LV12201B - Slāpekļa oksīda izmantošana bronhostenozes ārstēšanai vai profilaksei - Google Patents
Slāpekļa oksīda izmantošana bronhostenozes ārstēšanai vai profilaksei Download PDFInfo
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- LV12201B LV12201B LVP-98-169A LV980169A LV12201B LV 12201 B LV12201 B LV 12201B LV 980169 A LV980169 A LV 980169A LV 12201 B LV12201 B LV 12201B
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- pulmonary
- ppm
- gas
- nitric oxide
- treatment
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Claims (21)
- LV 12201 IZGUDROJUMA FORMULA 1. Gāzveida slāpekļa oksīda (NO) izmantošana inhalējama medikamenta 5 ražošanai bronhostenozes ārstēšanai vai profilaksei zīdītājiem ar metodi, kas ietver inhalāciju došanu ar tādu NO koncentrāciju, kas ir terapeitiski efektīva minētās slimības ārstēšanā vai profilaksē.
- 2. Gāzveida maisījuma, kas sastāv no NO un inertas gāzes (labāk N2), 10 izmantošana inhalējama medikamenta ražošanai bronhostenozes vai atgriezeniskas plaušu asinsvadu sašaurināšanās ārstēšanai vai profilaksei zīdītājiem.
- 3. Slāpekļa oksīda avota izmantošana inhalējama medikamenta 15 ražošanai atgriezeniskas plaušu asinsvadu sašaurināšanās ārstēšanai vai profilaksei zīdītājiem ar metodi, kas ietver atsevišķā zīdītāja, kam nepieciešama minētā ārstēšana vai profilakse, identifikāciju un inhalāciju došanu minētajam zīdītājam ar tādu minētā medikamenta daudzumu, kas nodrošina tādu NO daudzumu, kas ir terapeitiski efektīvs minētās slimības 20 ārstēšanā vai profilaksē.
- 4. Izmantošana, kā norādīts 3. punktā, kur minētais avots satur gāzes aerosoliepakojumu.
- 5. Izmantošana, kā norādīts 3. punktā, kur minētais avots satur slāpekļa oksīdu izdalošu savienojumu.
- 6. Izmantošana, kā norādīts 5. punktā, kur minētais slāpekļa oksīdu izdalošais savienojums ir S-nitrozo-N-acetilpenicilamīns, S-nitrozocisteīns, 30 nitroprusīds, nitrozoguanidīns, gliceriltrinitrāts (nitroglicerīns), izoamilnitrīts, neorganisks nitrīts, azīds vai hidroksilamīns.
- 7. Gāzveida maisījums, kas sastāv no NO un inertas gāzes (labāk N2), izmantošanai bronhostenozes vai atgriezeniskas plaušu asinsvadu 35 sašaurināšanās ārstēšanas metodē zīdītājiem. 2
- 8. Izmantošana, kā norādīts jebkurā no 1.-4. punktiem, kur NO daudzums minētajā inhalējamajā medikamentā ir vismaz viena daļa uz miljonu (ppm), labāk vismaz 20 ppm un vislabāk vismaz 80 ppm.
- 9. Izmantošana, kā norādīts jebkurā no 1.-4. punktiem, kur NO koncentrācija minētajā inhalējamajā medikamentā nepārsniedz 180 ppm.
- 10. Izmantošana, kā norādīts 9. punktā, kur minētā metode ietver minētās koncentrācijas kontrolēšanu, labāk ar hemiluminescences palīdzību.
- 11. Izmantošana, kā norādīts jebkurā no 1.-3. punktiem vai jebkurā punktā, kas atkarīgs no tā, kur minētajā inhalējamajā medikamentā tiek kontrolēta N02 koncentrācija, un tā tiek uzturēta mazāka par 1 ppm.
- 12. Izmantošana, kā norādīts 1., 2. vai 4. punktā vai jebkurā punktā, kas atkarīgs no tā, kur minētais inhalējamais medikaments satur maisījumu, kas ietver NO, 02 un N2, un kura F|02 (inhalētā skābekļa koncentrācija) ir labāk 0.21-0.99.
- 13. Maisījums saskaņā ar 7. punktu tajā norādītajam nolūkam, kur minētajam maisījumam ir piejaukta skābekli saturoša gāze, lai iegūtu inhalējamu maisījumu, kura Fj02 ir labāk 0.21-0.99.
- 14. Izmantošana, kā norādīts 1. punktā vai 2. punktā, vai jebkurā punktā, kas atkarīgs no tā, vai gāzveida maisījums izmantošanai, kā norādīts 7. punktā vai jebkurā punktā, kas atkarīgs no tā, kur bronhostenozi ir izsaukusi astma.
- 15. Izmantošana, kā norādīts 1. punktā vai 2. punktā, izmantošanai bronhostenozes ārstēšanai vai profilaksei, kur minētā metode ietver papildus stadiju, kurā minētajam zīdītājam liek ieelpot bronholītiska savienojuma terapeitiski efektīvu devu šķidrā vai cietā formā, labāk tikpat efektīvu, kā daļa no minētā inahalējamā medikamenta, un vienlaicīgi ar to.
- 16. Izmantošana, kā norādīts 15. punktā, kur minētais bronholītiskais savienojums ir slāpekļa oksīdu izdalošs savienojums. 3 LV 12201
- 17. Izmantošana, kā norādīts 16. punktā, kur minētais slāpekļa oksīdu izdalošais savienojums ir S-nitrozo-N-acetilpenicilamīns, S-nitrozocisteīns, nitroprusīds, nitrozoguanidīns, gliceriltrinitrāts, izoamilnitrīts, neorganisks nitrīts, azīds vai hidroksilamīns.
- 18. Izmantošana, kā norādīts 2. punktā vai 3. punktā, vai jebkurā punktā, kas atkarīgs no tā, vai gāzveida maisījums izmantošanai, kā norādīts 7. punktā vai jebkurā punktā, kas atkarīgs no tā, kur minēto plaušu asinsvadu sašaurināšanos izsauc pneimonija, traumatisks bojājums, aspirācijas vai inhalācijas trauma, tauku embolija plaušās, acidoze, plaušu iekaisums, pieaugušo respiratorais distresa sindroms (elpošanas pavājināšanās), akūta plaušu tūska, akūta kalnu slimība, astma, akūta mazā asinsrites loka hipertenzija pēc sirds operācijām, stabila jaundzimušo mazā asinsrites loka hipertenzija, perinatālais aspirācijas sindroms, jaundzimušo hialīna membrānu slimība (asfiktiskā pneimonija), akūta plaušu trombembolija, heparīna-protamīna reakcijas, sepse, astmātisks stāvoklis, hipoksija, hroniska mazā asinsrites loka hipertenzija, bronhu un plaušu audu displāzija, hroniska plaušu trombembolija, neskaidras izcelsmes vai primāra mazā asinsrites loka hipertenzija vai hroniska hipoksija.
- 19. Izmantošana, kā norādīts 1. punktā vai 2. punktā, vai jebkurā punktā, kas atkarīgs no tā, vai gāzveida maisījums izmantošanai, kā norādīts 7. punktā vai jebkurā punktā, kas atkarīgs no tā, kur minēto bronhostenozi izsaukusi astma.
- 20. Inhalējama medikamenta nodrošināšanas metode ar NO un skābekli saturošas gāzes nepārtrauktas sajaukšanas palīdzību.
- 21. Metode saskaņā ar 20. punktu, kur minētā nepārtrauktā sajaukšana notiek plaušu mākslīgās ventilācijas aparatūrā.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62286590A | 1990-12-05 | 1990-12-05 | |
| US76723491A | 1991-09-27 | 1991-09-27 |
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| LV12201A LV12201A (lv) | 1999-01-20 |
| LV12201B true LV12201B (lv) | 1999-05-20 |
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| LVP-98-169A LV12201B (lv) | 1990-12-05 | 1998-08-24 | Slāpekļa oksīda izmantošana bronhostenozes ārstēšanai vai profilaksei |
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| DE (9) | DE122008000012I2 (lv) |
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| ES (3) | ES2082732T3 (lv) |
| GR (3) | GR960300032T1 (lv) |
| HK (3) | HK1010101A1 (lv) |
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| FR3146810A1 (fr) | 2023-03-21 | 2024-09-27 | Inosystems | Dispositif de calibration des capteurs d’un appareil de délivrance de NO |
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| US3367332A (en) * | 1965-08-27 | 1968-02-06 | Gen Electric | Product and process for establishing a sterile area of skin |
| US3785377A (en) * | 1970-11-12 | 1974-01-15 | S Jorgensen | Plant, preferably for anaesthesia |
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| US4297123A (en) * | 1980-02-07 | 1981-10-27 | Wyse Harold G | Method and apparatus for producing a nitrate fertilizer |
| US4336798A (en) * | 1980-10-06 | 1982-06-29 | Anthony V. Beran | Medical corrugated respiratory tube |
| SE438261B (sv) * | 1981-07-08 | 1985-04-15 | Draco Ab | Anvendning i dosinhalator av ett perforerat membran |
| US4484577A (en) * | 1981-07-23 | 1984-11-27 | Key Pharmaceuticals, Inc. | Drug delivery method and inhalation device therefor |
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| US4852561A (en) * | 1988-07-27 | 1989-08-01 | Sperry C R | Inhalation device |
| US4877589A (en) * | 1988-09-19 | 1989-10-31 | Hare Louis R O | Nitrogen fixation by electric arc and catalyst |
| US4915915A (en) * | 1988-10-11 | 1990-04-10 | Treharne Richard W | Water-powdered piezoelectric unit for producing nitrogen fertilizer |
| US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
| US5208233A (en) * | 1989-09-15 | 1993-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
| US5007419A (en) * | 1989-09-25 | 1991-04-16 | Allan Weinstein | Inhaler device |
| US5178138A (en) * | 1990-09-11 | 1993-01-12 | Walstrom Dennis R | Drug delivery device |
| US5155137A (en) * | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
| US5187305A (en) * | 1990-11-26 | 1993-02-16 | Glaxo Inc. | S-nitroso-N-alkonoylpenicillamines |
| US5396882A (en) * | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
| DK1516639T4 (en) * | 1990-12-05 | 2015-06-29 | Gen Hospital Corp | Use of NO to treat persistent pulmonary hypertension in newborns |
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| US5427797A (en) * | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
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1991
- 1991-12-05 DK DK04029366.4T patent/DK1516639T4/en active
- 1991-12-05 DE DE200812000012 patent/DE122008000012I2/de active Active
- 1991-12-05 DK DK92902708.4T patent/DK0560928T3/da active
- 1991-12-05 DE DE69127756T patent/DE69127756T2/de not_active Expired - Lifetime
- 1991-12-05 ES ES92902708T patent/ES2082732T3/es not_active Expired - Lifetime
- 1991-12-05 ES ES04029366.4T patent/ES2288660T5/es not_active Expired - Lifetime
- 1991-12-05 AU AU91498/91A patent/AU657726B2/en not_active Expired
- 1991-12-05 DE DE69133575T patent/DE69133575T2/de not_active Expired - Lifetime
- 1991-12-05 DE DE69133584A patent/DE69133584D1/de not_active Expired - Lifetime
- 1991-12-05 JP JP4502844A patent/JP2701978B2/ja not_active Expired - Lifetime
- 1991-12-05 ES ES97105021T patent/ES2132043T3/es not_active Expired - Lifetime
- 1991-12-05 DK DK97105021T patent/DK0786264T3/da active
- 1991-12-05 DE DE0560928T patent/DE560928T1/de active Pending
- 1991-12-05 EP EP07119550A patent/EP1875917A3/en not_active Withdrawn
- 1991-12-05 EP EP20040029366 patent/EP1516639B2/en not_active Expired - Lifetime
- 1991-12-05 EP EP97105021A patent/EP0786264B1/en not_active Revoked
- 1991-12-05 DE DE69133584T patent/DE69133584T4/de not_active Expired - Lifetime
- 1991-12-05 AT AT04029366T patent/ATE367842T2/de active
- 1991-12-05 DE DE122007000103C patent/DE122007000103I1/de active Pending
- 1991-12-05 AT AT92902708T patent/ATE158509T1/de active
- 1991-12-05 AT AT97105021T patent/ATE376850T1/de active
- 1991-12-05 CA CA002097823A patent/CA2097823C/en not_active Expired - Lifetime
- 1991-12-05 DE DE0786264T patent/DE786264T1/de active Pending
- 1991-12-05 DE DE2002199002 patent/DE10299002I1/de active Pending
- 1991-12-05 EP EP92902708A patent/EP0560928B1/en not_active Revoked
- 1991-12-05 SG SG1996002651A patent/SG47527A1/en unknown
- 1991-12-05 WO PCT/US1991/009111 patent/WO1992010228A1/en not_active Application Discontinuation
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1994
- 1994-09-15 EE EE9400192A patent/EE03119B1/xx unknown
- 1994-12-09 US US08/353,508 patent/US5873359A/en not_active Expired - Lifetime
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1995
- 1995-02-10 US US08/384,792 patent/US5485827A/en not_active Expired - Lifetime
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1996
- 1996-06-30 GR GR960300032T patent/GR960300032T1/el unknown
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1997
- 1997-02-20 JP JP03678597A patent/JP3510755B2/ja not_active Expired - Lifetime
- 1997-09-25 GR GR970402498T patent/GR3024865T3/el unknown
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1998
- 1998-08-24 LV LVP-98-169A patent/LV12201B/lv unknown
- 1998-09-24 HK HK98110945A patent/HK1010101A1/xx not_active IP Right Cessation
- 1998-09-24 HK HK99105833A patent/HK1020686A1/xx not_active IP Right Cessation
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1999
- 1999-01-01 GR GR990300018T patent/GR990300018T1/el unknown
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2002
- 2002-01-24 LU LU90886C patent/LU90886I2/xx unknown
- 2002-01-30 NL NL300081C patent/NL300081I2/nl unknown
- 2002-07-26 JP JP2002217936A patent/JP3718491B2/ja not_active Expired - Lifetime
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2005
- 2005-09-22 HK HK05108350A patent/HK1076407A1/xx not_active IP Right Cessation
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2007
- 2007-12-14 NL NL300327C patent/NL300327I2/nl unknown
- 2007-12-21 LU LU91404C patent/LU91404I2/fr unknown
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2008
- 2008-04-01 NL NL300342C patent/NL300342I1/nl unknown
- 2008-04-30 LU LU91423C patent/LU91423I2/fr unknown
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