SE7714764L - Sett att framstella 7epsilon-(alkoxikarbonyl)-6epsilon-alkyl/halo-17-hydroxi-3-oxo-17alfa-pregn-4-en-21-karboxylsyra-gamma-laktoner och motsvarande 21-karboxylsyror samt estrar och salter derav - Google Patents

Sett att framstella 7epsilon-(alkoxikarbonyl)-6epsilon-alkyl/halo-17-hydroxi-3-oxo-17alfa-pregn-4-en-21-karboxylsyra-gamma-laktoner och motsvarande 21-karboxylsyror samt estrar och salter derav

Info

Publication number
SE7714764L
SE7714764L SE7714764A SE7714764A SE7714764L SE 7714764 L SE7714764 L SE 7714764L SE 7714764 A SE7714764 A SE 7714764A SE 7714764 A SE7714764 A SE 7714764A SE 7714764 L SE7714764 L SE 7714764L
Authority
SE
Sweden
Prior art keywords
oxyles
alcoxic
7epsilon
6epsilon
17alfa
Prior art date
Application number
SE7714764A
Other languages
English (en)
Inventor
R M Weier
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of SE7714764L publication Critical patent/SE7714764L/sv

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001Lactones
    • C07J21/003Lactones at position 17
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003Androstane derivatives
    • C07J1/0033Androstane derivatives substituted in position 17 alfa and 17 beta
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
SE7714764A 1976-12-27 1977-12-27 Sett att framstella 7epsilon-(alkoxikarbonyl)-6epsilon-alkyl/halo-17-hydroxi-3-oxo-17alfa-pregn-4-en-21-karboxylsyra-gamma-laktoner och motsvarande 21-karboxylsyror samt estrar och salter derav SE7714764L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/754,136 US4069219A (en) 1976-12-27 1976-12-27 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (1)

Publication Number Publication Date
SE7714764L true SE7714764L (sv) 1978-06-28

Family

ID=25033598

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7714764A SE7714764L (sv) 1976-12-27 1977-12-27 Sett att framstella 7epsilon-(alkoxikarbonyl)-6epsilon-alkyl/halo-17-hydroxi-3-oxo-17alfa-pregn-4-en-21-karboxylsyra-gamma-laktoner och motsvarande 21-karboxylsyror samt estrar och salter derav

Country Status (19)

Country Link
US (1) US4069219A (sv)
JP (1) JPS5382767A (sv)
AU (1) AU518862B2 (sv)
BE (1) BE862365A (sv)
CA (1) CA1099702A (sv)
CH (6) CH637403A5 (sv)
DE (1) DE2758279A1 (sv)
DK (1) DK577377A (sv)
FI (1) FI773936A (sv)
FR (1) FR2375253A1 (sv)
GB (1) GB1575986A (sv)
IE (1) IE46128B1 (sv)
IL (1) IL53692A (sv)
NL (1) NL7714428A (sv)
NO (2) NO774464L (sv)
NZ (1) NZ186119A (sv)
PT (1) PT67455B (sv)
SE (1) SE7714764L (sv)
ZA (1) ZA777684B (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト 17α−プレグネ−4−エン−3−オキソ−21−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) * 1983-08-17 1985-03-07 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
ATE365171T1 (de) * 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
SI1487859T1 (sl) * 2002-03-22 2008-10-31 Pharmacia & Upjohn Co Llc Postopek priprave eplerenona
PL376919A1 (pl) * 2002-11-06 2006-01-09 Pharmacia & Upjohn Company Llc Sposoby wytwarzania 7-karboksy-podstawionych steroidów
KR100667123B1 (ko) * 2002-11-07 2007-01-12 파마시아 앤드 업존 캄파니 엘엘씨 C-7 치환된 5-안드로스텐의 제조 방법
PT1910403T (pt) 2005-07-21 2016-07-14 Bayer Pharma AG Processo para a produção de 3-oxo-pregn-4-eno-21,17- carbolactonas através da oxidação isenta de metais de 17- (3-hidroxipropil)-3,17-diidroxiandrostanos
PL1746101T5 (pl) 2005-07-21 2014-11-28 Bayer Pharma AG Sposób wytwarzania 3-oksopreg-4-eno-21,17-karbolaktonów drogą bezmetalowego utleniania 17-(3-hydroksypropylo-3,17-dihydroksyandrostanu

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787940A (fr) * 1971-08-25 1973-02-26 Searle & Co Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
DK577377A (da) 1978-06-28
GB1575986A (en) 1980-10-01
CH637404A5 (de) 1983-07-29
IE46128L (en) 1978-06-27
FI773936A (fi) 1978-06-28
NL7714428A (nl) 1978-06-29
IE46128B1 (en) 1983-02-23
FR2375253A1 (fr) 1978-07-21
PT67455A (en) 1978-01-01
CA1099702A (en) 1981-04-21
IL53692A (en) 1982-07-30
FR2375253B1 (sv) 1981-04-30
AU3201277A (en) 1979-06-28
PT67455B (en) 1979-05-25
BE862365A (fr) 1978-06-27
CH637403A5 (de) 1983-07-29
NZ186119A (en) 1979-08-31
US4069219A (en) 1978-01-17
IL53692A0 (en) 1978-03-10
JPS5382767A (en) 1978-07-21
NO820059L (no) 1978-06-28
CH638536A5 (de) 1983-09-30
AU518862B2 (en) 1981-10-22
DE2758279A1 (de) 1978-06-29
CH637408A5 (de) 1983-07-29
CH637405A5 (de) 1983-07-29
ZA777684B (en) 1979-08-29
NO774464L (no) 1978-06-28
CH635595A5 (de) 1983-04-15

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