FR2430952A1 - Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament - Google Patents
Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicamentInfo
- Publication number
- FR2430952A1 FR2430952A1 FR7820971A FR7820971A FR2430952A1 FR 2430952 A1 FR2430952 A1 FR 2430952A1 FR 7820971 A FR7820971 A FR 7820971A FR 7820971 A FR7820971 A FR 7820971A FR 2430952 A1 FR2430952 A1 FR 2430952A1
- Authority
- FR
- France
- Prior art keywords
- androst
- ene
- medicament
- application
- preparation process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0048—Alkynyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention a pour objet les composés de formule I :
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7820971A FR2430952A1 (fr) | 1978-07-13 | 1978-07-13 | Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament |
OA56811A OA06258A (fr) | 1978-07-13 | 1979-05-18 | Procédé de préparation de nouveaux dérivés acétyléniques de l'androst-4-ène. |
SE7904431A SE440781B (sv) | 1978-07-13 | 1979-05-21 | Nya stereoidforeningar och anvendning derav sasom antiinflammatoriska medel |
IL57533A IL57533A (en) | 1978-07-13 | 1979-06-11 | 17alpha-acetylene derivatives of androst-4-ene,process for preparing them and pharmaceutical compositions containing them |
IL6869379A IL68693A (en) | 1978-07-13 | 1979-06-11 | 3-ethoxy-11beta-hydroxy-6-methylandrosta-3,5-dien-17-one and its preparation |
ZA793100A ZA793100B (en) | 1978-07-13 | 1979-06-21 | New acetylene derivatives of androst-4-ene,process for preparing them,their use as a medicament and the pharmaceutical compositions containing them |
US06/052,489 US4233297A (en) | 1978-07-13 | 1979-06-27 | Novel Δ4 -androstenes |
PH22725A PH17055A (en) | 1978-07-13 | 1979-07-02 | Delta4-androstenes derivative |
MA18713A MA18516A1 (fr) | 1978-07-13 | 1979-07-10 | Procede de preparation de nouveaux derives acetyleniques de l'androst-a-ene |
PT69906A PT69906A (fr) | 1978-07-13 | 1979-07-11 | Procede de preparation de nouveaux derives acetyleniques de l'androst-4-ene |
GR59570A GR81403B (fr) | 1978-07-13 | 1979-07-11 | |
ES482387A ES8101081A1 (es) | 1978-07-13 | 1979-07-11 | Procedimiento de preparacion de nuevos derivados acetileni- cos del androst-4-eno. |
CA000331652A CA1140110A (fr) | 1978-07-13 | 1979-07-12 | Procede de preparation de nouveaux derives de l'androst-4-ene |
BE0/196266A BE877658A (fr) | 1978-07-13 | 1979-07-12 | Nouveaux derives acetyleniques de l'androst-4-ene, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant |
LU81497A LU81497A1 (fr) | 1978-07-13 | 1979-07-12 | Nouveaux derives acetyleniques de l'androst-4-ene,leur procede de preparation,leur application comme medicament et les compositions pharmaceutiques les renfermant |
DK292679A DK160560C (da) | 1978-07-13 | 1979-07-12 | Analogifremgangsmaade til fremstilling af acetyleniske derivater af androstenforbindelser samt mellemprodukt til brug derved |
HU79RO1028A HU180519B (en) | 1978-07-13 | 1979-07-12 | Process for preparing new androst-4-ene derivatives |
IT49743/79A IT1164697B (it) | 1978-07-13 | 1979-07-12 | Procedimento per la preparazione di derivati acetilenici di androst-4-ene e composizioni farmaceutiche che li contengono e prodotto uttenuto |
AU48894/79A AU534841B2 (en) | 1978-07-13 | 1979-07-12 | Acetylene derivatives of androst-4-ene |
NL7905481A NL7905481A (nl) | 1978-07-13 | 1979-07-13 | Nieuwe ethynderivaten van androst-4-een, werkwijze ter bereiding daarvan, de toepassing daarvan als geneesmid- delen en de farmaceutische preparaten, die deze verbin- dingen bevatten. |
DE19792928374 DE2928374A1 (de) | 1978-07-13 | 1979-07-13 | Neue acetylenische derivate des androst-4-ens, verfahren zu deren herstellung, ihre verwendung als arzneimittel und die sie enthaltenden pharmazeutischen zusammensetzungen |
AT0488979A AT370109B (de) | 1978-07-13 | 1979-07-13 | Verfahren zur herstellung neuer acetylenderivate des androst-4-ens |
DE2954699A DE2954699C2 (fr) | 1978-07-13 | 1979-07-13 | |
CH657279A CH641475A5 (fr) | 1978-07-13 | 1979-07-13 | Derives acetyleniques de l'androst-4-ene, leur procede de preparation et medicament les renfermant. |
JP8839579A JPS5515474A (en) | 1978-07-13 | 1979-07-13 | Novel 17 alphaaacetylene derivative of 44androstene*its manufacture*use as drug and pharmaceutic composition containing it |
GB7924588A GB2025422B (en) | 1978-07-13 | 1979-07-13 | 17-acetylene derivatives of androst-4-ene |
IE753/85A IE49180B1 (en) | 1978-07-13 | 1979-08-08 | Intermediate for use in preparing 17a-acetylene derivatives of androst-4-ene |
IE133879A IE49179B1 (en) | 1978-07-13 | 1979-08-08 | 17a-acetylene derivatives of androst-4-ene |
GB08229532A GB2108503B (en) | 1978-07-13 | 1982-10-15 | 3-ethoxy-11b-hydroxy-6-methyl-androsta-3,5-dien-17-one |
IL68693A IL68693A0 (en) | 1978-07-13 | 1983-05-13 | 3-ethoxy-11beta-hydroxy-6-methyl-androsta-3,5-dien-17-one and its preparation |
CH440083A CH642977A5 (fr) | 1978-07-13 | 1983-08-11 | Derive de la 6-methyl androsta 3,5-diene 17-one. |
JP62131936A JPS6345295A (ja) | 1978-07-13 | 1987-05-29 | アンドロスタンの新誘導体 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7820971A FR2430952A1 (fr) | 1978-07-13 | 1978-07-13 | Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2430952A1 true FR2430952A1 (fr) | 1980-02-08 |
FR2430952B1 FR2430952B1 (fr) | 1980-12-05 |
Family
ID=9210731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7820971A Granted FR2430952A1 (fr) | 1978-07-13 | 1978-07-13 | Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament |
Country Status (24)
Country | Link |
---|---|
US (1) | US4233297A (fr) |
JP (2) | JPS5515474A (fr) |
AT (1) | AT370109B (fr) |
AU (1) | AU534841B2 (fr) |
BE (1) | BE877658A (fr) |
CA (1) | CA1140110A (fr) |
CH (2) | CH641475A5 (fr) |
DE (2) | DE2928374A1 (fr) |
DK (1) | DK160560C (fr) |
ES (1) | ES8101081A1 (fr) |
FR (1) | FR2430952A1 (fr) |
GB (2) | GB2025422B (fr) |
GR (1) | GR81403B (fr) |
HU (1) | HU180519B (fr) |
IL (1) | IL57533A (fr) |
IT (1) | IT1164697B (fr) |
LU (1) | LU81497A1 (fr) |
MA (1) | MA18516A1 (fr) |
NL (1) | NL7905481A (fr) |
OA (1) | OA06258A (fr) |
PH (1) | PH17055A (fr) |
PT (1) | PT69906A (fr) |
SE (1) | SE440781B (fr) |
ZA (1) | ZA793100B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2547587B1 (fr) * | 1983-06-14 | 1985-10-25 | Roussel Uclaf | Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation |
FR2644788B1 (fr) * | 1989-03-22 | 1995-02-03 | Roussel Uclaf | Nouveaux steroides 3-ceto comportant une chaine en 17 amino-substituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
JPH02141007U (fr) * | 1989-04-26 | 1990-11-27 | ||
EP0485392B1 (fr) * | 1989-07-07 | 1998-09-09 | Endorecherche Inc. | Derives d'androgene utilises pour inhiber l'activite des steroides sexuels |
AU680818B2 (en) * | 1992-05-21 | 1997-08-14 | Endorecherche Inc. | Improved antiandrogens |
CZ285893B6 (cs) * | 1993-05-17 | 1999-11-17 | Endorecherche Inc. | Antiandrogenní sloučenina, její prekursor a farmaceutický prostředek ji obsahující |
CN103145785B (zh) * | 2013-03-19 | 2016-03-02 | 浙江仙居仙乐药业有限公司 | 一种醋酸环丙孕酮脱氢物的合成方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3010957A (en) * | 1958-11-26 | 1961-11-28 | Schering Corp | Ethinyl androstadienes |
FR1349113A (fr) * | 1959-01-28 | 1964-01-17 | Upjohn Co | Procédé de fabrication de 6-fluoro-11 oxygéné-17-bêta-hydroxy-17 alpha-alkynyl inférieur-4-androstène-3-ones et leurs dérivés acylés |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2740798A (en) * | 1953-05-25 | 1956-04-03 | Searle & Co | 11 beta-hydroxy-17-ethynyl testosterone and esters thereof |
US3793308A (en) * | 1972-11-08 | 1974-02-19 | Upjohn Co | 4-spiro(cyclopropyl)androstenes and process for their production |
SE7801152L (sv) * | 1977-02-22 | 1978-08-23 | Roussel Uclaf | Sett att framstella 17alfa-acetylen-derivat av androst-4-en |
-
1978
- 1978-07-13 FR FR7820971A patent/FR2430952A1/fr active Granted
-
1979
- 1979-05-18 OA OA56811A patent/OA06258A/fr unknown
- 1979-05-21 SE SE7904431A patent/SE440781B/sv not_active IP Right Cessation
- 1979-06-11 IL IL57533A patent/IL57533A/xx unknown
- 1979-06-21 ZA ZA793100A patent/ZA793100B/xx unknown
- 1979-06-27 US US06/052,489 patent/US4233297A/en not_active Expired - Lifetime
- 1979-07-02 PH PH22725A patent/PH17055A/en unknown
- 1979-07-10 MA MA18713A patent/MA18516A1/fr unknown
- 1979-07-11 GR GR59570A patent/GR81403B/el unknown
- 1979-07-11 PT PT69906A patent/PT69906A/fr active IP Right Revival
- 1979-07-11 ES ES482387A patent/ES8101081A1/es not_active Expired
- 1979-07-12 LU LU81497A patent/LU81497A1/fr unknown
- 1979-07-12 CA CA000331652A patent/CA1140110A/fr not_active Expired
- 1979-07-12 DK DK292679A patent/DK160560C/da not_active IP Right Cessation
- 1979-07-12 HU HU79RO1028A patent/HU180519B/hu unknown
- 1979-07-12 AU AU48894/79A patent/AU534841B2/en not_active Expired
- 1979-07-12 BE BE0/196266A patent/BE877658A/fr not_active IP Right Cessation
- 1979-07-12 IT IT49743/79A patent/IT1164697B/it active
- 1979-07-13 DE DE19792928374 patent/DE2928374A1/de active Granted
- 1979-07-13 AT AT0488979A patent/AT370109B/de not_active IP Right Cessation
- 1979-07-13 JP JP8839579A patent/JPS5515474A/ja active Granted
- 1979-07-13 NL NL7905481A patent/NL7905481A/nl not_active Application Discontinuation
- 1979-07-13 DE DE2954699A patent/DE2954699C2/de not_active Expired - Lifetime
- 1979-07-13 CH CH657279A patent/CH641475A5/fr not_active IP Right Cessation
- 1979-07-13 GB GB7924588A patent/GB2025422B/en not_active Expired
-
1982
- 1982-10-15 GB GB08229532A patent/GB2108503B/en not_active Expired
-
1983
- 1983-08-11 CH CH440083A patent/CH642977A5/fr not_active IP Right Cessation
-
1987
- 1987-05-29 JP JP62131936A patent/JPS6345295A/ja active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3010957A (en) * | 1958-11-26 | 1961-11-28 | Schering Corp | Ethinyl androstadienes |
FR1349113A (fr) * | 1959-01-28 | 1964-01-17 | Upjohn Co | Procédé de fabrication de 6-fluoro-11 oxygéné-17-bêta-hydroxy-17 alpha-alkynyl inférieur-4-androstène-3-ones et leurs dérivés acylés |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CA | Change of address | ||
CD | Change of name or company name | ||
TP | Transmission of property |