FR2375253A1 - Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques - Google Patents

Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques

Info

Publication number
FR2375253A1
FR2375253A1 FR7739218A FR7739218A FR2375253A1 FR 2375253 A1 FR2375253 A1 FR 2375253A1 FR 7739218 A FR7739218 A FR 7739218A FR 7739218 A FR7739218 A FR 7739218A FR 2375253 A1 FR2375253 A1 FR 2375253A1
Authority
FR
France
Prior art keywords
carboxylic
acids
alcoxycarbonyl
halog
pregn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7739218A
Other languages
English (en)
Other versions
FR2375253B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of FR2375253A1 publication Critical patent/FR2375253A1/fr
Application granted granted Critical
Publication of FR2375253B1 publication Critical patent/FR2375253B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001Lactones
    • C07J21/003Lactones at position 17
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003Androstane derivatives
    • C07J1/0033Androstane derivatives substituted in position 17 alfa and 17 beta
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne de nouveaux composés de formule :
FR7739218A 1976-12-27 1977-12-26 Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques Granted FR2375253A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/754,136 US4069219A (en) 1976-12-27 1976-12-27 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (2)

Publication Number Publication Date
FR2375253A1 true FR2375253A1 (fr) 1978-07-21
FR2375253B1 FR2375253B1 (fr) 1981-04-30

Family

ID=25033598

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7739218A Granted FR2375253A1 (fr) 1976-12-27 1977-12-26 Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques

Country Status (19)

Country Link
US (1) US4069219A (fr)
JP (1) JPS5382767A (fr)
AU (1) AU518862B2 (fr)
BE (1) BE862365A (fr)
CA (1) CA1099702A (fr)
CH (6) CH637403A5 (fr)
DE (1) DE2758279A1 (fr)
DK (1) DK577377A (fr)
FI (1) FI773936A (fr)
FR (1) FR2375253A1 (fr)
GB (1) GB1575986A (fr)
IE (1) IE46128B1 (fr)
IL (1) IL53692A (fr)
NL (1) NL7714428A (fr)
NO (2) NO774464L (fr)
NZ (1) NZ186119A (fr)
PT (1) PT67455B (fr)
SE (1) SE7714764L (fr)
ZA (1) ZA777684B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト 17α−プレグネ−4−エン−3−オキソ−21−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) * 1983-08-17 1985-03-07 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
ATE365171T1 (de) * 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
SI1487859T1 (sl) * 2002-03-22 2008-10-31 Pharmacia & Upjohn Co Llc Postopek priprave eplerenona
PL376919A1 (pl) * 2002-11-06 2006-01-09 Pharmacia & Upjohn Company Llc Sposoby wytwarzania 7-karboksy-podstawionych steroidów
KR100667123B1 (ko) * 2002-11-07 2007-01-12 파마시아 앤드 업존 캄파니 엘엘씨 C-7 치환된 5-안드로스텐의 제조 방법
PT1910403T (pt) 2005-07-21 2016-07-14 Bayer Pharma AG Processo para a produção de 3-oxo-pregn-4-eno-21,17- carbolactonas através da oxidação isenta de metais de 17- (3-hidroxipropil)-3,17-diidroxiandrostanos
PL1746101T5 (pl) 2005-07-21 2014-11-28 Bayer Pharma AG Sposób wytwarzania 3-oksopreg-4-eno-21,17-karbolaktonów drogą bezmetalowego utleniania 17-(3-hydroksypropylo-3,17-dihydroksyandrostanu

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2150852A1 (fr) * 1971-08-25 1973-04-13 Searle & Co
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2150852A1 (fr) * 1971-08-25 1973-04-13 Searle & Co
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
DK577377A (da) 1978-06-28
GB1575986A (en) 1980-10-01
CH637404A5 (de) 1983-07-29
IE46128L (en) 1978-06-27
FI773936A (fi) 1978-06-28
NL7714428A (nl) 1978-06-29
IE46128B1 (en) 1983-02-23
PT67455A (en) 1978-01-01
CA1099702A (fr) 1981-04-21
IL53692A (en) 1982-07-30
FR2375253B1 (fr) 1981-04-30
AU3201277A (en) 1979-06-28
PT67455B (en) 1979-05-25
BE862365A (fr) 1978-06-27
CH637403A5 (de) 1983-07-29
NZ186119A (en) 1979-08-31
US4069219A (en) 1978-01-17
IL53692A0 (en) 1978-03-10
JPS5382767A (en) 1978-07-21
SE7714764L (sv) 1978-06-28
NO820059L (no) 1978-06-28
CH638536A5 (de) 1983-09-30
AU518862B2 (en) 1981-10-22
DE2758279A1 (de) 1978-06-29
CH637408A5 (de) 1983-07-29
CH637405A5 (de) 1983-07-29
ZA777684B (en) 1979-08-29
NO774464L (no) 1978-06-28
CH635595A5 (de) 1983-04-15

Similar Documents

Publication Publication Date Title
FR2416891A1 (fr) 6-n-propyl-8-methoxymethyl ou methylmercaptomethylergolines et composes apparentes, et leur utilisation therapeutique
FR2430411A1 (fr) Phenethanolamines et leur utilisation therapeutique
FR2421874A1 (fr) Carboxyalkylacylamino-acides utiles comme agents hypotenseurs
FR2417510A1 (fr) 9-amino- et imino-dibenzopyrannes et leur utilisation therapeutique
FR2417500A1 (fr) Derives d'amino-acides cycliques dehydrogenes et leur utilisation therapeutique
FR2446832A1 (fr) Octahydro-pyrazolo(3,4-g)quinoleines et leur utilisation therapeutique
FR2400517A1 (fr) Triazolo-2,4-benzodiazepines et leur utilisation therapeutique
FR2446283A1 (fr) Phenoxyphenylpiperidines, leur preparation et leurs applications therapeutiques
FR2392007A1 (fr) 3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy-piperidines, leurs derives, leur preparation et leur utilisation comme antidiarrheiques et analgesiques
FR2377402A1 (fr) 5h-imidazo(2,1-a)isoindole-2(3h),5-diones et leur utilisation comme herbicides
FR2445834A1 (fr) Derives heterobicycliques de l'acide 7-acylamido-3-cephem-4-carboxylique insature, procedes de preparation de ceux-ci et utilisation en therapeutique
FR2356651A1 (fr) Nouveaux derives d'acide penicillanique et leur utilisation therapeutique
FR2430409A1 (fr) Phenethanolamines et leur utilisation comme potentialisateurs des medicaments destructeurs des cellules cancereuses
FR2385682A1 (fr) Nouveaux 1-amino-indanes et leur utilisation comme medicaments
FR2375253A1 (fr) Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques
FR2430408A1 (fr) Phenethanolamines optiquement actives et leur utilisation therapeutique
FR2442836A1 (fr) 1,2,4,5-tetra-alkyl-4-arylpiperidines, leur preparation et leur utilisation therapeutique
FR2369260A1 (fr) 2-pyrrolidones 1,5-disubstituees et leurs procedes de preparation
FR2417499A1 (fr) Mercaptoacylamino-acides halogenes et leur utilisation therapeutique
FR2434805A1 (fr) 1-benzoyl-3-pyridinylurees, leur preparation et leur utilisation comme insecticides
FR2446282A1 (fr) Phenylthiophenylpiperidines, leur preparation et leurs applications therapeutiques
FR2445838A1 (fr) Nouveaux 1a,3b-dihydroxy-5-steroides
FR2399406A1 (fr) Derives de perhydronaphtalenepentol et leur utilisation therapeutique
FR2374311A2 (fr) Nouveaux 1-sulfonylbenzimidazoles 5(6)-substitues, et leur utilisation comme agents antiviraux
FR2446833A1 (fr) Octahydro-2h-pyrrolo(3,4-g)quinoleines et leur utilisation therapeutiques

Legal Events

Date Code Title Description
ST Notification of lapse