KR940004072B1 - 라파마이신 전구체의 제조방법 - Google Patents

라파마이신 전구체의 제조방법 Download PDF

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Publication number
KR940004072B1
KR940004072B1 KR1019860010339A KR860010339A KR940004072B1 KR 940004072 B1 KR940004072 B1 KR 940004072B1 KR 1019860010339 A KR1019860010339 A KR 1019860010339A KR 860010339 A KR860010339 A KR 860010339A KR 940004072 B1 KR940004072 B1 KR 940004072B1
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KR
South Korea
Prior art keywords
rapamycin
acid
precursor
carbon atoms
acylating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019860010339A
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English (en)
Korean (ko)
Other versions
KR870006072A (ko
Inventor
죤 스텔라 발렌티노
에드윈 케네디 파울
Original Assignee
더 유니버시티 오브 캔사스
프란세스 디. 호로위츠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 더 유니버시티 오브 캔사스, 프란세스 디. 호로위츠 filed Critical 더 유니버시티 오브 캔사스
Publication of KR870006072A publication Critical patent/KR870006072A/ko
Application granted granted Critical
Publication of KR940004072B1 publication Critical patent/KR940004072B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019860010339A 1985-12-06 1986-12-04 라파마이신 전구체의 제조방법 Expired - Fee Related KR940004072B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US806152 1985-12-06
US06/806,152 US4650803A (en) 1985-12-06 1985-12-06 Prodrugs of rapamycin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019910022103A Division KR940004073B1 (ko) 1985-12-06 1991-12-04 라파마이신 전구체의 제조방법

Publications (2)

Publication Number Publication Date
KR870006072A KR870006072A (ko) 1987-07-09
KR940004072B1 true KR940004072B1 (ko) 1994-05-11

Family

ID=25193443

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019860010339A Expired - Fee Related KR940004072B1 (ko) 1985-12-06 1986-12-04 라파마이신 전구체의 제조방법
KR1019910022103A Expired - Fee Related KR940004073B1 (ko) 1985-12-06 1991-12-04 라파마이신 전구체의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019910022103A Expired - Fee Related KR940004073B1 (ko) 1985-12-06 1991-12-04 라파마이신 전구체의 제조방법

Country Status (16)

Country Link
US (1) US4650803A (enExample)
EP (1) EP0227355B1 (enExample)
JP (2) JPH0670066B2 (enExample)
KR (2) KR940004072B1 (enExample)
AT (1) ATE74134T1 (enExample)
AU (1) AU583439B2 (enExample)
CA (2) CA1273920A (enExample)
DE (1) DE3684574D1 (enExample)
DK (2) DK169409B1 (enExample)
ES (1) ES2032750T3 (enExample)
GB (1) GB2183647A (enExample)
GR (1) GR3004530T3 (enExample)
HU (1) HU198054B (enExample)
IE (1) IE64506B1 (enExample)
PT (1) PT83843B (enExample)
ZA (1) ZA869181B (enExample)

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GR3004530T3 (enExample) 1993-04-28
AU583439B2 (en) 1989-04-27
PT83843B (pt) 1989-01-17
ATE74134T1 (de) 1992-04-15
ES2032750T3 (es) 1993-03-01
EP0227355B1 (en) 1992-03-25
DK584886A (da) 1987-06-07
ZA869181B (en) 1988-07-27
DE3684574D1 (de) 1992-04-30
CA1273920A (en) 1990-09-11
HU198054B (en) 1989-07-28
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CA1312076C (en) 1992-12-29
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IE863198L (en) 1987-06-06
GB8628994D0 (en) 1987-01-14
DK169409B1 (da) 1994-10-24
IE64506B1 (en) 1995-08-09
KR940004073B1 (ko) 1994-05-11
KR870006072A (ko) 1987-07-09
GB2183647A (en) 1987-06-10
JPH0747593B2 (ja) 1995-05-24
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PT83843A (en) 1987-01-01
US4650803A (en) 1987-03-17

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