WO2005090287A3 - Phenylethanolamine derivatives as beta-2 agonists - Google Patents

Phenylethanolamine derivatives as beta-2 agonists Download PDF

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Publication number
WO2005090287A3
WO2005090287A3 PCT/IB2005/000640 IB2005000640W WO2005090287A3 WO 2005090287 A3 WO2005090287 A3 WO 2005090287A3 IB 2005000640 W IB2005000640 W IB 2005000640W WO 2005090287 A3 WO2005090287 A3 WO 2005090287A3
Authority
WO
WIPO (PCT)
Prior art keywords
agonists
beta
derivatives
phenylethanolamine derivatives
disorders
Prior art date
Application number
PCT/IB2005/000640
Other languages
French (fr)
Other versions
WO2005090287A2 (en
Inventor
Alan Daniel Brown
Mark Edward Bunnage
Paul Alan Glossop
Kim James
Charlotte Alice Louise Lane
Russell Andrew Lewthwaite
Graham Lunn
David Anthony Price
Original Assignee
Pfizer Ltd
Pfizer
Alan Daniel Brown
Mark Edward Bunnage
Paul Alan Glossop
Kim James
Charlotte Alice Louise Lane
Russell Andrew Lewthwaite
Graham Lunn
David Anthony Price
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04290725A external-priority patent/EP1577291A1/en
Priority claimed from GB0425064A external-priority patent/GB0425064D0/en
Application filed by Pfizer Ltd, Pfizer, Alan Daniel Brown, Mark Edward Bunnage, Paul Alan Glossop, Kim James, Charlotte Alice Louise Lane, Russell Andrew Lewthwaite, Graham Lunn, David Anthony Price filed Critical Pfizer Ltd
Priority to AP2006003743A priority Critical patent/AP2006003743A0/en
Priority to AU2005223488A priority patent/AU2005223488A1/en
Priority to JP2007503437A priority patent/JP4054366B2/en
Priority to EP05708731A priority patent/EP1727789A2/en
Priority to EA200601510A priority patent/EA200601510A1/en
Priority to CA002559203A priority patent/CA2559203A1/en
Priority to BRPI0508927-1A priority patent/BRPI0508927A/en
Publication of WO2005090287A2 publication Critical patent/WO2005090287A2/en
Publication of WO2005090287A3 publication Critical patent/WO2005090287A3/en
Priority to IL177754A priority patent/IL177754A0/en
Priority to NO20063875A priority patent/NO20063875L/en
Priority to TNP2006000286A priority patent/TNSN06286A1/en
Priority to IS8549A priority patent/IS8549A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
PCT/IB2005/000640 2004-03-17 2005-03-10 Phenylethanolamine derivatives as beta-2 agonists WO2005090287A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AP2006003743A AP2006003743A0 (en) 2004-03-17 2005-03-10 Compounds useful for the treatment of diseases
AU2005223488A AU2005223488A1 (en) 2004-03-17 2005-03-10 Phenylethanolamine derivatives as Beta-2 agonists
JP2007503437A JP4054366B2 (en) 2004-03-17 2005-03-10 Compounds useful for the treatment of diseases
EP05708731A EP1727789A2 (en) 2004-03-17 2005-03-10 Phenylethanolamine derivatives as beta-2 agonists
EA200601510A EA200601510A1 (en) 2004-03-17 2005-03-10 DERIVATIVES OF PHENYLETHANOLAMINE AS BETA-2-AGONISTS
CA002559203A CA2559203A1 (en) 2004-03-17 2005-03-10 Phenylethanolamine derivatives as beta-2 agonists
BRPI0508927-1A BRPI0508927A (en) 2004-03-17 2005-03-10 compounds useful for treating diseases
IL177754A IL177754A0 (en) 2004-03-17 2006-08-29 Phenylethanolamine derivatives as beta-2 agonists
NO20063875A NO20063875L (en) 2004-03-17 2006-08-30 Compounds used for the treatment of diseases
TNP2006000286A TNSN06286A1 (en) 2004-11-12 2006-09-15 COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES
IS8549A IS8549A (en) 2004-11-12 2006-10-06 Phenylthanolamine derivatives acting as beta-2

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP04290725A EP1577291A1 (en) 2004-03-17 2004-03-17 Phenylethanolamine derivatives as beta-2 agonists
EP04290725.3 2004-03-17
US59179004P 2004-07-27 2004-07-27
US60/591,790 2004-07-27
GB0425064A GB0425064D0 (en) 2004-11-12 2004-11-12 Compounds useful for the treatment of diseases
GB0425064.3 2004-11-12

Publications (2)

Publication Number Publication Date
WO2005090287A2 WO2005090287A2 (en) 2005-09-29
WO2005090287A3 true WO2005090287A3 (en) 2006-02-16

Family

ID=56290672

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000640 WO2005090287A2 (en) 2004-03-17 2005-03-10 Phenylethanolamine derivatives as beta-2 agonists

Country Status (7)

Country Link
EP (1) EP1727789A2 (en)
JP (1) JP4054366B2 (en)
AU (1) AU2005223488A1 (en)
BR (1) BRPI0508927A (en)
CA (1) CA2559203A1 (en)
EA (1) EA200601510A1 (en)
WO (1) WO2005090287A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0425054D0 (en) * 2004-03-23 2004-12-15 Pfizer Ltd Formamide derivatives for the treatment of diseases
UA87854C2 (en) * 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
ES2320961B1 (en) * 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) PHENOL AS BETA2 ADRENERGIC RECEIVER AGONISTS.
MX2010007604A (en) 2008-01-11 2010-08-02 Novartis Ag Pyrimidines as kinase inhibitors.
JP5801997B2 (en) 2009-07-07 2015-10-28 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ Dosing unit, dosing unit pack, and inhaler for inhaling a combination of drugs
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (en) 2010-09-09 2012-04-30 Irm Llc COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE TRK
AP2013007103A0 (en) 2011-02-25 2013-09-30 Irm Llc Compounds and compositions as TRK inhibitors
AU2021296221A1 (en) 2020-06-26 2023-02-02 Mylan Pharma Uk Limited Formulations including 5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319334A1 (en) * 1975-07-29 1977-02-25 Allen & Hanburys Ltd COMPOUNDS WITH BETA-ADRENERGIC RECEPTOR STIMULATING ACTIVITY
EP0006735A1 (en) * 1978-06-28 1980-01-09 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
FR2562889A1 (en) * 1984-04-17 1985-10-18 Glaxo Group Ltd PHENETHANOLAMINE COMPOUNDS. PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
EP0236624A2 (en) * 1985-11-21 1987-09-16 Beecham Group Plc Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them
WO2001042193A1 (en) * 1999-12-08 2001-06-14 Theravance, Inc. β2-ADRENERGIC RECEPTOR AGONISTS
WO2003042160A1 (en) * 2001-11-13 2003-05-22 Theravance, Inc. Aryl aniline beta-2 adrenergic receptor agonists
WO2003091204A1 (en) * 2002-04-25 2003-11-06 Glaxo Group Limited Phenethanolamine derivatives
EP1477167A1 (en) * 2003-05-15 2004-11-17 Pfizer Limited [(2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethylamino)-propyl] phenyl derivatives as beta2 agonists

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319334A1 (en) * 1975-07-29 1977-02-25 Allen & Hanburys Ltd COMPOUNDS WITH BETA-ADRENERGIC RECEPTOR STIMULATING ACTIVITY
EP0006735A1 (en) * 1978-06-28 1980-01-09 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
FR2562889A1 (en) * 1984-04-17 1985-10-18 Glaxo Group Ltd PHENETHANOLAMINE COMPOUNDS. PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
EP0236624A2 (en) * 1985-11-21 1987-09-16 Beecham Group Plc Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them
WO2001042193A1 (en) * 1999-12-08 2001-06-14 Theravance, Inc. β2-ADRENERGIC RECEPTOR AGONISTS
WO2003042160A1 (en) * 2001-11-13 2003-05-22 Theravance, Inc. Aryl aniline beta-2 adrenergic receptor agonists
WO2003091204A1 (en) * 2002-04-25 2003-11-06 Glaxo Group Limited Phenethanolamine derivatives
EP1477167A1 (en) * 2003-05-15 2004-11-17 Pfizer Limited [(2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethylamino)-propyl] phenyl derivatives as beta2 agonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
APPERLEY G H ET AL: "Selectivity of Beta-adrenoceptor agonists and antagonists on bronchial, skeletal, vascular and cardiac muscle in the anaesthetized cat", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 57, no. 2, 1976, pages 235 - 246, XP000926140, ISSN: 0007-1188 *
BONNERT R V ET AL: "DUAL D2-RECEPTOR AND BETA2-ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF AIRWAY DISEASES. 1. DISCOVERY AND BIOLOGICAL EVALUATION OF SOME 7-(2-AMINOETHYL)- 4-HYDROXYBENZOTHIAZOL-2(3H)-ONE ANALOGUES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 25, 1998, pages 4915 - 4917, XP000978960, ISSN: 0022-2623 *
CAMPILLO N ET AL: "NOVEL BRONCHODILATORS IN THE TREATMENT OF ASTHMA AND COPD", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 1, no. 12, 2002, pages 53 - 63, XP008002080, ISSN: 1354-3776 *

Also Published As

Publication number Publication date
WO2005090287A2 (en) 2005-09-29
EA200601510A1 (en) 2007-04-27
JP2007529501A (en) 2007-10-25
AU2005223488A1 (en) 2005-09-29
CA2559203A1 (en) 2005-09-29
JP4054366B2 (en) 2008-02-27
EP1727789A2 (en) 2006-12-06
BRPI0508927A (en) 2007-08-14

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