NO178228C - Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,2-bisfosfonsyresalter - Google Patents

Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,2-bisfosfonsyresalter

Info

Publication number
NO178228C
NO178228C NO941726A NO941726A NO178228C NO 178228 C NO178228 C NO 178228C NO 941726 A NO941726 A NO 941726A NO 941726 A NO941726 A NO 941726A NO 178228 C NO178228 C NO 178228C
Authority
NO
Norway
Prior art keywords
amino
hydroxybutylidene
preparation
bisphosphonic acid
acid salts
Prior art date
Application number
NO941726A
Other languages
English (en)
Other versions
NO941726D0 (no
NO941726L (no
NO178228B (no
Inventor
Gerard R Kieczykowski
Ronald B Jobson
David G Melillo
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23431886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO178228(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of NO941726L publication Critical patent/NO941726L/no
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority to NO941726A priority Critical patent/NO178228C/no
Publication of NO941726D0 publication Critical patent/NO941726D0/no
Publication of NO178228B publication Critical patent/NO178228B/no
Publication of NO178228C publication Critical patent/NO178228C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
NO941726A 1989-06-09 1994-05-09 Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,2-bisfosfonsyresalter NO178228C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO941726A NO178228C (no) 1989-06-09 1994-05-09 Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,2-bisfosfonsyresalter

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/363,820 US4922007A (en) 1989-06-09 1989-06-09 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
NO902559A NO177997C (no) 1989-06-09 1990-06-08 Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,1-bisfosfonsyre
NO941726A NO178228C (no) 1989-06-09 1994-05-09 Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,2-bisfosfonsyresalter

Publications (4)

Publication Number Publication Date
NO941726L NO941726L (no) 1990-12-10
NO941726D0 NO941726D0 (no) 1994-05-09
NO178228B NO178228B (no) 1995-11-06
NO178228C true NO178228C (no) 1996-02-14

Family

ID=23431886

Family Applications (2)

Application Number Title Priority Date Filing Date
NO902559A NO177997C (no) 1989-06-09 1990-06-08 Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,1-bisfosfonsyre
NO941726A NO178228C (no) 1989-06-09 1994-05-09 Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,2-bisfosfonsyresalter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO902559A NO177997C (no) 1989-06-09 1990-06-08 Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,1-bisfosfonsyre

Country Status (23)

Country Link
US (1) US4922007A (no)
EP (1) EP0402152B1 (no)
JP (2) JPH0662651B2 (no)
KR (1) KR0137455B1 (no)
AT (1) ATE129713T1 (no)
AU (1) AU625704C (no)
CA (1) CA2018477C (no)
CH (1) CH0402152H1 (no)
CY (1) CY1894A (no)
DE (1) DE69023280T2 (no)
DK (1) DK0402152T3 (no)
ES (1) ES2080116T3 (no)
FI (1) FI93219C (no)
GR (1) GR3018379T3 (no)
HK (1) HK69596A (no)
HU (1) HU211908A9 (no)
IE (1) IE69564B1 (no)
IL (1) IL94612A (no)
LV (1) LV11472B (no)
NO (2) NO177997C (no)
NZ (1) NZ233972A (no)
PT (1) PT94306B (no)
ZA (1) ZA904446B (no)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356887A (en) * 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
RU2136691C1 (ru) * 1992-05-29 1999-09-10 Дзе Проктер энд Гэмбл Фармасьютикалз, Инк. Серусодержащие фосфоновые кислоты или их фармацевтически приемлемые соли или эфиры и фармацевтическая композиция на их основе
DE69319732T2 (de) * 1992-05-29 1999-02-11 Procter & Gamble Pharmaceuticals, Inc., Norwich, N.Y. Quaternare stickstoff-enthaltende phosphonat-verbindungen zur behandlung abnormalen calzium und phosphat-metabolismus sowie zahnsteinbildung
WO1993024500A1 (en) * 1992-05-29 1993-12-09 The Procter & Gamble Pharmaceuticals, Inc. Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
FR2694558B1 (fr) * 1992-08-05 1994-10-28 Sanofi Elf Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
TW257765B (no) * 1993-08-25 1995-09-21 Merck & Co Inc
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
US5589691A (en) * 1994-06-06 1996-12-31 Merck & Co., Inc. Process for recovery and recycle of methanesulfonic acid and phosphorous acid
US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
PL321835A1 (en) * 1995-02-17 1997-12-22 Merck & Co Inc Method of reducing the risk of non-vertebral bone fracture
JPH10506638A (ja) * 1995-05-12 1998-06-30 メルク エンド カンパニー インコーポレーテッド アレンドロネート又はその塩の投与による歯喪失の予防
AU5973496A (en) 1995-06-06 1996-12-24 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
JP3344726B2 (ja) * 1995-06-06 2002-11-18 メルク エンド カンパニー インコーポレーテッド 無水アレンドロネート一ナトリウム塩製剤
EP0837863A4 (en) * 1995-06-06 1999-06-16 Merck & Co Inc DISODIUM ALENDRONATE PREPARATIONS
TR199900730T2 (xx) * 1996-10-04 1999-07-21 Merck & Co., Inc S�v� alendronat form�lasyonlar�
JP2824453B2 (ja) * 1996-10-15 1998-11-11 株式会社ワカ製作所 コネクター
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
IL122009A0 (en) * 1997-10-21 1998-03-10 Unipharm Ltd Salt of a bisphosphonic acid derivative
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
AU757104B2 (en) 1998-06-24 2003-01-30 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6008207A (en) * 1998-08-13 1999-12-28 Merck & Co., Inc. Anhydrous alendronate monosodium salt formulations
CZ2001629A3 (cs) 1998-08-27 2001-08-15 Teva Pharmaceutical Industries Ltd. Nové formy hydrátů alendronátu sodného, způsob jejich výroby a farmaceutické kompozice na jejich bázi
EP1702924A3 (en) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
US6160165A (en) * 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
AR021347A1 (es) 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
AU7902800A (en) * 1999-10-26 2001-05-08 A/S Gea Farmaceutisk Fabrik Novel salts of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid, their preparation and use
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
US6558702B2 (en) 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
CA2347330C (en) * 2001-05-10 2002-03-12 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
GB2383042A (en) * 2001-10-18 2003-06-18 Cipla Ltd Amorphous alendronate sodium
PL371264A1 (en) * 2001-12-21 2005-06-13 The Procter & Gamble Company Method for the treatment of bone disorders
US20050070504A1 (en) * 2001-12-21 2005-03-31 The Procter & Gamble Co. Risedronate compositions and their methods of use
JP4502641B2 (ja) * 2002-01-24 2010-07-14 ティルタン ファーマ リミテッド 抗癌組み合わせおよびその使用方法
ITMI20020146A1 (it) * 2002-01-29 2003-07-29 Lyogen Ltd Alendronato monosodico amorfo e processo per la sua preparazione
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
ES2532393T3 (es) * 2002-05-10 2015-03-26 F. Hoffmann-La Roche Ag Acidos bisfosfónicos para tratamiento y prevención de osteoporosis
WO2003097655A1 (en) * 2002-05-17 2003-11-27 Teva Pharmaceutical Industries Ltd. Use of certain diluents for making bisphosphonic acids
WO2003103664A1 (en) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
US7109223B2 (en) * 2002-08-28 2006-09-19 Merck & Co. Inc. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EP4 receptor agonists in the treatment of glaucoma
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
RU2315603C2 (ru) * 2002-12-20 2008-01-27 Ф.Хоффманн-Ля Рош Аг Композиция с высокой дозой ибандроната
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
AU2004266623B8 (en) * 2003-08-12 2011-10-27 3M Deutschland Gmbh Self-etching dental compositions and methods
PL1656386T3 (pl) 2003-08-21 2010-05-31 Sun Pharmaceuticals Ind Ltd Proces wytwarzania związków kwasu difosfonowego
WO2005019161A1 (en) 2003-08-21 2005-03-03 Merck Frosst Canada Ltd. Cathepsin cysteine protease inhibitors
NZ545804A (en) * 2003-09-19 2009-09-25 Wisconsin Alumni Res Found Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-or-vitamin D derivatives and a bisphosphonate
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
DK1753395T3 (da) 2004-05-24 2010-11-08 Warner Chilcott Co Llc Enterisk, fast, oral doseringsform af et bisphosphonat, der indeholder et chelateringsmiddel
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CA2573020A1 (en) * 2004-07-08 2006-02-09 3M Innovative Properties Company Dental methods, compositions, and kits including acid-sensitive dyes
JP5037342B2 (ja) * 2004-08-11 2012-09-26 スリーエム イノベイティブ プロパティズ カンパニー 複数の酸性化合物を含む粘着性組成物
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
US7214818B2 (en) 2004-10-29 2007-05-08 Hoffmann-La Roche Inc. Method for synthesizing bisphosphonate
CN1304401C (zh) * 2004-12-28 2007-03-14 浙江工业大学 一种阿伦膦酸的制备方法
SI1855674T1 (sl) 2005-03-02 2014-10-30 Merck Sharp & Dohme Corp. Sestavek za inhibicijo katepsina k
NZ561666A (en) * 2005-03-17 2010-05-28 Elan Pharma Int Ltd Nanoparticulate biphosphonate compositions
EP1891081B1 (en) * 2005-06-13 2014-08-20 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
AR054673A1 (es) 2005-07-28 2007-07-11 Gador Sa Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
DE602006013689D1 (de) 2005-10-31 2010-05-27 Cabot Corp Modifizierte farbmittel und modifizierte farbmittel enthaltende farbstrahltintenzusammensetzungen
PT1803727E (pt) 2005-12-27 2009-06-15 Ipca Lab Ltd Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
US9943465B2 (en) 2006-12-13 2018-04-17 3M Innovative Properties Company Methods of using a dental composition having an acidic component and a photobleachable dye
EP2144919B1 (en) 2007-04-11 2015-12-02 F. Hoffmann-La Roche AG Multi step synthesis of ibandronate
WO2008157050A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
CN101932306A (zh) * 2008-02-05 2010-12-29 阿特维斯集团公司 阿仑膦酸盐制剂、其制备方法和使用方法
EP2310398A2 (en) * 2008-07-11 2011-04-20 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
WO2010143193A1 (en) 2009-06-11 2010-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
EA201270328A1 (ru) 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
WO2011040517A1 (ja) 2009-09-30 2011-04-07 大日本印刷株式会社 インク組成物
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
EP2609101B1 (en) 2010-07-14 2015-01-28 Pharmathen S.A. Process for the preparation of 3-(n-methyl-n-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid salt or derivatives thereof
US9056991B2 (en) 2010-07-30 2015-06-16 Cabot Corporation Polymeric pigment systems and methods
RU2608724C2 (ru) 2010-12-06 2017-01-23 Эффэрикс Фармасьютикалз Са Стабильные составы шипучего бисфосфоната со свойствами быстрой солюбилизации
EP2660066B1 (en) 2010-12-27 2016-04-20 DNP Fine Chemicals Co., Ltd. Inkjet recording method
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
CA2831368C (en) 2011-03-29 2014-12-16 Dai Nippon Printing Co., Ltd. Inkjet recording method and ink set for inkjet recording
US10085940B2 (en) 2011-07-13 2018-10-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomes co-encapsulating a bisphosphonate and an amphipathic agent
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
JP5722860B2 (ja) 2012-10-11 2015-05-27 株式会社Ｄｎｐファインケミカル 水性インクジェット受理溶液、この受理溶液を含むインクセット及びこのインクセットを用いたインクジェット記録方法
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
CN105593230B (zh) 2013-10-08 2018-07-06 默沙东公司 组织蛋白酶半胱氨酸蛋白酶抑制剂
JP5779630B2 (ja) 2013-11-27 2015-09-16 株式会社Ｄｎｐファインケミカル インクジェット記録用インク組成物、及びその製造方法、並びに、インクジェット記録方法
JP5676734B1 (ja) 2013-12-27 2015-02-25 株式会社Ｄｎｐファインケミカル インクジェット記録用インク組成物、インクジェット記録方法、及び印刷物の製造方法
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
CN104072538A (zh) * 2014-07-10 2014-10-01 陕西汉江药业集团股份有限公司 一种双膦酸盐类药物的合成方法
CA2988523A1 (en) 2015-06-12 2016-12-15 Simon Fraser University Amide-linked ep4 agonist-bisphosphonate compounds and uses thereof
CN112867724B (zh) 2018-07-23 2024-06-04 熙源安健医药(北京)有限公司 二膦酸盐药物缀合物
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici

Also Published As

Publication number Publication date
NO941726D0 (no) 1994-05-09
ES2080116T3 (es) 1996-02-01
NO177997B (no) 1995-09-25
KR910000768A (ko) 1991-01-30
DE69023280D1 (de) 1995-12-07
AU5701990A (en) 1990-12-13
NO941726L (no) 1990-12-10
AU625704C (en) 2001-07-26
PT94306B (pt) 1997-05-28
DE69023280T2 (de) 1996-06-20
ZA904446B (en) 1992-06-24
JPH0662651B2 (ja) 1994-08-17
EP0402152A2 (en) 1990-12-12
NO178228B (no) 1995-11-06
GR3018379T3 (en) 1996-03-31
EP0402152B1 (en) 1995-11-02
JPH03101684A (ja) 1991-04-26
KR0137455B1 (ko) 1998-05-01
JPH0748391A (ja) 1995-02-21
EP0402152A3 (en) 1991-07-03
NO902559L (no) 1990-12-10
HK69596A (en) 1996-04-26
IE902073L (en) 1990-12-09
CY1894A (en) 1990-06-08
FI93219C (fi) 1995-03-10
CH0402152H1 (fr) 2006-02-28
NO902559D0 (no) 1990-06-08
HU211908A9 (en) 1996-01-29
FI902845A0 (fi) 1990-06-07
AU625704B2 (en) 1992-07-16
LV11472B (en) 1996-12-20
PT94306A (pt) 1991-02-08
CA2018477A1 (en) 1990-12-09
ATE129713T1 (de) 1995-11-15
DK0402152T3 (da) 1995-12-04
IL94612A (en) 1995-03-30
CA2018477C (en) 1995-08-01
NO177997C (no) 1996-01-03
LV11472A (lv) 1996-08-20
IE69564B1 (en) 1996-10-02
FI93219B (fi) 1994-11-30
NZ233972A (en) 1992-05-26
IL94612A0 (en) 1991-04-15
US4922007A (en) 1990-05-01

Similar Documents

Publication Publication Date Title
NO178228C (no) Fremgangsmåte for fremstilling av 4-amino-1-hydroxybutyliden-1,2-bisfosfonsyresalter
DK0462663T3 (da) Forbedret fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1,1-bisphosphonsyre (ABP) eller salte deraf
BR9807568A (pt) Processo para a produção de ácido 4-amino-1-hidroxibutilideno-1
DK199489A (da) Fremgangsmaade til fremstilling af n-t-alkyl-1,2-diacylhydraziner
DE3067924D1 (en) A partial thromboplastine
DK0494844T3 (da) Fremgangsmåde til fremstilling af diphosphonsyre og salte deraf
PT96211A (pt) Processo para a preparacao de 2-acilamino-6-halogeno-purina a partir de 2,9-diacilguanina
BR9004018A (pt) Processo para a preparacao de tris(2,4-di-terc-butilfenil)fosfito

Legal Events

Date Code Title Description
MK1K Patent expired