 2007-11-21 JP JP2009545545A patent/JP2010515729A/ja not_active Ceased
- 2007-11-21 AU AU2007342223A patent/AU2007342223B2/en not_active Ceased
- 2007-11-21 EP EP07854747A patent/EP2104535B9/fr active Active
- 2007-11-21 US US11/943,845 patent/US20080176901A1/en not_active Abandoned
- 2007-11-21 PT PT07854747T patent/PT2104535E/pt unknown
- 2007-11-21 WO PCT/US2007/085366 patent/WO2008085608A1/fr active Application Filing
- 2007-11-21 EA EA200900920A patent/EA016199B1/ru not_active IP Right Cessation
- 2007-11-21 AT AT07854747T patent/ATE493174T1/de active
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2009
- 2009-06-30 MA MA32060A patent/MA31037B1/fr unknown
- 2009-07-08 GT GT200900196A patent/GT200900196A/es unknown
- 2009-07-08 HN HN2009001282A patent/HN2009001282A/es unknown
- 2009-07-08 TN TNP2009000294A patent/TN2009000294A1/fr unknown
- 2009-07-10 SV SV2009003330A patent/SV2009003330A/es not_active Application Discontinuation
- 2009-07-10 CU CU20090122A patent/CU23762B7/es not_active IP Right Cessation
- 2009-07-13 CO CO09072488A patent/CO6190626A2/es not_active Application Discontinuation
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