KR850000026A - 바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법 및 조성물 - Google Patents

바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법 및 조성물 Download PDF

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Publication number
KR850000026A
KR850000026A KR1019840003111A KR840003111A KR850000026A KR 850000026 A KR850000026 A KR 850000026A KR 1019840003111 A KR1019840003111 A KR 1019840003111A KR 840003111 A KR840003111 A KR 840003111A KR 850000026 A KR850000026 A KR 850000026A
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South Korea
Prior art keywords
formula
compound
iii
composition
active ingredient
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KR1019840003111A
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English (en)
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KR870002052B1 (ko
Inventor
게그렝 로베르 브와 (외 3)
Original Assignee
미쉘 드 아스
사노피(소시에떼 아노님)
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Publication of KR850000026A publication Critical patent/KR850000026A/ko
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Publication of KR870002052B1 publication Critical patent/KR870002052B1/ko

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H3/00—Separating articles from piles
    • B65H3/02—Separating articles from piles using friction forces between articles and separator
    • B65H3/06—Rollers or like rotary separators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법 및 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 식(Ⅱ)의 메틸 8-옥소-바이사이클로(3.2.1) 옥탄-3-카르복실산염을 환원 및 가수분해를 통하여 식(Ⅲ)의 산으로 전환하고, 식(Ⅲ)의 산을 강염기와 반응시켜 식(Ⅳ)의 중간체 유기금속 화합물을 생성하고 화합물(Ⅳ)을 할로겐화 알킬의 작용으로 Z가 OH를 나타내는 식(I)의 화합물을 제조하는 방법.
  2. 식(Ⅲ)의 유도체가 메틸 8-옥소-바이사이클로(3.2.1) 옥탄-3-카르복실산 염을 수산화칼륨 및 히드라진과 반응시켜 제조되는 특허청구의 범위 제1항에 따른 방법.
  3. 식(Ⅲ)의 산을 니트릴 또는 에스테르와 치환하여 식(V)의 화합물을 얻고 그 다음에 식(I)의 화합물로 전환하는 특허청구의 범위 제1항에 따른 방법.
  4. 특허청구의 범위 제1항에 주장된 화합물이 활성성분으로 항경련 및 항혈액 산소 결핍증 활성을 가진 조성물.
  5. 경구, 비경구 또는 직장 투여시 활성성분이 투여 가능한 형태로 조성될 수 있는 특허청구의 범위 제4항에 따른 조성물.
  6. 단위 투여 형태에서 각 단위 투여량이 활성성분을 0.050-0.500g 포함한 특허청구의 범위 제5항에 따른 조성물.
    여기서 R은 곧은 또는 가지달린 사슬 저급 알킬 라디칼을 나타낸다. Z는 OH기를 나타낸다.
    여기서 B는 알칼리 금속이다.
    여기서 Y는 니트릴 또는 에스테르기를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840003111A 1983-06-22 1984-06-01 바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법 KR870002052B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8310612 1983-06-22
FR8310612A FR2547814B1 (fr) 1983-06-22 1983-06-22 Derives de l'acide bicyclo (3.2.1.) octane carboxylique, leur procede de preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
KR850000026A true KR850000026A (ko) 1985-02-25
KR870002052B1 KR870002052B1 (ko) 1987-12-03

Family

ID=9290213

Family Applications (1)

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KR1019840003111A KR870002052B1 (ko) 1983-06-22 1984-06-01 바이 사이클로(3.2.1)-옥탄 카르복실산의 제조방법

Country Status (26)

Country Link
EP (1) EP0130882B1 (ko)
JP (1) JPS6013741A (ko)
KR (1) KR870002052B1 (ko)
AR (1) AR242370A1 (ko)
AT (1) ATE24711T1 (ko)
AU (1) AU564961B2 (ko)
CA (1) CA1226584A (ko)
CS (1) CS247083B2 (ko)
DD (1) DD235447A5 (ko)
DE (1) DE3461921D1 (ko)
DK (1) DK280284A (ko)
ES (1) ES8502961A1 (ko)
FI (1) FI842538A (ko)
FR (1) FR2547814B1 (ko)
GR (1) GR82132B (ko)
HU (1) HU191677B (ko)
IL (1) IL71905A (ko)
MA (1) MA20150A1 (ko)
NO (1) NO158254C (ko)
NZ (1) NZ208607A (ko)
OA (1) OA07728A (ko)
PH (1) PH22596A (ko)
PL (1) PL144486B1 (ko)
PT (1) PT78776B (ko)
YU (1) YU109684A (ko)
ZA (1) ZA844269B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61271025A (ja) * 1985-05-28 1986-12-01 Agency Of Ind Science & Technol 横型移動床を用いる粉体の連続処理方法
WO1999023056A1 (fr) * 1997-11-05 1999-05-14 Susanna Askanazovna Saakian Nouveaux medicaments anti-convulsions
CN1315692C (zh) * 2004-12-29 2007-05-16 大连理工大学 快速拆装式双体救捞船
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6515007A (ko) * 1964-11-19 1966-05-20

Also Published As

Publication number Publication date
CS247083B2 (en) 1986-11-13
KR870002052B1 (ko) 1987-12-03
AR242370A1 (es) 1993-03-31
DK280284D0 (da) 1984-06-07
ZA844269B (en) 1985-01-30
CA1226584A (fr) 1987-09-08
OA07728A (fr) 1985-08-30
PT78776B (fr) 1986-06-26
FI842538A0 (fi) 1984-06-21
HU191677B (en) 1987-03-30
NO842514L (no) 1984-12-27
FR2547814A1 (fr) 1984-12-28
FR2547814B1 (fr) 1985-10-18
YU109684A (en) 1986-10-31
EP0130882B1 (fr) 1987-01-07
AU2947084A (en) 1985-01-03
ES532983A0 (es) 1985-02-01
DD235447A5 (de) 1986-05-07
AU564961B2 (en) 1987-09-03
PT78776A (fr) 1984-07-01
ATE24711T1 (de) 1987-01-15
GR82132B (ko) 1984-12-13
DK280284A (da) 1984-12-23
DE3461921D1 (en) 1987-02-12
IL71905A (en) 1986-12-31
FI842538A (fi) 1984-12-23
PL144486B1 (en) 1988-05-31
EP0130882A3 (en) 1985-05-08
NZ208607A (en) 1986-08-08
PL248314A1 (en) 1985-04-09
JPS6013741A (ja) 1985-01-24
NO158254B (no) 1988-05-02
HUT34428A (en) 1985-03-28
ES8502961A1 (es) 1985-02-01
EP0130882A2 (fr) 1985-01-09
MA20150A1 (fr) 1984-12-31
IL71905A0 (en) 1984-09-30
JPS624378B2 (ko) 1987-01-30
PH22596A (en) 1988-10-17
NO158254C (no) 1988-08-10

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