HK1010108A1 - Process for the preparation of polypeptides with prourokinase activity - Google Patents
Process for the preparation of polypeptides with prourokinase activityInfo
- Publication number
- HK1010108A1 HK1010108A1 HK98110955A HK98110955A HK1010108A1 HK 1010108 A1 HK1010108 A1 HK 1010108A1 HK 98110955 A HK98110955 A HK 98110955A HK 98110955 A HK98110955 A HK 98110955A HK 1010108 A1 HK1010108 A1 HK 1010108A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- polypeptides
- rscupa
- amino acids
- preparation
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Polypeptides of the general formula Ser-X1-X2-rscuPA<143-411> (1) in which X1 and X2 are defined amino acids or lower peptide bridges, X2 can also be a single bond, and rscuPA<143-411> is the unglycosylated sequence region of amino acids 143 (Glu) to 411 (LeuOH) from scu-PA 54 k, which can be used as plasminogen activators are described. To obtain these compounds, plasmids which are described in detail as such or in terms of their isolation were produced and expression thereof in suitable bacterial hosts provides, in each case in high yields, an expression product which does not act as plasminogen activator but whose protein-chemical conversion then leads to the single-chain compounds of the formula I which are valuable as plasminogen activators. <IMAGE>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4101736A DE4101736A1 (en) | 1991-01-22 | 1991-01-22 | NEW PLASMINOGENACTIVATORS USEFUL POLYPEPTIDES, DAFUER CODING PLASMIDS AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1010108A1 true HK1010108A1 (en) | 1999-06-11 |
Family
ID=6423453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98110955A HK1010108A1 (en) | 1991-01-22 | 1998-09-25 | Process for the preparation of polypeptides with prourokinase activity |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0496327B1 (en) |
| JP (1) | JPH06169770A (en) |
| AT (1) | ATE204326T1 (en) |
| DE (2) | DE4101736A1 (en) |
| DK (1) | DK0496327T3 (en) |
| ES (1) | ES2164048T3 (en) |
| FI (1) | FI920263A (en) |
| HK (1) | HK1010108A1 (en) |
| HU (1) | HU212510B (en) |
| IE (1) | IE914040A1 (en) |
| IL (1) | IL100163A0 (en) |
| LT (1) | LT3948B (en) |
| LV (1) | LV10974A (en) |
| PT (1) | PT496327E (en) |
| RU (1) | RU2108387C1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US6017877A (en) * | 1990-04-06 | 2000-01-25 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| KR100225511B1 (en) * | 1994-12-30 | 1999-10-15 | 성재갑 | Process for the mass production of bovine growth hormone |
| JP2003521222A (en) * | 1998-03-06 | 2003-07-15 | アボット・ラボラトリーズ | Highly crystalline urokinase |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR78180B (en) * | 1982-04-15 | 1984-09-26 | Genentech Inc | |
| NL8601240A (en) | 1986-05-15 | 1987-12-01 | Leuven Res & Dev Vzw | PLASMINOGEN ACTIVATOR AND THROMBOLYTIC MEDICINAL PRODUCT. |
| EP0316068A1 (en) * | 1987-10-09 | 1989-05-17 | Collaborative Research Inc. | Modified low molecular weight plasminogen activator and method of preparation |
| DE3735917A1 (en) * | 1987-10-23 | 1989-05-03 | Basf Ag | NEW POLYPEPTIDES, THEIR PRODUCTION AND USE |
| DE3810474A1 (en) * | 1988-03-26 | 1989-10-05 | Boehringer Ingelheim Int | Expression vectors |
| GB8809093D0 (en) * | 1988-04-18 | 1988-05-18 | Erba Carlo Spa | Low molecular weight derivatives of prourokinase |
| AU5515790A (en) * | 1989-05-18 | 1990-11-22 | Green Cross Corporation, The | Human prourokinase variants, methods of producing same, dna sequences, plasmids and hosts therefor |
| IE901849A1 (en) * | 1989-07-19 | 1991-06-19 | Gruenenthal Gmbh | Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator |
-
1991
- 1991-01-22 DE DE4101736A patent/DE4101736A1/en not_active Withdrawn
- 1991-11-20 IE IE404091A patent/IE914040A1/en not_active Application Discontinuation
- 1991-11-27 IL IL100163A patent/IL100163A0/en unknown
-
1992
- 1992-01-09 RU SU5010518A patent/RU2108387C1/en active
- 1992-01-15 HU HU9200127A patent/HU212510B/en not_active IP Right Cessation
- 1992-01-20 ES ES92100864T patent/ES2164048T3/en not_active Expired - Lifetime
- 1992-01-20 AT AT92100864T patent/ATE204326T1/en not_active IP Right Cessation
- 1992-01-20 DK DK92100864T patent/DK0496327T3/en active
- 1992-01-20 PT PT92100864T patent/PT496327E/en unknown
- 1992-01-20 EP EP92100864A patent/EP0496327B1/en not_active Expired - Lifetime
- 1992-01-20 DE DE59209915T patent/DE59209915D1/en not_active Expired - Fee Related
- 1992-01-21 FI FI920263A patent/FI920263A/en unknown
- 1992-01-21 JP JP4008765A patent/JPH06169770A/en active Pending
-
1993
- 1993-12-06 LT LTIP1532A patent/LT3948B/en not_active IP Right Cessation
- 1993-12-08 LV LV931312A patent/LV10974A/en unknown
-
1998
- 1998-09-25 HK HK98110955A patent/HK1010108A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| LT3948B (en) | 1996-05-27 |
| HU212510B (en) | 1996-07-29 |
| FI920263A (en) | 1992-07-23 |
| IL100163A0 (en) | 1992-08-18 |
| DK0496327T3 (en) | 2001-12-03 |
| HUT63877A (en) | 1993-10-28 |
| LV10974A (en) | 1995-12-20 |
| IE914040A1 (en) | 1992-07-29 |
| LTIP1532A (en) | 1995-06-26 |
| FI920263A0 (en) | 1992-01-21 |
| PT496327E (en) | 2002-02-28 |
| EP0496327A1 (en) | 1992-07-29 |
| DE59209915D1 (en) | 2001-09-20 |
| EP0496327B1 (en) | 2001-08-16 |
| JPH06169770A (en) | 1994-06-21 |
| HU9200127D0 (en) | 1992-04-28 |
| ES2164048T3 (en) | 2002-02-16 |
| RU2108387C1 (en) | 1998-04-10 |
| DE4101736A1 (en) | 1992-07-23 |
| ATE204326T1 (en) | 2001-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20060120 |