ATE220404T1 - Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure - Google Patents

Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure

Info

Publication number
ATE220404T1
ATE220404T1 AT98902890T AT98902890T ATE220404T1 AT E220404 T1 ATE220404 T1 AT E220404T1 AT 98902890 T AT98902890 T AT 98902890T AT 98902890 T AT98902890 T AT 98902890T AT E220404 T1 ATE220404 T1 AT E220404T1
Authority
AT
Austria
Prior art keywords
hydroxybutylidene
amino
producing
acid
biphosphonic acid
Prior art date
Application number
AT98902890T
Other languages
English (en)
Inventor
Rudolf Kubela
Yong Tao
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Application granted granted Critical
Publication of ATE220404T1 publication Critical patent/ATE220404T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
AT98902890T 1997-02-11 1998-02-06 Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure ATE220404T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002197267A CA2197267C (en) 1997-02-11 1997-02-11 Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PCT/CA1998/000091 WO1998034940A1 (en) 1997-02-11 1998-02-06 Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid

Publications (1)

Publication Number Publication Date
ATE220404T1 true ATE220404T1 (de) 2002-07-15

Family

ID=4159900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98902890T ATE220404T1 (de) 1997-02-11 1998-02-06 Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure

Country Status (12)

Country Link
US (1) US5908959A (de)
EP (1) EP0971938B1 (de)
AT (1) ATE220404T1 (de)
AU (1) AU728164B2 (de)
BR (1) BR9807568A (de)
CA (1) CA2197267C (de)
DE (1) DE69806470T2 (de)
DK (1) DK0971938T3 (de)
ES (1) ES2180141T3 (de)
PL (1) PL335053A1 (de)
PT (1) PT971938E (de)
WO (1) WO1998034940A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ513551A (en) * 1999-02-17 2003-02-28 Teva Pharma Novel process for preparing alendronic acid
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6562974B2 (en) * 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
EP1465606A4 (de) * 2001-12-24 2009-04-22 Teva Pharma Dosierungsform mit einem von einem verpressten ringförmigen körper aus pulver- oder granulatmaterial umhüllten tablettenkern aus aktivem bestandteil sowie verfahren und gerät zur herstellung davon
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
CA2485443C (en) * 2002-05-17 2010-04-06 Teva Pharmaceutical Industries Ltd Use of aromatic hydrocarbons and silicone fluids for making bisphosphonic acids
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
HUP0300227A2 (hu) 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20040213917A1 (en) * 2003-04-23 2004-10-28 Courtney Douglas L. Spray booth and filter system
ES2337063T3 (es) 2003-08-21 2010-04-20 Sun Pharmaceuticals Industries Ltd. Proceso para la preparacion de acido bisfosfonico.
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
EP1891081B1 (de) * 2005-06-13 2014-08-20 Jubilant Organosys Limited Verfahren zur herstellung von bisphosphonsäuren und formen davon
US8003820B2 (en) 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
ATE425171T1 (de) 2005-12-27 2009-03-15 Ipca Lab Ltd Verbesserter herstellungsprozess von 4-amino- hydroxybutyliden-1,1-bisphosphonischer säure und ihrer salze
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CA2646418A1 (en) * 2006-03-21 2007-09-27 Albemarle Corporation Process for manufacturing bisphosphonic acids
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
KR20090005206A (ko) 2006-05-11 2009-01-12 인드-스위프트 래버러토리즈 리미티드 순수한 리세드론산 또는 염의 제조 방법
EP2041148A1 (de) * 2006-07-03 2009-04-01 Generics Ýuk¨Limited Neues verfahren zur herstellung von bisphosphonsäuren
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
CA2689504A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
WO2010003704A2 (en) 2008-07-11 2010-01-14 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
WO2010060619A1 (en) * 2008-11-26 2010-06-03 Synthon B.V. Process for making zoledronic acid
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
EP2192126B1 (de) 2008-11-26 2013-03-27 Synthon B.V. Verfahren zur Herstellung von Zoledronsäure
EA201270328A1 (ru) 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
WO2011039378A1 (en) 2009-10-02 2011-04-07 Straitmark Holding Ag Method for the manufacture of aminohydroxy diphosphonic acids

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163733A (en) * 1977-10-25 1979-08-07 Buckman Laboratories, Inc. Synergistic compositions for corrosion and scale control
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Also Published As

Publication number Publication date
BR9807568A (pt) 2000-03-21
PT971938E (pt) 2002-11-29
US5908959A (en) 1999-06-01
WO1998034940A1 (en) 1998-08-13
CA2197267C (en) 2000-02-08
ES2180141T3 (es) 2003-02-01
AU5977298A (en) 1998-08-26
CA2197267A1 (en) 1998-08-11
MX9801171A (es) 1998-12-31
EP0971938A1 (de) 2000-01-19
AU728164B2 (en) 2001-01-04
EP0971938B1 (de) 2002-07-10
DE69806470T2 (de) 2003-02-20
DK0971938T3 (da) 2002-10-14
PL335053A1 (en) 2000-03-27
DE69806470D1 (de) 2002-08-14

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