LU90285I2 - Gadobenate dimeglumine et ses sels et dérivés pharmaceutiquement acceptables - Google Patents

Gadobenate dimeglumine et ses sels et dérivés pharmaceutiquement acceptables

Info

Publication number
LU90285I2
LU90285I2 LU90285C LU90285C LU90285I2 LU 90285 I2 LU90285 I2 LU 90285I2 LU 90285 C LU90285 C LU 90285C LU 90285 C LU90285 C LU 90285C LU 90285 I2 LU90285 I2 LU 90285I2
Authority
LU
Luxembourg
Prior art keywords
sub
sup
alkyl
cooz
hydroxy
Prior art date
Application number
LU90285C
Other languages
English (en)
French (fr)
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of LU90285I2 publication Critical patent/LU90285I2/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
LU90285C 1986-01-30 1998-09-09 Gadobenate dimeglumine et ses sels et dérivés pharmaceutiquement acceptables LU90285I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8619236A IT1213029B (it) 1986-01-30 1986-01-30 Chelati di ioni metallici paramagnetici.

Publications (1)

Publication Number Publication Date
LU90285I2 true LU90285I2 (fr) 1999-02-25

Family

ID=11156003

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90285C LU90285I2 (fr) 1986-01-30 1998-09-09 Gadobenate dimeglumine et ses sels et dérivés pharmaceutiquement acceptables

Country Status (14)

Country Link
US (3) US4916246A (de)
EP (1) EP0230893B1 (de)
JP (1) JPS62195388A (de)
AT (1) ATE53571T1 (de)
AU (1) AU591225B2 (de)
CA (1) CA1324150C (de)
DE (2) DE3763189D1 (de)
ES (1) ES2031832T3 (de)
GR (1) GR3000563T3 (de)
HK (1) HK95793A (de)
IT (1) IT1213029B (de)
LU (1) LU90285I2 (de)
MX (1) MX9203254A (de)
NL (1) NL980024I2 (de)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
MX174467B (es) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos
AU605461B2 (en) * 1986-04-07 1991-01-17 Francois Dietlin New compositions usable in tomo-densitometry
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US6312679B1 (en) 1986-08-18 2001-11-06 The Dow Chemical Company Dense star polymer conjugates as dyes
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
WO1989000557A1 (en) * 1987-07-16 1989-01-26 Cockbain, Julian, Roderick, Michaelson Aminopolycarboxylic acids and derivatives thereof
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
US5342604A (en) * 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
US5696239A (en) * 1988-10-31 1997-12-09 The Dow Chemical Company Conjugates possessing ortho ligating functionality and complexes thereof
PH31170A (en) * 1988-10-31 1998-03-20 Dow Chemical Co Chelants possesing ortho ligating functionality and complexes thereof.
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
US6039931A (en) * 1989-06-30 2000-03-21 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
US5494655A (en) * 1990-03-09 1996-02-27 The Regents Of The University Of California Methods for detecting blood perfusion variations by magnetic resonance imaging
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
GB9006977D0 (en) 1990-03-28 1990-05-23 Nycomed As Compositions
WO1992017215A1 (en) 1990-03-28 1992-10-15 Nycomed Salutar, Inc. Contrast media
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
CA2102605A1 (en) * 1991-05-23 1992-11-24 Evan C. Unger Liposoluble compounds for magnetic resonance imaging
US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
US5330742A (en) * 1991-08-05 1994-07-19 Mallinckrodt Medical, Inc. Methods and compositions for magnetic resonance imaging
AU2468392A (en) * 1991-08-29 1993-04-05 Cytel Corporation Novel immunosuppressants
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
CA2146990A1 (en) * 1992-10-14 1994-04-28 Robert A. Snow Chelating polymers
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
US5756688A (en) * 1992-10-14 1998-05-26 Sterling Winthrop Inc. MR imaging compositions and methods
WO1994008624A2 (en) * 1992-10-14 1994-04-28 Sterling Winthrop Inc. Therapeutic and diagnostic imaging compositions and methods
US5401492A (en) * 1992-12-17 1995-03-28 Sterling Winthrop, Inc. Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents
DE4302287A1 (de) * 1993-01-25 1994-07-28 Schering Ag Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
JPH08510458A (ja) * 1993-06-02 1996-11-05 ブラッコ エッセ.ピ.ア. 沃素化された常磁性キレートおよびそれらの造影剤としての使用法
US5284972A (en) * 1993-06-14 1994-02-08 Hampshire Chemical Corp. N-acyl-N,N',N'-ethylenediaminetriacetic acid derivatives and process of preparing same
WO1995015319A1 (en) * 1993-12-03 1995-06-08 Bracco S.P.A. Paramagnetic chelates for nuclear magnetic resonance diagnosis
CA2161684C (en) * 1994-03-07 2010-11-09 Larry R. Wilson Bioactive and/or targeted dendrimer conjugates
US5730968A (en) * 1994-03-31 1998-03-24 Sterling Winthrop Inc. Segmented chelating polymers as imaging and therapeutic agents
JP3878208B2 (ja) * 1994-04-08 2007-02-07 ブラッコ インターナショナル ベスローテン フェンノートシャップ 芳香族アミド化合物およびそれらのキレート
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
DE69620582T2 (de) * 1995-01-26 2002-11-07 Nycomed Imaging As, Oslo Verwendung von WISMUTVERBINDUNGEN zur Herstellung eines Arzneimittels zur Behandlung von Magenverstimmungen, die durch Helicobacter pylori verursacht werden
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507819A1 (de) * 1995-02-21 1996-08-22 Schering Ag DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
IT1283650B1 (it) * 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US6458337B1 (en) 1996-08-02 2002-10-01 Dibra S.P.A Diagnostic imaging contrast agent with improved in serum relaxivity
US6403055B1 (en) 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity
DE19641197C2 (de) * 1996-09-24 1999-02-18 Schering Ag Ionenpaare und ihre Verwendung als Kontrastmittel
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
US5861138A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Ligands for MRI contrast agent
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US6495118B1 (en) * 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
IT1298614B1 (it) * 1998-03-10 2000-01-12 Bracco Spa Chelati complessi di manganese ad alta relassivita' in siero
IT1298613B1 (it) 1998-03-10 2000-01-12 Bracco Spa Chelati complessi di manganese ad alta relassivita' in siero
ITMI981583A1 (it) * 1998-07-10 2000-01-10 Bracco Spa Processo per la preparazione dell'acido 4 -carbossi-5,8,11-tris (carbossimetil)-1-fenil-2-oxa-5,8,11-triazatridecan-13-oico
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
US8198400B2 (en) 2001-03-27 2012-06-12 Oncothyreon, Inc. Vaccine for modulating between T1 and T2 immune responses
US7893223B2 (en) 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7157277B2 (en) * 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
WO2003089574A2 (en) * 2002-04-15 2003-10-30 Biomira, Inc. Synthetic glyco-lipo-peptides as vaccines
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
CA2522345A1 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
WO2006127896A2 (en) * 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated factor ix
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
JP4719686B2 (ja) * 2003-11-24 2011-07-06 バイオジェネリックス アーゲー GlycoPEG化エリスロポエチン
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) * 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
TW201204410A (en) 2004-04-01 2012-02-01 Oncothyreon Inc Mucinous glycoprotein (MUC-1) vaccine
US7988950B2 (en) 2004-07-02 2011-08-02 Bracco Imaging S.P.A. Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (MRI) which contain a chelating moiety with polyhydroxylated substituents
EP1771066A2 (de) 2004-07-13 2007-04-11 Neose Technologies, Inc. Remodellierung von verzweigtem peg und klykolysierung von glucagonähnlichem peptide-1 glp-1
KR100624670B1 (ko) 2004-10-28 2006-09-18 동국정밀화학(주) 가돌리늄-디에틸렌트리아민펜타아세트산 아미노알콜염 및이의 제조방법
EP3061461A1 (de) 2004-10-29 2016-08-31 ratiopharm GmbH Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf)
NZ556436A (en) 2005-01-10 2010-11-26 Biogenerix Ag Glycopegylated granulocyte colony stimulating factor
US20060210478A1 (en) * 2005-02-03 2006-09-21 Weisskoff Robert M Steady state perfusion methods
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006124726A2 (en) 2005-05-12 2006-11-23 The General Hospital Corporation Novel biotinylated compositions
EP1896051B1 (de) 2005-06-28 2014-10-15 Oncothyreon Inc. Verfahren zur behandlung von patienten mit einem muzin-(muc-1)-impfstoff
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
CN102719508A (zh) * 2005-08-19 2012-10-10 诺和诺德公司 糖基聚乙二醇化的因子vii和因子viia
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US9187532B2 (en) 2006-07-21 2015-11-17 Novo Nordisk A/S Glycosylation of peptides via O-linked glycosylation sequences
WO2008057683A2 (en) 2006-10-03 2008-05-15 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
BRPI0809670A8 (pt) 2007-04-03 2018-12-18 Biogenerix Ag métodos para aumentar a produção de célula tronco, para aumentar o número de granulócitos em um indivíduo, para prevenir, tratar e aliviar a mielossupressão que resulta de uma terapia contra o câncer, para tratar uma condição em um indivíduo, para tratar neutropenia e trombocitopenia em um mamífero, para expandir células tronco hematopoiéticas em cultura, para aumentar a hematopoiese em um indivíduo, para aumentar o número de célulars progenitoras hematopoiéticas em um indivíduo, e para fornecer enxerto estável da medula óssea, e, forma de dosagem oral.
MX2009013259A (es) 2007-06-12 2010-01-25 Novo Nordisk As Proceso mejorado para la produccion de azucares de nucleotidos.
RU2573587C2 (ru) 2008-02-27 2016-01-20 Ново Нордиск А/С Конъюгированные молекулы фактора viii
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
US8378134B2 (en) 2009-09-30 2013-02-19 General Electric Company Hydroxylated contrast enhancement agents
US20110077396A1 (en) * 2009-09-30 2011-03-31 General Electric Company Intermediates for hydroxylated contrast enhancement agents
EP2327395A1 (de) 2009-11-23 2011-06-01 Bracco Imaging S.p.A Verfahren zur Herstellung eines Gadobenatdimeglumin-Komplexes in einer festen Form
EP2338874A1 (de) 2009-12-16 2011-06-29 Bracco Imaging S.p.A Verfahren zur Herstellung von chelatierten Verbindungen
AU2012222188A1 (en) 2011-02-24 2013-08-15 Oncothyreon Inc. MUC1 based glycolipopeptide vaccine with adjuvant
JP5688500B2 (ja) * 2011-03-09 2015-03-25 樫原 宏 強磁性有機磁性流体
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102408348A (zh) * 2011-07-26 2012-04-11 天津市海文普宁科技发展有限公司 一种钆贝葡胺的制备新方法
CN102603550B (zh) * 2012-02-16 2014-11-26 佛山普正医药科技有限公司 一种中间体bopta的制备方法
JP5786218B2 (ja) * 2012-03-26 2015-09-30 樫原 宏 新しい強磁性有機磁性流体の合成方法と利用方法
AU2013308519A1 (en) 2012-08-31 2015-04-09 The General Hospital Corporation Biotin complexes for treatment and diagnosis of Alzheimer's disease
RU2528414C1 (ru) 2013-01-25 2014-09-20 Закрытое Акционерное Общество "Фарм-Синтез" Циклический октапептид, радиофармацевтическое средство на его основе и способ применения радиофармацевтического средства для получения лекарственных (фармацевтических) средств для лечения новообразований, экспрессирующих соматостатиновые рецепторы
CN103664672B (zh) * 2013-10-21 2016-01-13 河北一品制药有限公司 一种工业化生产钆喷酸葡胺的制备方法
EP2977369A1 (de) 2014-07-24 2016-01-27 Bracco Imaging SPA Herstellung einer festen Form von Gadobenatdimeglumin
FI3753929T3 (fi) 2015-12-10 2023-01-31 Dimeerisiä varjoaineita
KR102703312B1 (ko) 2015-12-10 2024-09-05 브라코 이미징 에스.피.에이. 조영제
WO2017178301A1 (en) 2016-04-13 2017-10-19 Bracco Imaging Spa Contrast agents
CN109963838B (zh) 2016-12-12 2023-04-11 伯拉考成像股份公司 二聚造影剂
RU2706359C1 (ru) * 2019-04-11 2019-11-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московская государственная академия ветеринарной медицины и биотехнологии - МВА имени К.И. Скрябина" (ФГБОУ ВО МГАВМиБ - МВА имени К.И. Скрябина) Способ получения триглицината кобальта дигидрата
CN114845998B (zh) 2019-12-13 2024-06-25 伯拉考成像股份公司 受保护的do3a的制备

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB723316A (en) * 1951-06-11 1955-02-09 Frederick Charles Bersworth Substituted alkylene polyamine acetic acid compounds
US3028407A (en) * 1958-04-18 1962-04-03 Geigy Chem Corp Substituted ethylenediamine compounds having aromatic rings
US3107260A (en) * 1960-11-29 1963-10-15 Geigy Chem Corp Triaminopropane hexa-acetic acid and metal chelates thereof
DE1223396B (de) * 1964-01-14 1966-08-25 Geigy Ag J R Verfahren zur Herstellung von Trinatriumsalzen der Zinkkomplexe der Diaethylentriamin-N, N. N', N", N"-pentaessigsaeure und der Triaethylentetramin-N, N, N', N", N''', N'''-hexaessigsaeure
US3679728A (en) * 1968-08-13 1972-07-25 Grace W R & Co Process for preparing methylenebisiminodiacetonitrile
US4069249A (en) * 1975-11-11 1978-01-17 W. R. Grace & Co. N,N-di-(hydroxybenzyl)-trimethylene diaminediacetic acids
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
SE8301395L (sv) * 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
DE3316703A1 (de) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
FR2550449B1 (fr) * 1983-08-12 1986-01-31 Commissariat Energie Atomique Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire
US4558145A (en) * 1983-10-21 1985-12-10 Ciba Geigy Corporation Preparation of Fe chelates
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
US4687659A (en) * 1984-11-13 1987-08-18 Salutar, Inc. Diamide-DTPA-paramagnetic contrast agents for MR imaging
US4828014A (en) * 1985-12-13 1989-05-09 Inland Steel Company Continuous casting tundish and assembly
US4822594A (en) * 1987-01-27 1989-04-18 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
DE3712329A1 (de) * 1987-04-11 1988-10-20 Basf Ag Verfahren zur herstellung von serin-n,n-diessigsaeure und derivaten, ihre verwendung insbesondere als komplexbildner und diese enthaltende wasch- und reinigungsmittel
DE3739610A1 (de) * 1987-11-23 1989-06-01 Basf Ag Nitrilo-di-aepfel-mono-essigsaeuren, verfahren zu ihrer herstellung und ihre verwendung
DE3914980A1 (de) * 1989-05-06 1990-12-06 Basf Ag 2-methyl- und 2-hydroxymethyl-serin-n,n-diessigsaeure und ihre derivate

Also Published As

Publication number Publication date
EP0230893A2 (de) 1987-08-05
EP0230893A3 (en) 1988-06-01
IT8619236A0 (it) 1986-01-30
MX9203254A (es) 1992-07-01
NL980024I1 (nl) 1998-11-02
US5182370A (en) 1993-01-26
NL980024I2 (nl) 1999-03-01
ES2031832T3 (es) 1993-01-01
HK95793A (en) 1993-09-24
AU6753987A (en) 1987-08-06
ATE53571T1 (de) 1990-06-15
EP0230893B1 (de) 1990-06-13
DE19875036I2 (de) 2001-06-13
US4916246A (en) 1990-04-10
GR3000563T3 (en) 1991-07-31
JPH0364504B2 (de) 1991-10-07
DE19875036I1 (de) 2000-01-20
CA1324150C (en) 1993-11-09
US4980502A (en) 1990-12-25
IT1213029B (it) 1989-12-07
AU591225B2 (en) 1989-11-30
DE3763189D1 (de) 1990-07-19
JPS62195388A (ja) 1987-08-28

Similar Documents

Publication Publication Date Title
LU90285I2 (fr) Gadobenate dimeglumine et ses sels et dérivés pharmaceutiquement acceptables
RU98115579A (ru) Перфторалкилсодержащие металлические комплексы, способ их получения и их применение в ямр-диагностике
US5348954A (en) Heterocyclic chelating agents
IE45225L (en) Dicarboxylic acid bis-(3,5-dicarbamoyl-2,4,6-triiodoanilide)¹compounds
ZA984635B (en) Orally active iron (III) chelators.
GB1442118A (en) Piperidine derivatives
US5869651A (en) Hydrazide derivatives of polyamides and their medical use as chelating agents
ATE28187T1 (de) Polyprenylcarbonsaeureamide und verfahren zu ihrer herstellung.
GB1499026A (en) Adriamycin esters
US6040432A (en) Metal complexes, of DTPA derivatives suitable for use in diagnosis and therapy
GB1490048A (en) N-substituted phenyl-piperidine derivatives
GB1369999A (en) Monomethyl-amino-triidobenzene compounds for use as x-ray shading agents
CA2098712A1 (en) Chelating agents
IE780952L (en) Phenylamino-phenylacetic acid amides
ES8707919A1 (es) Procedimiento para la obtencion de cosmeticos supresores delsebo a base de acidos alcoxi- o alquil-benciloxi- benzoicos o sus sales
CA2482327A1 (en) Pendant fatty acid imaging agents
IE44180L (en) Azaprostaglandins.
ES447495A1 (es) Un procedimiento de preparacion de derivados de tetrahidro- 4, 5, 6, 7-tieno-(3, 2-c)-piridina.
ES444957A1 (es) Procedimiento para preparar derivados de acido glicirretini-co.
ES428213A1 (es) Procedimiento para la obtencion de esteres dialquilaminoal-quilicos de penicilina.
ES8502961A1 (es) Procedimiento para la fabricacion de los derivados del acido bicilo (3.2.1) octan carboxilico-3
GB1503953A (en) Substituted-phenyl substituted-alkyl ethers and the preparation thereof
IE44093L (en) Salts of p-chlorophenoxy acetic acid dimethylaminoethyl¹ester
JPS5569563A (en) Preparation of 2-methoxy-5-sulfamoylbenzoic acid amide
ES429772A2 (es) Procedimiento para la preparacion de bencilaminas.