KR840008369A - 펜엠화합물의 제조방법 - Google Patents

펜엠화합물의 제조방법 Download PDF

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Publication number
KR840008369A
KR840008369A KR1019840001733A KR840001733A KR840008369A KR 840008369 A KR840008369 A KR 840008369A KR 1019840001733 A KR1019840001733 A KR 1019840001733A KR 840001733 A KR840001733 A KR 840001733A KR 840008369 A KR840008369 A KR 840008369A
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KR
South Korea
Prior art keywords
compound
formula
ester
reacting
conversion
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KR1019840001733A
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English (en)
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KR880001989B1 (ko
Inventor
무어필 기리자발라반 바이요어 (외 2)
Original Assignee
스타이나 칸스타드, 로즈마리 아이젠링
쉐링 코포레이션
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Application filed by 스타이나 칸스타드, 로즈마리 아이젠링, 쉐링 코포레이션 filed Critical 스타이나 칸스타드, 로즈마리 아이젠링
Publication of KR840008369A publication Critical patent/KR840008369A/ko
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Publication of KR880001989B1 publication Critical patent/KR880001989B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4

Abstract

내용 없음.

Description

펜엠화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 일반식(1)의 화합물을 트리플루로아세트산 또는 트리클로로아세트산 존재하에 알킬리금속 시아네이트와 바응시키거나, 일반식(II)의 화합물을 구조식(III)의 화합물 또는 그의 반응성 유도체와 반응시키거나, 구조식[IVa, IVb] 화합물을 일반식(V)의 화합물과 반응시키거나, 구조식(VI)의 화합물을 삼가의 유기인 화합물과 반응시키고, 필요하거나 원하면 i) 하나이상의 보호그룹의 탈보호, ii) (5R,6S,8R)입체이성체의 분리, iii) 유리산의 약학적으로 무독한 염 또는 대사가능한 에스테르로의 전환, iv) 염 또는 에스테르의 유리산으로의 전환, v) 에스테르의 에스테르교환 또는 약학적으로 무독한 염으로의 전환, vi) 염의 다른염 또는 에스테르로의 전환공정증 하나이상을 계속해서 수행함을 특징으로하여 신규의 구조식(A)의 5R,6S,8R-6-(1-하이드록시에틸)-2-(2-카바모일옥시에틸티오)펜엠-3-카복실산 및 그의 약학적으로 무독한 염 및 대사가능한 에스테르를 제조하는 방법.
    상기식에서 Pg는 하이드록시 보호그룹이며, Pr은 카복시보호그룹이고, R은 카바모일옥시에틸 이외의 유기라디칼이며, L은 이탈그룹이고, 일반식(II), 구조식[IVa, IVb] 및 구조식(VI)의 화합물에서 작용성그룹은 필요하거나 원하면 보호시킨다.
  2. 제1항이 있어, 알칼리금속염을 제조함을 특징으로 하는 방법.
  3. 제2항에 있어서, 나트륨염을 제조함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840001733A 1983-04-04 1984-04-02 펜엠 화합물의 제조방법 KR880001989B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/481,551 US4504485A (en) 1983-04-04 1983-04-04 5R,6S,8R-6-(1-Hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylic acid
US481551 1983-04-04
US481,551 1983-04-04

Publications (2)

Publication Number Publication Date
KR840008369A true KR840008369A (ko) 1984-12-14
KR880001989B1 KR880001989B1 (ko) 1988-10-10

Family

ID=23912395

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001733A KR880001989B1 (ko) 1983-04-04 1984-04-02 펜엠 화합물의 제조방법

Country Status (24)

Country Link
US (1) US4504485A (ko)
EP (1) EP0121502B1 (ko)
JP (1) JPS59184185A (ko)
KR (1) KR880001989B1 (ko)
AT (1) ATE26448T1 (ko)
AU (1) AU559521B2 (ko)
CA (1) CA1248520A (ko)
DE (1) DE3463050D1 (ko)
DK (1) DK162286C (ko)
ES (1) ES531131A0 (ko)
FI (1) FI77867C (ko)
GB (1) GB2138420B (ko)
GR (1) GR81464B (ko)
HK (1) HK59489A (ko)
HU (1) HU193430B (ko)
IE (1) IE57163B1 (ko)
IL (1) IL71413A (ko)
NO (1) NO163133C (ko)
NZ (1) NZ207704A (ko)
OA (1) OA07698A (ko)
PH (1) PH20548A (ko)
PT (1) PT78347B (ko)
SG (1) SG32589G (ko)
ZA (1) ZA842434B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634556A (en) * 1985-05-10 1987-01-06 Schering Corporation Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same
AT392903B (de) * 1987-10-08 1991-07-10 Hoechst Ag Pharmazeutische zubereitung enthaltend ein cephalosporin und ein penemantibiotikum
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
KR20010101030A (ko) 1999-09-17 2001-11-14 도리이 신이찌로 제약학적 항균 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
JPS55153789A (en) * 1979-04-11 1980-11-29 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
ZA815593B (en) * 1980-08-16 1982-10-27 Beecham Group Plc Process for the preparation of 2-thio penem derivatives,certain of these compounds and intermediates therefor
JPS57176988A (en) * 1981-04-09 1982-10-30 Sankyo Co Ltd Penam-3-carboxylic acid derivative and its preparation
JPS5843978A (ja) * 1981-09-10 1983-03-14 Sankyo Co Ltd ペネム−３−カルボン酸誘導体およびその製法

Also Published As

Publication number Publication date
GB2138420A (en) 1984-10-24
DK162286B (da) 1991-10-07
DK174584A (da) 1984-10-05
AU559521B2 (en) 1987-03-12
DK174584D0 (da) 1984-03-30
HK59489A (en) 1989-08-04
IL71413A (en) 1989-01-31
FI841272A (fi) 1984-10-05
EP0121502B1 (en) 1987-04-08
NO163133C (no) 1990-04-11
ES8602806A1 (es) 1985-12-01
GR81464B (ko) 1984-12-11
NZ207704A (en) 1987-06-30
FI77867C (fi) 1989-05-10
ATE26448T1 (de) 1987-04-15
FI77867B (fi) 1989-01-31
US4504485A (en) 1985-03-12
PT78347B (en) 1986-07-22
DE3463050D1 (en) 1987-05-14
GB8408240D0 (en) 1984-05-10
IE57163B1 (en) 1992-05-20
NO841292L (no) 1984-10-05
OA07698A (fr) 1985-08-30
DK162286C (da) 1992-03-16
CA1248520A (en) 1989-01-10
IL71413A0 (en) 1984-06-29
ZA842434B (en) 1985-08-28
NO163133B (no) 1990-01-02
JPH0470316B2 (ko) 1992-11-10
AU2630984A (en) 1984-10-11
ES531131A0 (es) 1985-12-01
IE840795L (en) 1984-10-04
FI841272A0 (fi) 1984-03-30
PT78347A (en) 1984-04-01
JPS59184185A (ja) 1984-10-19
SG32589G (en) 1989-09-22
PH20548A (en) 1987-02-09
KR880001989B1 (ko) 1988-10-10
GB2138420B (en) 1986-12-03
HU193430B (en) 1987-10-28
EP0121502A1 (en) 1984-10-10
HUT34032A (en) 1985-01-28

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