FR2399406A1 - Derives de perhydronaphtalenepentol et leur utilisation therapeutique - Google Patents

Derives de perhydronaphtalenepentol et leur utilisation therapeutique

Info

Publication number
FR2399406A1
FR2399406A1 FR7823183A FR7823183A FR2399406A1 FR 2399406 A1 FR2399406 A1 FR 2399406A1 FR 7823183 A FR7823183 A FR 7823183A FR 7823183 A FR7823183 A FR 7823183A FR 2399406 A1 FR2399406 A1 FR 2399406A1
Authority
FR
France
Prior art keywords
derivatives
perhydronaphtalenepentol
therapeutic use
therapeutic
perhydronaphthalenepentol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7823183A
Other languages
English (en)
Inventor
Frederic Peter Hauck
Michael Edward Condon
Joyce A Reid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/821,891 external-priority patent/US4173640A/en
Priority claimed from US05/821,889 external-priority patent/US4156723A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2399406A1 publication Critical patent/FR2399406A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/90—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having more than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans

Abstract

L'invention concerne des dérivés de perhydronaphtalènepentol de formule :
FR7823183A 1977-08-04 1978-08-04 Derives de perhydronaphtalenepentol et leur utilisation therapeutique Withdrawn FR2399406A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/821,891 US4173640A (en) 1977-08-04 1977-08-04 Hypotensive perhydro naphthalene pentol derivatives
US05/821,889 US4156723A (en) 1977-08-04 1977-08-04 Perhydro naphthalene pentol derivatives

Publications (1)

Publication Number Publication Date
FR2399406A1 true FR2399406A1 (fr) 1979-03-02

Family

ID=27124601

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7823183A Withdrawn FR2399406A1 (fr) 1977-08-04 1978-08-04 Derives de perhydronaphtalenepentol et leur utilisation therapeutique

Country Status (4)

Country Link
JP (1) JPS5436240A (fr)
DE (1) DE2834372A1 (fr)
FR (1) FR2399406A1 (fr)
GB (3) GB2037288B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006967A1 (fr) * 1990-10-12 1992-04-30 The Upjohn Company Derives de 2-aminotetraline a usage therapeutique
US6331636B1 (en) 1989-05-31 2001-12-18 The Upjohn Company Therapeutically useful 2-aminotetralin derivatives

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1241324A (fr) * 1984-03-08 1988-08-30 Paul A. Aristoff Derives d'interphenylene carbacycline
FR2664592B1 (fr) * 1990-07-10 1994-09-02 Adir Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4332008C2 (de) * 1993-09-21 1997-10-16 Ero Edelstahl Rohrtechnik Gmbh Schneidvorrichtung für dünnwandige Rohre
IT1303737B1 (it) * 1998-11-11 2001-02-23 Smithkline Beecham Spa Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2701408A1 (de) * 1976-01-14 1977-07-21 Squibb & Sons Inc Pentolderivate, verfahren zu ihrer herstellung und arzneipraeparate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2701408A1 (de) * 1976-01-14 1977-07-21 Squibb & Sons Inc Pentolderivate, verfahren zu ihrer herstellung und arzneipraeparate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331636B1 (en) 1989-05-31 2001-12-18 The Upjohn Company Therapeutically useful 2-aminotetralin derivatives
WO1992006967A1 (fr) * 1990-10-12 1992-04-30 The Upjohn Company Derives de 2-aminotetraline a usage therapeutique

Also Published As

Publication number Publication date
GB2037288B (en) 1982-07-14
GB2037287A (en) 1980-07-09
GB2037287B (en) 1982-07-14
GB2037288A (en) 1980-07-09
GB2005247A (en) 1979-04-19
JPS5436240A (en) 1979-03-16
GB2005247B (en) 1982-06-16
DE2834372A1 (de) 1979-02-15

Similar Documents

Publication Publication Date Title
FR2417500A1 (fr) Derives d'amino-acides cycliques dehydrogenes et leur utilisation therapeutique
FR2430411A1 (fr) Phenethanolamines et leur utilisation therapeutique
FR2417510A1 (fr) 9-amino- et imino-dibenzopyrannes et leur utilisation therapeutique
FR2400517A1 (fr) Triazolo-2,4-benzodiazepines et leur utilisation therapeutique
FR2446832A1 (fr) Octahydro-pyrazolo(3,4-g)quinoleines et leur utilisation therapeutique
FR2406641A1 (fr) 2,6-diaminonebularines et leur application therapeutique
FR2416891A1 (fr) 6-n-propyl-8-methoxymethyl ou methylmercaptomethylergolines et composes apparentes, et leur utilisation therapeutique
FR2371453A1 (fr) Thiadiazolotriazinediones substituees, leur preparation et leur utilisation comme herbicides et comme agents antiviraux et antimicrobiens
FR2446283A1 (fr) Phenoxyphenylpiperidines, leur preparation et leurs applications therapeutiques
FR2442836A1 (fr) 1,2,4,5-tetra-alkyl-4-arylpiperidines, leur preparation et leur utilisation therapeutique
FR2445834A1 (fr) Derives heterobicycliques de l'acide 7-acylamido-3-cephem-4-carboxylique insature, procedes de preparation de ceux-ci et utilisation en therapeutique
FR2385682A1 (fr) Nouveaux 1-amino-indanes et leur utilisation comme medicaments
FR2387988A1 (fr) Esters de cefuroxime, leur preparation et leur application therapeutique
FR2430408A1 (fr) Phenethanolamines optiquement actives et leur utilisation therapeutique
FR2404629A1 (fr) Nouveaux tetrapeptides et leur utilisation therapeutique
FR2387989A1 (fr) Analogues des alcaloides de l'ergot
FR2387214A1 (fr) Derives du p-aminomethyl benzene-sulfonamide, leur procede de preparation et leur application therapeutique
FR2399406A1 (fr) Derives de perhydronaphtalenepentol et leur utilisation therapeutique
FR2417499A1 (fr) Mercaptoacylamino-acides halogenes et leur utilisation therapeutique
FR2385707A1 (fr) 3-amino-6,7-dialcoxy-1h-1,2,4-benzothiadiazine-1-oxydes 1-substitues et leur utilisation comme medicaments
FR2419291A1 (fr) 2,3-dihydroimidazo(1,2-c)pyrimidines substituees et leur utilisation therapeutique
FR2389631A1 (fr)
FR2446833A1 (fr) Octahydro-2h-pyrrolo(3,4-g)quinoleines et leur utilisation therapeutiques
FR2446282A1 (fr) Phenylthiophenylpiperidines, leur preparation et leurs applications therapeutiques
FR2430407A1 (fr) R-n-(2-phenyl-2-hydroxyethyl)-3-phenylpropylamines et leur utilisation therapeutique

Legal Events

Date Code Title Description
ST Notification of lapse