ATE129713T1 - Kristalline 4-amino-1-hydroxybutyliden-1,1- bisphosphon-säure, verfahren zu ihrer herstellung, zusammensetzungen und deren verwendung. - Google Patents

Kristalline 4-amino-1-hydroxybutyliden-1,1- bisphosphon-säure, verfahren zu ihrer herstellung, zusammensetzungen und deren verwendung.

Info

Publication number
ATE129713T1
ATE129713T1 AT90306238T AT90306238T ATE129713T1 AT E129713 T1 ATE129713 T1 AT E129713T1 AT 90306238 T AT90306238 T AT 90306238T AT 90306238 T AT90306238 T AT 90306238T AT E129713 T1 ATE129713 T1 AT E129713T1
Authority
AT
Austria
Prior art keywords
acid
amino
hydroxybutylidene
bisphosphonoic
crystalline
Prior art date
Application number
AT90306238T
Other languages
English (en)
Inventor
Gerald R Kieczykowski
David G Melillo
Ronald B Jobson
Gerald S Brenner
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23431886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE129713(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE129713T1 publication Critical patent/ATE129713T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Seasonings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT90306238T 1989-06-09 1990-06-08 Kristalline 4-amino-1-hydroxybutyliden-1,1- bisphosphon-säure, verfahren zu ihrer herstellung, zusammensetzungen und deren verwendung. ATE129713T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/363,820 US4922007A (en) 1989-06-09 1989-06-09 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Publications (1)

Publication Number Publication Date
ATE129713T1 true ATE129713T1 (de) 1995-11-15

Family

ID=23431886

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90306238T ATE129713T1 (de) 1989-06-09 1990-06-08 Kristalline 4-amino-1-hydroxybutyliden-1,1- bisphosphon-säure, verfahren zu ihrer herstellung, zusammensetzungen und deren verwendung.

Country Status (23)

Country Link
US (1) US4922007A (de)
EP (1) EP0402152B1 (de)
JP (2) JPH0662651B2 (de)
KR (1) KR0137455B1 (de)
AT (1) ATE129713T1 (de)
AU (1) AU625704C (de)
CA (1) CA2018477C (de)
CH (1) CH0402152H1 (de)
CY (1) CY1894A (de)
DE (1) DE69023280T2 (de)
DK (1) DK0402152T3 (de)
ES (1) ES2080116T3 (de)
FI (1) FI93219C (de)
GR (1) GR3018379T3 (de)
HK (1) HK69596A (de)
HU (1) HU211908A9 (de)
IE (1) IE69564B1 (de)
IL (1) IL94612A (de)
LV (1) LV11472B (de)
NO (2) NO177997C (de)
NZ (1) NZ233972A (de)
PT (1) PT94306B (de)
ZA (1) ZA904446B (de)

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DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici

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CH0402152H1 (fr) 2006-02-28
KR0137455B1 (ko) 1998-05-01
JPH03101684A (ja) 1991-04-26
NO177997C (no) 1996-01-03
CA2018477A1 (en) 1990-12-09
PT94306A (pt) 1991-02-08
AU5701990A (en) 1990-12-13
NO178228B (no) 1995-11-06
FI93219C (fi) 1995-03-10
KR910000768A (ko) 1991-01-30
ES2080116T3 (es) 1996-02-01
IL94612A (en) 1995-03-30
LV11472B (en) 1996-12-20
EP0402152A3 (de) 1991-07-03
ZA904446B (en) 1992-06-24
AU625704C (en) 2001-07-26
NO178228C (no) 1996-02-14
AU625704B2 (en) 1992-07-16
DE69023280D1 (de) 1995-12-07
EP0402152B1 (de) 1995-11-02
FI902845A0 (fi) 1990-06-07
US4922007A (en) 1990-05-01
DE69023280T2 (de) 1996-06-20
JPH0662651B2 (ja) 1994-08-17
NO941726L (no) 1990-12-10
CA2018477C (en) 1995-08-01
GR3018379T3 (en) 1996-03-31
HU211908A9 (en) 1996-01-29
FI93219B (fi) 1994-11-30
NO902559D0 (no) 1990-06-08
IE902073L (en) 1990-12-09
NZ233972A (en) 1992-05-26
NO177997B (no) 1995-09-25
PT94306B (pt) 1997-05-28
IL94612A0 (en) 1991-04-15
CY1894A (en) 1990-06-08
EP0402152A2 (de) 1990-12-12
LV11472A (lv) 1996-08-20
DK0402152T3 (da) 1995-12-04
NO902559L (no) 1990-12-10
NO941726D0 (no) 1994-05-09
JPH0748391A (ja) 1995-02-21
HK69596A (en) 1996-04-26
IE69564B1 (en) 1996-10-02

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