LV12515B - NON-FERTILIZING LIGANDS FOR ESTROGENE RECYCLES - Google Patents
NON-FERTILIZING LIGANDS FOR ESTROGENE RECYCLES Download PDFInfo
- Publication number
- LV12515B LV12515B LVP-00-19A LV000019A LV12515B LV 12515 B LV12515 B LV 12515B LV 000019 A LV000019 A LV 000019A LV 12515 B LV12515 B LV 12515B
- Authority
- LV
- Latvia
- Prior art keywords
- phenyl
- enyl
- diphenyl
- alkyl
- independently
- Prior art date
Links
- 102000015694 estrogen receptors Human genes 0.000 title abstract description 10
- 108010038795 estrogen receptors Proteins 0.000 title abstract description 10
- 239000003446 ligand Substances 0.000 title abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims description 30
- -1 1,2-diphenyl-but-1-enyl Chemical group 0.000 claims description 24
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
- HJQQVNIORAQATK-UHFFFAOYSA-N 3-[4-(1,2-diphenylbut-1-enyl)phenyl]prop-2-enoic acid Chemical compound C=1C=CC=CC=1C(CC)=C(C=1C=CC(C=CC(O)=O)=CC=1)C1=CC=CC=C1 HJQQVNIORAQATK-UHFFFAOYSA-N 0.000 claims description 9
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- UZBQIPPOMKBLAS-UHFFFAOYSA-N diethylazanide Chemical compound CC[N-]CC UZBQIPPOMKBLAS-UHFFFAOYSA-N 0.000 claims description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 7
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- 230000002917 arthritic effect Effects 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- LEANVSLVLHRVSO-UHFFFAOYSA-N 3-[4-(1,2-diphenylbut-1-enyl)phenyl]-n,n-diethylprop-2-enamide Chemical compound C1=CC(C=CC(=O)N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C(CC)C1=CC=CC=C1 LEANVSLVLHRVSO-UHFFFAOYSA-N 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- UDVOIXWDQPZTFJ-UHFFFAOYSA-N methyl 3-[4-(1,2-diphenylbut-1-enyl)phenyl]prop-2-enoate Chemical compound C=1C=CC=CC=1C(CC)=C(C=1C=CC(C=CC(=O)OC)=CC=1)C1=CC=CC=C1 UDVOIXWDQPZTFJ-UHFFFAOYSA-N 0.000 claims description 2
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 2
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- CBPRAZUZJJFZRP-UHFFFAOYSA-N 3-[4-(1,2-diphenylbut-1-enyl)phenyl]-n,n-diethylpropanamide Chemical compound C1=CC(CCC(=O)N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C(CC)C1=CC=CC=C1 CBPRAZUZJJFZRP-UHFFFAOYSA-N 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
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Classifications
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
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- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
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- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
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- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
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- C07C57/48—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid having unsaturation outside the aromatic rings
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5847007A (en) | 1993-05-13 | 1998-12-08 | Neorx Corporation | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
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- 1997-08-12 GB GB0005931A patent/GB2344589B/en not_active Expired - Lifetime
- 1997-08-12 IL IL13435597A patent/IL134355A0/xx not_active IP Right Cessation
- 1997-08-12 CH CH00282/00A patent/CH694250A5/fr not_active IP Right Cessation
- 1997-08-12 RO ROA200000152A patent/RO121849B1/ro unknown
- 1997-08-12 WO PCT/US1997/013975 patent/WO1999007668A1/en active IP Right Grant
- 1997-08-12 BR BR9714820-2A patent/BR9714820A/pt not_active IP Right Cessation
- 1997-08-12 AU AU41472/97A patent/AU4147297A/en not_active Abandoned
- 1997-08-12 DE DE19782294A patent/DE19782294B4/de not_active Expired - Lifetime
- 1997-08-12 NZ NZ502625A patent/NZ502625A/en not_active IP Right Cessation
- 1997-08-12 JP JP2000507204A patent/JP4417548B2/ja not_active Expired - Lifetime
- 1997-08-12 CA CA002301189A patent/CA2301189C/en not_active Expired - Lifetime
- 1997-08-12 DE DE19782294T patent/DE19782294T1/de active Pending
- 1997-08-12 EE EEP200000070A patent/EE200000070A/xx unknown
- 1997-12-08 UA UA2000020770A patent/UA65580C2/uk unknown
-
1998
- 1998-10-30 US US09/182,244 patent/US6207716B1/en not_active Expired - Lifetime
-
2000
- 2000-02-08 LU LU90525A patent/LU90525B1/de active
- 2000-02-09 NO NO20000657A patent/NO20000657L/no not_active Application Discontinuation
- 2000-02-09 SE SE0000401A patent/SE0000401L/xx not_active Application Discontinuation
- 2000-02-09 DK DK200000198A patent/DK200000198A/da not_active Application Discontinuation
- 2000-02-11 FI FI20000294A patent/FI20000294A/fi not_active IP Right Cessation
- 2000-02-11 LV LVP-00-19A patent/LV12515B/en unknown
- 2000-12-14 US US09/735,504 patent/US20010053774A1/en not_active Abandoned
-
2001
- 2001-05-30 HK HK01103753A patent/HK1033126A1/xx not_active IP Right Cessation
-
2002
- 2002-07-31 US US10/208,007 patent/US20030073671A1/en not_active Abandoned
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