KR910000768A - 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법 - Google Patents

4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법 Download PDF

Info

Publication number
KR910000768A
KR910000768A KR1019900008394A KR900008394A KR910000768A KR 910000768 A KR910000768 A KR 910000768A KR 1019900008394 A KR1019900008394 A KR 1019900008394A KR 900008394 A KR900008394 A KR 900008394A KR 910000768 A KR910000768 A KR 910000768A
Authority
KR
South Korea
Prior art keywords
hydroxybutylidene
amino
bisphosphonic acid
salts
preparing
Prior art date
Application number
KR1019900008394A
Other languages
English (en)
Other versions
KR0137455B1 (ko
Inventor
알. 키자이코우스키 제랄드
비. 좁슨 로날드
지. 메릴로 데이비드
Original Assignee
제임스 에프. 너턴
머크 앤드 캄파니, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23431886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR910000768(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 제임스 에프. 너턴, 머크 앤드 캄파니, 인코포레이티드 filed Critical 제임스 에프. 너턴
Publication of KR910000768A publication Critical patent/KR910000768A/ko
Application granted granted Critical
Publication of KR0137455B1 publication Critical patent/KR0137455B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

4-아미노-1-하이드록시부틸리덴-1, 1-비스포스폰산 또는 이의 염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 메탄설폰산의 존재하에서 4-아미노부티르산을 아인산과 PCl3의 혼합물과 반응시킨 후, 4-아미노-1-하이드록시부틸리덴-1, 1-비스포스폰산 또는 이의 염을 회수함을 특징으로 하여, 4-아미노-1-하이드록시부틸리덴-1, 1-비스포스폰산 또는 이의 염을 제조하는 방법.
  2. 제 1항에 있어서, 반응을 45내지 125℃의 온도에서 수행하는 방법.
  3. 제 2항에 있어서, 반응을 약 65℃의 온도에서 수행하는 방법.
  4. 제 3항에 있어서, 4-아미노-1-하이드록시부틸리덴-1, 1-비스포스폰산 일나트륨염 삼수화물을 회수하는 방법.
  5. 제 3항에 있어서, 4-아미노-1-하이드록시부틸리덴-1, 1-비스포스폰산을 회수하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900008394A 1989-06-09 1990-06-08 4-아미노-1-하이드록시부틸리덴-1, 1-비스포스폰산 또는 이의 염의 제조방법 KR0137455B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US363,820 1989-06-09
US363820 1989-06-09
US07/363,820 US4922007A (en) 1989-06-09 1989-06-09 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Publications (2)

Publication Number Publication Date
KR910000768A true KR910000768A (ko) 1991-01-30
KR0137455B1 KR0137455B1 (ko) 1998-05-01

Family

ID=23431886

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900008394A KR0137455B1 (ko) 1989-06-09 1990-06-08 4-아미노-1-하이드록시부틸리덴-1, 1-비스포스폰산 또는 이의 염의 제조방법

Country Status (23)

Country Link
US (1) US4922007A (ko)
EP (1) EP0402152B1 (ko)
JP (2) JPH0662651B2 (ko)
KR (1) KR0137455B1 (ko)
AT (1) ATE129713T1 (ko)
AU (1) AU625704C (ko)
CA (1) CA2018477C (ko)
CH (1) CH0402152H1 (ko)
CY (1) CY1894A (ko)
DE (1) DE69023280T2 (ko)
DK (1) DK0402152T3 (ko)
ES (1) ES2080116T3 (ko)
FI (1) FI93219C (ko)
GR (1) GR3018379T3 (ko)
HK (1) HK69596A (ko)
HU (1) HU211908A9 (ko)
IE (1) IE69564B1 (ko)
IL (1) IL94612A (ko)
LV (1) LV11472B (ko)
NO (2) NO177997C (ko)
NZ (1) NZ233972A (ko)
PT (1) PT94306B (ko)
ZA (1) ZA904446B (ko)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356887A (en) * 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
SG47603A1 (en) * 1992-05-29 1998-04-17 Procter & Gamble Pharma Thio-substitute nitrogen containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
JPH07507315A (ja) * 1992-05-29 1995-08-10 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド カルシウムおよびホスフェート代謝異常治療用含硫ホスホネート化合物
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
CZ297094A3 (en) * 1992-05-29 1995-12-13 Procter & Gamble Pharma Phosphate compounds containing quaternary nitrogen, their use and pharmaceutical compositions containing thereof
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
FR2694558B1 (fr) * 1992-08-05 1994-10-28 Sanofi Elf Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
TW257765B (ko) * 1993-08-25 1995-09-21 Merck & Co Inc
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
US5589691A (en) * 1994-06-06 1996-12-31 Merck & Co., Inc. Process for recovery and recycle of methanesulfonic acid and phosphorous acid
US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
EP0809502A4 (en) * 1995-02-17 2001-12-05 Merck & Co Inc PROCESS FOR REDUCING THE RISK OF BONE FRACTURES OTHER THAN VERTEBRAL FRACTURES
EP0824341A4 (en) * 1995-05-12 1999-07-07 Merck & Co Inc PREVENTING TOOTH LOSS THROUGH ADMINISTRATION OF ALENDRONATE OR ITS SALTS
EP0831756A1 (en) 1995-06-06 1998-04-01 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
ATE289199T1 (de) * 1995-06-06 2005-03-15 Merck & Co Inc Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten
EP0837863A4 (en) * 1995-06-06 1999-06-16 Merck & Co Inc DISODIUM ALENDRONATE PREPARATIONS
AU723357B2 (en) * 1996-10-04 2000-08-24 Merck & Co., Inc. Liquid alendronate formulations
JP2824453B2 (ja) * 1996-10-15 1998-11-11 株式会社ワカ製作所 コネクター
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
IL122009A0 (en) * 1997-10-21 1998-03-10 Unipharm Ltd Salt of a bisphosphonic acid derivative
US6432931B1 (en) 1998-06-24 2002-08-13 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6008207A (en) * 1998-08-13 1999-12-28 Merck & Co., Inc. Anhydrous alendronate monosodium salt formulations
EP1702924A3 (en) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
RO122854B1 (ro) * 1998-08-27 2010-03-30 Teva Pharmaceutical Industries Ltd. Alendronat de sodiu hidrat, procedeu de obţinere şi compoziţie farmaceutică
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
US6160165A (en) * 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
AR021347A1 (es) 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
AU7902800A (en) * 1999-10-26 2001-05-08 A/S Gea Farmaceutisk Fabrik Novel salts of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid, their preparation and use
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
US6558702B2 (en) 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
CA2372450A1 (en) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB2383042A (en) * 2001-10-18 2003-06-18 Cipla Ltd Amorphous alendronate sodium
WO2003055496A1 (en) * 2001-12-21 2003-07-10 The Procter & Gamble Company Method for the treatment of bone disorders
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
CA2472578A1 (en) * 2002-01-24 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anti-cancer combination and use thereof
ITMI20020146A1 (it) * 2002-01-29 2003-07-29 Lyogen Ltd Alendronato monosodico amorfo e processo per la sua preparazione
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
KR20120065435A (ko) * 2002-05-10 2012-06-20 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
ATE461205T1 (de) * 2002-05-17 2010-04-15 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
JP2005534653A (ja) * 2002-06-06 2005-11-17 メルク フロスト カナダ アンド カンパニー 眼及び骨疾患の治療に於いてｅｐ４受容体作動薬として使用するための１，５−二置換イミダゾリジン−２−オン誘導体
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
EP1545517A1 (en) * 2002-08-28 2005-06-29 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
BR0309691A (pt) * 2002-12-20 2005-08-02 Hoffmann La Roche Formulação de ibandronato em alta dose
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005018581A2 (en) * 2003-08-12 2005-03-03 3M Innovative Properties Company Self-etching dental compositions and methods
US7411087B2 (en) * 2003-08-21 2008-08-12 Sun Pharmaceutical Industries Limited Process for preparation of bisphosphonic acid compounds
EP1673336B1 (en) 2003-08-21 2014-06-04 Merck Canada Inc. Cathepsin cysteine protease inhibitors
CA2539359A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
KR20080083068A (ko) 2004-05-24 2008-09-12 더 프록터 앤드 갬블 캄파니 킬레이팅제를 함유하는 비스포스포네이트의 고형의 장용 경구 투여 형태
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CA2573020A1 (en) * 2004-07-08 2006-02-09 3M Innovative Properties Company Dental methods, compositions, and kits including acid-sensitive dyes
EP1784155B1 (en) * 2004-08-11 2011-09-28 3M Innovative Properties Company Self-adhesive compositions including a plurality of acidic compounds
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
US7214818B2 (en) 2004-10-29 2007-05-08 Hoffmann-La Roche Inc. Method for synthesizing bisphosphonate
CN1304401C (zh) * 2004-12-28 2007-03-14 浙江工业大学 一种阿伦膦酸的制备方法
EP1855674B1 (en) 2005-03-02 2014-07-16 Merck Sharp & Dohme Corp. Composition for inhibition of cathepsin k
BRPI0606280A2 (pt) * 2005-03-17 2009-06-09 Elan Pharma Int Ltd composições de bisfosfonato nanoparticulado
EP1891081B1 (en) * 2005-06-13 2014-08-20 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
AR054673A1 (es) 2005-07-28 2007-07-11 Gador Sa Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
BRPI0618100B1 (pt) 2005-10-31 2018-03-27 Cabot Corporation Corantes modificados e composições de tinta para jatos de tinta compreendendo corantes modificados
ES2323728T3 (es) 2005-12-27 2009-07-23 Ipca Laboratories Limited Proceso mejorado para la fabricacion de 4-amino-hidroxibutilideno-1,1-bisfosfonico y sus sales.
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
EP2101716A2 (en) 2006-12-13 2009-09-23 3M Innovative Properties Company Methods of using a dental composition having an acidic component and a photobleachable dye
BRPI0809548A8 (pt) 2007-04-11 2018-10-16 Hoffmann La Roche processo para a preparação do sal ácido- (mono-hidratado)-3- (n-metil-n-pentil) amino-1-hidroxipropano-1, 1-difosfônico monossódico
WO2008157050A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
US20090197837A1 (en) * 2008-02-05 2009-08-06 Desai Vivek S Alendronate formulations, method of making and method of use thereof
US8026388B2 (en) * 2008-07-11 2011-09-27 Synthon Bv Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
US20120100206A1 (en) 2009-06-11 2012-04-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
EA201270328A1 (ru) 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
EP2484727A4 (en) 2009-09-30 2014-08-20 Dainippon Printing Co Ltd Ink Composition
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
EP2609101B1 (en) 2010-07-14 2015-01-28 Pharmathen S.A. Process for the preparation of 3-(n-methyl-n-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid salt or derivatives thereof
EP2598587B1 (en) 2010-07-30 2018-12-19 Cabot Corporation Polymeric pigment systems and methods
BR112013010476B1 (pt) 2010-12-06 2021-07-06 Effrx Pharmaceuticals Sa formulações efervescentes estáveis de bisfosfonato com características de solubilização rápida
CN103298620B (zh) 2010-12-27 2015-05-06 Dnp精细化工有限公司 喷墨记录方法
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
EP2692537B1 (en) 2011-03-29 2016-06-22 DNP Fine Chemicals Co., Ltd. Inkjet recording method and ink set for inkjet recording
PL2731591T3 (pl) 2011-07-13 2021-05-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomy zawierające bisfosfonian i środek amfipatyczny w wyniku ko-enkapsulacji
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
JP5722860B2 (ja) 2012-10-11 2015-05-27 株式会社Ｄｎｐファインケミカル 水性インクジェット受理溶液、この受理溶液を含むインクセット及びこのインクセットを用いたインクジェット記録方法
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
CN105593230B (zh) 2013-10-08 2018-07-06 默沙东公司 组织蛋白酶半胱氨酸蛋白酶抑制剂
JP5779630B2 (ja) 2013-11-27 2015-09-16 株式会社Ｄｎｐファインケミカル インクジェット記録用インク組成物、及びその製造方法、並びに、インクジェット記録方法
JP5676734B1 (ja) 2013-12-27 2015-02-25 株式会社Ｄｎｐファインケミカル インクジェット記録用インク組成物、インクジェット記録方法、及び印刷物の製造方法
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
CN104072538A (zh) * 2014-07-10 2014-10-01 陕西汉江药业集团股份有限公司 一种双膦酸盐类药物的合成方法
CN107849072B (zh) 2015-06-12 2020-12-15 西蒙弗雷泽大学 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途
EP3827010A4 (en) 2018-07-23 2022-03-16 Brise Pharmaceuticals Co., Ltd. BISPHOSPHONATE-DRUG CONJUGATES
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici

Also Published As

Publication number Publication date
NO178228C (no) 1996-02-14
HU211908A9 (en) 1996-01-29
CY1894A (en) 1990-06-08
CA2018477A1 (en) 1990-12-09
LV11472A (lv) 1996-08-20
DE69023280D1 (de) 1995-12-07
JPH0662651B2 (ja) 1994-08-17
CA2018477C (en) 1995-08-01
ZA904446B (en) 1992-06-24
NO902559L (no) 1990-12-10
IE69564B1 (en) 1996-10-02
LV11472B (en) 1996-12-20
PT94306B (pt) 1997-05-28
IL94612A (en) 1995-03-30
NZ233972A (en) 1992-05-26
IL94612A0 (en) 1991-04-15
KR0137455B1 (ko) 1998-05-01
NO902559D0 (no) 1990-06-08
ATE129713T1 (de) 1995-11-15
JPH03101684A (ja) 1991-04-26
PT94306A (pt) 1991-02-08
NO941726D0 (no) 1994-05-09
US4922007A (en) 1990-05-01
FI902845A0 (fi) 1990-06-07
EP0402152B1 (en) 1995-11-02
CH0402152H1 (fr) 2006-02-28
FI93219B (fi) 1994-11-30
IE902073L (en) 1990-12-09
NO177997B (no) 1995-09-25
HK69596A (en) 1996-04-26
NO177997C (no) 1996-01-03
GR3018379T3 (en) 1996-03-31
ES2080116T3 (es) 1996-02-01
EP0402152A3 (en) 1991-07-03
FI93219C (fi) 1995-03-10
NO941726L (no) 1990-12-10
AU625704C (en) 2001-07-26
JPH0748391A (ja) 1995-02-21
AU5701990A (en) 1990-12-13
DK0402152T3 (da) 1995-12-04
DE69023280T2 (de) 1996-06-20
EP0402152A2 (en) 1990-12-12
AU625704B2 (en) 1992-07-16
NO178228B (no) 1995-11-06

Similar Documents

Publication Publication Date Title
KR910000768A (ko) 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법
DK0462663T3 (da) Forbedret fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1,1-bisphosphonsyre (ABP) eller salte deraf
ATE1242T1 (de) Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure.
KR860004077A (ko) 7-할로-7-데옥시린코마이신, 클린다마이신 및 이들의 유사체의 제조방법
ATE16598T1 (de) Verfahren zur herstellung von sulfonierten arylphosphinen.
KR840007016A (ko) 결정성 세펨-산 부가염의 제조방법
DE58908590D1 (de) Verfahren zur Herstellung von 4,5-Dichlor-6-ethylpyrimidin.
KR900007859A (ko) N-아씰-아미노메틸 포스포네이트의 제조방법
KR890017264A (ko) N-포스포노메틸 글리신의 제조방법
KR830009077A (ko) 푸란 유도체의 제조방법
KR930002365A (ko) 리보플라빈 5'-포스페이트의 모노나트륨염의 제조방법
KR870007189A (ko) 유기포스피나이트의 제조방법
KR890009823A (ko) 2-(4-브로모페닐)-2-메틸 프로필 클로라이드의 제조방법
KR890002206A (ko) 페닐디클로로포스핀의 제조방법
KR880006253A (ko) 오염화인 및 염화암모늄으로부터 n-(디클로로포스포릴) 트리클로포스파젠의 제조방법
WO1995019341A3 (en) Process for making 5-nitrobarbituric acid and salts thereof
ATE16392T1 (de) Verfahren zur herstellung von dichlor-phenylphosphan.
ATE9792T1 (de) Verfahren zur herstellung von jodmethylthiocyanat.
KR860004074A (ko) N-포스포노 메틸 글리신 염의 제조방법
KR840000572A (ko) 유기 게르마늄 화합물의 제조방법
ATE45952T1 (de) Verfahren zur herstellung von o-alkyl-s-(alphaverzweigtes alkyl)alkylphosphonothioate.
KR900000375A (ko) N,n,n-트리메틸-2-(포스포옥시)에탄아미늄클로라이드 금속 염류의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
O035 Opposition [patent]: request for opposition
O035 Opposition [patent]: request for opposition
J210 Request for trial for objection to revocation decision
J301 Trial decision

Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION OF CANCELLATION REQUESTED 19991018

Effective date: 20010831

Free format text: TRIAL NUMBER: 1999103000019; TRIAL DECISION FOR APPEAL AGAINST DECISION OF CANCELLATION REQUESTED 19991018

Effective date: 20010831

Free format text: TRIAL NUMBER: 1999103000018; TRIAL DECISION FOR APPEAL AGAINST DECISION OF CANCELLATION REQUESTED 19991018

Effective date: 20010831

S901 Examination by remand of revocation
E902 Notification of reason for refusal
O132 Decision on opposition [patent]
J210 Request for trial for objection to revocation decision
J801 Dismissal of trial

Free format text: REJECTION OF TRIAL FOR APPEAL AGAINST DECISION OF CANCELLATION REQUESTED 20050224

Effective date: 20050803

Free format text: TRIAL NUMBER: 2005103000059; REJECTION OF TRIAL FOR APPEAL AGAINST DECISION OF CANCELLATION REQUESTED 20050224

Effective date: 20050803

Free format text: TRIAL NUMBER: 2005103000060; REJECTION OF TRIAL FOR APPEAL AGAINST DECISION OF CANCELLATION REQUESTED 20050224

Effective date: 20050803

FPAY Annual fee payment

Payment date: 20120131

Year of fee payment: 15

EXPY Expiration of term