FR2455027A1 - Esters d'acylcarnitines utiles comme medicaments, leurs procedes de preparation et compositions therapeutiques les contenant - Google Patents

Esters d'acylcarnitines utiles comme medicaments, leurs procedes de preparation et compositions therapeutiques les contenant

Info

Publication number
FR2455027A1
FR2455027A1 FR8009148A FR8009148A FR2455027A1 FR 2455027 A1 FR2455027 A1 FR 2455027A1 FR 8009148 A FR8009148 A FR 8009148A FR 8009148 A FR8009148 A FR 8009148A FR 2455027 A1 FR2455027 A1 FR 2455027A1
Authority
FR
France
Prior art keywords
substitute
acylcarnitin
preparation
medicaments
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8009148A
Other languages
English (en)
Other versions
FR2455027B1 (fr
Inventor
Claudio Cavazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of FR2455027A1 publication Critical patent/FR2455027A1/fr
Application granted granted Critical
Publication of FR2455027B1 publication Critical patent/FR2455027B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/89—Carboxylic acid amides having nitrogen atoms of carboxamide groups quaternised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX ESTERS D'ACYLCARNITINES REPONDANT A LA FORMULE GENERALE: (CF DESSIN DANS BOPI) OU X REPRESENTE UN ANION HALOGENE, R REPRESENTE UN RADICAL ACETYLE, PROPIONYLE, BUTYRYLE (NON SUBSTITUES OU HALOGENO-SUBSTITUES), ISOBUTYRYLE, B-HYDROXYBUTYRYLE, ACETOACETYLE, PANTOTHENYLE OU LINOLEYLE ET R REPRESENTE UN RADICAL ALCOXY NON SUBSTITUE (DE FACON TYPIQUE ISOBUTOXY) OU SUBSTITUE (DE FACON TYPIQUE DICHLOROETHOXY); ET DES PROCEDES POUR LEUR PREPARATION; LES ESTERS DE L'INVENTION SONT DES MEDICAMENTS UTILES NOTAMMENT POUR LE TRAITEMENT DE L'HYPOCONTRACTILITE DU MYOCARDE ET COMME ANTIDEPRESSEURS.
FR8009148A 1979-04-23 1980-04-23 Esters d'acylcarnitines utiles comme medicaments, leurs procedes de preparation et compositions therapeutiques les contenant Expired FR2455027B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48816/79A IT1116037B (it) 1979-04-23 1979-04-23 Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico

Publications (2)

Publication Number Publication Date
FR2455027A1 true FR2455027A1 (fr) 1980-11-21
FR2455027B1 FR2455027B1 (fr) 1985-08-09

Family

ID=11268672

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8009149A Granted FR2455028A1 (fr) 1979-04-23 1980-04-23 Nouveaux amides d'acylcarnitines, utiles notamment comme stimulants du systeme nerveux central, et leur procede de preparation
FR8009148A Expired FR2455027B1 (fr) 1979-04-23 1980-04-23 Esters d'acylcarnitines utiles comme medicaments, leurs procedes de preparation et compositions therapeutiques les contenant

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR8009149A Granted FR2455028A1 (fr) 1979-04-23 1980-04-23 Nouveaux amides d'acylcarnitines, utiles notamment comme stimulants du systeme nerveux central, et leur procede de preparation

Country Status (19)

Country Link
US (2) US4439438A (fr)
JP (3) JPS55167262A (fr)
AT (2) AT375336B (fr)
AU (2) AU538739B2 (fr)
BE (2) BE882936A (fr)
CH (2) CH642849A5 (fr)
DE (2) DE3015635A1 (fr)
DK (2) DK170680A (fr)
ES (2) ES8104987A1 (fr)
FR (2) FR2455028A1 (fr)
GB (2) GB2051779B (fr)
GR (2) GR68052B (fr)
IE (2) IE49701B1 (fr)
IL (2) IL59914A (fr)
IT (1) IT1116037B (fr)
LU (2) LU82386A1 (fr)
NL (2) NL8002370A (fr)
NO (2) NO151823C (fr)
SE (2) SE447244B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503149A1 (fr) * 1981-03-31 1982-10-08 Sigma Tau Ind Farmaceuti Esters de mercaptoacyl-carnitines, procede pour leur preparation et leurs utilisations therapeutiques, notamment dans le traitement des intoxications et des brulures et en tant qu'agents mucolytiques
FR2503150A1 (fr) * 1981-03-31 1982-10-08 Sigma Tau Ind Farmaceuti Mercaptoacyl-carnitines, procede pour leur preparation et leurs utilisations therapeutiques dans le traitement des intoxications et des brulures et en tant qu'agents mucolytiques
EP0596838A2 (fr) * 1992-10-20 1994-05-11 AVANTGARDE S.p.A. Esters de L-carnitine et alkanoyl L-carnitines avec l'acide glycolique ou leurs esters et compositions pharmaceutiques les contenant pour le traitement de dermatoses

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1120033B (it) 1979-10-05 1986-03-19 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale
IT1144077B (it) * 1980-01-29 1986-10-29 Sigma Tau Ind Farmaceuti Carnitinammidi di amminoacidi otticamente attivi e procedimento per la loro preparazione
IT1147079B (it) * 1980-05-30 1986-11-19 Sigma Tau Ind Farmacuetiche Ri Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
US4405642A (en) * 1980-11-28 1983-09-20 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
IT1171360B (it) * 1981-07-03 1987-06-10 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del cloruro acido di carnitina
IT1172127B (it) * 1981-12-03 1987-06-18 Sigma Tau Ind Farmaceuti Tioacil - carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono ad azione mucclitica
IT1177874B (it) * 1984-07-04 1987-08-26 Sigma Tau Ind Farmaceuti Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5550289A (en) * 1985-01-07 1996-08-27 Syntex (U.S.A.) Inc. N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy alk-1-yl-N-N,N-tetrasubstituted ammonium lipids and uses therefor
IT1201481B (it) * 1985-10-08 1989-02-02 Prodotti Antibiotici Spa Pantotenil derivati
US5008288A (en) * 1986-01-06 1991-04-16 Alfred Stracher Carnitine directed pharmaceutical agents
US4866040A (en) * 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
IT1224842B (it) * 1988-12-27 1990-10-24 Sigma Tau Ind Farmaceuti Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso
IT1230141B (it) * 1989-05-03 1991-10-14 Fidia Spa Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale.
IT1238344B (it) * 1989-10-20 1993-07-13 Sigma Tau Ind Farmaceuti Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1240775B (it) * 1990-02-23 1993-12-17 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.
IT1240799B (it) * 1990-03-15 1993-12-17 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti 3-metiltiopropionil l-carnitina ad attivita' sul sistema cardiovascolare.
US5168023A (en) * 1990-07-04 1992-12-01 Matsushita Electric Industrial Co., Ltd. Photosensitive element used in electrophotography
IT1248323B (it) * 1991-05-16 1995-01-05 Sigma Tau Ind Farmaceuti Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
IT1254135B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261688B (it) * 1993-05-28 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) * 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
IT1299172B1 (it) * 1998-05-06 2000-02-29 Sigma Tau Ind Farmaceuti Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
ITRM20020620A1 (it) * 2002-12-13 2004-06-14 Sigma Tau Ind Farmaceuti Uso delle carnitine per la prevenzione e/o il trattamento dei disturbi causati dall'andropausa.
FI20030769A0 (fi) * 2003-05-21 2003-05-21 Raisio Chem Oy Tärkkelysjohdannaiset, niiden valmistus ja käyttö
US20070178125A1 (en) * 2003-05-21 2007-08-02 Aki Laine Process for the preparation of carnitine esters and their use
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
JP5485492B2 (ja) * 2004-12-15 2014-05-07 大正製薬株式会社 うつ病の予防・治療薬
WO2008075366A2 (fr) * 2006-12-20 2008-06-26 Medwell Laboratories Ltd. Nouveaux conjugués d'acides gras poly-insaturés avec des amines et utilisations thérapeutiques de ceux-ci
CA2718276A1 (fr) * 2008-03-13 2009-09-17 Perkinelmer Las, Inc. Substrats enzymatiques pour systemes de detection multiples
EP2216321A1 (fr) * 2009-02-05 2010-08-11 Lonza Ltd. Processus de production de dérivé de carnitine/acide gras
CN102557972A (zh) * 2011-12-31 2012-07-11 南京海辰药业有限公司 氯化乙酰左卡尼汀的多晶型物
CN104161728A (zh) * 2013-05-17 2014-11-26 北京星昊医药股份有限公司 氯化丙酰左卡尼汀冻干粉针剂及其制备方法
CN104163769B (zh) * 2014-06-23 2016-06-15 海南霞迪药业有限公司 一种氯化丙酰左卡尼汀的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE719891C (de) * 1938-12-08 1942-04-21 Dr Erich Strack Verfahren zur Herstellung des Methyl- bzw. AEthylesters des acetylierten Carnitins
FR2209545A1 (fr) * 1972-12-07 1974-07-05 Otsuka Pharma Co Ltd
US4032641A (en) * 1976-06-09 1977-06-28 Tanabe Seiyaku Co., Ltd. Nicotinoyl carnitine derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968241A (en) * 1972-11-06 1976-07-06 Defelice Stephen L Method of treating cardiac arrhythmias and of improving myocardial contractility and systolic rhythm with carnitive or a pharmaceutically acceptable salt thereof
JPS5058213A (fr) * 1973-09-26 1975-05-21
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine
IT1143611B (it) * 1977-11-03 1986-10-22 Sigma Tau Ind Farmaceuti Applicazione della acetil-carnitina nella terapia delle affezioni cardiache di/tipo anossico,ischemico,cardiotossico e nelle sindromi aritmiche
DE2903579A1 (de) * 1978-02-03 1979-08-09 Sigma Tau Ind Farmaceuti Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE719891C (de) * 1938-12-08 1942-04-21 Dr Erich Strack Verfahren zur Herstellung des Methyl- bzw. AEthylesters des acetylierten Carnitins
FR2209545A1 (fr) * 1972-12-07 1974-07-05 Otsuka Pharma Co Ltd
US4032641A (en) * 1976-06-09 1977-06-28 Tanabe Seiyaku Co., Ltd. Nicotinoyl carnitine derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503149A1 (fr) * 1981-03-31 1982-10-08 Sigma Tau Ind Farmaceuti Esters de mercaptoacyl-carnitines, procede pour leur preparation et leurs utilisations therapeutiques, notamment dans le traitement des intoxications et des brulures et en tant qu'agents mucolytiques
FR2503150A1 (fr) * 1981-03-31 1982-10-08 Sigma Tau Ind Farmaceuti Mercaptoacyl-carnitines, procede pour leur preparation et leurs utilisations therapeutiques dans le traitement des intoxications et des brulures et en tant qu'agents mucolytiques
EP0596838A2 (fr) * 1992-10-20 1994-05-11 AVANTGARDE S.p.A. Esters de L-carnitine et alkanoyl L-carnitines avec l'acide glycolique ou leurs esters et compositions pharmaceutiques les contenant pour le traitement de dermatoses
EP0596838A3 (en) * 1992-10-20 1994-06-01 Avantgarde Spa Esters of l-carnitine and alkanoyl l-carnitines with glycolic acid or esters thereof and pharmaceutical compositions containing same for treating dermatoses.

Also Published As

Publication number Publication date
SE8003005L (sv) 1980-10-24
US4439438A (en) 1984-03-27
FR2455028A1 (fr) 1980-11-21
IL59915A (en) 1984-04-30
JPS55167262A (en) 1980-12-26
AU5773880A (en) 1980-10-30
NL8002370A (nl) 1980-10-27
CH642849A5 (it) 1984-05-15
NO151823B (no) 1985-03-04
NO801155L (no) 1980-10-24
IE800800L (en) 1980-10-23
DE3015635C2 (fr) 1989-06-15
GB2051779B (en) 1983-02-23
GB2048268B (en) 1983-05-18
GB2051779A (en) 1981-01-21
NO151822B (no) 1985-03-04
DK155595C (da) 1989-10-16
DK170680A (da) 1980-10-24
DK170580A (da) 1980-10-24
AU5773680A (en) 1980-10-30
JPS562945A (en) 1981-01-13
ATA215780A (de) 1984-05-15
ES490764A0 (es) 1981-04-01
FR2455028B1 (fr) 1983-04-08
SE448375B (sv) 1987-02-16
IT7948816A0 (it) 1979-04-23
DK155595B (da) 1989-04-24
NO151822C (no) 1985-06-12
ES490765A0 (es) 1981-05-16
ES8104987A1 (es) 1981-05-16
JPH0210821B2 (fr) 1990-03-09
CH642619A5 (it) 1984-04-30
IL59914A (en) 1984-04-30
JPH0314810B2 (fr) 1991-02-27
AU538739B2 (en) 1984-08-23
SE447244B (sv) 1986-11-03
FR2455027B1 (fr) 1985-08-09
LU82387A1 (fr) 1980-07-31
AU538740B2 (en) 1984-08-23
AT376656B (de) 1984-12-27
GB2048268A (en) 1980-12-10
SE8003004L (sv) 1980-10-24
DE3015636C2 (de) 1993-10-21
IE800801L (en) 1980-10-23
NL8002369A (nl) 1980-10-27
BE882936A (fr) 1980-08-18
NO801154L (no) 1980-10-24
IE49701B1 (en) 1985-11-27
ES8104191A1 (es) 1981-04-01
ATA215680A (de) 1983-12-15
LU82386A1 (fr) 1980-07-31
AT375336B (de) 1984-07-25
IE49700B1 (en) 1985-11-27
JPH03236318A (ja) 1991-10-22
IT1116037B (it) 1986-02-10
GR68051B (fr) 1981-10-29
BE882937A (fr) 1980-08-18
US4443475A (en) 1984-04-17
DE3015636A1 (de) 1980-11-06
DE3015635A1 (de) 1980-11-13
NO151823C (no) 1985-06-12
GR68052B (fr) 1981-10-29

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