ES8502961A1 - Procedimiento para la fabricacion de los derivados del acido bicilo (3.2.1) octan carboxilico-3 - Google Patents

Procedimiento para la fabricacion de los derivados del acido bicilo (3.2.1) octan carboxilico-3

Info

Publication number
ES8502961A1
ES8502961A1 ES532983A ES532983A ES8502961A1 ES 8502961 A1 ES8502961 A1 ES 8502961A1 ES 532983 A ES532983 A ES 532983A ES 532983 A ES532983 A ES 532983A ES 8502961 A1 ES8502961 A1 ES 8502961A1
Authority
ES
Spain
Prior art keywords
formula
see diagramm
bicyclo
hydrogen
octane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532983A
Other languages
English (en)
Other versions
ES532983A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8502961A1 publication Critical patent/ES8502961A1/es
Publication of ES532983A0 publication Critical patent/ES532983A0/es
Granted legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H3/00—Separating articles from piles
    • B65H3/02—Separating articles from piles using friction forces between articles and separator
    • B65H3/06—Rollers or like rotary separators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA FABRICACION DE LOS DERIVADOS DEL ACIDO BICICLO (3.2.1.) OCTAN CARBOXILICO-3.CONSISTE EN LA TRANSFORMACION DE OCTANONA-8 CARBOXILATO DE METILO-3 DE FORMULA (II) EN UN ACIDO DE FORMULA (III) EL CUAL SE HACE REACCIONAR CON UNA BASE FUERTE PARA FORMAR UN COMPUESTO ORGANOMETALICO DE FORMULA (IV) QUE POR ACCION DE UN HALURO DE ALQUILO DA COMO RESULTADO UN OCTAN CARBOXILICO-3 DE FORMULA (I). LA BASE FUERTE UTILIZADA ES AMIDURO DE SODIO. LAS TEMPERATURAS ENTRE LAS QUE SE REALIZAN LAS DISTINTAS FASES OSCILAN ENTRE 35J Y 200JC Y DAN UN PRODUCTO FINAL CUYO OUNTO DE FUSION ES DE 72-74JC. R ES UN ALQUILO, Z ES UN GRUPO OX DONDE X ES HIDROGENO O UNA BASE ALCALINA.LOS COMPUESTOS OBJETIDOS TIENEN ACTIVIDAD ANTICONVULSIVA Y ANOXICA.
ES532983A 1983-06-22 1984-05-31 Procedimiento para la fabricacion de los derivados del acido bicilo (3.2.1) octan carboxilico-3 Granted ES532983A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8310612A FR2547814B1 (fr) 1983-06-22 1983-06-22 Derives de l'acide bicyclo (3.2.1.) octane carboxylique, leur procede de preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
ES8502961A1 true ES8502961A1 (es) 1985-02-01
ES532983A0 ES532983A0 (es) 1985-02-01

Family

ID=9290213

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532983A Granted ES532983A0 (es) 1983-06-22 1984-05-31 Procedimiento para la fabricacion de los derivados del acido bicilo (3.2.1) octan carboxilico-3

Country Status (26)

Country Link
EP (1) EP0130882B1 (es)
JP (1) JPS6013741A (es)
KR (1) KR870002052B1 (es)
AR (1) AR242370A1 (es)
AT (1) ATE24711T1 (es)
AU (1) AU564961B2 (es)
CA (1) CA1226584A (es)
CS (1) CS247083B2 (es)
DD (1) DD235447A5 (es)
DE (1) DE3461921D1 (es)
DK (1) DK280284A (es)
ES (1) ES532983A0 (es)
FI (1) FI842538A (es)
FR (1) FR2547814B1 (es)
GR (1) GR82132B (es)
HU (1) HU191677B (es)
IL (1) IL71905A (es)
MA (1) MA20150A1 (es)
NO (1) NO158254C (es)
NZ (1) NZ208607A (es)
OA (1) OA07728A (es)
PH (1) PH22596A (es)
PL (1) PL144486B1 (es)
PT (1) PT78776B (es)
YU (1) YU109684A (es)
ZA (1) ZA844269B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61271025A (ja) * 1985-05-28 1986-12-01 Agency Of Ind Science & Technol 横型移動床を用いる粉体の連続処理方法
AU6425498A (en) * 1997-11-05 1999-05-24 Inessa Ivanovna Kritskaya New anticonvulsant drugs
CN1315692C (zh) * 2004-12-29 2007-05-16 大连理工大学 快速拆装式双体救捞船
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1127026A (en) * 1964-11-19 1968-09-11 Geigy Ag J R Agents for the treatment of virus diseases

Also Published As

Publication number Publication date
YU109684A (en) 1986-10-31
EP0130882A2 (fr) 1985-01-09
EP0130882B1 (fr) 1987-01-07
NO158254C (no) 1988-08-10
EP0130882A3 (en) 1985-05-08
NZ208607A (en) 1986-08-08
HU191677B (en) 1987-03-30
FI842538A0 (fi) 1984-06-21
NO158254B (no) 1988-05-02
IL71905A0 (en) 1984-09-30
DK280284A (da) 1984-12-23
AR242370A1 (es) 1993-03-31
ATE24711T1 (de) 1987-01-15
DD235447A5 (de) 1986-05-07
CA1226584A (fr) 1987-09-08
MA20150A1 (fr) 1984-12-31
FR2547814B1 (fr) 1985-10-18
DE3461921D1 (en) 1987-02-12
CS247083B2 (en) 1986-11-13
ES532983A0 (es) 1985-02-01
AU2947084A (en) 1985-01-03
JPS6013741A (ja) 1985-01-24
KR850000026A (ko) 1985-02-25
PL144486B1 (en) 1988-05-31
HUT34428A (en) 1985-03-28
JPS624378B2 (es) 1987-01-30
PH22596A (en) 1988-10-17
KR870002052B1 (ko) 1987-12-03
OA07728A (fr) 1985-08-30
FR2547814A1 (fr) 1984-12-28
ZA844269B (en) 1985-01-30
AU564961B2 (en) 1987-09-03
PT78776B (fr) 1986-06-26
GR82132B (es) 1984-12-13
IL71905A (en) 1986-12-31
DK280284D0 (da) 1984-06-07
NO842514L (no) 1984-12-27
FI842538A (fi) 1984-12-23
PL248314A1 (en) 1985-04-09
PT78776A (fr) 1984-07-01

Similar Documents

Publication Publication Date Title
ES8308850A1 (es) Procedimiento para la preparacion de nuevos derivados de aminoacidos biciclicos.
ES484167A1 (es) Un procedimiento para preparar 9-(hidroxialcohil)-purinas
ES8502961A1 (es) Procedimiento para la fabricacion de los derivados del acido bicilo (3.2.1) octan carboxilico-3
GB1369999A (en) Monomethyl-amino-triidobenzene compounds for use as x-ray shading agents
DE3372095D1 (en) Novel phenylpiperazine derivatives and process for producing the same
ES8106289A1 (es) Procedimiento de preparacion de nuevos derivados del a-fe- nil-2-pirrolidin-metanol
PL246206A1 (en) Process for preparing novel derivatives of neutral salts of aminopyridinium hydroxide
JPS5455565A (en) Novel thiazolidine derivative
ZA966283B (en) Process for the manufacturing of iodinated contrast agents.
ATE15029T1 (de) Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
ES8303450A1 (es) "procedimiento para la preparacion de 17a-alcohil-17b-hidroxi-1a-metil-4-androsten-3-onas".
ES8401761A1 (es) Un procedimiento para la preparacion de derivados de 1-(3,4,5-trimetoxicinamoil)-4-aminocarboniletil-piperazina sustituidos.
ES472708A1 (es) Procedimiento para la preparacion de derivados de bromhexina
ES8205219A1 (es) Un metodo para producir un compuesto de hidrouracilo
ES438736A1 (es) Procedimiento para preparar esteres del acido dihidro-16, 17 apovincaminico.
ES8102110A1 (es) Procedimiento para la preparacion de acido 1,2,3-tiadiazol- 5-il-tioglicolico
JPS51127068A (en) A process for preparing 8-azaprostanoic acid derivatives.
DE3477003D1 (en) Process for the preparation of 17-alpha-acyloxy-6-chloro-1-alpha,2-alpha-methylene-4,6-pregnadiene-3-20-diones
ES8305333A1 (es) "procedimiento para la preparacion de nuevas sulfiminas".
CA1274248C (en) METHOD FOR THE PREPARATION OF .alpha.-ARYLACANO ESTERS
ES8606368A1 (es) Un procedimiento para producir un derivado de bencil-fosfi- nato etilico
JPS5758890A (en) Preparation of glucosylmoranoline derivative
ZA889285B (en) 2-amino-tetrahydro-isoquinoline derivatives and a process for the preparation thereof and pharmaceutical composition containing same
JPS5279081A (en) Preparation of novel 7-methoxycephalosporins
ES482462A1 (es) Procedimiento para la preparacion de 2-fenilbiciclooctanos.