LT4944B - C-21 modifikuoti epotilonai - Google Patents

C-21 modifikuoti epotilonai Download PDF

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Publication number
LT4944B
LT4944B LT2001086A LT2001086A LT4944B LT 4944 B LT4944 B LT 4944B LT 2001086 A LT2001086 A LT 2001086A LT 2001086 A LT2001086 A LT 2001086A LT 4944 B LT4944 B LT 4944B
Authority
LT
Lithuania
Prior art keywords
group
methyl
dione
dihydroxy
thiazolyl
Prior art date
Application number
LT2001086A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2001086A (en
Inventor
Gerhard Hoefle
Nicole Glaser
Thomas Leibold
Gregory Vite
Soong Hoon Kim
Original Assignee
Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf)
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107588 external-priority patent/DE19907588A1/de
Priority claimed from DE1999130111 external-priority patent/DE19930111A1/de
Application filed by Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), Bristol-Myers Squibb Company filed Critical Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf)
Publication of LT2001086A publication Critical patent/LT2001086A/xx
Publication of LT4944B publication Critical patent/LT4944B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
LT2001086A 1999-02-22 2001-08-24 C-21 modifikuoti epotilonai LT4944B (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999107588 DE19907588A1 (de) 1999-02-22 1999-02-22 C-21 Modifizierte Epothilone
DE1999130111 DE19930111A1 (de) 1999-07-01 1999-07-01 C-21 Modifizierte Epothilone

Publications (2)

Publication Number Publication Date
LT2001086A LT2001086A (en) 2002-04-25
LT4944B true LT4944B (lt) 2002-08-26

Family

ID=26051995

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2001086A LT4944B (lt) 1999-02-22 2001-08-24 C-21 modifikuoti epotilonai

Country Status (37)

Country Link
US (1) US6262094B1 (sk)
EP (1) EP1157023B1 (sk)
JP (1) JP4598957B2 (sk)
KR (1) KR100685336B1 (sk)
CN (1) CN1205208C (sk)
AR (1) AR028815A1 (sk)
AT (1) ATE254615T1 (sk)
AU (1) AU771089B2 (sk)
BG (1) BG64987B1 (sk)
BR (1) BR0008379A (sk)
CA (1) CA2360452C (sk)
CO (1) CO5140093A1 (sk)
CZ (1) CZ301498B6 (sk)
DE (1) DE60006649T2 (sk)
DK (1) DK1157023T3 (sk)
EE (1) EE04852B1 (sk)
ES (1) ES2209831T3 (sk)
GE (1) GEP20033067B (sk)
HK (1) HK1038923B (sk)
HU (1) HUP0200076A3 (sk)
ID (1) ID29829A (sk)
IL (1) IL144501A0 (sk)
LT (1) LT4944B (sk)
LV (1) LV12755B (sk)
MX (1) MXPA01008374A (sk)
MY (1) MY120601A (sk)
NO (1) NO320806B1 (sk)
NZ (1) NZ513629A (sk)
PE (1) PE20001546A1 (sk)
PL (1) PL212545B1 (sk)
PT (1) PT1157023E (sk)
RU (1) RU2253652C2 (sk)
SK (1) SK287200B6 (sk)
TR (1) TR200102401T2 (sk)
TW (1) TWI270546B (sk)
UY (1) UY26024A1 (sk)
WO (1) WO2000050423A1 (sk)

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US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
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HUP0302567A2 (hu) 2001-01-25 2003-12-29 Bristol-Myers Squibb Co. Epotilon analógokat tartalmazó parenterális adagolási formák és eljárás az előállításukra
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ATE452896T1 (de) 2002-03-12 2010-01-15 Bristol Myers Squibb Co C3-cyanoepothilonderivate
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CN1759115A (zh) 2002-08-23 2006-04-12 索隆-基特林癌症研究协会 埃坡霉素(epothilone),合成埃坡霉素的中间体,其类似物及其用途
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
KR101406635B1 (ko) 2002-09-23 2014-06-11 브리스톨-마이어스 스큅 컴퍼니 에포틸론 ｂ의 제조, 분리 및 정제 방법, 및 에포틸론 ｂ의 ｘ-선 결정 구조
JP2006504745A (ja) * 2002-10-09 2006-02-09 コーザン バイオサイエンシス インコーポレイテッド エポｄ及び５−ｆｕ／ゲムシタビン
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WO2011049625A1 (en) 2009-10-20 2011-04-28 Mansour Samadpour Method for aflatoxin screening of products
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US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
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Also Published As

Publication number Publication date
UY26024A1 (es) 2000-09-29
TR200102401T2 (tr) 2001-12-21
AU3234800A (en) 2000-09-14
ID29829A (id) 2001-10-11
NO320806B1 (no) 2006-01-30
IL144501A0 (en) 2002-05-23
HUP0200076A2 (hu) 2002-12-28
AR028815A1 (es) 2003-05-28
MY120601A (en) 2005-11-30
PL212545B1 (pl) 2012-10-31
HK1038923A1 (en) 2002-04-04
CO5140093A1 (es) 2002-03-22
CN1341114A (zh) 2002-03-20
DE60006649T2 (de) 2004-09-30
CA2360452C (en) 2011-07-26
LV12755A (en) 2001-11-20
CA2360452A1 (en) 2000-08-31
EE04852B1 (et) 2007-06-15
NO20014017D0 (no) 2001-08-17
NZ513629A (en) 2004-01-30
EP1157023A1 (en) 2001-11-28
LV12755B (lv) 2002-04-20
WO2000050423A1 (en) 2000-08-31
CZ20012991A3 (cs) 2002-01-16
HUP0200076A3 (en) 2003-01-28
ES2209831T3 (es) 2004-07-01
GEP20033067B (en) 2003-09-25
BG105830A (en) 2002-03-29
LT2001086A (en) 2002-04-25
AU771089B2 (en) 2004-03-11
PT1157023E (pt) 2004-03-31
CZ301498B6 (cs) 2010-03-24
BR0008379A (pt) 2002-09-24
HK1038923B (zh) 2004-03-19
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MXPA01008374A (es) 2003-06-06
US6262094B1 (en) 2001-07-17
JP4598957B2 (ja) 2010-12-15
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PE20001546A1 (es) 2001-03-18
NO20014017L (no) 2001-10-17
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