LU82387A1 - Esters d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces esters - Google Patents

Esters d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces esters Download PDF

Info

Publication number
LU82387A1
LU82387A1 LU82387A LU82387A LU82387A1 LU 82387 A1 LU82387 A1 LU 82387A1 LU 82387 A LU82387 A LU 82387A LU 82387 A LU82387 A LU 82387A LU 82387 A1 LU82387 A1 LU 82387A1
Authority
LU
Luxembourg
Prior art keywords
group
formula
carnitine
ester
esters
Prior art date
Application number
LU82387A
Other languages
English (en)
French (fr)
Inventor
C Cavazza
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of LU82387A1 publication Critical patent/LU82387A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/89—Carboxylic acid amides having nitrogen atoms of carboxamide groups quaternised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LU82387A 1979-04-23 1980-04-22 Esters d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces esters LU82387A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT4881679 1979-04-23
IT48816/79A IT1116037B (it) 1979-04-23 1979-04-23 Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico

Publications (1)

Publication Number Publication Date
LU82387A1 true LU82387A1 (fr) 1980-07-31

Family

ID=11268672

Family Applications (2)

Application Number Title Priority Date Filing Date
LU82386A LU82386A1 (fr) 1979-04-23 1980-04-22 Amides d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces amides
LU82387A LU82387A1 (fr) 1979-04-23 1980-04-22 Esters d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces esters

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LU82386A LU82386A1 (fr) 1979-04-23 1980-04-22 Amides d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces amides

Country Status (19)

Country Link
US (2) US4439438A (es)
JP (3) JPS562945A (es)
AT (2) AT376656B (es)
AU (2) AU538739B2 (es)
BE (2) BE882937A (es)
CH (2) CH642849A5 (es)
DE (2) DE3015635A1 (es)
DK (2) DK155595C (es)
ES (2) ES490765A0 (es)
FR (2) FR2455028A1 (es)
GB (2) GB2048268B (es)
GR (2) GR68051B (es)
IE (2) IE49701B1 (es)
IL (2) IL59915A (es)
IT (1) IT1116037B (es)
LU (2) LU82386A1 (es)
NL (2) NL8002369A (es)
NO (2) NO151823C (es)
SE (2) SE448375B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1120033B (it) 1979-10-05 1986-03-19 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
US4405642A (en) * 1980-11-28 1983-09-20 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
IT1170862B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT1170861B (it) * 1981-03-31 1987-06-03 Sigma Tau Ind Farmaceuti Ester di mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico
IT1171360B (it) * 1981-07-03 1987-06-10 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del cloruro acido di carnitina
IT1172127B (it) * 1981-12-03 1987-06-18 Sigma Tau Ind Farmaceuti Tioacil - carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono ad azione mucclitica
IT1177874B (it) * 1984-07-04 1987-08-26 Sigma Tau Ind Farmaceuti Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5545412A (en) * 1985-01-07 1996-08-13 Syntex (U.S.A.) Inc. N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor
IT1201481B (it) * 1985-10-08 1989-02-02 Prodotti Antibiotici Spa Pantotenil derivati
US5008288A (en) * 1986-01-06 1991-04-16 Alfred Stracher Carnitine directed pharmaceutical agents
US4866040A (en) * 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
IT1224842B (it) * 1988-12-27 1990-10-24 Sigma Tau Ind Farmaceuti Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso
IT1230141B (it) * 1989-05-03 1991-10-14 Fidia Spa Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale.
IT1238344B (it) * 1989-10-20 1993-07-13 Sigma Tau Ind Farmaceuti Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1240775B (it) * 1990-02-23 1993-12-17 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.
IT1240799B (it) * 1990-03-15 1993-12-17 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti 3-metiltiopropionil l-carnitina ad attivita' sul sistema cardiovascolare.
EP0465984A1 (en) * 1990-07-04 1992-01-15 Matsushita Electric Industrial Co., Ltd. Photosensitive body used in electrophotography
IT1248323B (it) * 1991-05-16 1995-01-05 Sigma Tau Ind Farmaceuti Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
IT1254135B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261688B (it) * 1993-05-28 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) * 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
IT1299172B1 (it) * 1998-05-06 2000-02-29 Sigma Tau Ind Farmaceuti Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
ITRM20020620A1 (it) * 2002-12-13 2004-06-14 Sigma Tau Ind Farmaceuti Uso delle carnitine per la prevenzione e/o il trattamento dei disturbi causati dall'andropausa.
FI20030769A0 (fi) * 2003-05-21 2003-05-21 Raisio Chem Oy Tärkkelysjohdannaiset, niiden valmistus ja käyttö
ATE520717T1 (de) * 2003-05-21 2011-09-15 Basf Se Verfahren zur herstellung von estern des carnitins und ihre verwendung.
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
JP5485492B2 (ja) * 2004-12-15 2014-05-07 大正製薬株式会社 うつ病の予防・治療薬
US20100144827A1 (en) * 2006-12-20 2010-06-10 Medwell Laboratories Ltd. C/O Ngt Technological Incubator Novel conjugates of polyunsaturated fatty acids with amines and therapeutic uses thereof
CN102014929A (zh) * 2008-03-13 2011-04-13 珀金埃尔默健康科学有限公司 用于多种检测体系的酶底物
EP2216321A1 (en) * 2009-02-05 2010-08-11 Lonza Ltd. Process for the production of a fatty acid/carnitine derivative
CN102557972A (zh) * 2011-12-31 2012-07-11 南京海辰药业有限公司 氯化乙酰左卡尼汀的多晶型物
CN104161728A (zh) * 2013-05-17 2014-11-26 北京星昊医药股份有限公司 氯化丙酰左卡尼汀冻干粉针剂及其制备方法
CN104163769B (zh) * 2014-06-23 2016-06-15 海南霞迪药业有限公司 一种氯化丙酰左卡尼汀的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE719891C (de) * 1938-12-08 1942-04-21 Dr Erich Strack Verfahren zur Herstellung des Methyl- bzw. AEthylesters des acetylierten Carnitins
US3968241A (en) * 1972-11-06 1976-07-06 Defelice Stephen L Method of treating cardiac arrhythmias and of improving myocardial contractility and systolic rhythm with carnitive or a pharmaceutically acceptable salt thereof
JPS531812B2 (es) * 1972-12-07 1978-01-23
JPS5058213A (es) * 1973-09-26 1975-05-21
US4032641A (en) * 1976-06-09 1977-06-28 Tanabe Seiyaku Co., Ltd. Nicotinoyl carnitine derivatives
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine
IT1143611B (it) * 1977-11-03 1986-10-22 Sigma Tau Ind Farmaceuti Applicazione della acetil-carnitina nella terapia delle affezioni cardiache di/tipo anossico,ischemico,cardiotossico e nelle sindromi aritmiche
DE2903579A1 (de) * 1978-02-03 1979-08-09 Sigma Tau Ind Farmaceuti Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel

Also Published As

Publication number Publication date
LU82386A1 (fr) 1980-07-31
IT7948816A0 (it) 1979-04-23
JPH0210821B2 (es) 1990-03-09
AU5773680A (en) 1980-10-30
DE3015636C2 (de) 1993-10-21
DE3015636A1 (de) 1980-11-06
DK170580A (da) 1980-10-24
NO801155L (no) 1980-10-24
BE882936A (fr) 1980-08-18
AU538739B2 (en) 1984-08-23
AU5773880A (en) 1980-10-30
GB2048268A (en) 1980-12-10
ES8104191A1 (es) 1981-04-01
JPS55167262A (en) 1980-12-26
IE800800L (en) 1980-10-23
FR2455027A1 (fr) 1980-11-21
GB2048268B (en) 1983-05-18
NO151823C (no) 1985-06-12
IE800801L (en) 1980-10-23
JPS562945A (en) 1981-01-13
DE3015635C2 (es) 1989-06-15
JPH03236318A (ja) 1991-10-22
NL8002370A (nl) 1980-10-27
IL59914A (en) 1984-04-30
NO151822C (no) 1985-06-12
CH642619A5 (it) 1984-04-30
AT375336B (de) 1984-07-25
NL8002369A (nl) 1980-10-27
IL59915A (en) 1984-04-30
US4443475A (en) 1984-04-17
ES8104987A1 (es) 1981-05-16
GB2051779B (en) 1983-02-23
ES490764A0 (es) 1981-04-01
SE447244B (sv) 1986-11-03
FR2455028A1 (fr) 1980-11-21
DK155595C (da) 1989-10-16
AU538740B2 (en) 1984-08-23
BE882937A (fr) 1980-08-18
FR2455027B1 (fr) 1985-08-09
GR68051B (es) 1981-10-29
DK155595B (da) 1989-04-24
GB2051779A (en) 1981-01-21
NO151823B (no) 1985-03-04
SE8003005L (sv) 1980-10-24
ES490765A0 (es) 1981-05-16
IE49700B1 (en) 1985-11-27
SE448375B (sv) 1987-02-16
IE49701B1 (en) 1985-11-27
ATA215780A (de) 1984-05-15
DE3015635A1 (de) 1980-11-13
NO151822B (no) 1985-03-04
SE8003004L (sv) 1980-10-24
NO801154L (no) 1980-10-24
US4439438A (en) 1984-03-27
ATA215680A (de) 1983-12-15
DK170680A (da) 1980-10-24
IT1116037B (it) 1986-02-10
JPH0314810B2 (es) 1991-02-27
AT376656B (de) 1984-12-27
GR68052B (es) 1981-10-29
CH642849A5 (it) 1984-05-15
FR2455028B1 (es) 1983-04-08

Similar Documents

Publication Publication Date Title
LU82387A1 (fr) Esters d'acyl-carnitines,leur procede de preparation et compositions pharmaceutiques contenant ces esters
EP0506532A1 (fr) Nouveaux dérivés de l'indole, procédé de préparation et médicaments les contenant
LU82236A1 (fr) 9-aminoalkylfluorenes, leur preparation et leur utilisation therapeutique
EP0025727B1 (fr) Dérivés de l'indole, procédé pour leur préparation et médicaments les contenant
EP0446141A1 (fr) Nouveaux dérivés d'imidazo [1,2-C] quinazoline leur procédé de préparation et les compositions pharmaceutiques les renfermant
EP0062596B1 (fr) Nouveaux dérivés d'aminoéthoxy-4 isopropyl-5 méthyl-2 phénol, leur méthode de préparation et leur emploi en tant que médicaments
BE897617A (fr) Thioesters d'acide acetylsalicylique procede pour les preparer et compositions pharmaceutiques qui en renferment
FR2634766A1 (fr) Acides (rs)-2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofurannyl)-acetiques, et acides 2-(2,3-dihydro-5-acyloxy-4,6,7-trimethylbenzofurannyl)-acetiques et leurs esters, utiles comme medicaments mucoregulateurs et anti-ischemiques, procede pour leur preparation et compositions pharmaceutiques les contenant
EP0842148B1 (fr) Derives de benzenesulfonamide, leur preparation et leurs applications en therapeutique
BE861454A (fr) Derives d'acides thiazolidinecarboxyliques, leur preparation et leur utilisation
CH622795A5 (es)
EP0487423A1 (fr) Nouveaux dérivés de la benzosélénazolinone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
RU2073006C1 (ru) Производные n-метилдеацетилколхицинамида, способы их получения и противоопухолевая композиция
CA1093582A (fr) Procede d'obtention de nouvelles propylenediamines
FR2550530A1 (fr) Derives 2',4'-difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxyliques de la n-acetyl-cysteine et s-carboxymethyl-cysteine a activite anti-inflammatoire et mucolytique, leur procede de preparation et compositions pharmaceutiques correspondantes
CA1076117A (fr) Procede d'obtention de nouveaux ethers aryliques et les produits en resultant
CH654011A5 (fr) Phosphoramides, procede pour leur preparation et compositions pharmaceutiques les contenant.
CH658786A5 (fr) Medicaments qui contiennent d'alpha-(n-pyrrolyl)-acides ou de leurs sels ou esters.
EP0347305B1 (fr) [(Aryl-4-pipérazinyl-1)-2 éthoxy]-3 p-cymène, les dérivés ortho, méta, para monosubstitués ou disubstitués sur le noyau phényle dudit produit, le procédé de préparation desdits dérivés, et les médicaments contenant lesdits composés comme principe actif
FR2677355A1 (fr) Nouveaux derives de l'oxazole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2677477A1 (fr) Nouveaux derives de l'oxazole leur preparation, leur utilisation et les compositions pharmaceutiques qui les contiennent.
FR2491471A1 (fr) Benzoxazolinones substituees, leur preparation et leur application en therapeutique
CH618977A5 (es)
FR2496655A1 (fr) Thiocarnitines, procede pour leur preparation et leur utilisation therapeutique, notamment dans le traitement des intoxications et des troubles de la fonction hepatique, le traitement des brulures et des maladies de l'epithelium
BE876466A (fr) Derive de l'acide penicillanique et son procede de preparation