LT3948B - Polypeptide, plasmids, method for the preparation of plasmids, method for the preparation of polypeptide, thrombolytic material and applicatio of polypeptide - Google Patents

Polypeptide, plasmids, method for the preparation of plasmids, method for the preparation of polypeptide, thrombolytic material and applicatio of polypeptide Download PDF

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Publication number
LT3948B
LT3948B LTIP1532A LTIP1532A LT3948B LT 3948 B LT3948 B LT 3948B LT IP1532 A LTIP1532 A LT IP1532A LT IP1532 A LTIP1532 A LT IP1532A LT 3948 B LT3948 B LT 3948B
Authority
LT
Lithuania
Prior art keywords
plasmid
pro
glu
ser
plasmids
Prior art date
Application number
LTIP1532A
Other languages
English (en)
Lithuanian (lt)
Inventor
Gerd Josef Steffens
Wolfgang Amandus Guenzler
Leopold Flohe
Regina Elfried Brigelius-Flohe
Bernhard Wolf
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of LTIP1532A publication Critical patent/LTIP1532A/xx
Publication of LT3948B publication Critical patent/LT3948B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
LTIP1532A 1991-01-22 1993-12-06 Polypeptide, plasmids, method for the preparation of plasmids, method for the preparation of polypeptide, thrombolytic material and applicatio of polypeptide LT3948B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4101736A DE4101736A1 (de) 1991-01-22 1991-01-22 Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung

Publications (2)

Publication Number Publication Date
LTIP1532A LTIP1532A (en) 1995-06-26
LT3948B true LT3948B (en) 1996-05-27

Family

ID=6423453

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1532A LT3948B (en) 1991-01-22 1993-12-06 Polypeptide, plasmids, method for the preparation of plasmids, method for the preparation of polypeptide, thrombolytic material and applicatio of polypeptide

Country Status (15)

Country Link
EP (1) EP0496327B1 (xx)
JP (1) JPH06169770A (xx)
AT (1) ATE204326T1 (xx)
DE (2) DE4101736A1 (xx)
DK (1) DK0496327T3 (xx)
ES (1) ES2164048T3 (xx)
FI (1) FI920263A (xx)
HK (1) HK1010108A1 (xx)
HU (1) HU212510B (xx)
IE (1) IE914040A1 (xx)
IL (1) IL100163A0 (xx)
LT (1) LT3948B (xx)
LV (1) LV10974A (xx)
PT (1) PT496327E (xx)
RU (1) RU2108387C1 (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6017877A (en) * 1990-04-06 2000-01-25 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
KR100225511B1 (ko) * 1994-12-30 1999-10-15 성재갑 소 성장호르몬의 대량 생산 방법
JP2003521222A (ja) * 1998-03-06 2003-07-15 アボット・ラボラトリーズ 高度結晶性ウロキナーゼ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092182A2 (en) 1982-04-15 1983-10-26 Genentech, Inc. Preparation of functional human urokinase polypeptides
EP0247674A1 (en) 1986-05-15 1987-12-02 Leuven Research & Development V.Z.W. Plasminogen activator and thrombolytic composition
EP0312941A2 (de) 1987-10-23 1989-04-26 BASF Aktiengesellschaft Polypeptide mit Prourokinase-Aktivität, ihre Herstellung und Verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0316068A1 (en) * 1987-10-09 1989-05-17 Collaborative Research Inc. Modified low molecular weight plasminogen activator and method of preparation
DE3810474A1 (de) * 1988-03-26 1989-10-05 Boehringer Ingelheim Int Expressionsvektoren
GB8809093D0 (en) * 1988-04-18 1988-05-18 Erba Carlo Spa Low molecular weight derivatives of prourokinase
AU5515790A (en) * 1989-05-18 1990-11-22 Green Cross Corporation, The Human prourokinase variants, methods of producing same, dna sequences, plasmids and hosts therefor
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092182A2 (en) 1982-04-15 1983-10-26 Genentech, Inc. Preparation of functional human urokinase polypeptides
EP0247674A1 (en) 1986-05-15 1987-12-02 Leuven Research & Development V.Z.W. Plasminogen activator and thrombolytic composition
EP0312941A2 (de) 1987-10-23 1989-04-26 BASF Aktiengesellschaft Polypeptide mit Prourokinase-Aktivität, ihre Herstellung und Verwendung

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHRISTOPH BODE, MD,: "Intravenous Thrombolytic Therapy With a Combination of Single-Chain Urokinase-Type Plasminogen Activator and Recombinant Tissue-Type Plasminogen Activator in Acute Myocardial Infarction", CIRCULATION, 1990, pages 907 - 910
COHEN, E.J., KLATSKY, A.L., ARMSTRONG, M.A.: "Alcohol use and supraventricular arrhythmia", AM J CARDIOL., 1988, pages 971 - 973, XP023277756, DOI: doi:10.1016/0002-9149(88)90906-X
D.C. RIJKEN, D.J. BINNEMA, P. LOS: "Specific fibrinolytic properties of different molecular forms of pro-urokinase from a monkey kidney cell culture", THROMBOSIS RESEARCH, 1986, pages 761 - 768, XP022880198, DOI: doi:10.1016/0049-3848(86)90112-X
G. WIJNGAARDS ET AL.: "Characterization and fibrin-binding properties of different molecular forms of pro-urokinase from a monkey kidney cell culture", THROMBOSIS RESEARCH, 1986, pages 749 - 760, XP022880197, DOI: doi:10.1016/0049-3848(86)90111-8
KLAUS SCHOLLMEIER, DAGMAR GÄRTNER, AND WOLFG: "A bidirectionally active signal for termination of transcription is located between tetA and orfL on transposon Tn10", NUCL. ACIDS RES., 1985, pages 4227 - 4237
MARTIN WILHELM AND CORNELIS P. HOLLENBERG: "Nucleotide sequence of the Bacillus subtilis xylose isomerase gene: extensive homology between the Bacillus and Escherichia coli enzyme", NUCL. ACIDS RES., 1985, pages 5717 - 5722
NOLAN, C, HALL, LS, BARLOW, GH, TRIBBY, IIE: "Plasminogen activator from human embryonic kidney cell cultures: evidence for a proactivator", BIOCHIM BIOPHYS ACTA, 1977, pages 384 - 400, XP023498394, DOI: doi:10.1016/0304-4165(77)90321-X
STEVEN P. ADAMS ET AL.: "Hindered dialkylamino nucleoside phosphite reagents in the synthesis of two DNA 51-mers", J. AM. CHEM. SOC., 1983, pages 661 - 663
STUMP DC, LIJNEN HR, COLLEN D: "Purification and characterization of a novel low molecular weight form of single-chain urokinase-type plasminogen activator.", J BIOL CHEM., 1986, pages 17120 - 17126, XP001317375

Also Published As

Publication number Publication date
DE59209915D1 (de) 2001-09-20
EP0496327B1 (de) 2001-08-16
RU2108387C1 (ru) 1998-04-10
HK1010108A1 (en) 1999-06-11
LTIP1532A (en) 1995-06-26
FI920263A0 (fi) 1992-01-21
DE4101736A1 (de) 1992-07-23
ATE204326T1 (de) 2001-09-15
HU9200127D0 (en) 1992-04-28
FI920263A (fi) 1992-07-23
IE914040A1 (en) 1992-07-29
HU212510B (en) 1996-07-29
PT496327E (pt) 2002-02-28
EP0496327A1 (de) 1992-07-29
JPH06169770A (ja) 1994-06-21
HUT63877A (en) 1993-10-28
ES2164048T3 (es) 2002-02-16
LV10974A (lv) 1995-12-20
DK0496327T3 (da) 2001-12-03
IL100163A0 (en) 1992-08-18

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Effective date: 19961206