MA29925B1 - Composes d'amide de pyrimidine en tant qu'inhibiteurs de pgds - Google Patents

Composes d'amide de pyrimidine en tant qu'inhibiteurs de pgds

Info

Publication number
MA29925B1
MA29925B1 MA30891A MA30891A MA29925B1 MA 29925 B1 MA29925 B1 MA 29925B1 MA 30891 A MA30891 A MA 30891A MA 30891 A MA30891 A MA 30891A MA 29925 B1 MA29925 B1 MA 29925B1
Authority
MA
Morocco
Prior art keywords
amide compounds
compound
pgds inhibitors
pyrimidine amide
pyrimidine
Prior art date
Application number
MA30891A
Other languages
English (en)
Inventor
Suzanne C Aldous
John Ziqi Jiang
Jinqi Lu
Liang Ma
Lan Mu
Harry Randall Munson
Jeffrey Stephen Sabol
Sukanthini Thurairatnam
Christopher Loren Vandeusen
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of MA29925B1 publication Critical patent/MA29925B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un composé de formule (I) : dans lequel R1, R2, R3 et L1 sont comme présentement définis, une composition pharmaceutique comprenant le composé, et l'utilisation du composé pour traiter des troubles allergiques et/ou inflammatoires, en particulier des troubles tels que la rhinite allergique, l'asthme et/ou la bronchopneumopathie chronique obstructive (COPD).
MA30891A 2005-10-04 2008-05-02 Composes d'amide de pyrimidine en tant qu'inhibiteurs de pgds MA29925B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72357005P 2005-10-04 2005-10-04

Publications (1)

Publication Number Publication Date
MA29925B1 true MA29925B1 (fr) 2008-11-03

Family

ID=37635758

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30891A MA29925B1 (fr) 2005-10-04 2008-05-02 Composes d'amide de pyrimidine en tant qu'inhibiteurs de pgds

Country Status (27)

Country Link
US (1) US8202863B2 (fr)
EP (1) EP1937652B1 (fr)
JP (1) JP5452925B2 (fr)
KR (1) KR101457966B1 (fr)
CN (2) CN101538246B (fr)
AR (1) AR056871A1 (fr)
AU (1) AU2006299428B2 (fr)
BR (1) BRPI0616815A2 (fr)
CA (1) CA2624749C (fr)
CR (1) CR9832A (fr)
DO (1) DOP2006000210A (fr)
EC (1) ECSP088335A (fr)
ES (1) ES2514471T3 (fr)
IL (1) IL190411A (fr)
MA (1) MA29925B1 (fr)
MY (1) MY151172A (fr)
NO (1) NO20082000L (fr)
NZ (1) NZ567208A (fr)
PE (2) PE20110118A1 (fr)
RU (1) RU2420519C2 (fr)
SG (1) SG166121A1 (fr)
TN (1) TNSN08104A1 (fr)
TW (1) TWI415839B (fr)
UA (1) UA93213C2 (fr)
UY (1) UY29840A1 (fr)
WO (1) WO2007041634A1 (fr)
ZA (1) ZA200802222B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200802411B (en) * 2005-09-15 2009-09-30 Orchid Res Lab Ltd Novel pyrimidine carboxamides
PE20110118A1 (es) 2005-10-04 2011-03-08 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds
KR20080109918A (ko) 2006-04-11 2008-12-17 버텍스 파마슈티칼스 인코포레이티드 전압 개폐 나트륨 채널의 억제제로서 유용한 조성물
WO2008075172A2 (fr) 2006-12-19 2008-06-26 Pfizer Products Inc. Dérivés de nicotinamide
EP2132196A1 (fr) 2007-02-26 2009-12-16 Pfizer Products Inc. Composés hétérocycliques utiles dans le traitement de maladies et de conditions
CN104072489B (zh) * 2007-08-27 2017-07-07 达特神经科学(开曼)有限公司 治疗用异噁唑化合物
US8519137B2 (en) 2007-10-11 2013-08-27 Vertex Pharmaceuticals Incorporated Heteroaryl amides useful as inhibitors of voltage-gated sodium channels
US8389734B2 (en) 2007-10-11 2013-03-05 Vertex Pharmaceuticals Incorporated Amides useful as inhibitors of voltage-gated sodium channels
MX2010003865A (es) 2007-10-11 2010-06-01 Vertex Pharma Aril amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
JP2011503072A (ja) * 2007-11-13 2011-01-27 レノビス， インコーポレイテッド イオンチャネルのリガンドとしてのアミド誘導体ならびにそれを使用する薬学的組成物および方法
CA2711399C (fr) * 2008-02-06 2016-10-11 Banyu Pharmaceutical Co., Ltd. Derive de sulfonylpiperazine substitue en position 3
EP2286221A4 (fr) * 2008-05-13 2011-07-06 Cayman Chem Co Procédés d'évaluation de la capacité de composés ou d'agents à déplacer de puissants ligands de la prostaglandine d synthase hématopoïétique
WO2009153720A1 (fr) 2008-06-18 2009-12-23 Pfizer Limited Dérivés de nicotinamide
US20110306597A1 (en) 2008-06-18 2011-12-15 James Michael Crawforth Nicotinamide Derivatives
PE20110843A1 (es) 2008-09-22 2011-12-08 Cayman Chem Co Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica
KR101252335B1 (ko) 2009-07-16 2013-04-08 (주)아모레퍼시픽 피부 노화 방지용 조성물
KR101367057B1 (ko) 2009-03-17 2014-02-25 (주)아모레퍼시픽 피부 자극 완화용 조성물
WO2010056044A2 (fr) * 2008-11-11 2010-05-20 (주)아모레퍼시픽 Nouveau composé faisant fonction d'antagoniste du récepteur vanilloïde, isomère ou sel pharmaceutiquement acceptable dudit composé, et composition pharmaceutique le contenant
JP5111657B2 (ja) 2009-03-09 2013-01-09 大鵬薬品工業株式会社 プロスタグランジンｄ合成酵素を阻害するピペラジン化合物
BR112012007635B1 (pt) * 2009-10-08 2019-07-09 Sanofi Compostos derivados de feniloxadiazol como inibidores de pgds, composição farmacêutica compreendendo os mesmos e seus processos de preparação
CN102712626B (zh) 2010-01-22 2014-09-17 大鹏药品工业株式会社 具有pgds抑制作用的哌嗪化合物
US9320723B2 (en) * 2010-05-03 2016-04-26 University Of Rochester Methods of treating thyroid eye disease
WO2011150457A2 (fr) * 2010-06-01 2011-12-08 The University Of Queensland Inhibiteurs de la prostaglandine d2 synthase hématopoïétique
AU2011299904A1 (en) 2010-09-07 2013-05-02 Taiho Pharmaceutical Co., Ltd. Prostaglandin D synthase inhibitory piperidine compounds
KR101271223B1 (ko) 2011-01-27 2013-06-07 한국과학기술연구원 아미노피리미딘 유도체 및 이를 포함하는 세포외 신호조절 키나제의 제해제
BR112014016804A8 (pt) 2012-01-06 2017-07-04 Univ California composições, métodos de uso e métodos de tratamento
ES2640049T3 (es) * 2012-08-24 2017-10-31 Sunshine Lake Pharma Co., Ltd. Derivados de 3,6-dihidropirimidina 2,4,5,6-sustituidos como inhibidores de la polimerasa del virus de la hepatitis B (VHB) para el tratamiento de, por ejemplo, la hepatitis crónica
RU2018126105A (ru) 2015-12-17 2020-01-17 Астекс Терапьютикс Лимитед Хинолин-3-карбоксамиды в качестве ингибиторов h-pgds
US10669270B2 (en) * 2016-03-14 2020-06-02 Emory University Amide-sulfamide derivatives, compositions, and uses related to CXCR4 inhibition
JOP20190072A1 (ar) * 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
BR112019026452A2 (pt) 2017-06-13 2020-07-14 Glaxosmithkline Intellectual Property Development Limited compostos químicos como inibidores de h-pgds
EP3700521B1 (fr) * 2017-10-29 2024-06-12 China Medical University Utilisation d'un compose inhibiteur d'adam9 et d'une composition comprenant un compose inhibiteur d'adam9
WO2019116256A1 (fr) 2017-12-13 2019-06-20 Glaxosmithkline Intellectual Property Development Limited Pyridines fusionnées agissant en tant qu'inhibiteurs de h-pgds
WO2019179652A1 (fr) * 2018-03-23 2019-09-26 Step Pharma S.A.S. Dérivés d'aminopyrimidine utilisés comme inhibiteurs de ctps1
EP3877384A1 (fr) 2018-11-08 2021-09-15 GlaxoSmithKline Intellectual Property Development Ltd Composés chimiques
CN116997548A (zh) * 2020-05-13 2023-11-03 Chdi基金会股份有限公司 用于治疗亨廷顿病的htt调节剂
JPWO2021256569A1 (fr) 2020-06-19 2021-12-23
EP4232425A4 (fr) * 2020-10-23 2024-07-24 Nimbus Clotho Inc Inhibiteurs de ctps1 et leurs utilisations
CN113004208A (zh) * 2021-03-08 2021-06-22 沈阳药科大学 一种抑制黄嘌呤氧化酶活性的化合物及制备方法和应用
EP4433471A1 (fr) * 2021-11-17 2024-09-25 CHDI Foundation, Inc. Dérivés de n-(2h-indazol-5-yl)pyrazine-2-carboxamide et composés similaires utilisés en tant que modulateurs htt pour le traitement de la maladie de huntington
JPWO2023113023A1 (fr) 2021-12-17 2023-06-22

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03112985A (ja) * 1989-09-28 1991-05-14 Morishita Pharmaceut Co Ltd Ｎ―（１ｈ―テトラゾール―５―イル）―２―フェニル―５―ピリミジンカルボキシアミド類及びその合成用中間体
GB9405347D0 (en) * 1994-03-18 1994-05-04 Agrevo Uk Ltd Fungicides
JP2000226372A (ja) * 1999-02-01 2000-08-15 Nippon Soda Co Ltd アミド化合物、その製造方法及び農園芸用殺虫剤
WO2001021577A2 (fr) * 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Antagoniste de l'hormone de concentration de la melanine
JP2002003370A (ja) * 1999-09-20 2002-01-09 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
MY138097A (en) * 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
JP2003112985A (ja) 2001-10-01 2003-04-18 Nre Happiness Kk 食品残渣肥、飼料原料化システムおよびそれに使用する破砕貯留処理ユニット並びに乾燥冷却処理ユニット
AU2003248122A1 (en) * 2002-07-25 2004-02-16 Kotobuki Pharmaceutical Co., Ltd. Sodium channel inhibitor
CA2494102A1 (fr) * 2002-07-30 2004-02-05 Banyu Pharmaceutical Co., Ltd. Antagoniste de recepteur d'hormone concentrant de la melanine comprenant un derive de benzimidazole en tant qu'ingredient actif
ATE450533T1 (de) * 2003-02-14 2009-12-15 Glaxo Group Ltd Carboxamidderivate
DE60303238T2 (de) * 2003-04-25 2006-09-14 Actimis Pharmaceuticals, Inc., La Jolla Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten
WO2005032493A2 (fr) 2003-10-07 2005-04-14 Renovis, Inc. Composes d'amides utilises en tant que ligands de canaux ioniques et utilisations correspondantes
US20050165028A1 (en) * 2004-01-23 2005-07-28 Norman Mark H. Vanilloid receptor ligands and their use in treatments
PE20110118A1 (es) 2005-10-04 2011-03-08 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds

Also Published As

Publication number Publication date
IL190411A0 (en) 2008-11-03
WO2007041634A1 (fr) 2007-04-12
CA2624749C (fr) 2011-08-16
ZA200802222B (en) 2009-09-30
CN101538246A (zh) 2009-09-23
IL190411A (en) 2013-09-30
RU2008117170A (ru) 2009-11-10
SG166121A1 (en) 2010-11-29
CN101538246B (zh) 2014-07-16
KR101457966B1 (ko) 2014-11-04
AU2006299428B2 (en) 2012-04-26
JP2009510170A (ja) 2009-03-12
AR056871A1 (es) 2007-10-31
EP1937652A1 (fr) 2008-07-02
CN101282943A (zh) 2008-10-08
BRPI0616815A2 (pt) 2011-07-05
PE20070589A1 (es) 2007-06-22
CR9832A (es) 2008-06-18
RU2420519C2 (ru) 2011-06-10
DOP2006000210A (es) 2007-06-15
AU2006299428A1 (en) 2007-04-12
TNSN08104A1 (en) 2009-07-14
MY151172A (en) 2014-04-30
EP1937652B1 (fr) 2014-07-30
CA2624749A1 (fr) 2007-04-12
JP5452925B2 (ja) 2014-03-26
UY29840A1 (es) 2007-05-31
NO20082000L (no) 2008-06-09
PE20110118A1 (es) 2011-03-08
ECSP088335A (es) 2008-05-30
ES2514471T3 (es) 2014-10-28
KR20080050611A (ko) 2008-06-09
US8202863B2 (en) 2012-06-19
UA93213C2 (en) 2011-01-25
TWI415839B (zh) 2013-11-21
US20080227782A1 (en) 2008-09-18
NZ567208A (en) 2011-03-31
TW200812977A (en) 2008-03-16

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