LV10309B - Method for enzymatic splitting of recombinant proteine with iga proteases, fusioned proteine,recombinant dna, cell - Google Patents
Method for enzymatic splitting of recombinant proteine with iga proteases, fusioned proteine,recombinant dna, cell Download PDFInfo
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- LV10309B LV10309B LVP-93-1094A LV931094A LV10309B LV 10309 B LV10309 B LV 10309B LV 931094 A LV931094 A LV 931094A LV 10309 B LV10309 B LV 10309B
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- 230000037431 insertion Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 206010039447 salmonellosis Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 101150061972 zur gene Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5409—IL-5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4003149 | 1990-02-03 | ||
| DE4015922A DE4015922A1 (de) | 1990-05-17 | 1990-05-17 | Verfahren zur enzymatischen prozessierung von proteinen unter verwendung von iga-proteasen (igase) |
| DE4015921 | 1990-05-17 | ||
| DE4039415A DE4039415A1 (de) | 1990-02-03 | 1990-12-10 | Verfahren zur herstellung rekombinanter proteine ohne n-terminalen methioninrest |
| PCT/EP1991/000192 WO1991011520A1 (de) | 1990-02-03 | 1991-02-01 | VERFAHREN ZUR ENZYMATISCHEN SPALTUNG REKOMBINANTER PROTEINE UNTER VERWENDUNG VON IgA-PROTEASEN |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV10309A LV10309A (lv) | 1994-10-20 |
| LV10309B true LV10309B (en) | 1995-12-20 |
Family
ID=27434868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-93-1094A LV10309B (en) | 1990-02-03 | 1993-09-24 | Method for enzymatic splitting of recombinant proteine with iga proteases, fusioned proteine,recombinant dna, cell |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5427927A (fi) |
| EP (2) | EP0513073B1 (fi) |
| JP (2) | JPH0789952B2 (fi) |
| KR (1) | KR960011919B1 (fi) |
| AT (2) | ATE219518T1 (fi) |
| AU (1) | AU638309B2 (fi) |
| CA (1) | CA2074943C (fi) |
| CZ (1) | CZ284774B6 (fi) |
| DK (1) | DK0513073T3 (fi) |
| ES (2) | ES2177536T3 (fi) |
| FI (1) | FI109810B (fi) |
| HU (1) | HU217103B (fi) |
| IE (1) | IE64938B1 (fi) |
| IL (1) | IL97119A0 (fi) |
| LV (1) | LV10309B (fi) |
| NO (1) | NO311142B1 (fi) |
| NZ (1) | NZ236819A (fi) |
| PT (1) | PT96658B (fi) |
| WO (1) | WO1991011520A1 (fi) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5718893A (en) * | 1984-04-15 | 1998-02-17 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
| DE4344350C2 (de) * | 1993-12-23 | 1995-09-21 | Max Planck Gesellschaft | Bakterien zur Herstellung stabiler Fusionsproteine und Verfahren zu deren Nachweis |
| US5536495A (en) * | 1994-04-15 | 1996-07-16 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
| WO1996009395A2 (de) * | 1994-09-21 | 1996-03-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Arzneimittel zur prophylaxe und behandlung von und diagnostika zur erkennung von autoimmunkrankheiten und viralen erkrankungen |
| AT404838B (de) * | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
| DE19549232C2 (de) * | 1995-12-20 | 1998-05-20 | Boehringer Mannheim Gmbh | Verwendung von G-CSF in Kombination mit einem Chemotherapeutikum bei der Behandlung von Erkrankungen, die eine periphere Stammzelltransplantation erfordern |
| GB9618960D0 (en) | 1996-09-11 | 1996-10-23 | Medical Science Sys Inc | Proteases |
| US6444202B1 (en) | 1996-11-25 | 2002-09-03 | Bundesrepublic Deutschland, Vertreten Durch Den Bundesminister Fur Gesundheit | Processed polypeptides with IL-16 activity, processes for their production and their use |
| US20030190740A1 (en) * | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
| EP1121425B1 (en) * | 1998-10-13 | 2005-06-29 | The University Of Georgia Research Foundation, Inc. | Stabilized bioactive peptides and methods of identification, synthesis and use |
| KR100356140B1 (ko) * | 1999-07-08 | 2002-10-19 | 한미약품공업 주식회사 | 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법 |
| US20030190644A1 (en) * | 1999-10-13 | 2003-10-09 | Andreas Braun | Methods for generating databases and databases for identifying polymorphic genetic markers |
| CN1774511B (zh) * | 2002-11-27 | 2013-08-21 | 斯昆诺有限公司 | 用于序列变异检测和发现的基于断裂的方法和系统 |
| CN100418985C (zh) | 2003-04-23 | 2008-09-17 | 弗·哈夫曼-拉罗切有限公司 | 使用粒酶b蛋白酶切割融合蛋白 |
| CA2523490A1 (en) * | 2003-04-25 | 2004-11-11 | Sequenom, Inc. | Fragmentation-based methods and systems for de novo sequencing |
| US9394565B2 (en) * | 2003-09-05 | 2016-07-19 | Agena Bioscience, Inc. | Allele-specific sequence variation analysis |
| EP2305798A3 (en) | 2003-10-23 | 2011-04-20 | Illumigen Biosciences, Inc. | Detection of mutations in a gene associated with resistance to viral infection, OAS1 |
| US7220407B2 (en) | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
| SI21639A (sl) * | 2003-12-23 | 2005-06-30 | LEK farmacevtska dru�ba d.d. | Farmacevtski pripravek, ki vsebuje nemicelarne sulfobetaine |
| US7608394B2 (en) | 2004-03-26 | 2009-10-27 | Sequenom, Inc. | Methods and compositions for phenotype identification based on nucleic acid methylation |
| EP2395098B1 (en) * | 2004-03-26 | 2015-07-15 | Agena Bioscience, Inc. | Base specific cleavage of methylation-specific amplification products in combination with mass analysis |
| WO2006031745A2 (en) * | 2004-09-10 | 2006-03-23 | Sequenom, Inc. | Methods for long-range sequence analysis of nucleic acids |
| CA2586365A1 (en) | 2004-11-05 | 2006-05-26 | Northwestern University | Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders |
| UA95446C2 (ru) | 2005-05-04 | 2011-08-10 | Іллюміджен Байосайєнсіз, Інк. | Мутаци в генах oas1 |
| MX2009001691A (es) * | 2006-08-31 | 2009-02-25 | Hoffmann La Roche | Metodo para produccion del factor de crecimiento i tipo insulina. |
| CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
| US20090006002A1 (en) * | 2007-04-13 | 2009-01-01 | Sequenom, Inc. | Comparative sequence analysis processes and systems |
| DE102007040932A1 (de) | 2007-08-27 | 2009-03-05 | Biogenerix Ag | Flüssigformulierung von G-CSF |
| CN101795670A (zh) | 2007-08-27 | 2010-08-04 | 百奥杰诺瑞克斯股份有限公司 | G-csf的液体制剂 |
| US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
| BRPI0911266A2 (pt) * | 2008-04-03 | 2015-09-29 | Hoffmann La Roche | ensaio de fator de crescimento similar à insulina peguilado |
| BRPI0910338A2 (pt) * | 2008-04-03 | 2020-08-18 | F. Hoffmann-La Roche Ag | uso de variantes peguiladas de igf-i para o tratamento de distúbios neuromusculares |
| US8053222B2 (en) * | 2009-02-12 | 2011-11-08 | Academia Sinica, Taiwan | Protein expression system involving mutated severe respiratory syndrome-associated coronavirus 3C-like protease |
| US20110152188A1 (en) * | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
| RU2519031C1 (ru) | 2010-01-19 | 2014-06-10 | Ханми Сайенс Ко., Лтд. | Жидкие препаративные формы для длительно действующего конъюгата g-csf |
| CN103025875A (zh) * | 2010-08-30 | 2013-04-03 | 霍夫曼-拉罗奇有限公司 | 原核表达构建体 |
| US20160122793A1 (en) * | 2013-05-24 | 2016-05-05 | Novo Nordisk A/S | Fusion Protease |
| US10370692B2 (en) * | 2013-12-20 | 2019-08-06 | Hoffmann-La Roche Inc. | Recombinant polypeptide production methods |
| PE20221008A1 (es) | 2015-06-24 | 2022-06-15 | Hoffmann La Roche | Anticuerpos anti-receptor de transferrina con afinidad disenada |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| PE20181004A1 (es) | 2015-10-02 | 2018-06-26 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso |
| US10446928B2 (en) | 2017-06-09 | 2019-10-15 | Mitsubishi Electric Corporation | Phased array antenna |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL60184A (en) * | 1979-05-31 | 1984-05-31 | Schering Ag | Process for the specific cleavage of protein sequences from proteins |
| JPS62129298A (ja) * | 1985-12-02 | 1987-06-11 | Chugai Pharmaceut Co Ltd | 新規ポリペプチド |
| ATE65798T1 (de) * | 1985-02-08 | 1991-08-15 | Chugai Pharmaceutical Co Ltd | Menschlicher granuloxcyt-koloniestimulierungsfaktor. |
| US5087564A (en) * | 1985-06-20 | 1992-02-11 | Monsanto Company | Release of recombinant peptides from polypeptides using V8 endopeptidase |
| DE3681551D1 (de) * | 1985-09-30 | 1991-10-24 | Chugai Pharmaceutical Co Ltd | Menschlicher granulozyten-colony stimulierender faktor. |
| DE3545568A1 (de) * | 1985-12-21 | 1987-07-16 | Hoechst Ag | Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung |
| FR2594846B1 (fr) * | 1986-02-21 | 1989-10-20 | Genetica | Procede de preparation de la serum albumine humaine mature |
| US4828988A (en) * | 1986-05-15 | 1989-05-09 | Smith Kline - Rit | Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine |
| DE3622221A1 (de) * | 1986-07-02 | 1988-01-14 | Max Planck Gesellschaft | Verfahren zur gentechnologischen gewinnung von proteinen unter verwendung gramnegativer wirtszellen |
| EP0256843A1 (en) * | 1986-08-11 | 1988-02-24 | Cetus Corporation | Expression of g-csf and muteins thereof and their use |
| IT1223577B (it) * | 1987-12-22 | 1990-09-19 | Eniricerche Spa | Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura |
| ES2063783T3 (es) * | 1988-06-03 | 1995-01-16 | Chugai Pharmaceutical Co Ltd | Factor de cristalino humano de estimulacion de colonias de granulocitos y procedimiento para su preparacion. |
| PT92479A (pt) * | 1988-12-01 | 1990-06-29 | Univ North Carolina | Processo de preparacao de genes recombinantes e suas proteinas de codificacao |
| US5055555A (en) * | 1989-01-05 | 1991-10-08 | Helmut Sassenfeld | Purification of G-CSF |
| US5073627A (en) * | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
-
1991
- 1991-01-18 NZ NZ236819A patent/NZ236819A/xx unknown
- 1991-01-31 IL IL97119A patent/IL97119A0/xx not_active IP Right Cessation
- 1991-02-01 HU HU9202511A patent/HU217103B/hu unknown
- 1991-02-01 KR KR1019920701858A patent/KR960011919B1/ko not_active IP Right Cessation
- 1991-02-01 CA CA002074943A patent/CA2074943C/en not_active Expired - Lifetime
- 1991-02-01 ES ES93121015T patent/ES2177536T3/es not_active Expired - Lifetime
- 1991-02-01 JP JP3503102A patent/JPH0789952B2/ja not_active Expired - Lifetime
- 1991-02-01 EP EP91902956A patent/EP0513073B1/de not_active Expired - Lifetime
- 1991-02-01 ES ES91902956T patent/ES2076521T3/es not_active Expired - Lifetime
- 1991-02-01 PT PT96658A patent/PT96658B/pt not_active IP Right Cessation
- 1991-02-01 EP EP93121015A patent/EP0602688B1/de not_active Expired - Lifetime
- 1991-02-01 WO PCT/EP1991/000192 patent/WO1991011520A1/de active IP Right Grant
- 1991-02-01 AT AT93121015T patent/ATE219518T1/de not_active IP Right Cessation
- 1991-02-01 AT AT91902956T patent/ATE124456T1/de not_active IP Right Cessation
- 1991-02-01 CZ CS91241A patent/CZ284774B6/cs not_active IP Right Cessation
- 1991-02-01 AU AU71496/91A patent/AU638309B2/en not_active Ceased
- 1991-02-01 US US07/917,034 patent/US5427927A/en not_active Expired - Lifetime
- 1991-02-01 IE IE35891A patent/IE64938B1/en not_active IP Right Cessation
- 1991-02-01 DK DK91902956.1T patent/DK0513073T3/da active
-
1992
- 1992-07-30 NO NO19923010A patent/NO311142B1/no unknown
- 1992-07-31 FI FI923463A patent/FI109810B/fi active
-
1993
- 1993-09-24 LV LVP-93-1094A patent/LV10309B/lv unknown
-
1995
- 1995-01-04 JP JP7000120A patent/JP2766621B2/ja not_active Expired - Lifetime
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