MA29925B1 - Composes d'amide de pyrimidine en tant qu'inhibiteurs de pgds - Google Patents

Composes d'amide de pyrimidine en tant qu'inhibiteurs de pgds

Info

Publication number
MA29925B1
MA29925B1 MA30891A MA30891A MA29925B1 MA 29925 B1 MA29925 B1 MA 29925B1 MA 30891 A MA30891 A MA 30891A MA 30891 A MA30891 A MA 30891A MA 29925 B1 MA29925 B1 MA 29925B1
Authority
MA
Morocco
Prior art keywords
amide compounds
compound
pgds inhibitors
pyrimidine amide
pyrimidine
Prior art date
Application number
MA30891A
Other languages
English (en)
French (fr)
Inventor
Suzanne C Aldous
John Ziqi Jiang
Jinqi Lu
Liang Ma
Lan Mu
Harry Randall Munson
Jeffrey Stephen Sabol
Sukanthini Thurairatnam
Christopher Loren Vandeusen
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of MA29925B1 publication Critical patent/MA29925B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA30891A 2005-10-04 2008-05-02 Composes d'amide de pyrimidine en tant qu'inhibiteurs de pgds MA29925B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72357005P 2005-10-04 2005-10-04

Publications (1)

Publication Number Publication Date
MA29925B1 true MA29925B1 (fr) 2008-11-03

Family

ID=37635758

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30891A MA29925B1 (fr) 2005-10-04 2008-05-02 Composes d'amide de pyrimidine en tant qu'inhibiteurs de pgds

Country Status (27)

Country Link
US (1) US8202863B2 (OSRAM)
EP (1) EP1937652B1 (OSRAM)
JP (1) JP5452925B2 (OSRAM)
KR (1) KR101457966B1 (OSRAM)
CN (2) CN101538246B (OSRAM)
AR (1) AR056871A1 (OSRAM)
AU (1) AU2006299428B2 (OSRAM)
BR (1) BRPI0616815A2 (OSRAM)
CA (1) CA2624749C (OSRAM)
CR (1) CR9832A (OSRAM)
DO (1) DOP2006000210A (OSRAM)
EC (1) ECSP088335A (OSRAM)
ES (1) ES2514471T3 (OSRAM)
IL (1) IL190411A (OSRAM)
MA (1) MA29925B1 (OSRAM)
MY (1) MY151172A (OSRAM)
NO (1) NO20082000L (OSRAM)
NZ (1) NZ567208A (OSRAM)
PE (2) PE20070589A1 (OSRAM)
RU (1) RU2420519C2 (OSRAM)
SG (1) SG166121A1 (OSRAM)
TN (1) TNSN08104A1 (OSRAM)
TW (1) TWI415839B (OSRAM)
UA (1) UA93213C2 (OSRAM)
UY (1) UY29840A1 (OSRAM)
WO (1) WO2007041634A1 (OSRAM)
ZA (1) ZA200802222B (OSRAM)

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KR101669432B1 (ko) 2007-08-27 2016-10-26 다트 뉴로사이언스 (케이만) 엘티디. 치료적 이속사졸 화합물
CN101855210A (zh) 2007-10-11 2010-10-06 沃泰克斯药物股份有限公司 用作电压-门控钠通道抑制剂的酰胺类
EP2227453B1 (en) * 2007-10-11 2016-03-09 Vertex Pharmaceuticals Incorporated Heteroaryl amides useful as inhibitors of voltage-gated sodium channels
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KR101367057B1 (ko) 2009-03-17 2014-02-25 (주)아모레퍼시픽 피부 자극 완화용 조성물
ES2564454T3 (es) 2009-03-09 2016-03-22 Taiho Pharmaceutical Co., Ltd. Compuesto de piperazina que puede inhibir la prostaglandina D sintasa
SG179199A1 (en) * 2009-10-08 2012-04-27 Sanofi Sa Phenyloxadiazole derivatives as pgds inhibitors
EP2527340B1 (en) 2010-01-22 2016-08-17 Taiho Pharmaceutical Co., Ltd. Piperazine compound having a pgds inhibitory effect
US9320723B2 (en) * 2010-05-03 2016-04-26 University Of Rochester Methods of treating thyroid eye disease
WO2011150457A2 (en) * 2010-06-01 2011-12-08 The University Of Queensland Haematopoietic-prostaglandin d2 synthase inhibitors
AU2011299904A1 (en) 2010-09-07 2013-05-02 Taiho Pharmaceutical Co., Ltd. Prostaglandin D synthase inhibitory piperidine compounds
KR101271223B1 (ko) 2011-01-27 2013-06-07 한국과학기술연구원 아미노피리미딘 유도체 및 이를 포함하는 세포외 신호조절 키나제의 제해제
EP2800568A4 (en) 2012-01-06 2015-06-10 Univ South Florida COMPOSITIONS, USE METHOD AND TREATMENT METHOD THEREFOR
JP6263533B2 (ja) * 2012-08-24 2018-01-17 サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. ジヒドロピリミジン化合物及び医薬におけるその適用
UY37028A (es) 2015-12-17 2017-07-31 Astex Therapeutics Ltd Compuestos inhibidores de prostaglandina d sintasa ematopoyética (h-pgds
US10669270B2 (en) * 2016-03-14 2020-06-02 Emory University Amide-sulfamide derivatives, compositions, and uses related to CXCR4 inhibition
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US11357759B2 (en) 2017-10-29 2022-06-14 China Medical University Composition including ADAM9 inhibitor and the use thereof
EP3724197A1 (en) 2017-12-13 2020-10-21 GlaxoSmithKline Intellectual Property Development Ltd Fused pyridines which act as inhibitors of h-pgds
CN111868051B (zh) * 2018-03-23 2024-04-09 斯泰普制药股份公司 作为ctps1抑制剂的氨基嘧啶衍生物
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Also Published As

Publication number Publication date
AU2006299428A1 (en) 2007-04-12
CN101282943A (zh) 2008-10-08
ES2514471T3 (es) 2014-10-28
US20080227782A1 (en) 2008-09-18
NO20082000L (no) 2008-06-09
EP1937652B1 (en) 2014-07-30
CN101538246B (zh) 2014-07-16
KR101457966B1 (ko) 2014-11-04
UA93213C2 (en) 2011-01-25
TWI415839B (zh) 2013-11-21
CA2624749C (en) 2011-08-16
US8202863B2 (en) 2012-06-19
NZ567208A (en) 2011-03-31
TNSN08104A1 (en) 2009-07-14
ECSP088335A (es) 2008-05-30
CN101538246A (zh) 2009-09-23
ZA200802222B (en) 2009-09-30
MY151172A (en) 2014-04-30
SG166121A1 (en) 2010-11-29
JP5452925B2 (ja) 2014-03-26
AR056871A1 (es) 2007-10-31
PE20070589A1 (es) 2007-06-22
IL190411A (en) 2013-09-30
DOP2006000210A (es) 2007-06-15
TW200812977A (en) 2008-03-16
CA2624749A1 (en) 2007-04-12
WO2007041634A1 (en) 2007-04-12
AU2006299428B2 (en) 2012-04-26
PE20110118A1 (es) 2011-03-08
JP2009510170A (ja) 2009-03-12
CR9832A (es) 2008-06-18
IL190411A0 (en) 2008-11-03
RU2008117170A (ru) 2009-11-10
BRPI0616815A2 (pt) 2011-07-05
EP1937652A1 (en) 2008-07-02
KR20080050611A (ko) 2008-06-09
UY29840A1 (es) 2007-05-31
RU2420519C2 (ru) 2011-06-10

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